Novel gene functionally related to dyslexia

ABSTRACT

The present invention describes a novel human gene, DYXC1, which is functionally related to dyslexia. DYXC1 gene encodes a 420-amino acid residue protein. DYXC1 is expressed in several tissues, including the brain, and is localized in the nucleus. In addition, four single nucleotide polymorphisms (SNPs) in DYXC1 mRNA have been characterized in this invention. The invention provides diagnostic methods and materials for analysing allelic variation in DYXC1 gene. This invention also provides polypeptides encoded by DYXC1 gene and antibodies binding to said polypeptides.

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority under 35 U.S.C. § 120 to PCTInternational Application No. PCT/FI03/00110, which has an internationalfiling date of Feb. 12, 2003, which designated the United States, whichclaims priority under 35 U.S.C. § 119(e) to U.S. Provisional ApplicationNo. 60/355,782, filed on Feb. 12, 2002. This application is also aContinuation-in-Part of copending application Ser. No. 10/364,505, filedon Feb. 12, 2003, which claims priority under 35 U.S.C. § 119(e) to U.S.Provisional Application No. 60/355,782, filed on Feb. 12, 2002. Theentire contents of all of the above application are hereby incorporatedby reference.

[0002] The present invention relates to a novel human gene functionallyrelated to dyslexia, especially variant forms (e.g. alleles) thereofthat predispose an individual to develop dyslexia. Thus, this inventionalso relates to the polymorphism of said gene as well as diagnosticmethods and materials for analysing allelic variation in said gene. Thisinvention also provides polypeptides encoded by said gene and antibodiesbinding to said polypeptides. The materials of the invention can be usedto study the brain processes such as reading, phonological processing,rapid naming and verbal short term memory.

BACKGROUND OF THE INVENTION

[0003] Dyslexia, or specific reading disability, is the most commonchildhood learning disorder. It is estimated that about 3-10% of peoplehave specific difficulties in reading, despite adequate intelligence,education and social environment. Several different theories have beenput forth to account for the diverse symptoms seen in dyslexic subjects.At present, it is thought that dyslexia is primarily a phonologicaldeficit, emphasizing the linguistic basis of this condition (1-3).However, it is possible that dyslexia is not specific to language.Rather, it may result from a deficit in processing fast temporal data,be it visual or auditory. This temporal processing deficit would,consequently, manifest itself primarily as dyslexia (4).

[0004] Available evidence suggests that dyslexia is a neurologicaldisorder with a genetic basis. Functional brain imaging studies haveillustrated that dyslexia has universal neurobiological correlates (5).There is extensive evidence of genetic factors which contribute todyslexia. There are significant differences, however, in theheritability of different components of dyslexia (6). Linkage andassociation studies have pinpointed several loci for dyslexia. Inparticular, two loci have been promising. DYX1 in chromosome 15q21 wasthe first locus to be associated with dyslexia (7), and the results havebeen replicated in three independent studies thereafter (8-10). Thepresence of a second dyslexia locus, DYX2, in chromosome 6p21 has alsobeen established (11).

[0005] We have previously reported a translocation t(2; 15)(q11;q21)which segregates with dyslexia (12). In the present invention, we havecloned the breakpoint and narrowed down the breakpoint interval within a3229 bp region with Southern hybridization. This region contains a 301bp AT rich sequence. Considering that AT rich repeats are known to occurat many chromosomal rearrangement sites (13), the 301 bp AT richsequence is likely to be the exact breakpoint site. Furthermore, we haveunexpectedly discovered and characterized a novel gene residing in thebreakpoint region, which gene we named DYXC1 and which is causallycorrelated with dyslexia.

[0006] A candidate gene for developmental dyslexia is disclosed inTaipale et al. (Proceedings of the National Academic of Sciences100:11553-11558, 2003), which is incorporated herein by reference.

SUMMARY OF THE INVENTION

[0007] The present invention describes a novel human gene, DYXC1, whichis causally correlated with dyslexia. The coding sequence of DYXC1 is1260 bp in length (SEQ ID NO: 1), and it encodes a predicted protein of420 amino acids (SEQ ID NO: 3). DYXC1 is expressed in several tissues,most abundantly in brain, lung, kidney and testis. DYXC1 protein residesin cell nuclei, and in brain, it localizes to a subset of corticalneurons and glial cells. DYXC1 protein appears rapidly upregulated andtranslocated after brain ischemia. The predicted 420 amino-acid proteincontains three C-terminal tetratricopeptide repeat (TPR) domains,thought to mediate protein-protein interactions. Besides these domains,it bears no similarity to known proteins. Transfection andimmunofluorescence studies indicate that DYXC1 is a nuclear protein.

[0008] The coding sequence of DYXC1 was predicted from the genomicsequence of BAC clones RP11-178D12 and CTD-2137J4. The length of DYXC1mRNA is 1993 bp (SEQ ID NO: 2), and it encodes a predicted protein of420 amino acids. DYXC1 consists of 10 exons spanning approximately 78 kbof genomic DNA (FIG. 1D). The start codon (AUG) of DYXC1 is located 369bp from the predicted transcription initiation site in exon 2. Putativepromoter of DYXC1 has a TATA box (TATAAAT) at position −31.

[0009] In one aspect, the invention features isolated DYXC1 nucleic acidmolecules having the sequence of SEQ ID NO:1 or a complement thereof;homologs and variants thereof as well as fragments thereof. In apreferred embodiment the isolated DYXC1 nucleic acid is mammalian. In aneven more preferred embodiment the isolated DYXC1 nucleic acid is from aprimate, most preferably the DYXC1 nucleic acid is human. The inventionfeatures also vectors comprising the disclosed nucleic acid as well ashost cells for the expression or amplification of such vectors.

[0010] In addition, we have characterized in this invention five singlenucleotide polymorphisms (SNPs) in DYXC1 mRNA. One sequence variant(1249G→T) introduces a premature stop codon and is inherited withdyslexia in a three-generation family. The frequency of the polymorphismis significantly (p=0.0278) elevated in dyslexic subjects, compared tocontrol samples. The polymorphism truncates the predicted DYXC1 proteinby four amino acids, suggesting that it is a functional SNP. Thus, inanother aspect, the invention features nucleic acids comprising at leastone single nucleotide polymorphism in any one of the following positionsas defined by SEQ ID NO: 1: position 4 (C preferably to T), 572 (Gpreferably to A), 1249 (G preferably to T), 1259 (C preferably to G);and SEQ ID NO:2: position 205 (C preferably to T).

[0011] The invention further provides polypeptides encoded by DYXC1 geneor allelic variants thereof and antibodies binding to said polypeptides.The invention also relates to diagnostic methods, kits and materials foranalysing allelic variation in DYXC1 gene and its cellular function.

DESCRIPTION OF THE DRAWINGS

[0012]FIGS. 1A, 1B, 1C and 1D. 1A, Pedigree of the studied family. Blackfill denotes translocation, grey fill dyslexia. 1B, Fluorescent in situhybridization with BAC clone 178D12 as a probe, showing hybridisationsignals in chromosomes 15, der(15), and der(2). 1C, Southernhybridization with a probe derived from 178D12 shows genomicrearrangement with six restriction enzymes in the studied sample (T)compared to the control sample (C). 1D, Physical map of the breakpointregion, including DYXC1 (black) and an intronic pseudogene (white),drawn to scale. Black triangle illustrates the Southern hybridisationprobe position, grey bar denotes the breakpoint interval.

[0013]FIGS. 2A, 2B, 2C, 2D and 2E. 2A, Comparison of the proteinsequences of human DYXC1 and mouse mdyxc1. The SNPs found in thisinvention are marked with a circumflex accent, and the three TPR domainsare marked with asteriks. 2B, RT-PCR from human multiple tissue cDNApanels I and II (Clontech). Lanes: 1)λ/φX174 size marker, 2) heart, 3)brain, 4) placenta, 5) lung, 6) liver, 7) skeletal muscle, 8) kidney, 9)pancreas, 10) spleen, 11) thymus, 12) prostate, 13) testis, 14) ovary,15) small intestine, 16) colon, and 17) leukocyte. 2C and 2D, DYXC1Northern blot from Multiple Tissue Northern (MTN) Blot panels I and II(Clontech). Lanes in FIG. 2C: 1) heart, 2) brain, 3) placenta, 4) lung,5) liver, 6) skeletal muscle, 7) kidney, 8) pancreas; Lanes in FIG. 2D:9) spleen, 10) thymus, 11) prostate, 12) testis, 13) ovary, 14) smallintestine, 15) colon, and 16) leukocyte. 2E, Cellular localization ofDYXC1 protein. Cos-1 cells transfected with DYXC1-V5 fusion constructwere stained with monoclonal mouse a-V5 antibody and FITC-conjugatedα-mouse-IgG (grey). DAPI stained nuclei are shown in light grey.

[0014]FIG. 3. Pedigree of the family in which two DYXC1 polymorphismsare transmitted with dyslexia. Alleles for four loci are shown belowindividuals. Black rectangle indicates the haplotype transmitted withdyslexia in this family.

[0015]FIG. 4. Immunostaining patterns for DYXC1 observed in normal humanbrain tissue from an individual died immediately after sudden cardiacarrest. A, Characteristic immunoreactivity in cortical brain tissuedemonstrating a variable density of nuclear expression in a minority ofneurons. (Original magnification ×30). B, Typical staining result inwhite matter, where also a fraction of cell nuclei are densely positivein contrast to clearly negative adjacent cell nuclei. (×40). C, Positiveneuronal nucleus adjacent to negative glial cell nuclei (×100). D,Negative neuronal cell body adjacent to neighboring small cellsrepresenting probably glial cells (×100). E, High magnificationillustration of a large pyramidal neuron expressing clearly intranuclearlocalization of DYXC1 protein (×100). F, Typical view of an adjacenttissue section stained with preimmune (control) serum indicating thelack of non-specific staining in neuronal and glial cell nuclei (×30).

[0016]FIG. 5. Immunostaining patterns for DYXC1 observed in humanischemic brain tissue of three victims of acute ischemic stroke. A,Typical immunostaining result in a subject deceased at 23 h after theonset of stroke symptoms. Note the characteristically cytoplasmicstaining pattern present in a subset of ischemic neurons. Compare toFIG. 4 from non-ischemic brain tissue, where typically nuclearexpression was found. (×40). B, Same neuronal population identified fromadjacent section stained with preimmune (control) serum (×40). C,Typical immunostaining pattern in ischemic brain tissue area of anothersubject deceased 26 h after the onset of stroke symptoms. Note theincreased fraction of pyknotic neurons expressing dense, predominantlynuclear, DYXC1 immunoreactivity. (×20). D, Same neuronal populationidentified from adjacent section stained with preimmune (control) serum(×20). E, Immunoreactivity for DYXC1 observed in a more advanced,vacuolized, stage of tissue ischemia demonstrating faint expression alsoin neuronal processes. This subject died 60 h after the onset of strokesymptoms. (×40). F, Same tissue area identified from adjacent sectionstained with preimmune (control) serum (×40).

DETAILED DESCRIPTION OF THE INVENTION

[0017] This invention is based on the discovery and characterization ofa novel human gene termed DYXC1. The human DYXC1 gene is 1260 bp inlength (SEQ ID NO: 1) and it encodes a 420-amino acid residue protein(SEQ ID NO: 3). The cDNA of total DYXC1 mRNA (SEQ ID NO:2) has beendeposited in GenBank with accession number AF337549. DYXC1 maps to humanchromosome 15q21. The present invention shows that previously reportedbalanced translocation breakpoint t(2;15)(q11;q21) segregatingcoincidentally with developmental dyslexia is located in DYXC1 thusindicating that DYXC1 is linked to dyslexia. In addition, it wasunexpectedly discovered in the present invention that point mutations,i.e. SNPs, in DYXC1 segregate with the susceptibility to developdyslexia.

[0018] The present invention provides DYXC1 nucleic acids, homologsthereof and fragments thereof. The human DYXC1 cDNA sequence isdisclosed in SEQ ID NO: 1. Preferred homologs, such as chimpanzee (SEQID NO:13), pygmy chimpanzee (SEQ ID NO:19), gorilla (SEQ ID NO:15),orangutan (SEQ ID NO:17) and mouse dyxc1 (SEQ ID NO: 4), have a sequenceat least about 79% homologous with a nucleotide sequence of SEQ IDNO: 1. In a preferred embodiment, the DYXC1 nucleic acid is from amammal, e.g. a mouse, primate or human. In another preferred embodimentthe nucleic acid has the sequence of SEQ ID NO: 1 a complement thereofor a fragment thereof. In one embodiment of the invention the fragmentdisclosed can be a primer or probe, which is capable to hybridisespecifically to the DYXC1 nucleic acids described herein. Thepreparation and modification of primers and probes capable of binding toa known nucleic acid are well-established techniques in the art (see,for example, Current Protocols in Molecular Biology, eds. Ausubel et al,John Wiley & Sons: 1992). Generally, a primer or a probe is asubstantially purified oligonucleotide being 12 to 60 nucleotides long,preferably 16 to 40 nucleotides. A primer or probe need not reflect theexact sequence of a template, i.e. a target nucleic acid, but must besufficiently complementary to hybridise with the template understringent conditions.

[0019] The invention also involves nucleotide sequence variants capableof encoding DYXC1 polypeptides. Such variants include sequences thatdiffer from the disclosed DYXC1 nucleic acids by one or more nucleotidesubstitutions, additions or deletions, such as allelic variants. Saidnucleotide substitutions may also arise due to the degeneracy of thegenetic code. The nucleic acids of the invention can also be describedas capable of hybridising under stringent conditions to the nucleic acidsequence of SEQ ID NO: 1 or 2 or a complement thereof. Such stringentDNA hybridisation conditions are well-known in the art, e.g.6×NaCl/sodium citrate (SSC) at about 45° C. is applied for ahybridisation step, followed by a wash of 2×SSC at 50° C. or, e.g.,alternatively hybridization at 42° C. in 5×SSC, 20 mM NaPO4, pH 6.8, 50%formamide; and washing at 42° C. in 0.2×SSC. Those skilled in the artunderstand that it is desirable to vary these conditions empiricallybased on the length and the GC nucleotide base content of the sequencesto be hybridised, and that formulas for determining such variation exist(See, for example, Sambrook et al, “Molecular Cloning: A LaboratoryManual”, Second Edition, pages 9.47-9.51, Cold Spring Harbor, N.Y.: ColdSpring Harbor Laboratory Press (1989)). Nucleic acids of the invention,fragments thereof and variants thereof with sufficient similarity to thenon-coding strand of said nucleic acids to hybridise thereto understringent conditions are useful for identifying, purifying, andisolating nucleic acids encoding other, non-human, mammalian forms ofDYXC1. Thus, such polynucleotide fragments and variants are intended asaspects of the invention.

[0020] The present invention also provides plasmids and vectors encodingan DYXC1 polypeptide, which constructs can be used in the expression ofsaid DYXC1 polypeptide in or from a host cell. The selecting of asuitable plasmid or vector for a certain use is within the abilities ofa skilled artisan. As the host cell may be any prokaryotic or eukaryoticcell, a plasmid or vector encoding an DYXC1 polypeptide can be used tothe production of said DYXC1 polypeptide as a recombinant protein viamicrobial or eukaryotic cellular processes. Typically, said plasmids andvectors comprises a ligated nucleic acid encoding a recombinant protein,said nucleic acid operably linked to at least one transcriptionalregulatory sequence (See, for example, Sambrook et al, “MolecularCloning: A Laboratory Manual”, Second Edition, Cold Spring Harbor, N.Y.:Cold Spring Harbor Laboratory Press (1989)).

[0021] The present invention further describes the characterization ofsingle nucleotide polymorphisms (SNPs) in human DYXC1 gene. SNPs can beused in mapping the human genome and, when a SNP is linked with adisease or condition, to clarify genetic basis of the disease orcondition, in this particular case, at least of dyslexia. In thisinvention we have characterized five single nucleotide polymorphisms(SNPs) in DYXC1 mRNA (SEQ ID NOS:1 and 2). Accordingly, the presentinvention provides an DYXC1 nucleic acid comprising a SNP in any one ofthe following positions in the nucleic acid sequence of SEQ ID NO:1:position 4; 572; 1249 or 1259. Allelic variation at position 4 consistsof a single base substitution from C preferably to T. Allelic variationat position 572 consists of a single base substitution from G preferablyto A. Allelic variation at position 1249 consists of a single basesubstitution from G preferably to T. Allelic variation at position 1259consists of a single base substitution from C preferably to G. Thepresent invention also describes a SNP in DYXC1 mRNA at position-164outside the coding sequence of DYXC1. This position corresponds toposition 205 set forth in SEQ ID NO:2. Allelic variation at position−164 consists of a single base substitution from C preferably to T.

[0022] The SNP variant of DYXC1, wherein the single base substitution isat position 1249 (G→T), introduces a premature stop codon and isinherited with dyslexia in a three-generation family. The frequency ofthe polymorphism is significantly (p=0.0278) elevated in dyslexicsubjects, compared to control samples as shown in Examples. Thepolymorphism truncates the predicted DYXC1 protein by four amino acids,suggesting that it is a functional SNP.

[0023] Further, new polymorphic gene regions in DYXC1 nucleic acids canbe identified by determining the DYXC1 nucleic acid sequences inpopulation of inviduals. If new polymorphic region (e.g. SNP) is found,then the link with a specific disease can be determined by studyingspecific populations of individuals, such as dyslexics. A polymorphicsite or region may be located in any part of a gene, e.g., exons,introns and promoter region.

[0024] The present invention makes available DYXC1 polypeptides. Suchpolypeptides can be recombinant proteins produced by, e.g., the hostcells described hereinabove, said recombinant proteins being isolatedfrom other cellular proteins. Preferably, said polypeptides have anamino acid which is at least about 78% identical or homologous to humanDYXC1 protein of sequence set forth in SEQ ID NO: 3. In a preferredembodiment, an DYXC1 polypeptide of the present invention is mammalian,e.g. murine or human, DYXC1 protein. In addition, the present inventionprovides splice variants of DYXC1 protein.

[0025] An DYXC1 polypeptide of the invention can also be used as anantigen to produce antibodies. Techniques of preparing antisera, poly-or monoclonal antibodies are well-known protocols in the art (see, forexample, Antibodies: A laboratory Manual, eds. Harlow and Lane, ColdSpring Harbor Laboratory Press: 1988). Thus, the present invention makesavailable DYXC1 specific antibodies. Especially, the antibodies of theinvention can be labeled with a detectable label and used in thedetermination of the presence of DYXC1 polypeptides in a sample, e.g.for diagnosis of dyslexia.

[0026] The present invention further provides means for prognostic ordiagnostic assays for determining if a subject has or is likely todevelop dyslexia, which is associated with the variation or dysfunctionof DYXC1. Basically, such assays comprise a detection step, wherein thepresence or absence of a genetic alteration or defect in DYXC1 isdetermined in a biological sample from the subject. Said detection stepcan be performed, e.g., by methods involving sequence analysis, nucleicacid hybridisation, primer extension, restriction enzyme site mapping orantibody binding. These methods are well-known in the art (see, forexample, Current Protocols in Molecular Biology, eds. Ausubel et al,John Wiley & Sons:1992).

[0027] In particular, the present invention is directed to a method ofdetermining the presence or absence of an DYXC1 SNP of the invention ina biological sample from a human for diagnostics of dyslexia or forassessing the predisposition of an individual to dyslexia. Said methodcomprises determining the sequence of the nucleic acid of a human at oneor more positions 4, 572, 1249 and 1259 in the DYXC1 gene or mRNA asdefined in SEQ ID NO:1 and position 205 as defined by SEQ ID NO:2 anddetermining the status of the human by reference to polymorphism inDYXC1 gene. In a preferred embodiment the sample is contacted witholigonucleotide primers so that the nucleic acid region containing thepotential single nucleotide polymorphism is amplified by polymerasechain reaction prior to determining the sequence. The final results canbe obtained by using a method selected from, e.g., allele specificnucleic acid amplification, allele specific nucleic acid hybridisation,oligonucleotide ligation assay or restriction fragment lengthpolymorphism (RFLP). These methods are well-known for a skilled personof the art (see, for example, Current Protocols in Molecular Biology,eds. Ausubel et al, John Wiley & Sons: 1992, or Landegren et al,“Reading Bits of Genetic Information: Methods for Single-NucleotidePolymorphism Analysis”, Genome Research 8:769-776).

[0028] The invention also features diagnostic or prognostic kits for usein detecting the presence of DYXC1 SNP in a biological sample. The kitprovides means for the diagnostics of dyslexia or for assessing thepredisposition of an individual to dyslexia mediated by variation ordysfunction of DYXC1. The kit can comprise a labeled compound capable ofdetecting DYXC1 polypeptide or nucleic acid (e.g. mRNA) in a biologicalsample. The kit can also comprise nucleic acid primers or probes capableof hybridising specifically to at least of portion of an DYXC1 gene orallelic variant thereof. The kit can be packaged in a suitable containerand preferably it contains instructions for using the kit.

[0029] It is also realised in the present invention that transgenicnon-human animals, such as transgenic mice, which include a heterologousform of an DYXC1 gene, can be designed and produced utilising thedisclosure presented herein (see, for example, Manipulating the MouseEmbryo: A laboratory Manual, eds. Hogan et al, Cold Spring HarborLaboratory Press, 1986). Such transgenic animals can be useful as animalmodels for studying, e.g., the function of DYXC1 gene and allelesthereof, or for expressing recombinant DYXC1 polypeptides.

[0030] A further embodiment of the present invention is a method foridentifying a mutant DYXC1 nucleotide sequence in a suspected mutantDYXC1 allele which comprises comparing the nucleotide sequence of thesuspected mutant DYXC1 allele with a wild-type DYXC1 nucleotide sequenceor a part thereof, wherein a difference between the suspected mutant andthe wild-type sequence identifies a mutant DYXC1 nucleotide sequence. Insaid method the sequence of said suspected mutant DYXC1 allele can becompared with the sequence of one or more wild-type DYXC1 gene sequencesselected from the sequences set forth in SEQ ID NO: 1, SEQ ID NO:2, SEQID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 andwild-type allelic variants thereof. For the screening of new pointmutations, deletion mutations and insertion mutations in DYXC1 aplentiful of techniques well-known for a skilled artisan can beutilised, such as methods involving sequence analysis, nucleic acidhybridisation, primer extension, restriction enzyme site mapping andparticularly methods described below in Experimental Section andMaterials and Methods.

[0031] Screening Assays

[0032] The subject methods include screens for agents which modulate theactivity of DYXC1 gene or protein. The methods are amenable toautomated, cost-effective high throughput screening of chemicallibraries for lead compounds. Identified reagents find use in thepharmaceutical industries for animal and human trials; for example, thereagents may be derivatized and rescreened in vitro and in vivo assaysto optimize activity and minimize toxicity for pharmaceuticaldevelopment. More specifically, identified reagents may find use in thetreatment of dyslexia or brain ischemia.

[0033] The invention further provides methods (also referred to hereinas “screening assays”) for identifying modulators, i.e., candidate ortest compounds or agents (e.g., peptides, peptidomimetics, peptoids,small molecules or other drugs) which bind to DYXC1 protein, have astimulatory or inhibitory effect on, for example, DYXC1 expression orDYXC1 activity, or have a stimulatory or inhibitory effect on, forexample, the expression or activity of a DYXC1 substrate. Compounds thusidentified can be used to modulate the activity of DYXC1 in atherapeutic protocol, to elaborate the biological function of the DYXC1,or to identify compounds that disrupt normal DYXC1 activity. Thepreferred DYXC1 used in this embodiment are human, primate or mouseDYXC1 of the present invention.

[0034] In one embodiment, the invention provides assays for screeningcandidate or test compounds which are substrates of a DYXC1 protein orpolypeptide or biologically active portion thereof. In anotherembodiment, the invention provides assays for screening candidate ortest compounds which bind to or modulate the activity of a DYXC1 proteinor polypeptide or biologically active portion thereof.

[0035] The test compounds of the present invention can be obtained usingany of the numerous approaches in combinatorial library methods known inthe art, including: biological libraries; peptoid libraries [librariesof molecules having the functionalities of peptides, but with a novel,non-peptide backbone which are resistant to enzymatic degradation butwhich nevertheless remain bioactive] (see, e.g., Zuckermann, R. N. etal. J. Med. Chem. 1994, 37: 2678-85); spatially addressable parallelsolid phase or solution phase libraries; synthetic library methodsrequiring deconvolution; the ‘one-bead one-compound’ library method; andsynthetic library methods using affinity chromatography selection. Thebiological library and peptoid library approaches are limited to peptidelibraries, while the other four approaches are applicable to peptide,non-peptide oligomer or small molecule libraries of compounds (Lam, K.S. (1997) Anticancer Drug Des. 12:145).

[0036] In one embodiment, an assay is a cell-based assay in which a cellwhich undergoes a simulated ischaemia is contacted with a test compoundand the ability of the test compound to modulate DYXC1 activity isdetermined. Determining the ability of the test compound to modulateDYXC1 activity can be accomplished by monitoring, for example, celldeath, cell growth, cell attachment, and cell chemotaxis. The cell, forexample, can be of mammalian origin, e.g., a neuronal cell or anon-neuronal cell. In preferred embodiment, the ability of the testcompound to modulate DYXC1 activity is accomplished by monitoring DYXC1activation with Western blot, immunohistochemical staining using antiDYXC1 antibodies, or fluorometric assays.

[0037] Determining the ability of DYXC1 protein or a biologically activefragment thereof, to bind to or interact with an agent can beaccomplished by one of the methods described above for determiningdirect binding. In a preferred embodiment, determining the ability ofDYXC1 protein to bind to or interact with an agent can be accomplishedby determining the activity of DYXC1 protein. For example, the activityof DYXC1 can be determined by detecting the induction of a reporter gene(recombinant DYXC1 gene products labelled with detectable marker), ordetecting a target-regulated cellular response (i.e., cell attachment,cell adhesion, cell growth, cell death, neurite outgrowth or cellmigration).

[0038] In yet another embodiment, an assay of the present invention is acell-free assay in which DYXC1 protein or biologically active portionthereof is contacted with a test compound and the ability of the testcompound to bind to DYXC1 protein or biologically active portion thereofis determined.

[0039] Assays for the Detection of the Ability of a Test Compound toModulate Expression of DYXC1

[0040] In another embodiment, modulators of DYXC1 expression areidentified in a method wherein a cell is contacted with a candidatecompound/agent and the expression of DYXC1 mRNA or protein in the cellis determined. The level of expression of DYXC1 mRNA or protein in thepresence of the candidate compound is compared to the level ofexpression of DYXC1 mRNA or protein in the absence of the candidatecompound. The candidate compound can then be identified as a modulatorof DYXC1 expression based on this comparison. For example, when theexpression of DYXC1 mRNA or protein is higher (i.e. statisticallysignificantly higher) in the presence of the candidate compound than inits absence, the candidate compound is identified as a stimulator ofDYXC1 mRNA or protein expression. Alternatively, when expression ofDYXC1 mRNA or protein is lower (i.e. statistically significantly lower)in the presence of the candidate compound than in its absence, thecandidate compound is identified as an inhibitor of DYXC1 mRNA orprotein expression. The level of DYXC1 mRNA or protein expression in thecells can be determined by methods described herein for detecting DYXC1mRNA or protein or by methods which a skilled artisan can readily adaptfor use in the present invention.

[0041] Combination Assays

[0042] In another aspect, the invention pertains to a combination of twoor more of the assays described herein. For example, a modulating agentcan be identified using a cell-based or a cell free assay, and theability of the agent to modulate the activity of DYXC1 protein can beconfirmed in vivo, e.g., in an animal such as an animal model for brainischemia.

[0043] This invention further pertains to novel agents identified by theabove-described screening assays. Accordingly, it is within the scope ofthis invention to further use an agent identified as described herein inan appropriate animal model. For example, an agent identified asdescribed herein (e.g., a DYXC1 modulating agent, an antisense DYXC1nucleic acid molecule, a DYXC1-specific antibody, or a DYXC1-bindingpartner) can be used in an animal model to determine the efficacy,toxicity, or side effects of treatment with such an agent.Alternatively, an agent identified as described herein can be used in ananimal model to determine the mechanism of action of such an agent.Furthermore, this invention pertains to uses of novel agents identifiedby the above-described screening assays for treatments as describedherein.

[0044] The choice of assay format will be based primarily on the natureand type of sensitivity/resistance protein being assayed. A skilledartisan can readily adapt protein activity assays for use in the presentinvention with the genes identified herein.

[0045] One preferred embodiment of the invention is a screening method,wherein a compound that modulates the expression of DYXC1 is identified,the method comprising:

[0046] (a) incubating a cell that can express DYXC1 gene with a compoundunder conditions and for a time sufficient required for the cell toexpress DYXC1 gene, when the compound is not present;

[0047] (b) incubating a control cell under the same conditions and forthe same time without the compound;

[0048] (c) measuring expression of DYXC1 gene in the cell in thepresence of the compound;

[0049] (d) measuring expression of DYXC1 gene in the control cell; and

[0050] (e) comparing the amount of expression of DYXC1 gene in thepresence and absence of the compound, wherein a difference in the levelof expression indicates that the compound modulates the expression ofDYXC1 gene

[0051] Another preferred embodiment of the invention is a method ofidentifying a compound that modulates DYXC1 activity, the methodcomprising:

[0052] (a) incubating a cell that has said activity with a compoundunder conditions and for a time sufficient required for the cell toexpress said activity, when the compound is not present;

[0053] (b) incubating a control cell under the same conditions and forthe same time without the compound;

[0054] (c) measuring said activity in the cell in the presence of thecompound;

[0055] (d) measuring said activity in the control cell; and

[0056] (e) comparing the amount of said acitivity in the presence andabsence of the compound, wherein a difference in the level of activityindicates that the compound modulates the activity of said gene

[0057] Another preferred emdiment of the invention is a method foraffinity purification of a substance that binds to the DYXC1, comprisingthe following steps: a) contacting a source suspected to contain saidsubstance with an immobilized DYXC1 under conditions whereby saidsubstance to be purified is selectively adsorbed onto the immobilizedDYXC1; (b) washing the immobilized DYXC1 and its support to removenon-adsorbed material; and (c) eluting said substance from theimmobilized DYXC1 to which they are adsorbed with an elution buffer.

Experimental Section

[0058] Fine Mapping of the Translocation Breakpoint

[0059] The translocation and the phenotypes of the members of the familystudied here (FIG. 1A) have been described previously (12). Fluorescentin situ hybridization (FISH) restricted the location of thetranslocation breakpoint within the BAC clone RP-11-178D12 (AC013355;FIG. 1B). The clone contained two known genes, cell-cycle restorationprotein 8 (CPR8) and complementation class B phosphoinositol glycan(PIG-B), in addition to the genes described herein. To further localizethe breakpoint, we used amplified non-repetitive genomic DNA fragmentsfrom the BAC clone RPCI-11-178D12 as probes in Southern hybridization. Aprobe corresponding to nucleotides 102317-102837 of the completesequence of 178D12 revealed a genomic rearrangement with 6 differentrestriction enzymes (FIG. 1C). Thus, we could pinpoint the breakpoint toa region of 3229 bp, limited by the restriction sites for PstI andHindIII (FIG. 1D). The breakpoint region includes exons 8 and 9 of anovel gene, DYXC1 (see below).

[0060] Characterization of DYXC1

[0061] The coding sequence of DYXC1 was predicted in silico from thegenomic sequence of BAC clones RP11-178D12 and CTD-2137J4. Exon-intronboundaries were confirmed with RT-PCR. The length of DYXC1 mRNA,obtained by RT-PCR, is 1993 bp, and it encodes a predicted protein of420 amino acids. DYXC1 consists of 10 exons spanning approximately 78 kbof genomic DNA (FIG. 1D). Three promoter prediction programs (see below)identified a promoter precisely before the 5′ end of the RT-PCR obtainedmRNA, suggesting that the cloned mRNA is nearly complete. The startcodon (AUG) of DYXC1 is located 369 bp from the predicted transcriptioninitiation site in exon 2. Putative promoter of DYXC1 has a TATA box(TATAAAT) at position −31.

[0062] Database searches revealed several mouse ESTs homologous to thehuman DYXC1 mRNA. We could thus construct the mouse mDYXC1 in silico byconnecting the overlapping EST clones. The mDYXC1 mRNA (SEQ ID NO: 4)encodes a 421-residue protein (SEQ ID NO: 5) that is 78% identical withthe human DYXC1 (FIG. 2A). The human DYXC1 protein does not have anysignificant homologies to other known proteins. It has, however, threeC-terminal tetratricopeptide repeat (TPR) domains, corresponding toamino acids 290-323, 324-357, and 366-399. These TPR domains are thoughtto mediate protein-protein interactions (14, 15).

[0063] The human DYXC1 mRNA appears to exist in several different spliceforms: exons 9 and 2 can be omitted, and there is an alternativeacceptor splice site in intron 2. All these arrangements, however, alterthe reading frame, leading to truncated protein products. DYXC1 mRNA canbe found in several tissues. It is most abundantly expressed in brain,lung, kidney and testis (FIG. 2B). Northern blot of human adult kidneytissue revealed an approximately 2 kb transcript, corresponding to thepredicted size of DYXC1 mRNA (FIG. 2C).

[0064] The cellular localization of DYXC1 in transfected monkey kidneyCOS-1 cells was studied using immunofluorescence. The full-length DYXC1cDNA was cloned into a mammalian expression vector containing aC-terminal V5 epitope and a polyhistidine tail. DYXC1-V5/His fusionprotein showed a staining pattern similar to DAPI staining, suggestingthat DYXC1 is a nuclear protein (FIG. 2E).

[0065] Association Analysis of DYXC1 SNPs

[0066] The present invention also describes single nucleotidepolymorphism in DYXC1. In order to find polymorphisms in DYXC1, wescreened the DYXC1 cDNA from 57 dyslexic individuals from 22 unrelatedfamilies with single-stranded conformation polymorphism (SSCP) analysisto characterize sequence variants. As a control, we screened 91anonymous blood donors from Turku and Kuopio, and 15 non-dyslexicsubjects from the 22 dyslexia families. In this way, we found threeSNPs. Two of the SNPs (4→T, 572G→A) were in the coding region, whereas athird one (−164C→T) resided in the 5′ untranslated region (Table 1).Both the SNPs in the coding region resulted in amino acid substitutions.TABLE 1 Frequency of single nucleotide polymorphisms in dyslexicsubjects and controls. Amino acid Frequency SNP Codon change positionDyslexia n Control n p-value -164C→T* — — 0.0517 58 0.0286 105 0.2219-3G→A** — — 0.083 54 0.031 113 0.0020 -2G→A*** — — 0.009 54 0 113 0.71504C→T Pro → Ser 2 0.0172 58 0 105 0.1259 271G→A Val → Ile 90 0.019 540.053 113 0.9248 572G→A Gly → Glu 191 0.4811 53 0.5202 99 0.7792 1249G→TGlu → STOP 417 0.1228 57 0.0545 101 0.0278 1259C→G Ser → Cys 420 0.078957 0.0769 104 0.9482

[0067] 4C→T, a nonconservative substitution of proline-2 to serine-2,was found from two dyslexic individuals (a father and a son), but not inany of the control subjects. Further examination showed that thisalteration did not segregate with dyslexia in the extended pedigree.Likewise, the frequency of 572G→A did not differ significantly betweenthe two groups. The third SNP, −1164C→T was found in 6 dyslexicindividuals from three families and in 5 control subjects. In onethree-generation family, the T allele segregated with dyslexia (FIG. 3).In the other two families, there was no consistent pattern ofinheritance with dyslexia.

[0068] To search for additional SNPs, we sequenced the whole codingregion of DYXC1 from an individual carrying the T allele in the familypresented in FIG. 3. We found a G to T transversion at position 1249 ofthe DYXC1 mRNA, which results in a substitution of a glutamic acid foran ochre stop codon at amino acid position 417. The appearance of a stopcodon leads to the deletion of the C-terminal tetrapeptideGlu-Leu-Lys-Ser. In the family of FIG. 3, 1249G→T was transmitted in thesame chromosome as −164C→T, thus segregating with dyslexia.

[0069] Screening of all 57 dyslexic subjects for 1249G→T showed that theSNP is relatively common with a frequency of 0.123 (14/114 chromosomes).In the control group, the frequency was only 0.055 (10/174 chromosomesin blood donor samples, 1/28 chromosomes in control subjects of dyslexiafamilies). All the control subjects were heterozygous for the SNP,whereas there was one dyslexic subject homozygous for the SNP. Inconclusion, the frequency of 1249G→T is significantly (p=0.0278) higherin dyslexic individuals.

[0070] In further studies we found three more SNPs. One of the SNPs (271G→A) was in the coding region and resulted in amino acid substitution,whereas two (−3G→A and −2G→A) resided in the 5′ untranslated region(Table 1). SNP −3G→A showed significant association with dyslexia(P=0.006). SNP −3G→A is located in the binding sequence of thetranscription factors Elk-1, HSTF, and TFII-1. Elk-1 is atranscriptional activator expressed in rat brain neurons and itsactivation has been associated with learning in rats. The −3G→A SNPaffects also the Kozak sequence near the translation initiation site.

[0071] Primate Genes

[0072] The nonhuman primates chimpanzee, pygmy chimpanzee, gorilla andorangutan were sequenced for the genomic sequences corresponding tohuman exons and differed for 3, 2, 5 and 6 amino acids (0.7%, 0.5%, 1.2%and 1.4% of residues), respectively (Table 2). TABLE 2 Comparison ofDYXC1 cDNA between human and four nonhuman primates. Nucleic acid andamino acid changes are shown for each exon of DYXC1 in comparison to thehuman sequence; + indicates the presence of a change in a nonhumanspecies. Nucleic Amino acid acid Pygmy Exon change change Chimpanzeechimpanzee Gorilla Orangutan 1 none 2   6T > C + + + + 2  47C > T A16 >V + 2  48G > C + 2 107C > T T36 > M + 3 none 4 284T > C M95 > T + 4384C > T + + + + 5 473C > A A158 > E + + + + 5 516A > C Q172 > H + 5520A > G K174 > E + 5 540A > G + 5 572G > A G191 > E + + + + 5 583A > TI195 > L + + 5 591T > C + 5 611T > C L204 > S + 5 624T > C + 6 639G >A + 7 789A > G + 8 909G > A + + + + 9 none 10 none

[0073] Remarkably, the DYXC1 protein differs from its pygmy chimpanzeeand chimpanzee counterparts at 2-3 amino acids, but from gorilla andorangutan at 5-6 residues. For comparison, the level of codingdivergence is higher for DYXC1 than that observed for FOXP2, the productof a gene implicated in a speech and language disorder (26). Thus, assuggested for FOXP2, the DYXC1 gene may reveal important evolutionarydifferences related to brain functions between the primates.

[0074] Expression of DYXC1 Protein in Human Brain

[0075] Light microscopy of normal human brain sections revealed astrikingly nuclear expression pattern for DYXC1 immunoreactivity,consistent with the transfection results. Both in cortical neuronal cellpopulations and white matter glial cells, a minority of cell nucleiexpressed DYXC1 immunoreactivity (FIGS. 4A,B,E). Characteristically,even neighbouring, identical appearing cells had different expression(FIGS. 4C,D), which, together with the lack of staining obtained withpreimmune serum (FIG. 4F), supports the specificity of the observedimmunoreactivity.

[0076] We studied DYXC1 immunoreactivity also in individuals died soonafter the onset of acute ischemic stroke (FIG. 5). In contrast to thetypically nuclear expression in the normal brain, also cytoplasmicexpression was observed in ischemic brain areas (FIG. 5A). In corticalareas representing early ischemic morphology, the fraction of positivecell nuclei or cytoplasms appeared increased (FIG. 5C) as compared tonon-ischemic brain or contralateral hemispheres. In most ischemicsections studied, also structures corresponding to neuronal processeswere frequently found to be immunoreactive for DYXC1 (FIG. 5E). Sinceonly a limited number of subjects with short post-ischemic intervalswere available, quantitative or statistical analysis of expression wasnot attempted.

[0077] Observations from both normal and ischemic human brainsdemonstrated that DYXC1 protein is expressed in a fraction of humanglial and neuronal cells. Since only a fraction of neighbouring,identical appearing cells expressed DYXC1 immunoreactivity, we suggestthat DYXC1 does not represent a structural house-keeping element ofbrain cells. Instead, it may relate to the functional state of thecells. Examination of DYXC1 expression in ischemic brain tissuesuggested that it is involved dynamically in the functional cell statechanging in the face of metabolic challenge. Since the topographicexpression in the ischemic tissue included cytoplasms and even neuronalprocesses, DYXC1 may also have extranuclear functions, and may berapidly translocated from nuclei to cytoplasms when the cell undergoesmetabolic stress. These results from human cerebral ischemia warrantmore systematic studies on the role of DYXC1 in cell stress and ischemiaas well as dyslexia.

MATERIALS AND METHODS

[0078] Ascertainment of Patients and Psychological Assessment

[0079] Patients were selected among families of dyslexic children fromthe Department of Pediatric Neurology at the Hospital for Children andAdolescents, University of Helsinki, Finland and from the Association ofLearning Disabled Individuals of Helsinki (HERO), participating in thegenetic study of dyslexia. The study was approved by the EthicalCommittee of The Children's Castle Hospital and informed consent wasobtained from the participants. Pedigrees of two families are shown inFIG. 1A and FIG. 3. The diagnosis and degree of dyslexia was determinedby Finnish reading and spelling tests designed for children (16) andadults (17). The intelligence quotient (IQ) was determined by WAIS-R(18) or WISC-R (19). Reading-related neurocognitive skills (phonologicalawareness, rapid naming and verbal short-term memory) were assessed byneuropsychological tests (20-23).

[0080] FISH and Southern Blotting.

[0081] RPCI-11 BAC clone 178D12 (Genbank accession number AC013355) wasused as a probe in fluorescent in situ hybridization. The protocol forFISH has been previously described (12). 15 μg of total genomic DNA froman individual carrying the translocation and from an unrelated controlperson was digested with BamHI, EcoRI, HindIII, BsaAI, PstI, or SphI,and run in 0.7% agarose gel. DNA was transferred to Hybond N+membrane(Amersham Pharmacia Biotech) with standard alkaline blotting method. PCRfragments derived from human genomic DNA were TA-cloned into pCR2.1TOPO-TA vector (Invitrogen, Carlsbad, Calif.), and insert was removedwith EcoRI digestion and gel-purified (Qiagen, Venlo, The Netherlands).α32P-labeled insert was used as a probe in Southern hybridization.Hybridization was performed overnight at 65° C. in Church buffer (0.5 MNaHPO₄, 1 mM EDTA, 7% SDS, 1% BSA), and the filter was washed in 2×SSC,0.05% SDS at 65° C. for 1 hour. Filters were autoradiographed with aphosphoimager plate.

[0082] Cloning of DYXC1 and Sequence Analysis

[0083] Novel genes in the sequence of clone 178D12 were predicted insilico with Genscan (24) and Fgenes software. Predicted genes wereconfirmed by sequencing RT-PCR products. DYXC1 cDNA has been depositedin GenBank with accession number AF337549. Mouse mDYXC1 was constructedfrom two overlapping EST sequences (accession numbers BG242087 andAK005832) and verified by comparing it to all available mouse mDYXC1 ESTsequences. cDNA sequences of mDYXC1 and hDYXC1 were aligned withClustaIX. The alignment was improved manually, and shaded with BOXSHADE.The secondary structure of the TA rich region was predicted with MFOLD(available at http://bioinfo.math.rpi.edu/˜mfold/dna/form1.cgi) withdefault parameters. The expression of DYXC1 was analyzed by RT-PCR fromClontech's multiple tissue cDNA panels 1 and 2. RT-PCR was performed in25 μl volume in the following conditions: 94° C. 2′ (94° C. 1′, 68° C.2′)×30, 1×DyNAzyme buffer with MgCl₂ (Finnzymes, Espoo, Finland), 0.2 uDyNAzyme II polymerase (Finnzymes), 15 pmol forward primerGTTGACAGAATGCTGTTCCACGTCG (SEQ ID NO:11), 15 pmol reverse primerCAAGCTGAGGCACGAAGAGCAATGA (SEQ ID NO:12). Promoter region of DYXC1 waspredicted with TSSG and TSSW software at Baylor College of Medicine,available athttp://searchlauncher.bcm.tmc.edu/seq-search/gene-search.html, andneural network promoter prediction (NNPP) software at University ofCalifornia, Berkeley, available athttp://www.fruitfly.org/seq_tools/promoter.html. The genomic sequencesof nonhuman primates corresponding to all exons were determined bydirect sequencing after PCR amplification with human-specific intronicprimers (primer sequences are listed in Table 3). TABLE 3 Human-specificintronic primers for DYXC1. Primer Primer Product Name Primer SequenceLength Length Exon EKN1-1F AACAGACTGCCTGGTGCTCT 20 268 bp exon 1 EKN1-1RCACACCAAAGTTTGAGAACCACT 23 EKN1-2.1R AAGATGAGCCTGTTGCTCGT 20 476 bp exon2 EKN1-2.1F CAAGCAGAGGGTATGGGTCTAC 22 EKN1-2R AGAAGCTTCGGACCACACC 19 431bp exon 2 EKN1-3F CGCGTGCTTAATTTGTGTAA 20 299 bp exon 3 EKN1-3RTCCCCTACACAATATAGGTGCTT 23 EKN1-4F AAAGAAATCTCATCCTGGGTCA 22 327 bp exon4 EKN1-4R GAAAATGCTGAGGAAGTCCAG 21 EKN1-5F CAATGGCAAGAGTTTAGAGGTATG 24456 bp exon 5 EKN1-5R TCAATGTGCCAAAACAGTAACC 22 EKN1-6FTGTTTAGGATTTGGGGGTGA 20 395 bp exon 6 EKN1-6R GGAAATTCTAAAACATATTCATGACG26 EKN1-7F CCACTGGAGGAAGATGGAAA 20 244 bp exon 7 EKN1-7RTGTCTTCATACATGATAAAGCTCAT 25 EKN1-8F GGTAAGCCATCCTCTTTGTCA 21 337 bpexon 8 EKN1-8R TCAACTGAACAGAAAAAGATCATCA 25 EKN1-9F CTCCCCAAGTGTTGGGATTA20 305 bp exon 9 EKN1-9R TGGAGTCCTTAAAAGTCACGA 21 EKN1-10FGGTACTTGTTCTGAACCATGCTACTA 26 502 bp exon 10 126403-FCAAGGGCAAGCTTAATTCAGTAACACA 27

[0084] Single-Strand Conformational Polymorphism Analysis (SSCP)

[0085] DYXC1 exons were amplified with PCR (primer sequences availablefrom the inventors on request) and digested with suitable enzymes toobtain 100-300 bp fragments. Denaturing gel was run for 16 hours at roomtemperature with 5 W constant power. Gels were stained with silveraccording to standard protocols.

[0086] SNP Analysis

[0087] Polymorphisms −164C→T, 4C→T, and 572G→A introduced novel Tsp45I,MnlI, and MboII restriction sites, respectively. Exon-specific PCRproducts were digested with the appropriate enzyme and run on a 1.5%agarose gel (−164C→T, 4C→T) or on a polyacrylamide gel (572G→A),followed by silver staining. As 1249G T had no effect on restrictionsites, exon 10 was directly sequenced from all subjects. A standardone-tailed Fisher exact test was used to evaluate the statisticalsignificance.

[0088] Cellular Localization of DYXC1

[0089] Full-length DYXC1 cDNA was cloned into pcDNA3.1/V5-6×Hisexpression vector (Invitrogen). Monkey kidney COS-1 cell line wastransfected with 3 μg of the construct, with FuGENE6 (Roche) as atransfection reagent, according to manufacturer's protocols. Cells werestained with mouse anti-V5 antibody (Invitrogen) and FITC-conjugatedgoat anti-mouse IgG (Sigma-Aldrich). Nuclei were stained with DAPI. Thespecificity of anti-V5 antibody was tested with standard westernblotting methods.

[0090] Immunohistochemical Study of Brain

[0091] To investigate whether DYXC1 is expressed in mature human brain,brain tissue from six deceased individuals was stained withanti-DYXC1-antiserum raised in rabbits against the peptideCATEAKAAAKREDQK (SEQ ID NO:21) (antibody production purchased fromSigma-Genosys). The patients had died of cardiac arrest or ischemicstroke. In the five individuals with stroke, the post-ischemic timebefore death varied from 15 to 60 h, and brain samples were obtained atrapid autopsies with post-mortem delays varying from 10 to 40 h. Tissueblocks with cortical and some subcortical tissue were obtained from thecore or an area close to the core of the infarction with no specificreference to the topographic location and control samples were dissectedfrom homologous contralateral locations for comparison. Tissues werefixed in formalin and embedded in paraffin, and used for research bypermission of the appropriate Ethical Review Board of the HelsinkiUniversity Central Hospital. Immunohistochemical methods and use of thispost mortem autopsy material for studies on other proteins have beendescribed (25). The dilutions of antiserum used were 1:100-1:200, andall stained sections were compared to adjacent tissue sections incubatedwith the preimmune serum in identical conditions and dilutions. Noantigen retrieval methods were necessary. Light microscopy of tissuesections was performed with Leitz Laborlux D microscope (Leitz, Wetzlar,Germany) equipped with Nikon Coolpix 995 digital camera (Nikon, Japan).

[0092] The publications and other materials used herein to illuminatethe invention, and in particular, to provide details with respect to itspractice, are incorporated herein by reference.

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[0119]

1 42 1 1263 DNA Homo sapiens coding sequence for human DYXC1 (cDNA) 1atgcctcttc aggttagcga ttacagctgg cagcagacga agactgcggt ctttctgtct 60ctgcccctca aaggcgtgtg cgtcagagac acggacgtgt tctgcacgga aaactatctg 120aaggtcaact ttcctccatt tttatttgag gcatttcttt atgctcccat agacgatgag 180agcagcaaag caaagattgg gaatgacacc attgtcttca ccttgtataa aaaagaagcg 240gccatgtggg agaccctttc tgtgacgggt gttgacaaag agatgatgca aagaattaga 300gaaaaatcta ttttacaagc acaagagaga gcaaaagaag ctacagaagc aaaagctgca 360gcaaagcggg aagatcaaaa atacgcacta agtgtcatga tgaagattga agaagaagag 420aggaaaaaaa tagaagatat gaaagaaaat gaacggataa aagccactaa agcattggaa 480gcctggaaag aatatcaaag aaaagctgag gagcaaaaaa aaattcagag agaagagaaa 540ttatgtcaaa aagaaaagca aattaaagaa ggaagaaaaa aaataaaata taagagtctt 600actagaaatt tggcatctag aaatcttgct ccaaaaggga gaaattcaga aaatatattt 660actgagaagt taaaggaaga cagtattcct gctcctcgct ctgttggcag tattaaaatc 720aactttaccc ctcgagtatt cccaacagct cttcgtgaat cacaagtagc agaagaggag 780gagtggctac acaaacaagc tgaggcacga agagcaatga atactgacat agctgaactt 840tgcgatttaa aagaagaaga aaagaaccca gaatggttga aggataaagg aaacaaattg 900tttgcaacgg aaaactattt ggcagctatc aatgcatata atttagccat aagactaaat 960aataagatgc cactattgta tttgaaccgg gctgcttgcc acctaaaact aaaaaactta 1020cacaaggcta ttgaagattc ttctaaggca ctggaattat tgatgccacc tgttacagac 1080aatgctaatg caagaatgaa ggcacatgta cgacgtggaa cagcattctg tcaactagaa 1140ttgtatgtag aaggcctaca ggattatgaa gcggcactta agattgatcc atccaacaaa 1200attgtacaaa ttgatgctga gaagattcgg aatgtaattc aaggaacaga actaaaatct 1260taa 1263 2 1993 DNA Homo sapiens CDS (369)..(1628) human DYXC1 mRNA ascDNA 2 tcctctccta ttatgcaaac ccacaccatg gatccagcag actactctgg ccccagcatg60 ctgctccttg ggatgatggg agaaggggga aacctgtgtt ttctcttggt tttagggtat 120gggtctactt ctttgaacat tcgctcagat cgtaaggtaa ccccaagaat cggcatcact 180ctctggtctg ggcgcctgga tagtcacgca tggagtccgc gaggtgctgg cgccggagca 240cgctgggaac gccgggctcc cggccggcct gacccggaag ggctggcgca tggtaacccc 300agcttcccta gcaaccaagc aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg 360ctaccgga atg cct ctt cag gtt agc gat tac agc tgg cag cag acg aag 410 MetPro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys 1 5 10 act gcg gtcttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac 458 Thr Ala Val PheLeu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp 15 20 25 30 acg gac gtgttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca 506 Thr Asp Val PheCys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro 35 40 45 ttt tta ttt gaggca ttt ctt tat gct ccc ata gac gat gag agc agc 554 Phe Leu Phe Glu AlaPhe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser 50 55 60 aaa gca aag att gggaat gac acc att gtc ttc acc ttg tat aaa aaa 602 Lys Ala Lys Ile Gly AsnAsp Thr Ile Val Phe Thr Leu Tyr Lys Lys 65 70 75 gaa gcg gcc atg tgg gagacc ctt tct gtg acg ggt gtt gac aaa gag 650 Glu Ala Ala Met Trp Glu ThrLeu Ser Val Thr Gly Val Asp Lys Glu 80 85 90 atg atg caa aga att aga gaaaaa tct att tta caa gca caa gag aga 698 Met Met Gln Arg Ile Arg Glu LysSer Ile Leu Gln Ala Gln Glu Arg 95 100 105 110 gca aaa gaa gct aca gaagca aaa gct gca gca aag cgg gaa gat caa 746 Ala Lys Glu Ala Thr Glu AlaLys Ala Ala Ala Lys Arg Glu Asp Gln 115 120 125 aaa tac gca cta agt gtcatg atg aag att gaa gaa gaa gag agg aaa 794 Lys Tyr Ala Leu Ser Val MetMet Lys Ile Glu Glu Glu Glu Arg Lys 130 135 140 aaa ata gaa gat atg aaagaa aat gaa cgg ata aaa gcc act aaa gca 842 Lys Ile Glu Asp Met Lys GluAsn Glu Arg Ile Lys Ala Thr Lys Ala 145 150 155 ttg gaa gcc tgg aaa gaatat caa aga aaa gct gag gag caa aaa aaa 890 Leu Glu Ala Trp Lys Glu TyrGln Arg Lys Ala Glu Glu Gln Lys Lys 160 165 170 att cag aga gaa gag aaatta tgt caa aaa gaa aag caa att aaa gaa 938 Ile Gln Arg Glu Glu Lys LeuCys Gln Lys Glu Lys Gln Ile Lys Glu 175 180 185 190 gga aga aaa aaa ataaaa tat aag agt ctt act aga aat ttg gca tct 986 Gly Arg Lys Lys Ile LysTyr Lys Ser Leu Thr Arg Asn Leu Ala Ser 195 200 205 aga aat ctt gct ccaaaa ggg aga aat tca gaa aat ata ttt act gag 1034 Arg Asn Leu Ala Pro LysGly Arg Asn Ser Glu Asn Ile Phe Thr Glu 210 215 220 aag tta aag gaa gacagt att cct gct cct cgc tct gtt ggc agt att 1082 Lys Leu Lys Glu Asp SerIle Pro Ala Pro Arg Ser Val Gly Ser Ile 225 230 235 aaa atc aac ttt acccct cga gta ttc cca aca gct ctt cgt gaa tca 1130 Lys Ile Asn Phe Thr ProArg Val Phe Pro Thr Ala Leu Arg Glu Ser 240 245 250 caa gta gca gaa gaggag gag tgg cta cac aaa caa gct gag gca cga 1178 Gln Val Ala Glu Glu GluGlu Trp Leu His Lys Gln Ala Glu Ala Arg 255 260 265 270 aga gca atg aatact gac ata gct gaa ctt tgc gat tta aaa gaa gaa 1226 Arg Ala Met Asn ThrAsp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu 275 280 285 gaa aag aac ccagaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca 1274 Glu Lys Asn Pro GluTrp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala 290 295 300 acg gaa aac tatttg gca gct atc aat gca tat aat tta gcc ata aga 1322 Thr Glu Asn Tyr LeuAla Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg 305 310 315 cta aat aat aagatg cca cta ttg tat ttg aac cgg gct gct tgc cac 1370 Leu Asn Asn Lys MetPro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His 320 325 330 cta aaa cta aaaaac tta cac aag gct att gaa gat tct tct aag gca 1418 Leu Lys Leu Lys AsnLeu His Lys Ala Ile Glu Asp Ser Ser Lys Ala 335 340 345 350 ctg gaa ttattg atg cca cct gtt aca gac aat gct aat gca aga atg 1466 Leu Glu Leu LeuMet Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met 355 360 365 aag gca catgta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat 1514 Lys Ala His ValArg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr 370 375 380 gta gaa ggccta cag gat tat gaa gcg gca ctt aag att gat cca tcc 1562 Val Glu Gly LeuGln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser 385 390 395 aac aaa attgta caa att gat gct gag aag att cgg aat gta att caa 1610 Asn Lys Ile ValGln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln 400 405 410 gga aca gaacta aaa tct taatgactat tagaagtaac taagtattgt 1658 Gly Thr Glu Leu LysSer 415 420 tataagtttt ttaaaaacaa ctggaggcat ctttgtacat attatggccagttgtacaga 1718 atcgctttct gtttagtact ttagttctgt tgagggcaaa atattataaatctatagaaa 1778 ataaactgtt tgacttgaat catttctgaa taagtaaatc taaataagaatctattttaa 1838 ttccttattt cttcatatta atacatatgt atactttttt gtgttactgaattaagcttg 1898 cccttgtaac aaaatatgtt ttggtatagt taccaggaca cttactgattaatttttaac 1958 aaggtagaat tttaaaataa aagatttata aataa 1993 3 420 PRTHomo sapiens human DYXC1 mRNA as cDNA 3 Met Pro Leu Gln Val Ser Asp TyrSer Trp Gln Gln Thr Lys Thr Ala 1 5 10 15 Val Phe Leu Ser Leu Pro LeuLys Gly Val Cys Val Arg Asp Thr Asp 20 25 30 Val Phe Cys Thr Glu Asn TyrLeu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 Phe Glu Ala Phe Leu Tyr AlaPro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60 Lys Ile Gly Asn Asp Thr IleVal Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80 Ala Met Trp Glu Thr LeuSer Val Thr Gly Val Asp Lys Glu Met Met 85 90 95 Gln Arg Ile Arg Glu LysSer Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110 Glu Ala Thr Glu AlaLys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125 Ala Leu Ser ValMet Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140 Glu Asp MetLys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 145 150 155 160 AlaTrp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Gly Arg 180 185190 Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195200 205 Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu210 215 220 Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile LysIle 225 230 235 240 Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg GluSer Gln Val 245 250 255 Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala GluAla Arg Arg Ala 260 265 270 Met Asn Thr Asp Ile Ala Glu Leu Cys Asp LeuLys Glu Glu Glu Lys 275 280 285 Asn Pro Glu Trp Leu Lys Asp Lys Gly AsnLys Leu Phe Ala Thr Glu 290 295 300 Asn Tyr Leu Ala Ala Ile Asn Ala TyrAsn Leu Ala Ile Arg Leu Asn 305 310 315 320 Asn Lys Met Pro Leu Leu TyrLeu Asn Arg Ala Ala Cys His Leu Lys 325 330 335 Leu Lys Asn Leu His LysAla Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350 Leu Leu Met Pro ProVal Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365 His Val Arg ArgGly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380 Gly Leu GlnAsp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys 385 390 395 400 IleVal Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 420 4 1697 DNA Mus musculus CDS (48)..(1307) murineDYXC1 mRNA as cDNA 4 cggacgcgtg ggcgacgtaa agtggctgtg cagtccctgg tcccgccatg cca gtg 56 Met Pro Val 1 cga gtg agc gaa ttc agc tgg cag cag acg ccggcc acg atc ttc ctg 104 Arg Val Ser Glu Phe Ser Trp Gln Gln Thr Pro AlaThr Ile Phe Leu 5 10 15 tcg ctg cct ctg cgg ggc gtc tgc gtg cgc gat gctgac gta ttc tgt 152 Ser Leu Pro Leu Arg Gly Val Cys Val Arg Asp Ala AspVal Phe Cys 20 25 30 35 ggg gaa agt tac ctg aag gtt aac ttt cct cca ttttta ttt gag ctg 200 Gly Glu Ser Tyr Leu Lys Val Asn Phe Pro Pro Phe LeuPhe Glu Leu 40 45 50 ttt ctc tat gct ccc ata gat gat ggg aag agc aaa gccaag att gga 248 Phe Leu Tyr Ala Pro Ile Asp Asp Gly Lys Ser Lys Ala LysIle Gly 55 60 65 aat gac acg att ctt ttc aca ttg tat aaa aag gag cca gttctg tgg 296 Asn Asp Thr Ile Leu Phe Thr Leu Tyr Lys Lys Glu Pro Val LeuTrp 70 75 80 gat agc ctt tct gtg ccg ggt gtt gat aaa gag atg atg cag agaata 344 Asp Ser Leu Ser Val Pro Gly Val Asp Lys Glu Met Met Gln Arg Ile85 90 95 aga gaa aaa tct atc ttg caa gca cag gag aaa gca aaa gag gcc aca392 Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Lys Ala Lys Glu Ala Thr 100105 110 115 gaa gca aaa gct gtt gcc aag cga gaa gac cag aga tac gca ctaggc 440 Glu Ala Lys Ala Val Ala Lys Arg Glu Asp Gln Arg Tyr Ala Leu Gly120 125 130 gag atg atg aag att gaa gaa gaa gag agg aaa aaa ctc gaa gatctg 488 Glu Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Leu Glu Asp Leu135 140 145 aaa gaa aat gaa cgg aaa aag gca act agc gaa tta gaa gcg tggaaa 536 Lys Glu Asn Glu Arg Lys Lys Ala Thr Ser Glu Leu Glu Ala Trp Lys150 155 160 gaa tgt caa aag aaa gct gac gga caa aaa aga gtc cag agg aaggag 584 Glu Cys Gln Lys Lys Ala Asp Gly Gln Lys Arg Val Gln Arg Lys Glu165 170 175 aaa ccg ctc gag gga aag caa gct gaa gag acc aaa gct cta aaacct 632 Lys Pro Leu Glu Gly Lys Gln Ala Glu Glu Thr Lys Ala Leu Lys Pro180 185 190 195 cgg ggt ttg ccc cgg aag gcc cca ccc act cgc ctc ccc acaaga ggg 680 Arg Gly Leu Pro Arg Lys Ala Pro Pro Thr Arg Leu Pro Thr ArgGly 200 205 210 agg aat tgg gaa aac ata ttt cct gag aag tta aag gaa gacaga gtc 728 Arg Asn Trp Glu Asn Ile Phe Pro Glu Lys Leu Lys Glu Asp ArgVal 215 220 225 cct gcg cct cgc tcc gct ggc agt att caa atc agc ttt acccct cga 776 Pro Ala Pro Arg Ser Ala Gly Ser Ile Gln Ile Ser Phe Thr ProArg 230 235 240 gtg ttc cca aca gca ctt cgg gaa tcc caa gtc gca gaa gaggag gag 824 Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val Ala Glu Glu GluGlu 245 250 255 tgg ctg cat aaa caa gca gaa gca cgg aga gcc atg agc actgac ctt 872 Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala Met Ser Thr AspLeu 260 265 270 275 cct gag ttc ttt gac tta aaa gaa gaa gag agg aat ccagac tgg ttg 920 Pro Glu Phe Phe Asp Leu Lys Glu Glu Glu Arg Asn Pro AspTrp Leu 280 285 290 aaa gac aag gga aac aaa ttg ttt gca aca gaa aac tatttg gca gcg 968 Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu Asn Tyr LeuAla Ala 295 300 305 gtt gat gca tat aat tta gcc ata cga ctg aac tgt aagatc cca tta 1016 Val Asp Ala Tyr Asn Leu Ala Ile Arg Leu Asn Cys Lys IlePro Leu 310 315 320 ttg tat ttg aat cgg gct gct tgc cac ctc aaa tta aaaaac cta cac 1064 Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys Leu Lys AsnLeu His 325 330 335 aag gcc atc gag gac tct tct aag gca cta gag tta ttgaca cca cct 1112 Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu Leu Leu ThrPro Pro 340 345 350 355 gtt gct gac aat gcc aat gca aga atg aag gca cacgtc cga cga ggg 1160 Val Ala Asp Asn Ala Asn Ala Arg Met Lys Ala His ValArg Arg Gly 360 365 370 aca gcg ttc tgt caa cta gaa ttg tat gtt gaa ggcttg caa gat tat 1208 Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu Gly LeuGln Asp Tyr 375 380 385 gaa gct gca ctt aag att gac cca gcc aac aca gttgta cag aac gat 1256 Glu Ala Ala Leu Lys Ile Asp Pro Ala Asn Thr Val ValGln Asn Asp 390 395 400 gca gag aag att cgg aat ata att caa ggg acg gcactg aag tct cgt 1304 Ala Glu Lys Ile Arg Asn Ile Ile Gln Gly Thr Ala LeuLys Ser Arg 405 410 415 gac tagaggcagc taggcacagg agtctctgca agtactgtagctctgtacag 1357 Asp 420 taccgggcta gtgagccttt ggaatggcag tgcctgacgaatcatctcca aggggaaaat 1417 ggcctagctc tcactgcctt tgatcccagt accgggaaggcagaggtagg caagtctcta 1477 tgagcttgag gccagccaga gctcgacagc atgcaaaacacaaaagaaag ccagagaaca 1537 ggctgtttga gtcctcaatc ttggcacagg gattggctgggctctgatgt tgctgttgaa 1597 attgccagga tactactgag gaatctacag aatagaatttccacataaaa gattgtgcat 1657 ataaaatatt cttattatat taaatatagt atttcattcc1697 5 420 PRT Mus musculus murine DYXC1 mRNA as cDNA 5 Met Pro Val ArgVal Ser Glu Phe Ser Trp Gln Gln Thr Pro Ala Thr 1 5 10 15 Ile Phe LeuSer Leu Pro Leu Arg Gly Val Cys Val Arg Asp Ala Asp 20 25 30 Val Phe CysGly Glu Ser Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 Phe Glu LeuPhe Leu Tyr Ala Pro Ile Asp Asp Gly Lys Ser Lys Ala 50 55 60 Lys Ile GlyAsn Asp Thr Ile Leu Phe Thr Leu Tyr Lys Lys Glu Pro 65 70 75 80 Val LeuTrp Asp Ser Leu Ser Val Pro Gly Val Asp Lys Glu Met Met 85 90 95 Gln ArgIle Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Lys Ala Lys 100 105 110 GluAla Thr Glu Ala Lys Ala Val Ala Lys Arg Glu Asp Gln Arg Tyr 115 120 125Ala Leu Gly Glu Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Leu 130 135140 Glu Asp Leu Lys Glu Asn Glu Arg Lys Lys Ala Thr Ser Glu Leu Glu 145150 155 160 Ala Trp Lys Glu Cys Gln Lys Lys Ala Asp Gly Gln Lys Arg ValGln 165 170 175 Arg Lys Glu Lys Pro Leu Glu Gly Lys Gln Ala Glu Glu ThrLys Ala 180 185 190 Leu Lys Pro Arg Gly Leu Pro Arg Lys Ala Pro Pro ThrArg Leu Pro 195 200 205 Thr Arg Gly Arg Asn Trp Glu Asn Ile Phe Pro GluLys Leu Lys Glu 210 215 220 Asp Arg Val Pro Ala Pro Arg Ser Ala Gly SerIle Gln Ile Ser Phe 225 230 235 240 Thr Pro Arg Val Phe Pro Thr Ala LeuArg Glu Ser Gln Val Ala Glu 245 250 255 Glu Glu Glu Trp Leu His Lys GlnAla Glu Ala Arg Arg Ala Met Ser 260 265 270 Thr Asp Leu Pro Glu Phe PheAsp Leu Lys Glu Glu Glu Arg Asn Pro 275 280 285 Asp Trp Leu Lys Asp LysGly Asn Lys Leu Phe Ala Thr Glu Asn Tyr 290 295 300 Leu Ala Ala Val AspAla Tyr Asn Leu Ala Ile Arg Leu Asn Cys Lys 305 310 315 320 Ile Pro LeuLeu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys Leu Lys 325 330 335 Asn LeuHis Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu Leu Leu 340 345 350 ThrPro Pro Val Ala Asp Asn Ala Asn Ala Arg Met Lys Ala His Val 355 360 365Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu Gly Leu 370 375380 Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ala Asn Thr Val Val 385390 395 400 Gln Asn Asp Ala Glu Lys Ile Arg Asn Ile Ile Gln Gly Thr AlaLeu 405 410 415 Lys Ser Arg Asp 420 6 50000 DNA Homo sapiens human DYXC1chromosomal gene region, nucleotides 1-50000 6 aagcttttgc tttccttgatcatgtactgt tgagaaagca atatttggaa acattgttgc 60 atttttaaca ttatctttaagaattaaaag gcacatacct ttgatgccat aattctggtt 120 ctaggagcta cttgtaaatctctctaaagg catttataca tggattttta ttgcagcaac 180 agcagaggct tggaaacaacttaaacattg atcaatatgg aggggactag tttaatgaat 240 catggtgtag tcacactgtagaatactact cagctattac aaaataaaga agttctaaat 300 agagtgatat ggaatgatctccaagtaaga aagcaaggta cactgtgtgt actgtgtgta 360 ctttgtctca tttgtgtcctccccgccaaa aaaataataa taatatactt taatatatct 420 agattatctt tggaaaggtaggccagaaac tagtaatagt ggtggcctct gagacaggga 480 accagttact aaagattttagagtgagaga gagagacttg ctttttcact gaaagaataa 540 taaatatggg agcagggatgaatggctatt tctggctcaa actatgggaa agactttttt 600 gaaacagata atgataataaaagtattgct cttgtctaac gaaaatagaa aacattaaca 660 ggtaaatata atagatattactatgagata taaagtaact tcacttacaa gtgggaaata 720 ttacctgaat ttttttttttttaggtggtg atagtggact ggatgggtta ggaggaccag 780 gtgtacaact aggaagcccagataagaaaa agcgcaaggc aaatacacag gtaaactgac 840 attttcttta ataaaagtttttctttgcta gtatggtcag gctgatgagg taaatttgaa 900 cttggtcata agttttgttttctattcaag tgattgtact tttaatcatt cattgtactt 960 tcaatcaatc attccagtgatggtactttc tttttttttt tttttttttt tttttttttt 1020 tttttttttt ttaggtggattcttgctctg ttgccagact ggagtgagtg cagtggggtg 1080 atctcagctc actgcaacctccacctccca ggttgaagcg attctcctgc ctcagcctcc 1140 caagtagctg gaattacaggcacgcgccac catgcccagc taatttttgt atttttagta 1200 gagacgggct ttcaccatgttgatcaggat ggtctcaatc tcttgacctc gtgatccacc 1260 cgcctcggcc tcccaaagtgctaggattac aggtgtgagc caccacgcct cgctgtattt 1320 ttttttgttt aagtctgtaactagtggcta ttgtcagact ataggcatag actagatact 1380 gcaaaaagga agtgtgggcaaattaaaatg cttgttctta ggctgggcat ggtggctcat 1440 gcctataatc ccagccctttgggaggccaa ggtgggtgga ttacttgagg ccaggagttc 1500 gagaccagac tggccaacatggggaaagcc cttctctact aaaaatataa aaattagccg 1560 ggtgtggtgg cacactcctgtaatcccagc tattgcggag gctgaggcat gagaattgct 1620 tgaacctgga aggtagaggttgcaatgagc tgagatcacg ccactgcact ccagccttgg 1680 tgacagcgtg agactctgtctcaaaaaaaa attaaaatta aaatgcttgt tcttaaatct 1740 aatttaaagg tttttaaagggcatgaatgc ctgcagttct attaaaagat ttcaaaatat 1800 atagtaacaa ttttaacctgaaataattgt tcaactataa tagtgattta gtattatgtg 1860 catatcacga agcaatcatgatggaggcct ttttttgtta taacttgtgg ttgtaacaag 1920 caattatata tacaggctctcactgtttta ttctttataa atttgaagca ctctttctat 1980 gataaaggct actagtaagtatgtgtgtac agattactga tctttttatc attttgacca 2040 ccatctgtta aacttgcagtgtgactaaaa ctggcagttt attttttcag tctgaggccc 2100 agaacttaat gttttggaaatattttaatt gtatctccct gaagttaagc taggggaaaa 2160 acttagattc tgattgttgttatttaactt tatgactgtt tggtgtatga gaggtatttt 2220 aggttagact gctttagtatttaagtgaaa gtttctagag ttataggtaa gcatattaaa 2280 tgaaaattag gataatgaagcttcttttga aagttaacta cttttggttt ttgaagttac 2340 aatggatttg agctcagaaaatcatacttt attttctttt ggaaatgaaa taaaactaaa 2400 tatttttatc agcaagtataattaaatata aacattagtc aaaattgaaa ggtcaagtga 2460 agataataaa tgtttgttaacactgcaaga gaaatttgac taatactagg ttcacaggta 2520 ttaaggtaac aggacaattttaataatgta tttgatcgaa aacatgtatt ttactttaca 2580 ttctcatttc agggaccttctttccctcca ttgtctgagt atgctccacc accgaatcca 2640 aactctgacc atctagtggctgctaatcca tttgatgaca actataatac tatttcctat 2700 aaaccactac cttcgtcaaatccatatctt ggccctggtt atcctggctt tggaggctat 2760 agtacattca gaatgccacctcacgttccc ccaagaatgt cttccccata ctgtggtcct 2820 tactcactca ggaaccagccacacccattt cctcagaatc ctctgggcat gggttttaat 2880 cgacctcatg cttttaactttgggccacat gataattcaa gtttcggtaa tccatcttat 2940 aataatgcac taagtcagaatgtcaacatg cctaatcaac attttagaca aaatcctgct 3000 gaaaatttca gtcaaattcctccacagaat gctagccaag tttctaaccc cgatttggca 3060 tctaattttg ttcctggaaataattcaaat tttacttctc cgttagaatc taatcattct 3120 tttattcctc ccccaaacacttttggtcaa gcaaaagcac cacccccaaa acaagacttt 3180 actcaaggag caaccaaaaacactaatcaa aattcctctg ctcatccacc tcacttgaat 3240 atggatgaca cagtgaatcagagtaatatt gaattaaaaa atgttaatcg aaacaatgca 3300 gtaaatcagg agaacagccgttcaagtagc actgaagcca caaacaataa ccctgcaaat 3360 gggacgcaga ataagccacgacaaccaaga ggtgcagcag atgcctgcac cacagaaaaa 3420 agcaataaat cctctcttcacccaaaccgt catggccatt cgtcttctga cccagtgtat 3480 ccttgtggaa tttgtacaaacgaggtgaac gatgatcagg atgccatctt atgtgaggcc 3540 tcttgtcaga aatggtttcatcggatctgt actggaatga ctgaaacagc ttatggcctc 3600 ttaactgcag aagcatctgcagtatggggc tgtgatacct gtatggctga caaagatgtc 3660 cagttaatgc gtactagagaaacttttggt ccatctgcag tgggcagtga tgcttaatca 3720 aaggcattaa ctaaagtgggtttattttcc tgtgcattgc agaagttcat tgacacagga 3780 ttttaatgtt ttacattatttttttaaatg catacacaaa aacattattt acttagtttt 3840 tattaatcac ttcatcactagagcaaattt tttattgtct ttgcttgctg tcttaaatga 3900 gaataatgta tatgggggtgctttagaaac ataaataaat gttagttgtt gttatttatc 3960 acaaacataa aagcctcttgaaacttcaaa ataatatata acaaatgtag gcaagtttta 4020 acttttaaaa gttagaatcattgaaaaacg tgtatttcag tgctgaactt tggttgtacc 4080 atattaaaga tttagttcaaaaagtttatc aaggatccac ttaacacgtc ttcacaacat 4140 aatatatgta actgtaacatgggggaaagc atacattttt atggattaaa aaaataatag 4200 tatgacacca gattcctcctccactagggt ctttggaatc aatgaatttc atatttcaag 4260 tgagttttca ggatatctgtttgtacagat acgagacaga tcttagcata tagtaaattc 4320 tcagtaagta ttgttgattaacttgtggat ggtaccacat gaaattgcta atattagatc 4380 agttgaaaat tgactgcaattagtaaagtt ggtataacgt acgttcccag ttgtgctatt 4440 tagaattatg atagtattatgctcctactt ttctttgata ttgagttgtc ttgttattgt 4500 ttattgtttt ccagagaaatactatagtat ccacagaaga attgtgaata cttttttata 4560 attttgaact gggacatattgcagatgagg aaggtagaaa catccatttg gccttagagg 4620 gctctgctag taaaagaactactcagtggt ggtttgaaaa atcttgttct ggggatctga 4680 atttcaaaaa tgaaccctaggggagatcaa aatccatttt aaacaaagat caattaagag 4740 ccaaagtgaa atctaacttgcaaacaacaa tttgaagcct tgcagcagac ttaaggaatt 4800 cccgctctga ctggggaaaagtataaaaat ggacctgaga gtaccctctt gagggatgat 4860 caagaatgga gacagttggagttgtgctca ttaagattca aaacagcaga aatccatttt 4920 tggagcagat tataacctgtggccaaaaaa aaaaaatgtg tgctgtttga cagctaatgg 4980 caatttatac aatcattggaggctggtaaa gctccctaat atgttgccac cattatcatt 5040 gcaaccaaaa aaattctgaagattgtgtgg tgatctacga aagagataaa taattactgt 5100 tatttaaacc caagtgaaacaatgacggca gcagcatatt atcaagaaat ttaaattatg 5160 catgaaaatg tgatttaaaaacaatgtcct ttgggtaaca cacaagaacc tacactttca 5220 cagacaagga ctcgacctcacatgtcacaa gctactaaag caaagttaag tgacttgggc 5280 tatgaaattt tgtcatgtccattttagtca ctggaccttt attccatgga ctactgtcta 5340 tcatttggag ctttttctaagaaacaatgc attccccaat cgagatgaag taactggaag 5400 atgttaacaa tttatacagcctaacaaatg atgaatttta taaaagttag acctttaata 5460 ttctgttgga agaaaactattcatgctcct gatgcatatt ttgattgaat aaaacttatt 5520 tttttaaata cattgttttaattttgacct acaaaaacag caatttcata tggtacaagg 5580 taatacaagg ttttctccatttacccttga ctagttagag gtgagtacaa aatattttca 5640 gtagttgtaa aatatttatctttacaattt taggaaacaa aatgatataa actatacttc 5700 taggtactcc tttgtgtgaaaactttacca gttgaagcag gttaaaatgc agtattttgg 5760 gctgacaggc atttgatggtgttcagtagt gtacttgaag atctcatttt acttggattt 5820 tttattatac atatttctctaaatgtttaa ggacctagtt atgttgctcc tgaaagttta 5880 atgagtgctg atttttaataaatgatgcac tgtatgctgt atgcctagtt gtagcatcag 5940 atcatgattt attattaccctgaatagagc tagatgatag atattttgag tagaactttc 6000 cagtgttctc aggagttaacactttacatg gtagtacttg agttgtgatc attactaaaa 6060 tcaattatgc agtttcttaaaccctttatc tctttaagtt tcagtagtta gctgtttttg 6120 tgaaaatgaa ataacttctcccaagctagt ctaaaggtat gtgttatgca atataattca 6180 ttttctattt ccacatagttgtttttaaaa acctacaaac aggtgaattt ttattcaggt 6240 gtttaggtct tcaaagcaccttacttaaat aagaatctgt aaatattcaa aagaaaaact 6300 cacggttcat tctgatagtgaatcatagcc aaactgtaat catagctgat gaatagcgtt 6360 catgtgtttg aattaattttcctgctagtt ctacatttgt ctctacataa tgctaagtca 6420 aaagttatat agatgcttttggatggaata agtgatgaac tgtaagaata gccagatgat 6480 aatttgtctg aagaaggctattatacaaac tgaaatggct tcttaggata aatgataagc 6540 tgccttcaac tttaaaaatatgcagtgatg gaaaaaaaca caggtggaat tgtacctttt 6600 ttggtataat ccctttccttcactgaaagt cctcatctta cacacacaca cacacacaca 6660 caccccccac agtttctccaacatccttga gttttgctta aattcaacct ggctaactat 6720 gagcatctag gtttactcaccaaagctagg ttattgacag aaaggtgggt ttttttttgt 6780 tttttttgtt ttgttttgttttgtttttgt tttttgccag tcttgctctg ttgcccaggc 6840 tggagtgcag tgatgagatctcggctcact gcaacgtctg ccttcctggt tcaagtgatt 6900 ctcctgcctc agcctcctgagtagctggga ttacagtcgc ccaccatcac acctggctaa 6960 tttttgtatt tttagtagagacgggttcac catgttggcc aggctggtgt caaactcctg 7020 acctcaagtg atctgcccgcctcagcctcc caaagtgctg ggattacagg tgtaagccac 7080 cacgcctggc cagacagaaaattttaaaaa gcatcagttc ctttctcaga acttgacttg 7140 ctcatgcact agagaatttgtggtccacat gcttctaggt gttactcgat tcactaatac 7200 tgaaacagct cagcttgtgaaagataaatt gttcttcaga cagagtgctt agaattagat 7260 ttgtgatcag tgttttccttttgtgtgaaa tactttagag tactgctata attgttattc 7320 aaattagaag gttatatacataaaactaaa gattttcttg tactagtgct tattcttcat 7380 aaacacagtg taaagaaatctacttttttg gtggtttgtt ttagactccc aactctgcct 7440 agtggcagaa aaacctcttaatagtgtggg tcatcataaa atctgccaac tttaatccaa 7500 ataagtatca agagtcttcattcaatattc tttcaaactt gtttgtctcg aacaaattag 7560 agttttagca cttattgttcaatgtactat agtaattgta tttaatagta agaaaatata 7620 taagcaatga ttttttaaaagggagttctc aagagttttg gatttctttc tgccgtgtat 7680 agaggtttct tatgcatggacatttgtgct gttttatatc tttttcaatt aaaaaaaaat 7740 ttaaaggcat caggctccctaagttcattt gtaaatagtg gcttggaact ctacacaata 7800 gggaagctcc taaaggctcatttagaccat aatctagtta atagtatcat gctgaactct 7860 cagttttctt taggaaaccaatcaatcagt gtaggaggga gaaagaagca gaggtcttgt 7920 ctttttcctg atgtgattaggaggttaagt tctttggtgt gggtttcttt gcatttgccc 7980 ccttaccatg ctaaactctggtgaaatgta taagcagcct tggcttttcc tctcctgggt 8040 gctctgtgct tcaacattttatatctttcc tcccatcaga aatcctgtgt ctttgtgtgg 8100 cagtagtagt tggctagactttaagagaaa agcattttct actaaggtat gaatgaagat 8160 agtgggaaaa gtgtcattaaatttcttttt taaaaaagta tgtttattaa gaatgaatct 8220 ttaatatcta acatttcagacaatatgacc gcatttcaga taccatggga agcagtacat 8280 ttagtgaatt agctggtactgtctgagggt acttccagtt tcctttaggc tgttgtgact 8340 tttcacagct tcctctcctctaattctgaa cttagagatt ttcttctcat ttctaatttt 8400 tagtagctta ttgttccatccagtagagca ttataaaagt cacatctgca tcttccaact 8460 tatggtacag tgatgggaatttggaagcac ccctggagca aagaggctag ggatagcatt 8520 aacatctccc aagacaagtggtatagggga aatgaaggaa agactgtggc catgtatatg 8580 ccaggcgtta atacatcagagctgcctgta tttaatttaa aacttttgat gaaactcagt 8640 ggataagcat ctttgtcatattttgtcaat aatacattac ttgcaattat attaaaactt 8700 attctaaata cctgtacctttcttgttctg tagatgtgta gatgatgttg cttgtttgtc 8760 aaaatattat cttttataaaagaaagtcct gcttcttatc atgatgtatg tgacttaaat 8820 gattgtttca tattaaaactatttcttcct tatgtactgt ttacatatac ctctttttgg 8880 gatattagtt cagtacttttatacaaatct gagtgtgttc cacattggtg acatgtattt 8940 ttgcagtaac tttttgttttgttcttagaa catgtctaaa gtaacacatg cactagtgct 9000 gtggtctgtg gcaaaattactgtaattcaa attggaaaaa aaaatgtttc cagactttgt 9060 ccaacattta ttcctatggcaaaggaaatt actatgtaat actaattatt tcttatgctg 9120 gtatgtttta agctactctatgaagtatgt gaaacatcaa tatttatgga ttaatagatg 9180 gcctgatgtc tttcaaatgggagaggagta aattttagtg ttaccaactc atgacacttg 9240 taatacaata aatcttaaaatttttatttt ccacttacag gtatacttta ctaaataatt 9300 accttaaatg gcagtgcatattaggatttt ttagcacata ctactaaaat tatatagtaa 9360 cttttaactt gtgctgatatttcccaacca aaaaagacat cattcacttc atcataacca 9420 aaataagtag tactgtaatatttatcttca tttatttaga catgattaag ataccgtaag 9480 actcctctaa tttacctggaatttttagcc attgattcaa ggacttgaat gctgtttact 9540 tggtactacc taatgaaaggatttggtaat aaaggttata atcacgattt taaagaaaaa 9600 tgtttcatct tgaaggcaaatttttaagct ttttatttag aggtgtttac ttaagaatag 9660 taatttaaaa gcattcttattttgtcatta agacaagtac ccaaaagaat tgtaataagt 9720 aatacttggc caatgcaaatttgtacattt gaaatcatac acttgaaaga aaaaaatgaa 9780 ggcttgtgag tgcttaaactgcatatcttt ttaaaaattc aaattttaga catatcagtt 9840 taaattatcc ttaataaggttttactatgt cagtgatgta tattacaaaa tgtctaccta 9900 tgttatgtta atgatatctctatactgcat catattcggc atggttatgg tatattttgt 9960 acttttgatt gtggactattgataggattg atatagcaat aaatctgatt cagacttaat 10020 attttttaaa acgctagataccatactgta tcataatcct attatatttg acttgaatgc 10080 ccaaaatttt catagttctatattttatgt taaaaattta gtattacatg ttagggattt 10140 atttttgtct gctattttcacatacattct tttagaactg agtctgtttc tatttagatc 10200 atagacgtct aaagaagtattattaattca tgaactgctt tgtggaaaaa tttaaataaa 10260 gtatgaaatg actagattaccccaaattgt ttattttttt ttttggttaa tgaccaggtt 10320 acaattctca gacaaatgaaattggcttga taactgattg aatatagtag ataatggaaa 10380 gtttgactct ttaagggcttccaagtgtta aatacattct caattctgaa ttacttcata 10440 gtaactactt aaataatggtaagccaattc tcctttttct ttttgagata tttaacacaa 10500 tttgcgtctt ctgatcccattcccttcttc cccaaaaacc atgctagaat ttaaaattgg 10560 aagagtttaa tttgtcatctacattttagt ttttttattc tatagataag taagaagaca 10620 agtagacgtt ctgctgtcaagacagtccat gttattgttg gccattcttt tcagggataa 10680 tgcttaatgt tatttgtgcgttgtataagg aatgttgttt atcagtatat agacctacca 10740 ttagtagaaa tgatgtatggcaggctttct tgaataatat gtattgtaag tttgtttcct 10800 atagtgttat tatggttcagattcttttaa ataaagctag tttttaaaga gaaaaataac 10860 tttttaaagc gtttgactttcatcaggaca agtaggtgtg agaatcttgg ctttgggtgg 10920 gagatgtcca gtataacatcaagcagggaa tagcctacaa tttatcagtg taattttata 10980 ctaaggagag aaccagtatttttagtcagg ccttgctgta tacatatttt ttctgtgaag 11040 tctattcaga aaactgagtcctggatttcc ttaagaaatt gtgagcatga catatttact 11100 ttgattttaa cagtttgtgacttcagttct gttagtaaaa attatttgga gaagagtttt 11160 acaacttcag cagcttaatgacccctgggg cagagacacc actgtagcaa atattaagaa 11220 caaacttgtg gctgggtgcagtgactcacg cctgtaattc cagctactcg ggaggctgcg 11280 gcacgggaat cacttgaatccaggaagcag aggttgcagt gacagtgagc tgagattgtg 11340 ccgctgcact ccagcctgggcgacggagcg agactcacga gactctgtct caaaaaaaaa 11400 aaaaaaaaag aaaagaaaaaaagaacaaac tttcttgaat gataagacct ctagtttcct 11460 tgaaacaatc atcagttgccttgagtctgt tacataaaaa gaggctgaat aaaataatgt 11520 gtcaactgat gaaagcttgacattataggt aagaagtgat aagatgaaat ctcaagataa 11580 aatttgaatg cgtgacatttcaaatttaat aggaaaaaat aaaaatatgt gtatctcgct 11640 gaaggagaga gaagatatatatagagagaa ttcttatcaa ataacattga tgctctaagt 11700 tactccctct gttttaaacatatagcagtg ataaatatga aaagataaaa ttgaactcaa 11760 aaccatgcta aatccaaggacaagtaatat tgtacagaaa gaaagcatga gccatggtga 11820 agcagtagcc tgcctgactctgagttctca agcagaaact tgcagtagga aattctaatc 11880 tgacaaggta atgaggtctaaacatcttaa aacatgagat gcaataacag tgctaaaagg 11940 gaaatatata gctttagattatttttaagt ccaaagtatg atgagctaag ttgatctcaa 12000 gagactaaga aaacaacaacaacaaaaaac ttgaaagtag aaggaaggaa ataataagaa 12060 ataaaatagg aaaacactagaaggaataag aagaccataa ataggttatt taaacaataa 12120 agatgaggcc cagagcggtggctcatgcct gtaattccac actttgggag gccaaggtgg 12180 gaggatcact taagcccaggagttcaagat caacctgggc aacataagga gactctgtct 12240 acaaaaaatt tttttaattagctaagtgtg gtggtgcaca cctgtggtct cagctgctca 12300 ggaggctgag gtgggagtattgcttgagcc caggagttga ggctatagtg ggccttgata 12360 tgccgctgca cttcagtctgagcaagagaa caagaccttg tctaaaaaaa aaaaaaaaac 12420 tgagcctctg acaagactgatttttttttt tttttttttt tttttttttt ttgagatgga 12480 aacttgttct atcacccaggctagagtgca gtggcacgat cttggctcgc tgcaatctcc 12540 acctcccagg gtcaagcaattctcgtgcct cagcctcctg agtagccggg attacaggcg 12600 catgccacca tacctagctaatttttgtat ttttagtaaa gacggggttt caccatgttg 12660 gctaggctgg tcttgaactcctgacctcaa gtgatccgcc tgcctcagcc tcccaaagtg 12720 ctgagattac aggcatgagccactgtgccc ggccaaaact gatttttttt ttttttttaa 12780 tggtaggcag aaatatcaggaatgaaaatg gaggcaagca tagcactgct ttaagccggt 12840 gctgagctgg gatttctctccgctgctgta ccacttgtga aaggaagcta aaaactgaaa 12900 cctaccttca actgatacctggggctctaa tttataggaa gatgcagggc taagggggta 12960 gaaatacgca gtttttaaaatgtacagagt tggtaactgg tttacaatat gaagaaagaa 13020 ttgaagcagt gaattagcatgtaacacctc gctgaattgg ggtccctaag acacaagttg 13080 gaggcaaccc aaaattgctagaaagaaaag gatgaaccca gaggaaagaa agataaatga 13140 agggaacaaa aaagacactgcgaatcaaaa tttctgaaca catgagatct gaagacagga 13200 aaaccagcaa atcaataccttttgaaattt cagtccactc aagatgaaaa taatggaata 13260 aactgaaact ttaaataagtttgcttagga ctttgaaaag taagctaaac aataaaatag 13320 aaatgatgaa acccaaataagtagacatta atccattcaa tattttactg tcttaatatg 13380 ttcaggcgct cttctggatgctagaactat agcagtaaat caaacagaca aaaatcacta 13440 ttcatgaggt ttttattctaatgatacaga cagtaaaagg gtaagtgcaa ttaagaaatg 13500 aaggggctag gtgcagtggctcacacctgt aataggaaaa taataggaaa ataataggaa 13560 aaagaaaaat actaatcaaagaaatatagc aggccgggtg cggtggctca cgcctgtaat 13620 cccagcactt tgggaggccaaggtggacgg atcacctgag gtcaagggtt tgagagcagc 13680 ctgaccaaca tagtgaaaccccgtctctac taaaaataca aaaattagcc gggggtggtg 13740 gcatgcacct gtaatcctaactactcggga ggctgaggca ggagaatcgc ttgaacctgg 13800 gatgcggagg ttgcagtgagccgagatctt gctactgcac tccagcctgg gcaacagagc 13860 aagactccat ctcaaaaaaaaaaaaaaaaa agatagaaaa aagtatacca gaaaaatact 13920 aatcaaagaa atatagcaggctgggcacct tgttcacatg agccagcagc agcagcagta 13980 gtggcatagt ggcagcatggtgggggcaca cccatccgct gcagcaggat gtagcaggtg 14040 ctggggtgcc tgcctttgtgcaggcattca ccacagtggc gaaggagtac agcttccagg 14100 ggcccctgct ggtgactatgtgtgcggttg gctggtggta gtgttagaat ggggtgcagg 14160 caggcgcaat ctgtatgtgttctctgtgca ccacaggcag gggtggtcac tcaagtcggg 14220 ggaggttccg ctggtctctgtgcctagttt cattcccatg gcagtgttgg tgcaagggca 14280 tgccagcaaa gcaatgtggggggttgctgt gggccaggca aaacagcgtg tagggaggga 14340 gtgggtggcc tggtgtgtggctgtgggggc tgtcctgctg tagttctctt gatggtcagg 14400 catggtccac cagcacagaaactatgatgt gagcccccag gacacccaag gctgtttgac 14460 aggcaggctc aatcaggcctgggccccagg aggggccagc agaccaacgg atgctcatgt 14520 cagaccggcc tgtctgatgggcaagaccac gtaacagagt tcaggtccaa cacttcctct 14580 agggctaaag tctcctatgggagcatgttg agcctagaga gatgggttat cctggccatg 14640 cttcgctaca gatgctcccacaccaaaccc tctgggctcc tcttcagcag acgtgctgcc 14700 cctaccagtt ctctgagcagctatccctgc caactcaagg gtccttggtg gtcagggggt 14760 ctcctgccag gattccagaggcacgcagtg agagtgggtt gctccttacc agttcaactt 14820 acctgttccc tcagagtttctgagggccag gaatgagtcc tggtgcatag tagccccatg 14880 cagggctccc agcttcctcctgcttcagcc tagcttctgt gtcttccctt tgttcattct 14940 ggtgccttcc ctctgaagatctgttaggag tataacagtc atctcagtcc ctcagtggca 15000 gctgttccat ctggttgcatctagttggcc accttgcccc cattttcacc caagaaaaca 15060 ttttataaat atttttaaaaccccaccaaa atgataaaat aatcatggac atgtatgatt 15120 gcaaaagagc ctcaacatatataaagcaga agatacaatc acagagaatt atagggagaa 15180 ataagcagca attgcttaagattttaaaac aaatttcttt cagaaaatga tagtccaagc 15240 atcaaatttt ttaaaattatttttaatata tatttttgtc cacttaggct gctataacag 15300 aatactattg actaggtagtatgcagacta tgttgtctga ccaaaagata atgaaaaaaa 15360 actatgtatg tttagaaaatgaaagtaaac tcttgacctc atgttccgcc tgcctcggat 15420 tgagaccatc ctggcaaacatggtgaaacc ccgtctctac taaaaatata aaagttagcc 15480 aggtgtggtg gcaggcacctgtagtcccag ctactcggga ggctgaggca ggagaatcac 15540 ttgaatctag gaggcagacgttgcagtgag ccaagatcat gccactgtac tccagcctgg 15600 tgacagagcg agattccatcaaaaaaaaaa aaaaaaaaaa aaaaggtaaa ctctttagta 15660 cttaattcat cagaaggaaagttatgtaac atttatacct taaagacaac ttaaatacta 15720 cacatcaaaa ccacaggggtaggtttagga tatagaaaac tgcaaagaac ctcatttcca 15780 ctctaaccat gagaaaaagctggataatcc acaaaaccat gactttttct aaaaccatca 15840 tagagctaat tttaaaggcaatcaagtaat ctgaatagca aagagaaaca agattctcca 15900 aggagagaaa gcacattaacgatttcacat ttagcaaagt ggaagagaaa ggtggccatc 15960 atatcaatgg gaaagaagaaatcaactaaa ttgttttaaa ggccatatat gggttagtgt 16020 gtcagtttgt cataggtgggggcctcagac accaagtgag tttgcactcc cttgtaggcc 16080 ttcactggat gctcaagaaaatgactgggg gcaggagaga agactgaaga aatccccctc 16140 acccaccacc cacagcagtggttcaaatgt tcatgtgatt agtagattct tggcgacagg 16200 cataaagtgc aattttctaaccccttctct cctacaaatc aaaagtctta aaacattggg 16260 gaggatcatc aaactcttttgtccctggac acaggcaaag aattattgtt tttaggggag 16320 ggccagaaga aaagcttgtttgcttcttgg taacagatag gaaactatcc caataccaga 16380 acaaaggcaa agatccattgctgctggaat ggtaagggag gaagggtaaa ggaaaaaact 16440 ctttgccact gtaggaaggacagggaattt cttgggcaaa ggaggcttca ttgatatcaa 16500 gcagattatg agaggaagtcctggaagggg gtaggaaact gtgtccctag accaatcaca 16560 aagataaggc agagctggtggccatgagag gaaggaaaag aataatgagg aagtcccact 16620 actgagacac aggtcctgtgcctctcccct aagcacaaga ccttagtagc acacctgtag 16680 aggaatctga agtttgtgttgcactaaaga cagctctacc aacaacaaaa cccaaaccca 16740 gctcagccaa ggcaaacaaaagctgagaat ttgttgcaag cagacctgtg ctaccagaaa 16800 gattaaagga tgttcttcacgtcgtatgtt ctcataagtg ggagctaagc tatgaggatg 16860 tgaagccata ataatgacacatggactttg gggactcggg gaaagggtgg taagggggtc 16920 aaggataaaa gactacaaattgggttcagt gtatgctgct cgggtgatgg gcgcaccaaa 16980 atctcgcaaa tcaccactgaagaacttact catgtaacca aataccacct gttccccaaa 17040 aacctatgga aataaaacacacacacacac acgaaaagaa ataaataatt cttcttttga 17100 gaagtctgaa aaaaaggatgttcttcaggc agaaggatta tattgcagag aaacttgtat 17160 ccacaccaaa aaatgaatagtgttggaagt agtaaaaatg aaggtaaata taaaagatat 17220 ttcttcttgt ttgtaattgctttgacccac atattatata tatatgtcta tatatagaga 17280 gagagactgt ctatatatatatagtctatt gatttctgaa aacattgcca agataattca 17340 atggagaaag ggtacactttttaaacacat gatacgagac aattggacaa ccatatgtga 17400 aaaaatgagc ctggacctatacttggtatc atataaaaat ttaactcaaa atgaaacaca 17460 gatctacatt taagacctaaaaccataaca tttctagaag aaaatcaaaa agctttgtgt 17520 gttaggttag aaaactatttcttagttaag actcaaacaa atattttaaa tgttgttaaa 17580 ctgagcttta tcacaaaacttctattattt aaaagacatt gtgaaggatg aaaagacaaa 17640 catacaataa aataaaataattgaaaagca catatctcat aaaggattct tgtatccaga 17700 atacataaca cacatgtagcagacatatca ccgaagagtg aaacaaataa gcacatgaaa 17760 agatgcttaa catcactggtcaccagacaa atgcaaatta aaactgtagt gaggtacaaa 17820 tagacaacta ctagatttaataaaatgttt taaaagccca caaaactact gatacccagt 17880 cctggtgaat atgcagagtaatggaaactt ttatacattg ctggtagaaa tgtaaaattt 17940 gtacttttga agtagtttagtagtttctta taacattagt aaacttaaac ctatcatatg 18000 gcccagcaat tatatttttaagtatttact cctgaatgtt tatagcagtt ttattcataa 18060 ttaccaaaaa ctggaaacaaccaaaatgtc taccaactat agaatggaca aacgactctt 18120 tgtacatgta tatcatataatacttagtaa aaaaaaagaa tgcatgaaac acaacagcac 18180 agacggatct ccaaagcattgagctaaata agaagaaaac gaaagggttc atactacatg 18240 atttccttat ataacattctgaaaaagaca aaacaataag aaaagaattc agttcagtgg 18300 ttgccaggga tcggggctgggaggatgtaa ctgagtagct taggttcaaa atgcattttg 18360 agactttttt ttcttccttttcttcctttt agccttgaaa cataccttaa tactctttgt 18420 ttccctgcct tcccaccagacactcttgtg cactggtagt ttatctaatt atgtgcccag 18480 aagttgcagg ggctaatcttgagataaacc aggcatggaa acccaggtgt gaaattctag 18540 agattacctc agagcagttagtcaacagcc tcaccattgt tgagatgatg ccagcctgca 18600 ctccaagtgg accatgactcaggataacca gtggaacaag acacacagac ctcgtaccca 18660 gcaccattcc tgcatgccttccattccaag ttcccctctt taaacccctg tccacggcct 18720 aaagtttgaa atagtctgttaagagcacga gtctggacat tccccatctg ctagcgtttg 18780 aataaaagct gtttccctttggtcacacct catttctcat actttgactt ctaacagtga 18840 gcagttgaac ttgagtcagttacaggagga ggaaattgac tgcaaagaaa tacgagaaaa 18900 ctttggtgag atggaaatattttatatctt ggttgtggtt gaggttacat agctgtttat 18960 attgatcaaa actctagaacaatatatctc aaacgagtgg attttactgc atgtaaatta 19020 tacctcagta aacctaactttaaaattcta agatacagct ctcgcaatat ttggaaggcc 19080 aatttgcagt cttaaatgaacctataaaaa ccaaggagct tttaaaaaaa tgaattatga 19140 tttaactcaa gagtttgaagaataacaagt agaagaatgg aaacaaatgt aagagcaaaa 19200 gttaatgaaa tgaaaaatgggagaagatca acaaaaataa aggttatttt tactagtctt 19260 tcaaaaaact aataaacatgtaataagaga gatgggacag aaagagatta tacaaacaag 19320 caatattagg aataaaaacatgattatctt agataaagta gaaaatgcta taagtagctt 19380 tatgtcaatg gaggctaagactagttgcag gaagaataag aaataggata ttggtgtgat 19440 tgcagattat ctgtctcccacaaaacacta atcaattaca aagaagaaaa ttatgacttt 19500 acagtgaaga aacttggcagacaccaatat gacaggtgat gaccaatgtt accagtggtg 19560 ggaacagtca accgcatatgtccgtactat ggctgatact cttacaaggg catagtttca 19620 tttccatgat attcctgccatgaatgcatg acctgagtgt gatcataagg aaacatccag 19680 ctcaaggatc actctacaaaaggtaaggcc tgtactcttt caaagactaa ggagcttttt 19740 gagattggag aaaactgaagagacttgata actgtattag tccattttca cgctgctgat 19800 aaagacatac ccgagactgggaagaaaaag agttttaatt ggacttacag ttccacaggt 19860 ttaactctgt gcacaaactagtcagtccac tgaaaaggat aacagacagg tgagtttgtg 19920 tcctttgatt gcttaggatctgttgctaat ttgctgaact gaagctgcaa gagccttgtg 19980 tttttgagca tctagtgggaaaagtcttta cctctggttg tgtgagtttg agatatattc 20040 ctacctcagc gggggtggagggggagggta taagtaaaat aaattagaag actctttaaa 20100 gagtaccgtt atgattgttttggagcaatg tcaccactct ctcctcaggg attttaggca 20160 atgtctggag acattttgggctgttacaat ttgggggtgc ttttggcatc taatgggtag 20220 agatttggtg tgctgccacacagctcacaa tgctcaggac cgccctgcat gacaaaacaa 20280 ttatctggct taaaatgacaatcgttttag agaaactgaa aagcacttat ataaatctaa 20340 tattctcaac atttcctcaacataaattga atgtctaatg ctttaaatgt gatagcctgc 20400 ttaaaaaaaa aaagtccttctcacagaagc tgctagctca aaagcacttt aaaaaaaagc 20460 acttagaaaa aaaaaaaaaaacaagaaatc aagttcatgc aattaaacta gactgataat 20520 ttgggtttaa aaaataactgtatcaggccg tgtgtagtgg ctcatgcctg tactctcagc 20580 actttgggga ctgagttgggtgggtctctt gaggccagga gttcaagacc agcctggcca 20640 gcatggtgac accccgtctctactaaaaaa aaaaaacaaa aaaacaaaaa aacattagct 20700 gggtgtggtg gcacatgcctttaattccag ctactactgg ggaggctgaa gcacgagaaa 20760 tgcttgaacc tgggagacagagtttgcagt gagccaagat tgcaccactg cagtccagcc 20820 tgagagacag agtgagactgtttccaggaa aaaaaaaaaa aaaaaaaaaa acaccaaaaa 20880 agtcgtatat ttttctgattatatcagtgt gaagaaaaaa tacaagtata caagttttat 20940 tctttttaaa aatatggattgtttacataa aggtaatttt gtttttgttc cttttttttc 21000 aggttcagga atacatgtgcaggtttgctg tataggtaaa ttgcgtgtca tggagatttg 21060 gtatacagat tattttatcactcaggtaat aagcatagcg ccgggtgggt agtttgttga 21120 tcctcacctt ccttccgcccttcactctta agcaggccct agtgtctctt gtttccttca 21180 ttgtgtctat atgcacttaatgtttagctc ccacttgtaa gtgagaacat gcagtatttg 21240 gttttctgtt cctgtgttagttcacttaga ataatggcct tcagctccat ccatgttgct 21300 gcaaaaaaca tgatcttgttcttttttatg gctgcgtagt aatccatggt gtatatgtac 21360 tacattttct ttatccagttcaccattcgt gagcatctag gttgattcca tgtctttgct 21420 gttgtgaata gtgctgtgatggacatatgt gtgcatgtgt cattatggta gaattattta 21480 tattcctttg ggtatatacacaataatggt attgctgggt tgaatggtga ttctgctttg 21540 tgttctttga gaaatcaccaaactgctttc cacagtggct gaaataagtt acattcccac 21600 caacagtgta taagtgttcccttttctctg caaccttgcc agcatctatt attttttgac 21660 tttttaataa tagccattcttactggtgtg agatgttatc tcattgtggg tttgatttgc 21720 atttcgaaga gaattgctactttgaatttc tgacatttct tatacagatt taatctgata 21780 agctaatatt attcctacgtaatatttagg atgaggaaca gtgaataatt ttgtttaagt 21840 ggattggttt ataattctgacaaacttttt tttgttattt gtttgttttg gtttgttttc 21900 ttcttagaga caggtctcgctctgttgccc aggctggagc acagtggtgc tatcatagct 21960 caccgtaacc tcaaactcctgggtataagt gatcatccta tctcagcctc ctgagcagct 22020 aggactacag gtccatgccaccatgtctgg ctaatttatt tgttttgtaa agatgggggt 22080 ctcactttga tgcccatgctggtctcaaac tcctggcctc aagcaattat ctggccttac 22140 cctcccaaag tgctggaattgcaggcatga gccactgctc ctggcctctg acaaagtttt 22200 taatatcaac agtacattaggggcctccag acctgggccc ccagcacagc ttcccaggcc 22260 ctgcctgatc acttcaatccgttgcagctc tgcatttctc tgaggaggaa atcccagaga 22320 ccatccacag gctgtctgccattgccactg cagtggtacc cacctttgct gccctctggc 22380 tggggaagga acaaagagcctaattgcttt gctggcagct cccatatgtg gaggagccca 22440 gtctctcttt cctataatccctcaacccac tgcttttcac caggtagggc ccccagcttg 22500 ggcctgtagc acagcctgcagtaggtttgt gtttttctag ggtggagctt ctgcaggcaa 22560 ctgacagccc ctctgttactgtagcagtat ctgcccttcc tgccatcagg ctggggaagg 22620 aaaaaatagc ctgagtgctttactcacacc tccagcacgc catagccgcc ctgcagagaa 22680 gaagtcagac tcttccccatgggccctcca tccccctgct attcaccaag cagggatccc 22740 agacttgagc ccacagtgcagcctcctcac cttgggctga ttgttctgat tggcagtggc 22800 cctgcgtttc tctggggcagagacccaaga gacgagtgaa aggccctcta ccattgccac 22860 tgccaaggtt cctgcccctgctgcccccaa gctggggagg gaacaaaaag cctgagcttg 22920 ccacaaagct gtgttgtgcaggcctggagt gccaagccga gatctgtggc cagcactcaa 22980 gtggaagagg agcccacattcagagagcac tgacagggag catggctgcg tatgtgagga 23040 aatgaaagag gagccacgtggctaagagct accggcccta tggttagcgc catctactgg 23100 atcacagctc aaacttcaacatcaaaaata cttctgttag tagaccctgt gaaaccaagg 23160 acaaaaatcc agccccaaataaacaccctg cacaaagcct cagccctctg aaaacatcca 23220 gaaacaaatc caactggctatattgaaatt acaccacagt taaggaacat cagcacacag 23280 atgagaaaga accagtacaagaactcaggc aactctaaaa gccatagcgt ttgcttacct 23340 ccaaatgact gcgctagctccccagcaata gttcttaacc agaatgaaat ggctgaaatg 23400 acagacatag aattcagaatctggatggca atgaagatca ttgagattca gtagagagct 23460 gaaatccatt ccaaggaatctaagaaatcc agtaaaatga ttcaagagat gaaagatgaa 23520 atagccatat agggaaccaaactgagctga tagagctgaa aaactcacta caagaatctt 23580 ataatacaat cagaagtattaacagtataa taaaccaagc tgaagaaaca atctcagagc 23640 ttgacaatca gttcttcaaattattcaatc agacaaaaat aaggaatttt tttgaataag 23700 caaaacctct gagtaatatgggattatgta aagagaccaa atcaatgacc cattgacatc 23760 cctgaaagag aagaagagagagaaagcagc ttggaaaaca tatttgggaa tattaaccat 23820 gaaaatttcc ccaaccttactagaaaggtt gacattcaaa ttcaggaaat ttagagaagc 23880 cctgcaaggt actattcaaggctatcaccc tgaagacaca tagtcattag attcttcaag 23940 gtcaacatga aagaaaaaatgttaaaggca gctagagaga aggggcaagt caccaacaaa 24000 gggaacccca tcaggctaacaatggacctt tcaacagaaa tcctacaagc cagaaaaact 24060 tggggctaat agtcagcatccttaaagaaa agaaattcca accaagaatt tcatatccag 24120 ccaaatgaag cttcataagtgaaggagaaa taaaatcctt ttcagacaag caaatgctaa 24180 gggaattcat taccaccagacttgccttac gagaggtttt taagggagtg ctaaacaggg 24240 aaatgaaaga ccattactgaccaccacaaa aagacactca agcatattga ccattgaaac 24300 taaagcaaat atgcaatcaagtcttcaagt ctacataaca accacctaac aatacaatga 24360 tgtgatcaaa tcagcacacatcaatactaa ctttgaatgt aaaggggcta aaaatcccac 24420 ttaaagggca tggagtggcaagctggataa agaagcaaga cccagtggta tgctatcatc 24480 aagagaccca tctcacatgcaaggacaccc acaggctcaa agtaaaggga tgaagaaaga 24540 tctctcaagt aaacagaaaacaaaagagta ggagctgcaa ttcttatttc agacaaaaca 24600 gactttaaat gaagaatgatcaaaaaggac aaagaaggca ttacacagtg ataaagagct 24660 cagttcaaca agaagatttaactagactaa atatatatta accgaacact ggagcactag 24720 attcataaga caacttcttacagacttaca aagagactta gataaccaca caataatagt 24780 gaaagacttc aatgcccactgacagtattg gacagatcac tgaggcagaa taactgacaa 24840 agatatttgg gatctaaacttgacacttga ccaaatagac ctaacagaca tctacagaac 24900 acttcaccca acaaaagcagaatatacatt cttctcatct gcacatggca tacactctga 24960 aattgaccac atgctgagccatgaagcaat tctcaactaa ataaaaaaaa atcataccaa 25020 ccacattctc agaccaccatgcaataaaaa tagaaatttt tatttctatt attttatttc 25080 tattattatt tatttaccaagaagatctct caaaaccaca caattaaatg gaaattaaat 25140 aatctgctct ggaatgacttttgggtaaac aataaaatta aggcagaaac taagaaatta 25200 tttgaaatga atgaaaatgaagatacaaaa taccagaatc tctaggacat agctaaagca 25260 atgttaagag gaaagtttaggctgggcgca gtggctcaca cctgtgatcc cagcagcact 25320 ttgggaggcc aaggcaggcgaatcacaatg tcaagagatt gagaccatcc tggccaacaa 25380 cgtgaaactc cgtctctactaaaaatacaa aaattagctg ggcgtggtgg caagtgcctg 25440 tagtcccaac tactagggaggctgaggcag gagaatcact tgaacccggg aggcggagct 25500 tgcagtgagc cgagatcatgccactgcact ccagcctggt gacaattaaa tggaacctca 25560 cctgctcggg aggctgaggttggagaatgg catgaaccca ggagacagag gttgcagtga 25620 gccaagatcg cgccactgcactccagcctg ggtgacagag caagactccg tctcaaaaaa 25680 aaaaaaaaaa aaaaaaaattaaataagtga gaaagatctc aaattaacaa cctaacttta 25740 cacctagaga aactagaagaaaaacacaaa gccagcccca acgctggcag aagaaaagaa 25800 ataatcaaaa gcagagctgaactgaacaaa atggagatga gaaaagccat acaaaagatc 25860 aacaaaacca aaagctgcttttccgaaaga ataagattga tagactgtta gctaaactaa 25920 taaaaaaaga gagaagatccaaataaacgc aatcagaaat gacaaagagg acatgaacac 25980 caaccccata gaaatacaaaaaccatcaga aactattatg aacatctcta tgcacacaag 26040 ctagaaaacc tacagcaaatgggtaaattc caggaaacat acaacctcca aagattaaac 26100 cagaaagaaa ttgaaaccccaaaaagatca ataatgagtt ctgaaactga atcagtaatg 26160 aaaatcctac ccgaccctggaccacatgga ttcacaactg cattctacga aatgtataaa 26220 gcagagctgg taccaatcctactgaaacta ttccaaaaaa ttgaggagga gggtatcctt 26280 cctaactcat tctatgaggccagcatcatt gtgatacaaa aacctggcag agacacaaca 26340 aaaaggagaa ctttaggtcaatatctctgg taaagatagg tgcaaaaatc ttctacaaaa 26400 tactaacaaa ccaagtccagtagcatatca aaaagcgaat ccaccacaac caagtaggct 26460 ttttccctgg gatgcaaggttggttcaaca caggtaaatt aataaatgtg atttatcaca 26520 taaacagaac taaaaacaaaactaaatgac catctcaata aagaagaaaa ggcattcagt 26580 aaaactcaac acactttcatgttaaaaacc ctcaacaaac caggcgttga agatacattc 26640 ctcaaaataa taagagccatctatgacaaa cccacagtca acatcatatt gaatgggcaa 26700 aagctgtaag tattccccttgagaactgga acaagacaag gatgcctgct cttatcactc 26760 ctattcagta cagtactggagctcctagat agagcaatca ggcaagagaa agaaataaaa 26820 gacatcaaaa taagaagagaggaagctaaa ctatctctct tcacagaaaa tatgattcta 26880 tacctagaaa accctacagtctctgcccaa aatctcctaa tctgataaac aacctcaaag 26940 tctcccagat ctgataaacaacttcagcaa agtttcagga taaaaaaaat cgatgtacaa 27000 aattcaggag catttctacacaccaataat gtcccagctg agagccaaat taaaaaaaaa 27060 aatctcattc acaataaccacaaaaagaat aaaacaccta ggaatacatg tattagtccg 27120 ttttcatgct gctgataaagacatacctga gactgggcaa tttgcaaaag aaagaggttt 27180 aattggactt agagttccatgtggctgggg aaagctcaca atcacggtag aaagcaagga 27240 ggagcaagtc acatcttacgtggatggtgg caggcaaaga gaggagcact tgtgcatgga 27300 aactcctgtt tttataatcatcagatctcg tgagacttac tctctctcat gagaacagca 27360 tggaaaatac ctgcccccatgattcaatta cctccctcca ggtccctctc acaacacgtg 27420 ggaattcaag atgagatttgggtggggaca cagccaaacc atatcaatac atctaaccag 27480 ggaagtgaaa gatttctataatgagaatta caaaacagtg ctgaaagaaa tcagagacaa 27540 aacaaacaaa cggaaaaacatcccatgctc atggacagga agaatcaata ttgttaaaat 27600 ggtcatactg ctcaaagcaatttacagatt cgatgctgtt cctatcaaac tcctcacatt 27660 ttccacagaa ttagaaaaaaactattttaa gattcatttg gaaccaaaaa agagcctgta 27720 tagccaaagc aatcctaagcaaaaagaaca aagccagaga catcacacta cctgacttca 27780 aactatacta caaggcttccgtaacaaaaa caggatggtg ctagtacaga aacagacata 27840 taaagcaatg gaacaagttagaggacccac agataaagtc acgcatctgc aaccatatga 27900 tcttcagcaa agctgatgctaacaagcagt gggaaaagaa ctcactagtc aaaaaatggt 27960 gctaggataa ctggctagccatatacagaa tgttgaaact ggaaccctat gtttcaccat 28020 gtacaaaaat gaactcaacatggattaaag actgaagtgt aaaacctaaa agtataaaaa 28080 ccctagaaga aaacctaggaaatactcttc tgggcatcag acctgacaaa gacttcatga 28140 tgagaattcc aaaagcaattgcaacaaaag caaagactga caatagggac ctaattaaac 28200 taaagagctt ctacacagcaaaagaaacta tcaacagagt taacaggcaa cctagagaat 28260 ggaagaaaat ctttgcaaactatgcatctg acaaaagtct aatattcagc atctataaag 28320 aacttagatc aacaagcaaaaatcaaatga ccccattaaa aaaatggcaa aggacatgaa 28380 cagatacttc tcaaaagaagacatacacac caataagcat atgaataaat gctcaatatc 28440 actaatgatt agagaaatgcaaatcaaaac cacaatgaga taaccatctc acactagtca 28500 gaatggctac taataaaaagtcaaaaaata acagatgctg gtgaggttgt ggagaaaagc 28560 aaatgcttat acactgttggtgggaatgta aattagttca gccactgtgg aaagcagtct 28620 ggagatttct taaggaacttaaaatagagc taccatttga cccagcaatc ccattactgg 28680 gtatatactc agaggaatataaatcattct gccaagatca taaagacaca tgcataaaga 28740 cacatgcatg catatgttcattgcagtact attcacaata gcaaagacat ggaatcaacc 28800 taaatgccca tcaatggtagactggataaa gaaaaagtgg tccatatata ccatggaaca 28860 ttatgcagcc ataaaaaaggacaagatcgt gtcctttgta gcaacatggg tggggttgga 28920 agtcattatc ctaagcgagttaacataggt acagaaaacc aaataccaca tgttctcact 28980 gataagtggg agccaaacattcactttaag attctgaact atattcaatt aagtcataaa 29040 taatctttga atgctttgataatttctttt tttttttttt ttttgagatg gagtctcgct 29100 ctgtcgccca ggctggagtgcagtggcaca atctcggctc actgcaagct ccgcctcgcg 29160 ggttcacacc attctcctgcctcagcctcc cgagtagctg ggactacagg cacccgccac 29220 cacacctggc caatttttttgtatttttag tagagatggg atttcaccgt gttagccagg 29280 atggtctcgg tctcctgacctcgtgatccg cctgcctcgg cctcccaaag tgctaggatt 29340 acaggtgtga gccatcgtgcccggcctgct ttgataattt ctaagtaata tagaatcccc 29400 agaccaatct cagttgttatttcgtacaca tgcttttgga ttttattttt ataagttata 29460 gagtggttct ttgagtcttactaatgagcg tgttaatttt ttccacttca atgtgtgaaa 29520 gggatgtgtg tggacatatgaggttgcatt atgtgaactt atgagctttt ctgggctact 29580 aaatgcttct tatatgtaacaaatagttct caattgccac ttcttagtag tttccatgaa 29640 gtaaaagtag cttctttgattacagttcta aataatacaa gtggtagaga ttattgcagg 29700 tgcagtgtga cagagaagtatgaagagaac actattattt aaagcaaagt gtttggtgta 29760 gaatgttaaa gaagatagtaaaggatgaaa cttggatggt gaggaaaatt aaagtcatgc 29820 aaacagtgaa ctttatttgccttggtttat cataactaca gataatgagc ctgaaaagaa 29880 gcaataaaat ttattacaactgttagtaag ttttgcccaa tttttatgag ttttacgagt 29940 agaaatttaa gataaagtaaaaatgtaaag tttttaactg cctaaagttt aggttaatac 30000 aaaattataa tttattttttcccttatgtt aaaatgataa attggtttca gagccttcag 30060 tctgttgtta accacaggcaggttattttt ttaccttcaa tttaatctac tcagataatg 30120 aaactttatt tttttgagacagggtcttgc tctgtcaccc aggctggagt gcagtggtgc 30180 caacatggat cattgcagccttccattcct gtactcaagc aatcctccca cctaagctcc 30240 ctgagtagct gggactacaggtgtgagcca ccacgcctga gtaatttttt ttttttttta 30300 gagacattat ctcactatgttgctcaggct ggtttcaaac tactgagctc aagcgtcaag 30360 tgctctgccc acctcagtttcccaaagtgc tagggttata ggtgtgagcc actgtgccca 30420 gcctgcaatt ttatatctcacaagaaaagt tttctgattt tgtcatggcc ttgattacag 30480 tacttaaaaa caaaaacaaaaaacaaagta ctcatgctga aaaagctgaa gttccttaca 30540 attgtgttat cttttaggatttttttcacc ctatattttt cttttctcta gtgtcaactc 30600 ctgtgccaac cttgatttataggtagtcaa gttaaaataa ttcattgttc tcagatttct 30660 atgatttttt cttaatcaagtgacaaattc tgctatgata actttttgat tatgcttttc 30720 caagatcgaa ccctaaattatattttcaaa aattcaagat gtcttttaga cctaactgtt 30780 tttgagtttt cccaagaggcccctaaaaat catgaagatt tattcttttt tttttttttt 30840 ttgtgagata gagcctcactccattgccag gctagagtgc aatggcgtga tcttgccact 30900 agatttattc tttactcaaaaaggaatggt aaaaataatt gaaattgcct gatatatttc 30960 atatttctga agtagcagaacattattgta agaactgcat gggaaaagct gtcaaattta 31020 aagttcaacc atttctagttcaatttttag gtaaatagta ccaatataaa catgtttcag 31080 agattatgca cttagcataatttttcaatg tcttcactat ccatagtatg ttctttcctt 31140 tgaggaaaat attgaccaaatcctttttaa acagttatat attgtatacc agtagagagt 31200 ttttctcttc tccattttcatttagcatca ggcattcagt attatcatcg gcaggttatt 31260 tctgcttttc tctcatgctcacctgaagcc tttgctataa gctgtaggtt agaaagggtc 31320 ttggctgggc gcagtggctcacagcacttt gggaggccaa gatgagagga tcgcttgagg 31380 ccaggagttc aagaccagcctggtcaacag agcgagatcc catctctcag aaagaaaaaa 31440 aaagaaagaa agaagaaaaaaagaaagaaa caaaggaagg aaggaaggaa aagaaagaag 31500 gaaggaagga aaagaaagaaagaaggaagg aaagaaagga aggaaggaaa agaaagaaag 31560 aaggaaagaa agagagagagagagagagaa tgaaagaaag agagaaagaa agaaagaaaa 31620 gaaaggaaaa gaaaaaaagaaagaaagatt gcctcaatct aaggaggaaa cacttagggc 31680 attgcagaag actatagaattgatatcctc agctattgat acgtcaagaa attaagacag 31740 aggcagtgaa aagtggatggatctgagaga tatttaggac tctgaggttg attggatttg 31800 tggcacctat ctgatatgatttggatgttg tcccctccaa atctcatgtt gaaatggaat 31860 cctcagtgtt gaaattagggcctgctggga ggtgtttgga tcatggggga ggatcccttg 31920 tgaatagctt agcaccgtccctttggtgat gagcgaattc ttgctctgag ttcacccaag 31980 atctggttgt ttaaaagtctgtggcacctc ctcctgtctc tcttgctccc actctcacta 32040 tgggacatgc tagctttctgttgccttcca ccatgattgt aagctttctg aggcctcacc 32100 agaagcagat ggcaacactacgcttcttgt aaagcctgca gaaccattag ccaattaaac 32160 atgttttctt tataaattatccatttgtat ttatagcatg caaaaatgac cgaacacact 32220 atcataggta taattatcaaattcaaaagc attcagttcg tgaatattaa aagcttcagt 32280 tttgttctca ctcagatagaaaaaaccatt tcatgtctgt caggatgtga atcagaaaaa 32340 tgactgtggc tgggcatggtggctcgtgct tgtaattcca acacattggg aggctgaagt 32400 gggaagattg cttaaagccaagagttcaaa accagcctgg gaaaaatata aagaccctgt 32460 ctctacagaa aagttaaaaaaaaaaatgct tctggtaaag tccaagaaga aaacgataga 32520 tctgctcaaa tgtctgaataaagtattgat aatatgaggg ctttacacaa aatcataatt 32580 aatcctttca ataccctacatatagatatt attgcttgca ttttacagat aaggaaactg 32640 aggcttgggg ggagaaccttactcagggtc atacagctaa taaaagtaga attggctgag 32700 tgtagtggtg cacgcctgaaattccagcac tttgggaggc tgaggtggga gggaggcttc 32760 tgcccaggtt gcagtgagctatgatgacag tgccactgga ttcctgcctg ggtgacagag 32820 tgggaccctg tcactaaaaaaaaaaataac gataattaaa aaaaaaaaaa agaaaagtag 32880 actaggcata ctaacccaatttgtccagtt acaaacactt gattagagga ccaaattttg 32940 atgctaagga attaaaaaaaaaaaaaagga ttttaccctg gaaagatgtt aacattccca 33000 acattcctga ccttagatcctgagccccct ggtttaaagg ccgcctctct gaaccacttc 33060 cagttgcact ttctccaagtgtaaggaagc tgttcacctg caacctgctc acccttctac 33120 atcatggttt ggctacctcgaatccctgcc caacagcccc aggctacttc ccggagtctt 33180 ttctctggct agtccttctgagggtggcct gtgagtcttg agtgtacatc tctatgtcca 33240 atgacaggct gttagctctgctatgttcct gcatgaaacc ccaaggagac tgagaattcc 33300 aaatgtaaat ttggccttccaggtcattat gaatgcatat tcagactatg taaggaaata 33360 gagtttattt tattaaatactttcttagct taatttataa ctaccgtgta acatttgatt 33420 cacatgtata agggaggagcccacccctca tattgtctta tgccctaggc tgcgtcttgc 33480 tcctgtacac ggatgaccttctgctggaac atgccatggc agttgggtgt gcgaagggga 33540 cggatgccct gcttcagcacctggagaact gtgtgtataa ggtgtccaag aagaaagctc 33600 agatctgcag acagcaggtacactacctgg gattcgctat tcggaaaggg gagcgcagcc 33660 tggggtcaga aagaaagcgggtcatctgca gcctacagga acctaaaacc agaaggcaag 33720 taagggaatt cctgggagctgtggggtttt gcagattatg gattccaaac tttgctgtac 33780 tggtcaagtc tttgtatggagttacaaagg ggggcgaccg ggagtctttt gaatggggac 33840 ctctacaaca gcaagcctttcgtgagttaa aggaaaacct tatgtcggcc ccagtcctag 33900 gactaccaga tttgacaaagccctttacac tgtatgtgtc agaaagagat aaaatggcag 33960 ttggagtttt aacccagactgtggggccct ggccaaggcc agtagcctat ctctcaaaac 34020 aactagatgg ggtttctaaaggctgggccc catgtctaag ggccctggca gcaacagccc 34080 tgttagcaca agaaggagataaactaaccc ttgggcaaaa cctgaatata aaggcccccc 34140 gtgctgtggt aactttgatgaataccaaag gacagcatca gctaacaaac gctagattaa 34200 ccaagtacca aagctggctgtgtgaaaatt cccacataac cactgaagtc tgtaacaccc 34260 taaatcccac caccctgctcccagtatgag agcccagtcg agcataactg tgtagaagtg 34320 ttggactcag tttgttctagcagacctgac tttcaggacc agccatgggc atcagtagac 34380 tgggagttat acgtggatgggagcagcttc atcaacccac aaggagaaag acatgcagga 34440 tatgtggtgg taactttggatgctatcatt gaagccaaac tgttgccaca gggacgtcag 34500 cccagaaggc tgagctcactgctttaactt gggctctaga actcagtgaa ggtaagactg 34560 taaacatcga cactgactctcgatatgcct ttctaaccct ccaagtgcgt ggagcattat 34620 ataaggaaaa gggccggttaaactctgggg gaaaggacat aaaatatcaa caagaaattc 34680 tacaattatt agaggcagtgtggaaacctc agagagtggc agtcatgcac tgcaggggac 34740 accagcgaac ctccacttcagtggccttag gaaactcccg agctgactca gaagctcaaa 34800 aagcagcatc taccccttactgggcatcgg tagcagcctc cttactccct caaacacctg 34860 acctggtacc tacctattctaaggaagaaa aagaatgttt caacacagaa gggggcaagt 34920 aataaaagaa ggatggatcagactgccaga tgggagggaa gctgtgccgc agttgctggg 34980 agccacaatc atactggccatgcatgaaac cactcatcta ggtcaagagt cacttgaaaa 35040 gttgttaggc cggtacttctacacttgcca gcccttgcca aagcagtagc acaacggtgc 35100 gttacttgca gacagcagaacgcaaggcaa ggccccactg ttctgcccgg cctataagct 35160 tacggagtag ctccttttgaggatcttcag gtggaattca cagaaatgcc aaaatgtaga 35220 ggtaacaagt atttgctggttcttgtgtgt acttactctg ggtgggcgga gtcttcccca 35280 acacgaaccg aaaaggcctacgaagtaacc cttgtgcttc tccgagacct tattcctagg 35340 tttggactgc ccttatgaatcagctcagat aacgggccgg cgtttgtggc tgacttggta 35400 cggaagacag caaaggcattaggaatcact tggaagctgc gtgccgccta ctgacctcag 35460 agtttcggaa aggtggagcgaattaatcgg actatcaaaa atggtttagg gaaagcacgt 35520 caggaaacag gattaaaatggatacaggcc cttcctatgg tattgtttaa aattagatgc 35580 accccttcta agaaaacaggatactcccct tatgaaatac tgtatcatag gcctcctact 35640 atactacggg gacttccaggcactccccga gagttaggtg acattgagtt acagcgacag 35700 ctacaggctt tgggaaaaattacacagaca atctcgactt gggtaaatga gaggtgtcct 35760 gtcagcttgt tctccccagttcatcctttc tttccagttg atcgtgtgtg gatcaaggac 35820 tggaacgtag cccctttgcggccatggtgg aaaggacctc agaccgtcat cctgaccacc 35880 cccacggctg taaaggtagaaggaatccca gcctggatcc accacagcca tgtgaaactg 35940 gcagccgctg aaacctgggaggcaaaaccg agcccggaca acccctgcga agtgactctg 36000 aggaggccga caaaccctgctccagtcaca cccggaagct gactggtcta cgcacggccg 36060 aagcatgagg agaatcatcgtgggactcat tttccttata atttggactt gtatagtaaa 36120 aacttccact gattttccccgcatggagga ctgctctcag tgtatacatc aggttactga 36180 ggtaaggcaa caagttaaaacaatctttct gttctatagt tactgtgaat gcctaggaac 36240 tttaaaagga acatgtttatatactgacac tcagtacaag gtatgtagcc taggaaacga 36300 ccggccagct gtgtgttatgacccctctga gcttatccaa cacgaaactg aaaaggccta 36360 cgaagtaacc cgtgtgcttccctgagacct tattcctagg tttggactgc ccttacgaat 36420 tggcttagat aatgggccggcgtttgtggc tgacggtttt tgaaataaga ttaagggctg 36480 aagactagtg gggacgcgtaaatgatacaa gtaaagtaat agccagaaca gaagagaaag 36540 gggtgcccaa acacataatcttgaaatttg atgcctgtgc tgtcattagt ggcagtaaat 36600 taggaaaggg atgtggctcttttgggaaaa aggcgatatg actgaaaata agtacatttg 36660 tcatgaatta ggactgtgtggaaatgaatg tgaacactgg tcttgtgtca tttaggccac 36720 ttggataaaa aaatgaaaaggatccagtcc acttcagaaa ggaaaaagtg gcccttcctg 36780 tactaaggga caatgtaaccccttagagct agcaacaacc aatccccttg atccttgctg 36840 gaaaagaggg gagcatgtgaccttaggaat cgatggggca ggactggatc cttgagtaaa 36900 tatcttagtt cgaggagaagtttacaaacg ctctgctcag ccagtgtttc aaactttcta 36960 agatgaacta aatgtgccagtaccagaaat tccaggaaaa acaagaaatt tgtttttgca 37020 attagccaag catgtagcccagtctctcag tgtcacttca tgttatgtat gtggaggaac 37080 tgtgatggga gatcaatggccatgggaagc ccaagaatta gtacctacag acccagttcc 37140 caatgaattc ccagctcaaaagagtcacct tgataatttc tggaccctga agcctcaatt 37200 attggacaat attgcatagctagagaagga aaataattca ctcacccctt aggacaactt 37260 agttgtctgg gacagaaactgtataatggt accacaaaaa cagtcacttg gtggagttca 37320 aatcacacag aaaggaatccatttagtaaa ttcccaaggt tgcaaaccat gtggacccac 37380 ctggagtccc actaggactggacagccccc actggattat actggctatg tgggcataga 37440 gcttacgcta aattacctggccagtgggca ggtagttgta ttactggcac tattaaacca 37500 tctttcttcc tactgtccataaagacaggc gaactcctgg gcttccctgt ctatgcttcc 37560 catgaaaaaa gaagcatagctataggaaat tggaaagata atgaatggcc cccagagaga 37620 atcatacaat attatggacctgctacttgg ggacgagatg gttcatgggg atactagacc 37680 cccatttaca tgctcaaccaaatcatatgg ttacaagctg tcttagaaat aatcactaat 37740 atgggctggg cgcggtggctcacacctgta atcccagcac tttgggaggc caacgcaggt 37800 ggatcacgag gtcaggagattgagaccatc ctggctaaca tggtgaaacc ccgtctctac 37860 taacaataca aaaaattagccaggggtggt ggcgggtgcc tgtggttcca gctacttggg 37920 aggctgaggc aggagaatggcgtgaacctg ggaggcagag cttgcagcga gccgagattg 37980 tgccactgca ctccagcctgggcgacagag tgagactcca tctcaaaaaa aaaaaaaaaa 38040 agaaaagaaa gaaagaatcactaataaaac cgacagagcc ttgactattc tggcctgtca 38100 agagactcag atgagaaatgctatctatca aaatagattg gctcttgact acttgctagc 38160 agctgaagga ggggtctgtgggaaatttaa ccttactaat tgctgtctac acgtagatga 38220 tcaagggcaa gtagttgaagacatagtcag agatatgata aaactgtcac atgtgcccat 38280 gcaagtgtgg catggatttgatcctggggc catgtttgga aaatggttcc cagtgttagg 38340 aggatttaaa actcttataataggagttat attagtaata ggaacctgct tactgctccc 38400 ttgtttgcta cctgtacttcttcaaatgat aaaaagcttc atcgctacct tagttcacca 38460 aaatgcttca gaacaactgtactatatgaa tcactatcga tctgtcttgc aagaatacat 38520 gggtagtgag gatgaaagtgagaactccca ctaattgact gaggttctca aagtggggga 38580 ataagggagg agaccacccctcatattgtc ttatgcccaa tttctgcctc caaagaaaga 38640 agtaaaaatt aaaaggcagaaatggaatcc acaggcagat agcccagcat cacgccctgg 38700 gcctggtagt taagaatcaacccctgacct aactgctcgt gttatctata gatttcagac 38760 attgtatgga aaaacattgtgaaaatccct gtcctgtttt attccgttct gatgaccggt 38820 gcatgcagct cccagtcacgtacccactgc ttgcttaatt gatcacgacc ctctcacgcg 38880 gaccccgtta gagttgtaagcccttaaaag ggacaggaat tgctcactcg gggagctcgg 38940 tttttggaaa cgtgagtctgctgatgcttc cagctgaata aagccctttc cttccacaac 39000 tcggtgtcgt ctgaggggttcttgtctgtg gttcgtcccg ctacacgtac agggtaatgg 39060 tttaatattt catgaataatattaattgta tttcaaaatt aatgtggtta aatatactga 39120 tatactttaa tacattttttcaacagttta atgttttggc atagataata aatacaaata 39180 ggaatttgca tttatctaatgacaaaatgt taacatttta aactctactc agttataaac 39240 taaactcaat tttaaaatgtttaaaaaatg tgtggatgac acaaaaacaa accttcatgt 39300 ttgtttatat tctccccttattaatcctct ttaaggatta attaagccta caaaattcta 39360 ctttaataat agttgttctccttaagagtc ccttaaaact ttttttttta attaaataac 39420 taggccaggt gtggtggctcacacctgtaa tcccagcact ttgggaggct gaggtgggta 39480 gatcccctga ggtcaggcattcaagaccag cctggccaac atggtgaaac cccgtctcta 39540 ctaaaaatac aaaaaaattagccaggcatg gtggcgcatg cctgtactcc cagttactag 39600 ggaagctgag gcaggagaatcacttgaacc caggaggtgg aggtttcagt gagccaggat 39660 cacaccactg cactccagtctgggcaatgg agcgagactc cgttttgaaa aaaaaaaaat 39720 gaaataagtg gtattgtgccaaaacaagtc taataggaaa aacaatcaag ctcataccct 39780 ataaatatat atctaagatattaggaccca aaagaaaagg aaaattatgc agggtcactt 39840 cacattctac atgacctctacctagatatt ctcatttaat tttaaatcac attatcattt 39900 ccgaaagccc aaatttaaaatagtaaaata actaatgcat ttaacaccta gtgcctagag 39960 tttggtctgt aaagctattctccactaaat agaactaaaa gttcttggag aatttcaatt 40020 cctagagaaa aaaaaagaaaagaaaaacct ttaaggtgga cctaagtgat cttgctacta 40080 gaatgaggga tttttttaaatgccttttaa agttccaaag tggtgttaag aaaacataga 40140 aagcaacctt ttccaatggcaaaatttcga attttgcaca tcaaaagtaa ataaaattat 40200 aggtaattaa ttttaggttacgaatagtaa atcatactta atttttgctc cataatgtat 40260 gcttacactc tctaagaacctcaggatatg aaataaggaa ataagtatgc ttgtgtacta 40320 tagagattgt tttgaaatttttactttaaa cttgtaatat tttttacaaa caaaataatt 40380 tatggattta catacataaactattaataa taaaaggaat aagtataaat ctatcactga 40440 aaattacaga gagaggaaaaaaataacctg gtgatatggt ttggctgtgt caccacccaa 40500 atctcatctt gaattgtagttcccataatc ccaacgtggg gacccagtgg gtgataaccg 40560 aatcatgggg gcagttacctccatgctgct cttgtggtag tgggtgagtt ctcatgagat 40620 ctgatgattt tataaggggcttccccctac tttgctctgc acttctcctt gctgcggtca 40680 tgtgaagaag gacgtgtttgctttcccttc caccaagatt gtaagattcc tgaggcctcc 40740 ccagccttgc agaattgtgagtcaattaaa cctctttcct ttataaccca gtcttgggta 40800 tgtctttatt agcagcgtgagaacagacta atacacctgt cagtctcctt catgctttct 40860 gattgcacgc tttaatgcaatgaccagaat caaacagaaa cgaccttggg tgttttctct 40920 ggattttcct gggcaaccagccagtgggac ctggaccttc tggctcacag ttggaggggc 40980 tacacctgaa ctcagcttttcatgggatgg acagtttctt ccaacacaag ttccaacaac 41040 tttctgtttg acccaaggtctccagatact ggataatggg ctttttcaaa aaatacctat 41100 cgggccgggc gcagtggctcacgtctgtaa tcccagcact ttgggaggcc gaggggggcg 41160 catcacgagg tcaggagattaagaccatcc tggctaacac agtgaaaccc cgtctctact 41220 aaaaatacaa aaaattagccgggcatggtg gcgggcgcct gtagtcccag ctactgggga 41280 ggctgaggca gaagaatggcgtgaacccgg gaggtggagc ttgcagtgag ctgagatcgt 41340 gccactgcac tccagcctgggcgacagagt gagagtctgt ctcagacaaa caaacaaaca 41400 aataaatgcc tgtaaacagactgcctggtg ctctagtagt ttccttactg acaaaattct 41460 ttttgtgtgt gccctataaataggagagca acaagaggat gggattcctc tcctattatg 41520 caaacccaca ccatggatccagcagactac tctggcccca gcatgctgct ccttgggatg 41580 atgggagaag ggggaaacctgtgttttctc ttggttttgt aagtttcccc tttccccagt 41640 aaaactcatc ccttaatctagtggttctca aactttggtg tgtatcaaaa ttatctggta 41700 ggctggataa aacacagattgctgtgcccc acttccagaa cttctggttc aatagatcta 41760 gaaggagact gggaatttgcatttctaaca ggtccccaga tgatggtaat attgctggtg 41820 gtggtgggga ggaccacattctgagaacct ctgtatttaa ttttatttgt atttatttat 41880 tttatttatt gttttaatttaatttttgag tccctgttac tcaggctaga gtgcagtggc 41940 ataatcatag tccactgtaacctgaactcc tggcctcaag tgacactccc aaagtgctga 42000 gattacaggc gtgagacacaatgtgcatcc cgggccttcg ttttaattca tacagtgtga 42060 ctatgtggta atcagttctgttggttacca aaaaggctcc cacttgtatg aacttcacat 42120 aagagttaac cactctcctttctagtgcct atctttacag acgacccctg acttatgatg 42180 gtttctcttt gatttcctaactttacagtg atgcaaaagc tatatgcatt cagtagaaac 42240 catgctgtga gtacccatacaaccattctg tttttcattt ttaatacagt attcaataaa 42300 ttacagggta tattagacactttattacac cttattatgt tagatgactt tgcccaactg 42360 taggctaatg taagtgttctgagcatgttt aaggtagggt agcctaagct atggtgtttg 42420 gtaggttagg tgttttacatgtatttttga cataggatat tttcaactta tgatgggttt 42480 atcaggaggt aaccacattgtaagtagaga agtgtttgta tagttttacc acatacctag 42540 gaatccttat ctagtggattcagtttccgt tgttcaaaag ttttataaag gccaggcatg 42600 gtagctcatg cctgtaatcccagcactttg ggagatggaa gtgaacggat cacctgaggt 42660 cagaagttcg agaccagcctggccaacatg gtgaaacccc acctctaata aaaatacaaa 42720 aaattagcca ggcttggtggtgggtgcctg taatcccagc tactcaggag gctgagacag 42780 gagaatcgct tgaacctgggaggcagagat tgcagtgagc caagatgccc cattgcactc 42840 cagcctgggt gacaagagtgaaactccatc aaaaaaagaa aaaagaaaaa taaaaaagta 42900 aaagttgtat aaaatagcattatttcttga ggatattatt tgacttgctt ttttcactca 42960 tccatccaat gtatagctatcattcactca tttttattgt tgtataatat tctgttttgt 43020 gtatatacct gttgaaagacatttggctta ttttcaggtt tttttctatg aagttgctat 43080 gaacacctat aaatgtttcctagtgtatag gaccaagact ttttctaggg cagtaattct 43140 cagatggggg aaattttgctattcccaccc acccctgaaa cccagaagac atttggcaat 43200 gtctggagac acttttattattagaactca ggagtgttac tagaattaag agggtggatg 43260 ctgctaaaca tcttaaaatgcacagagcag cctaaattat acaaaatgat ccagcctata 43320 atgttaatag tgtggaggctgaaaaaccct gttgtaggac agtggttcac aaagcatcag 43380 catcacctag gaacttgctagaaatctcta agatagatac ataggagtgg aattgctggt 43440 tataaaataa gcaggtattcacattaataa gattatgcca atttgcccat tttattgtgg 43500 ggttgtgttt ctttttctctatatattttg tttatatgtt ctctttgttt attattgaga 43560 aagagggcaa aaagcagcccctgatattca gaagctgacc tggcactcac agcttggcca 43620 taatattatt ctgttgaacattaacaattt aaatctcata gaataccaag ctgagacaaa 43680 agtactctga gatcacaataaaatgagaca aggccacttc atagcattat ctaagcatag 43740 gcaaaaacaa ggtctttgtgtcacccataa gataacagac accccctttc tggataaaat 43800 gtacaacagc tactttttttattattatac tctaagttct aaggtacatg tgcacaacgt 43860 gcaggtttgt tacataggtatacatgtgcc atgttggttt gctgcaccca tcaacttgtc 43920 acttacatta ggtatttctcctaacgctat ccctccccca gcccccccac ctctcaacag 43980 gccccagtgt gtaatgttcccctccctgtg tccatgtgtt ctcatttttc aactcccact 44040 tacgagtgag aacacgtggtgtttggtttt ctgcccttgt gctattttgc tgagagtgat 44100 ggtttccaga ttcatccatgtccctgcaaa ggacgtgaac tcctcctttt ttatggctgc 44160 atagtattcc atggtgtatatgtgccacat tttctttatc cagtctatta ttgatggaca 44220 tttgggttgg ttccaagtctttgctattgt gaatagtgcc tcagtaaaca tacgtgtgca 44280 tgtgtcttta tagtagcatgatttataatc ttttatatat acccagtaat gggattgctg 44340 ggtcaaatgg tatttctagttctagatcct tcaggaatct tcacactgtc ttccataatg 44400 gttgaactaa tttacactcccaccaaaagt gtaaaagtgt tcctatttct ccacatcctc 44460 tccagcatct attgtttcttgacgttttaa tgatcaccat tctgactggt gtgagatggt 44520 atctcactgt ggttttgatttgcatttctt tgatgaccag tgatgacaag cattttttca 44580 tatgtctgtt ggatgcataaatgtcttctt ttgagaagtg tctgttcata tcctttgctc 44640 actttttgat ggggttgtttttttcttgta aatttgttta agttctttgt agattctgga 44700 tattagccct ttgtcagatggatagattgc aaaaattttc tcccattctg taggttgcct 44760 gttcactctg atgatagtttcttttgctgt gcagaagctc tttagtttaa ttagatccca 44820 tttgtcaatt ttggcttttgttgccattgc ttttggtgct ttagtcatga agtttttgcc 44880 catgcctatg tcctaaatggtattgcctaa gttttcttct agggttttta tggttttagg 44940 tcttacattt aagtctttaatccatcttga gttaattttt gtataaggtg taaggaaggg 45000 atccagtttc agctttctacatatggctag acagttttcc cagcacattt attaaatagg 45060 gaatcatttc cccattgcttgtttttatca ggtttgtgaa agatcagatg gttgtagatg 45120 tatagtgtta tttctgaggcctctgttctg ttccattggt ctatatatct cttttggtac 45180 cagtgccatg ctgttttggttactgtagcc ttgtagtata gtttgaagtc aggtagtgta 45240 atgcctccag ctttgatctttttgtttagg attgtcttgg ctatgcgggt tcttttttgg 45300 ttccatatga accttaaagtagttttttcc aattctgtga agaaagtcat tggtagcttg 45360 ttggggatag cattgaatctataaattacc ttgggcagta ggaccatttt cgcaatattg 45420 atttttccta tccatgagcatggaatggtc ttccatttgt ttgtgtcctc ttttatttca 45480 ctgagcagtg ttttgtagttctccttgaag aggtccttca catcccttgt aagttggatt 45540 cctaggtatt ttattctctttgtagcaatt gtgaatggga gttcactcat gatttggttc 45600 tctgtctgtt aatggtgtataggaacgctt gtgatttttg cacattgatt ttgtatcctg 45660 agactttgct gaagttgcttatcagcttaa ggagattttg ggctgaggct atgcggtttt 45720 ctaaatagac aatcatgtcgtctgcaaaca gagacaattt gacttcctct cttcctactt 45780 gaatacccta tattgctttctcttgcctga ttgccctggc cagaacttcc attactatat 45840 tgaattggag tggtgagagagggcatcctt gtcttgtgcc ggttttcaaa gggaatgctt 45900 ccagtttttg cccattcagtttgatattgg ctgtgggttc ctcataaata gctcttatta 45960 ttttgagata cgttccaacaatacctagtt tattgagagt ttttagcatg aaaggctatc 46020 gaattttgtc aaaagccttttctgcatcta ttcagatgat catgtggttt ttgtctttgg 46080 ttctgtttat gtgatggattatgtttattg atttgcgtat attgaaccag ccttacatcc 46140 cagggatgga gccgacttgatcgtggtgga taagctttct gaggtgctgc tggattcggt 46200 ttgccagtat tttattgaggatttttgcat cgatgttcct tagggatatt ggcctaaaat 46260 tatctttttt tgttgtgtttctgccaggct ttggtatcag gatgatgctg gctcataaaa 46320 tgagttgggg aggattccctcttttccgat tgattggaat agtttcagaa ggaatggtac 46380 cagctcctcc ttgtacctccagtagaattc ggctctgaat ccgtctggtc ctggactttt 46440 tttggttggt aggttattaattattgcttc aattgcagag cctgttattg gtctgttcag 46500 agattcaaat tcttcctggtttagttttgg gagggtgtat gtgtcgagga atttatgcat 46560 ttcttctaga ttttctagtttatttgcgta gaggtgttta tagtattctc tgatggtagt 46620 ttgtatttct gtggtatcggtggtgatatc ccgtttatca ttttttattg cgtctatttg 46680 attcttttct cttttcttctttattagtct tgctacaggt ctatcaattt tgttgatctt 46740 ttcaaaaaac cagctgctggattcactgat ttttttgaat ggttttttgt gtctctatct 46800 ccttcagttc ttttctgatcttagttattt cttgccttct gctagctttt gaatgtgttt 46860 gctcttgctt ctctagttcttttaattgtg atgttagggt gtcgatttta gatctttcct 46920 gctttctttt gtgggcatttagtgctataa atttccctct acacactgct ttaaatgtgc 46980 cccagagatt ctggtacgttgtgtctttgt tcttactggt ttcaaataac atctttattt 47040 ctgccttcat ttcgatatttacccagtaat tcaagagcaa cagctacttt tttttaccag 47100 tcatcacgta gggaagaaaaaatatcttct ccttctaccc ttctaagttc ttgactgggg 47160 cctttgtaag aaaagagagattaacaatac aaaaaacata caaatttatt caatataagt 47220 ttacataaca tgggaaccttcttaaggaca tgaagaatgg aagaaatgat taaacctgag 47280 catttttatg ctaggtttgatagagaatga aaagtcatag gaaaacctaa taacacaaag 47340 gatatgagct gcaattccttcagcttaaaa taattaattt ttaaatattt aaattttaaa 47400 aatttaatta aagtgtcataatttggggta gcatgtcctg aactccatca atagaattac 47460 ccttgctttc tgaaaacactcatactatgg gggaaccaaa cctccttctc ctaaattcta 47520 aaactgtctt actgagacaccccatgatgt gtgttctctc ttgctcagtg agcaatgaat 47580 tcatcttgtt caaccacaaatgtccctgtg tctctggctg aagggcatat ttcagagatc 47640 ttaatagtct ttattatgccttttggtgag caccacttct tttttttttt tcttttgaga 47700 cagagtcttg ctcttgttgcctaggctgga gtgcagtggc atgatctcgg ctcaatgcaa 47760 cttccgcctc ccaggttcaagcgattctcc tgcctcagcc tcctgagtag ctgggattac 47820 aggcacacac caccacctctggctaatttt tgtattttta atagagatgg ggtttcacca 47880 tgttggccag gctggtctcaaactcttaac ctcaagtgat ccacctgcct cggcctccca 47940 aagtgctggg attacaggcgtgagccaccc cgcccagccc agtgagcaac acttcttaat 48000 tttagttcgt ttttaattttttgcctccct aatgagtgct ttttatgtta tatttaagaa 48060 atcctggccc ggcgtggtggcttacacctg taatcccggc actttgggag gccgaggtgg 48120 gttgatcacg aggtcaggagatcgagacca tcctggctaa cacggtgaaa ccccgtctct 48180 actaaaaatg caaaaaatcagccggatgcg gtggcgggca cctgtagtcc cagctactag 48240 ggaggctgag gcaggagaatggcgtgaacc caggaggcgg agcttgcagt gagccgagat 48300 agcgccactg cactccagcctgggcgaaag agcgagactc cgcctcaaaa aaaaaaaaaa 48360 aaagaaagaa agaaatcctgccaggcacag tggctcacgc ctgtaatccc agcactttgg 48420 gaggccgagg tgggcggatcatgaggtcag gagatcgaga ccatcttggc caatacggtg 48480 aaaccccgtc cctactaaaaatacaaaaat tagctgggct tcgtggtgca tgcccatagt 48540 gccagctact caggaggctgaggcaggaga atcgcttgaa ccccggaggt ggaggttgca 48600 gtgagccgag atcgcgccactgcactccag cctggtgaga gagtgagact ccgtctgaaa 48660 aaacaacaac aaaaaaatcctttcttactc caatatcata caggtatttt tttttttaag 48720 tttccatttt tttttttttttttttttgag actcagtttc actcttgttg ctcaggctgg 48780 agtgcaatgg cacgctctcagctcatggca acctctgcct cctgggttca agcaattctc 48840 ctgcctcagc ctcccgagtagctgggatta cagacatgtg ccaccatgcc tggctaattt 48900 tgtattttta gtagaaacgagctttctcta tgttcgtcag gctggtcttg aactcccaac 48960 ctcaggtgat ccgcccacctcggccttcca aagtggtggg attacaggca tgagccacca 49020 cgcccggcca acttgacaagtttttaaggt ataattcatt cagagtctaa aagtttagta 49080 ggatcatggt agtcaggagaataatttcac tgcagaggtg tgtatgtgtt tagcaaagtg 49140 attgctaaca gattttcctgaaatccccga cagcacaaag tatcctttac attattatct 49200 ttcatgcata taaaatctcacatatttctg tatagtggga gaacctggac tttaacattt 49260 tatatgaaag aaatgcataaaccctgtctt tagaagataa tgtaagattt ggaaacaata 49320 tggtaaaagt aggaatagaacaaaaggggg aaaatgacaa aagaaatttt tttaaaaaag 49380 tccatgggat tcgtgggtttctcagcttaa agggacaagg gaaagcaagt ctaggatgac 49440 tcccagtatt caaagttaccagaagcttga gatgatgaac tgctaaggta gtgagtgtgc 49500 cctattttgg ggaaaagatggttttctctt caagtctgtt gctccttatc tttcctcaat 49560 gaatttctaa ggagcattgaaatttgtgtg aaagaaaggc ttccaaaagt aaataagttt 49620 aaaatccagg gttttgtattatactttcag atttccacaa aggcccagtt tctctgtttt 49680 ttttttaaag ttaaaaaaaagttgaaaatc aaaagcccca agtgggaagt aatttgtgtg 49740 tatctaaata ttgtatacattcactgtttt atcccagcaa tttataaact gggtgtgcag 49800 aaagcagcct ggagcaaaaacattgtaatg ggagttaaga gatcaggatt ttaatgatgg 49860 tctgctacta atctatacgaaaatggtttg tgtataggtt tcagattcct taaatatgta 49920 gaataagact acataatcttcaagcttctc tgcagcactt aagttcagat tctacttaag 49980 cacttacgga atgtgtcagt50000 7 50000 DNA Homo sapiens human DYXC1 chromosomal gene region,nucleotides 50001-100000 7 gtaattccaa tttaccctat tccagatttg tagcaaagcatttgtcagat gaatcatagg 60 gtggtttctc ttcagttttc aaactttgga gcaaaacctatataggtgct tttggcggcc 120 ttacagttaa taggatttgc aggatacaat agttttagacaagctcctgg tatgtgttgt 180 gaacaaacgt tttctgaaga ggaatttgga gcaaagcaactatttcaggg aacagtttgc 240 aaactgggga gttgaagcct taggtgtaaa acaaaggtgcattccagaga acaaagggag 300 ggtttgggtt ttacagcaaa agtttctgcc caggttcccagtcaggttcg tttatacaaa 360 tgaacgattg aaccgcactt agttctgatt ggttgatacagctgagccct gattggttga 420 ggcaggtgag ccctataaga cccaacactc aacagaggtgtgggtttggg gagaacgcag 480 agtccatgtg tgacctctag taggtaaatg accacgtgtctctattttaa atttagaccc 540 agttagccgc tctggatgtt gacggattgg ctctttcaggttcacatttg ttcacagtct 600 gtatgaccaa gaaatttgca aaacagaaca actagcgctaactcttaata gcctcagtca 660 gaataaacag acaagacact gcaccaaggg cgtatgggcattgcacctgc tcctcatggg 720 ctgctttccc gagccttatg cccacagccc tccttagcattatcgcatta tgaggctgga 780 agtgcttttt tttttctttc tttctttttc ttttctttttttttttttga gacggagttt 840 cgctcttgtt tcccaggctg gagtgcaatg gcgcgatttcggctcactgc gacccctgcc 900 tcccgggttc aagcgattct gctgcctcag cctcagcctccagagtagct gagattacag 960 gcatgcacca ccacgcccgg ctaattttgt atttttagtagaggcggggt ttctccatgt 1020 tggtcaggct ggtctcgaac tcccaacctc aggtgatccgcccgcctcgg cctcccaaag 1080 ttctgggatt acaggcgtga gctagcgcgc ccgacccacagagtgctttt tttttttttt 1140 ttttttctca agcagagggt atgggtctac ttctttgaacattcgctcag atcgtaaggt 1200 aaccccaaga atcggcatca ctctctggtc tgggcgcctggatagtcacg catggagtcc 1260 gcgaggtgct ggcgccggag cacgctggga acgccgggctcccggccggc ctgacccgga 1320 agggctggcg catggtaacc ccagcttccc tagcaaccaagcaggcgcaa gaagcaacca 1380 gccgcgctat ccgctcccgt tgctaccgga atgcctcttcaggttagcga ttacagctgg 1440 cagcagacga agactgcggt ctttctgtct ctgcccctcaaaggcgtgtg cgtcagagac 1500 acggacgtgt tctgcacgga aaactatctg aaggtaagaatgcaagtctt gcctgccggt 1560 ctccgggggt gtggtccgaa gcttctgcaa gagcgcagctgggcacgagc aacaggctca 1620 tctttgccga taaacgtcct aaatttttaa tcctattaaaaaaatgaatc ccatacaggt 1680 aacacaccat ctgtagacag ataatcagat cagagactacttttatccag ggcttcctca 1740 tatgccttgc taatctttca ctacctggca taaatttagtgggcctttta gaaagttatt 1800 ttaccttttt cacgtgtttc ttaatacgcg tgcttaatttgtgtaactaa cttagtttct 1860 gttttcaccc ttctgcatag gtcaactttc ctccatttttatttgaggca tttctttatg 1920 ctcccataga cgatgagagc agcaaagcaa agattgggaatgacaccatt gtcttcacct 1980 tgtataaaaa agaagcggcc atgtgggaga ccctttctgtgacgggtggt aagttcttta 2040 ttaaaagatg ttcatctggt tgtacctttt cggtttcagaccttttaaaa aattttattt 2100 tgaagcacct atattgtgta ggggaagata gattttttttttttaagagt cttgctctgt 2160 cgcccaggct ggagtgcagt gacatgatct cggcttactgcaacctctgc ccccggggtt 2220 caagggattc tcctacctca gcctctcaag tagctgggattataggtgtc cgccaccacg 2280 cccggctaaa tttttttgta tttttggtag agcgttttgccatgttggcc aggctggtct 2340 cacactcctg accggtcatt aagtgatcca cccgccttgacctcccaaag tgctgggatt 2400 acgggtgcga gccaccacac ccggccagat agactttccttttactctcc aaggttcaat 2460 agctgggtct ataaaataaa ctaacaacag aaggattgacagaagaaaat gtatagaaat 2520 ttatgaattt ttaatattag tgcttgaggg catcacagggaaaaaagtga atacccccca 2580 agcggtgaga tttgagagtt tagggactgt cttaataggggaagggggag gggatgtagg 2640 ccgcttagaa caggaaatga tttttaggaa agatgaatggatccttagaa gaatagatag 2700 gaaatgtgat agcttttaac aaaatttgtc agagtgtggtgttgacttgt agtttccttt 2760 tctgggagaa tagtcaatat tccctggtta atgaaactccaggggaagag atttatgaca 2820 cttgggttcc tttggaaaat ctgtttttag gcagataagaggagttctgg caaaacctct 2880 ccctgcattt gctgctttca agtgccttta actcaaaatgatcgctatat gaaagcagca 2940 tattttgggg tggcatatcc tgaactcatt caattgctgttttagaaaaa aaaaaaggct 3000 tatgagccta atttaagtga tacagtgctt cagcagccatttaaataaac ctaaaggctg 3060 aattagtcaa agttagagca cattaagcag aagatgtgggctcatgtctt aagggtaagc 3120 cctcctgata tatagccttt attgagtact taactttgcgttaggtgtta acatgcctgt 3180 aattccatga aacaacctgt cacttaggta ttattaccctttttttacag gggaggctac 3240 tgacatatgg aaagtttgag taattggcaa aatcacacagctagtgactg gcagcctgga 3300 actggagcct tagcagtttc actctagagc agatgttcccaaccctggct acatatttga 3360 atcagctatg gaattttaaa ataatactct aatccagtgaaatcagtttc tgggaatagg 3420 actcaggtgt tggaagtttt gaaaagcttt ccaggaattataatgtgcag ccaaagttga 3480 aatccccagt tgttgtttgt ttgtttggaa agacagagtctcgctcagtc acccaggctg 3540 gagtgcagtg atgcgatctc ggctcactgc aacctccgcctccctaggtt taagtgattc 3600 ttcagcctca gcctcccaag tagctgggac tacaggcacgtgccaccacg tccagctaat 3660 ttttgtattt tttagtagag acaaggtttc actatatgttggccaggctg gtctcaaact 3720 cctgacctca agtgatccac ccacctcggc ctcccgaagtgccgggatta cagccatgag 3780 ccaccgcgac cggcctgaca tccccagttt taaagctagttctctgtagt cttattaagc 3840 tagttgtcag tgctttgtac taataccaag atcagcttccatagtcagta attgtcctct 3900 actgctttag ccctgttttc ctccttcctt ctttagttgtcatgttttct aatactttat 3960 gtttactgcc tggaatttat tttttttaat tttgagttttttaagagata gaatctcacc 4020 ctatcaccaa cgctggagtg cggttggtgt taccatagctcattgtaacc tcaaactcct 4080 aggttccagc aattctcctg cctcgacctc ctgagtagcagggactacag gtgtgcacca 4140 aaacacctag gtaattgttt ttatttttgt agagacagggtctcactatg ttgccgatag 4200 gtcttgaact cctaggctca agtgatcctc ccactttggcctcccaaatg ctgggatttc 4260 aggcgtgagc cactgcaccc agactactgc ctggaatttcttttaagcct ttggcattaa 4320 gccttgaata tggactcttg agggtagaaa gagttgcaaccattctttct atcaaggctt 4380 tcttggtatc ttgtagtgga atttaatttt taatttccaagaccaaggta gaatttattt 4440 ttctaagatc gggtattcag ctcagagaat actggttaaggtaggttaac atagccagtt 4500 tacttaattt tttttttttt tttttttttt tttttagtgagccccagact acctaaagag 4560 ttttaaagaa tcaggttcct gttttttgac ctcttacttcctctgtgact cagtaagtct 4620 atgttggggc ctgaggatgt cataacacac ccagtctgttttgacttctt acctaaaatt 4680 gaatatacat ttattttgac tcttgtaaat taactttttctgtaaaggac cagatagtat 4740 tttagacttc acaggccata tggtctctgt catatctattcagctctgcc attgtagcac 4800 aaaagtagcc acaggtgatt catatttatg gacaatgaaatttgaatttc atctaatttt 4860 taaatgccac aaaatgttat tttgattttt ttcatccatttaaaaatgtg aaaattattc 4920 aaggcttgtg ggctgagggg aaacaggtgg caggtcggatttggcccatg ggtcatagtt 4980 tgccaacctc tgatttagac aaatcaaaac agtcttaaaactgacttaag ctcagcgcag 5040 tggctcatgc ttgtaatccc atcactttgg gaggccgaggcaggtgaatc acctgaggtc 5100 aggagtttga gaccagcctg gccaacatgg tgaaaccctgtctctactaa aaatacaaaa 5160 cttcgtcagg cgtggtagtg gatgcctgta gtcccagctacttgggaggc tgatgcagga 5220 gaatcgcttg aacccgggtg gtggaggttg cagcgagctgagatctcacc actgcactcc 5280 agcctgcgca acagagcgag actccatctc aaaaaaaataaaaaataaaa aaccactaat 5340 ttatatcaca atgaacattg attctacttc agaaaccaggtttgagattc ctttagaaat 5400 caaactcagt ttgccgggcg cgctggctca cgcctgtaatcccagcactt tggtaggccg 5460 aggcgggctg atcatctgag gttgggagtc cgagaccagcctaaccaaca tggagaaacc 5520 ccgtctctac taaaaataca aaattagccg ggcatggtggcgcatacctg caatcccagc 5580 tactcaggag gctgaggcag gagaatcact ttaacccgggaggcggaggt tgcggtgagc 5640 cgagattgtg ccattgcact tcagcctggg caacaagagcgaaactcagt ctcaaaaaaa 5700 aaaaaaaaca agaaagaaat caaactcagt tttgccaggttacagtggct catgcctaaa 5760 gtaatctcag cactttagga ggccaaggtg ggaggatcatttgagcccag gaattcaaga 5820 ccagcctggg caacataggg agacttcacc tctattaaaaaaaaaaaatt agccgggcat 5880 agtggcatgt gccttatagt cccagctact tgggaggctgaggttggagg atcacttgag 5940 cccaagaggt ggaggctgca gtaagccatg ctcataatgctgcactccaa cctgggtgac 6000 agtatgtgat cctctctcaa aaaaaagaaa tcaaactcaattttacttgc aattcagtgg 6060 gattatttat ttaaccattt ttttttcaca taaaatattgtggaactcca gtttatacac 6120 gtagactgtc tacctcatta ttcagactct aatttttctcattttttctg gaaattcctt 6180 cttgatacac tctttatttc tattagacat ggagtatttcatttgggaag ttaatgttct 6240 tccagttatt tctgccgctg aagctgactt agctgtctaccttcctgttt ttaaacagca 6300 ggagagatga gaagaggctt cagacctaac ttcagtactagttcttagcc aagatcttag 6360 atgaataaaa ttacacactt ttacttacct ctaactgatatttaacattc tcttcaattg 6420 tgaagatagg caacaaataa tagtagtatc ttagtctgtttgggtactat aacaaaatac 6480 catcaactga gaagcttata aacaacagaa ctttatttctcacactcctg taggctggga 6540 agtccagatc aaggtcctgg caggtttggt atgcggtgagggctcacttt cctgtagatg 6600 gcaccgtact gtgtcctcac atggtggaag gggcaagtctgctttctggg gccttctgta 6660 taaggacact acctcccaaa aggcctcacc tacaaataatatcacattaa gggttgggat 6720 tttaacataa gagttttagg gagacataaa cattcagaccatagcaagta gtatcaacaa 6780 aaacaaaagt atgtttatat cagagatacc tcttttatactctactttga aattacaata 6840 ttagacttgt tgctatatat taatgcatta ataaagaagcacataatcgt gtatcacaat 6900 ttggccggcc gcagtggctc acgcctgtaa tcccagcactttcggaggcc aaggcaggcg 6960 gatcacaagg tcaggagatc aagaccatcc tggccaacatggtgaaaccc cgtctgtact 7020 aaaaatataa aaattaggtg ggcgtggtga tgcccacccgtagtcccggc tacttgggag 7080 gctgaggcag gagaattgct tgaacccagg aggcgggggttgcagtgagc tgagatcgga 7140 ccacagcact ccagcctggc aacagagcaa gactccggctcaaaaaaaaa aagtatatca 7200 caattttatt tcttaatgtt ttataagtgt tttgatataactgagtttct ttgtagacct 7260 gtatatttta tttcatacat tttaaaacat tgtgaaaggatttataagga ttcactactc 7320 tgccaaggtg tctgctgcac aaaaaaggtt aagaacccatgcctggggta tgattcatcc 7380 ctctacccac cccttatcta ctctccccta ctttgtcttcccctcaagtt ttctcctctc 7440 cccttctgtt tttttttttc tgcttaaagg ctagatcttttcccttaggc tctgatcctt 7500 ccctttgtaa gataatttac ccattgatcg tagtcttcagtttgtgaaac tttgggccac 7560 atcaaatata aagataactg tgagatcttg cgtggtggctcatgcctgta attccagcac 7620 tttgggaggc caaggtagga gcatcgcttg agcccaggagttcaagacca gcctgggcaa 7680 tatagtgaga cctcgtctct acataaaatt taaaaattagccagatgtgt tggcacacac 7740 ctgtagtccc agctactcag gaagctgagg taggaggattgcttgagccc aggaggttaa 7800 ggttacatta agctgtgatt gcttaactgc actccagcagcctgggtgac agagagagac 7860 ctagtctcag gaaaacaaac aaacaagctg tggatggtaaggttttatat atatttatat 7920 atattatata aaatattata tataaatata tataaaaccttacctattat attattatat 7980 actattataa tataatatta tatattatat tatatactattatataataa tagtatataa 8040 tattattata taataatata atattatcta taatatataatatatatttt atattttata 8100 tattatataa atgatgattt attgtgatca ggtttataagcaaatagccc tagtttctta 8160 acagagaagg aagaggataa atgtgtcctt gcaccttcatcctcaccctc tccctctcat 8220 tacctgcctc ttgtgtccct cccccatccc ttcttcttcctctccacccc cttcattctc 8280 tagtcattca ttattattac agttagttgc ttaccttttaacattagctt cttggccagt 8340 ttaatattga aaaatatttt ccatgttcct tgtgaagttgggtacaaaga aatctcatcc 8400 tgggtcagtt tatttaagta gttttctcat aagtaaagcaaatttgtcat aattctaatt 8460 tagcaatatt ctgtacattt tagttgacaa agagatgatgcaaagaatta gagaaaaatc 8520 tattttacaa gcacaagaga gagcaaaaga agctacagaagcaaaagctg cagcaaagcg 8580 ggaagatcaa aaatacgcac taagtgtcat gatgaaggtaagttgcagaa tgacaggcaa 8640 gtcctctaaa gagataatag tagactatgt gaggatagtgagttccagct gctggacttc 8700 ctcagcattt tcttcatact ttgtttagag gacttactatgttatataga ctgtctgcta 8760 tttatatgtg tgtttttttt tttcttgaga ccgagtctcactctgtcgcc caggctggag 8820 tgcagtgcgg tgatctgggc tcactgcaag ctccacttcccgggttcatg ccattctcct 8880 gcctcagcct cctgagtagc tgggactaca ggcacctgccaccatgccag gctaattttt 8940 ttgtgttttt agtagagaca gggtttcacc gtgttagccgggatggtctc gatctcctga 9000 cctcgtgatc tgcccgtctc ggcctcccaa agtgctgggattagaggcgt gagccaccgt 9060 gcccggccca tgtttgttct tgaaatctga atgaaagtcaaaggtgtaaa agttggacag 9120 ttgtttcagg gagagggttc tatttctagg ggagtaaaaataaagtttca atggtgcaag 9180 tgttttactt ctttttaaat cttggaataa cagatatgattttaaaacag aagcatattt 9240 aaaacattat tgtcaaattt ttttaactgt taagggttttaagtgaaagt tttaatcagc 9300 aatatatttt ttgagaaaca attcacattc catataatttacccatttaa agtgtacaat 9360 ttaatagttt ttagtacatt cagagttgtg taaccattactacagtcaat tttagaacat 9420 tttcatcacc ccccaaaaag caccaatacc cctaagcagccactccccat ttcccctaac 9480 acttagtcct aggcaactgc ttatctattt tctgtctcaatagatatacc tattttgagt 9540 aatttttaca aaaaaattct tatctcaggc caagcgcagtggctcatgcc tgtaatccca 9600 gcacttttgg gaggccgagg cgggcggatc atgaggtcagtagttcaaca ccagcctggc 9660 caacacagtg aaaccctgtc tctactaaaa atacaaaaatcagccgcgcg tggtggtggg 9720 cacctgtaat cccagctact cggtaggctg aggcaggaaaatcgcttgaa cccaggaggt 9780 ggaggttgca gtgagcggag attgcgccac tgcactccagcctgggcgac agagtgagac 9840 gccgtctcaa aaaaaaaaaa aaaacttctt atctcgaattcccattttga catgttgcag 9900 tgactaagga atctataata cgcattattt aagatttttgtggacccatg actgtttttt 9960 ggattttcat aactagcatt gttttctatt atcaacagtttatgattcca aagatttgtc 10020 cacttttttt atcacttcca cttaactttt tttttttttttttttgaaat ggtgtctggc 10080 tctgttgccc aggctggagt gcagtggtga gatctcagctcactgcaacc tctgccactc 10140 gggttcaaga gattctcatg cctcagtctc ctgagtagctgggactacag atgtgcacca 10200 ccacgcctgg ctaatttttt atatttttag tagagacagggcttcaccat attggccagg 10260 ttggtgtcga gctcctgacc tcaagtgatt cacccgccttggcctcccaa agtgttggga 10320 ttacaggcat gagtcaccgc actgagccat atactttgtcttttacttaa taattgaact 10380 ggtcagctgg tcaaagattc ctgcctttag catacttaattccatctttt ctttattgta 10440 tgatcacagc tgttggcctt ttgattttat cattttcatgaatttaaaaa aattaatata 10500 gaatttgtgg caatagatat tcactgaaat aataaaacagttaaataatg gcacacttac 10560 tgctgtattg gtatgtcaaa acagaacagt tgaccagcaggaagcaccac tatgttgtac 10620 cttgaaggtt tgttttttgt tttttttttt tgagatggagtcttgcttag tcgcccaggc 10680 tggagtgcag cggcgcaatc tcagctcact gcaagctctgcatcctgggt tcacaccatt 10740 cttctgcctc agcctcccga ataggtggga ctacaggtgcctgccactac gcctggctaa 10800 tttttttgta tttttagtag agacagggtt tcactgtgttagccaggatg gtctcgctct 10860 cctaacctcg tgatctgccc gtcttggctt cccgaagtgctgggattaca ggtgtgagct 10920 gccgcaccca gctgaagttt tcaatttact aatgtatgaaagcttgactt tggtattggg 10980 aaaggtgatt tagaggaatt aatatataaa atatgaagatacgggttata ttaagaggac 11040 agaacctaca aaagccagta tcctgttcca caaattgtctgttttctctc ttccctcagt 11100 agtgttgaga gttgggagta tgttttgttt catccttattatagccatta tcaagtaaat 11160 tggtgctcaa acatttgaat aaattaatat gaatgcattactctagtact atgtacccgt 11220 agcaaacgtc tactttggtg aattagctga agctattttcactctgtgca atcctagaca 11280 ctgttaagaa aagaactttg acgatccagt aagagcaaatagtaacaaaa ggcaacatat 11340 tgttagctta agttagcata aattaattta aaacttgaaggacatctacc aaaaataagt 11400 ggtttttaag tagtaacctt ttaaaaaata attagtggggctgtgtcaat tcgctatact 11460 gtgtgtacag gtattattct gcttgggcta ccctaacaaaatgttgttta acagaaattt 11520 attttctcat agatcaaggt ctggtagggt ctctttctggttagactctc tgtttttggg 11580 gccttcttgc tgcgctctta cgcagcaaaa aaaaaaaaagaaaaagaaaa agattggtat 11640 ttcatcctga gagtatggtc aaggaatcca aagcagtattgtttgtgctg aatcctggaa 11700 aatgaatcac aattaggttc ctggtagaaa gagagggaaaacctcattgc agaagtgctt 11760 ttaaagcccc tgctgtgtca tatttgctaa tgtaccattagccaaatcaa gtcacatagc 11820 caagtccaga tttaaagatt ggaaaaatag actatacttcttggaaagag aggtataatg 11880 ggaaaatgac attacaattt ggataggtat atgaaaataaggcacacaaa ggaacattta 11940 ttggtcagaa ataatatcct aatgtgtcca gaatttattccctctggtgg gttcttggtc 12000 tcactgactt caagaatgaa gccgcatacc tcatggtgtgttacagctct taatggtggc 12060 gcgtccggag ttgtttgttc ctctcggtag gttcgtggtcttgctgagtt caggaattaa 12120 gctgcagacc ctcacggtga ctgttacagc tcttaaaggtggcgcggacc cgaagagtga 12180 gcagcagcaa gatttattat gaagagtgaa agaacaaagcttccacagca tggaagggga 12240 cccgagccag ttgccgctgc tggctggggt ggccagcttttattccctta tttgtccccg 12300 tctatgtcct gcggattggt ccattttaca gagtgctgattggtccattt tacagagtgc 12360 tgattggtgc gtttacaatt gttaagctaa acacagagcactgattggtg catttttcca 12420 gaatgctgat tggcgcgttt acaatccttt agctagacacagagcactga ttggtgcatt 12480 tttgcagagt gctgattggt atgtttacaa tcctttagctagacacagag cgctgattgg 12540 tgcattttta cagagtgctg attggtgcgt ttacaatcctttagctagac aggaaaagtt 12600 ctccaagtcc ccacttgacc caggaagtcc agctggcttcacctctcact aagattttga 12660 aaaatttctc aaaggttata gagaactctc ttaagggattttccacaaaa gtgtaaaatt 12720 agttgagttt gtcttttaga aagctcgttc tggctaatgagtttgaagag gttgcaggga 12780 ggaggcagag tttttgttaa gatggagaaa ttttgagcatacgtatgttg aggaaggaag 12840 ccagtaaaga gggaaaggtt aataatacaa tgaagagagaagattgatga tggagcagtt 12900 ttctggtgat atggggatat tttatcattt ttgctaattaaaaataaact tttttttttt 12960 tttgagacag ggtctgttgc ccaggctgga atgcaaaatggcgcaattac agctcactac 13020 attgacctcg caggttcgag agatcctccc acctcagcttcccaagtagc taggactata 13080 ggtgtatgcc accatgccct gctaattttt ttgtagtttttgtagagatg gggtctaact 13140 atgttgccca gcaggaacaa agaatagata tctaaggatctggaaaattc ttaagcacac 13200 agataattaa aggaattttt actttgcttg gtaaagaagcagggtcatct gggcatggtg 13260 gctcatgcct gtaatcccag cactttggaa ggccgaggcaggtggatcac ctgaagtcag 13320 gagttcaaga tcagcctggt caatatggtg aaaacctgtctctactaaaa atacaaaaat 13380 tagctgggcg tggtggcagg cacctgtaat cttagctactctggaggttg aggcaggaga 13440 atggctggaa cccaggaagc ggaggttgca gtgagctgagatcatgccat tgcactcccg 13500 cctgggtaac aaagagtgaa acttcatctc caaaaaaaaaaaaaaccaac caaccaacca 13560 accaaacaaa cagaaaaacg aggcagggtc atcaacagaaagggagagat tgaggtggag 13620 gtatagggat atgaggtgat tagtggaagc ttggaatactgatgccagag tcttccaaaa 13680 tgtgcttttt tttcctcttc gctaatcttg gctgctactgcctccttttt tttttttttt 13740 tttttgagat ggagtctcgc tctgttgtcc aggctggagtgcagtggcgc agtcttggct 13800 cactgcaagc tctgcctcct gggttcatgc cattctcctgcctaagtttc ccgagtagct 13860 gcgactacag gtgcccgcca ccacgcccat ctaattttttgtattttttg gtagagatgg 13920 ggtttcaccg tgttagccag gatggtctcg atctcctgacctcgtgattt gcctgcctca 13980 gcctcccaaa gtgctgggat tacaggcgtg agccactgcgcttggccgcc tacttttcct 14040 gtcttcttca ctattttgtt ctgtacatta cccacttctatcttgaattt tttttttatc 14100 atttcttgtt tttgttttgt tttccgcttc aatggaactcttttttccaa ctgatctttt 14160 aaactggata ggtcaaattt gaagtgcatt tttctgctgtggtttcttaa agttgaaacc 14220 cagaaacctt aatctttgaa agaggtttgc ctgatcatgcagataaggta tgagttgcta 14280 gttgtctatt taatgccata ggacctcaaa atgatccttatcagtgaata cacatgccct 14340 gtttatcatg ggcatgtata actaatgtac aaaaagaccacaatgaactg ctttgccatt 14400 ttattctatt ttatgataat aactttcatg attctggcatttaaaaaatc ctcccatctt 14460 tcttttttct ttcatctcat tcctcttcag tgtatgtcagactttctcag cagcctgtct 14520 tccactttta catgttttgt attttctcca taaacccgttcttagagctc tgtacttttg 14580 gtatctcctg ttctgatgtc tttggccagt gtttattcatttatgtgtta ttggacactt 14640 gggttgcttc caccctttgg ctagtgtgaa taatgctgctgtgaacatga tgtgatggtt 14700 aatactgact gtcaactgat tggattgaag gatgcaaagtattgatcctg ggtgtgtctg 14760 cgagggtgtt gccaaaggaa attaacattt gagtcagtgggctgggaaag gcagacccac 14820 ccttaatctg ggtggtcacc attgaattgg ctgccagcatggctagtata taaagcaggc 14880 agaaaaatat gaaaagacga gactggccta gcctcccagcccacatcttt tgctcgtgct 14940 gggtgtttcc tgccctcgaa catgggactt caagttcttcagttttggaa cttggactgg 15000 ttctccttgc ttcacagctt gcagcaggcc tattgtgataccttgtgatt gtgtgagtta 15060 atacttaata aactcccctt tatatatatc tatctatactattagttatg tctctctaaa 15120 gaaccctgac taatatacac gagtataaaa atatccctttgaaatcttgc tttcaattgt 15180 tttgggcttg tatctagaag tggatatagc agatcatatggtaatggtaa ttctgttttt 15240 tttttttttt ttcctgagac ggagtctcac tctgttgcccaggctggagt gcagtggtgc 15300 gatctcggct cactgcaagc tccgcctccc aggttcaagccattctcctg cctcagcctc 15360 cccagtagct gggactacag gtgctcacca ccacgcctggctaatttttt ttgtattttt 15420 agtagagaca gggtttcacc atgttagcca ggatgatctcgatctcctga cctcgtgatt 15480 cacctgtctc agcctcccaa agtgctggga ttacaggcatgagccaccgc gcccggccta 15540 tttttaattt tttgaggaat tgccatactg tattccatggcatttggacc attttatgtt 15600 ttcatcacag tgtgcaagga ttccggtttc tcccattctcactaacactt gttattttgg 15660 ttttttgaga gtagccatcc taatgggtgt gaagtggtatctcattgtgg ttttgatgtg 15720 ctcttcagtg ccattttaat ttgaactata tctctgaaacccactcattc ccttttttcc 15780 taaatctttg agatattggt aagtataaca tttattcttgcttgctcttt tcctctcttc 15840 tcccattatt tggcctatgc tttctcttaa aaaaaaaaaaaaaaaaaaaa aaaaaaaaaa 15900 aaaaaagctt tattggctgg gtgtgatggc tcatgcctgtaatcccagca ctttgggagg 15960 ctgagcaggt ggactgcttg aggtcaggaa tccgagaccagcctggccca tctctactaa 16020 aaatacaaaa aattagccgt gtgtggtggt gtgcacttgtaatcccagct actccggagg 16080 ctgaggcagg agaatcactt gaacccagaa gacagaggttgcagtgggcc aagattgtgc 16140 cactgtattc cagcctgggc gacagagtga gactccatttcaaaaacaaa aacaaacccc 16200 agctttattg agatataatt tatataccat aaagttcattcttttaaagt gtagaattca 16260 ttgtttctta gtatgtatac aagttattca gccatcaccactatgtaatt ctggaacatt 16320 tcataaccat aaaaagagac ctattggcca ggcatggtggctcacacctg taatcccagc 16380 actttgggag gctgaggggg gcggatcaca aggtcaagagtttgagacca gcctggccaa 16440 tatggtgaat tcccatcact attaaaaata caaaaattagccaggtgtgg tggtgtgcat 16500 ctgtagtccc agctactcgg aaggctgagg caggagaattgcttgaacct gggaggcaga 16560 ggttgcattg agccgagatt gagccactgc actacagcctaagcgacaga gcaaaactct 16620 gtctcaaaat aaataaataa ataaataaat aaagagccctattttcatta gcagtcactc 16680 cctacttttc cctccaccat agcccctgga ggagacagaatctactgtct gtttctatag 16740 atttgtttac tctagacatt tcacatacag tgtgtggtctttggatgtga tgcccatcag 16800 tctttatggg aggctttctt tcacttagca aaatgtatatagggcttata catattgtag 16860 catgtataag tttttcattc ctttttatgg atgaataatatggcatagta tggatggcac 16920 cacattttgt ttatccattc atcagttggt gaaaatttaggttctcttca ccttttggct 16980 attacaaata gtactactat gaccattcat gtacttctagtatttaagta tctgtttttt 17040 gttttgtttt gttttgtttt tgagatggaa tcttgctctgttgcccaggc tggagtgcaa 17100 tggcatgatc tcagctcact gcaacctctc cttcctgggttcaagtgatt ctcctgcctc 17160 agcctcctga gtagctggga ttacaggcaa gcaccaccatgcccagctcg ttttttgtat 17220 tttttggtag agagggggtt ttgccatgtt agccaggctggtctctaact cttgacctca 17280 ggtgatccac ccacctcggc ctcccaaagt gctgagattgcatgcatgag ccaccacgcc 17340 tggccttgag tgtctgtttt taattctttc atgtatatacttaggaatag aattgctggg 17400 tcatttgtaa ttctgtttag ctttttgggg aatcatcaaatagttttcca caatggctat 17460 actatttttc attcccacca acaatgtatg atgattctaatttttttaca tctttgccaa 17520 cacttctgtt gttgccagat ggaaagtctt gactatgagttgtcccagtt cttggcacat 17580 taaacaaaga attgaacaaa atgcacaaac aaagcaataaaagaacaaaa caacgaaagt 17640 gcaggtttac tgaagcaaaa gtacactcca cagagtgtaagcgggctcaa gcaagcagct 17700 caagagcccc gattgcaatg ttctttcagg tttgtactaaactaaaagaa tttggtagca 17760 ttcctgggta ccgtttagag gcttcccatt ggttgcaccctacacaaatg aaggcttggc 17820 ccattactaa tcagaggctg aagtgaagtc ttggcccataactaattagc aataggggag 17880 agagggggtt ttgtagaggg aggggcctct ggcccttggcatggagaggt ggggtttttc 17940 ttttggccca attccaataa gccagctgct agttggcctcaggctccctg ttccagaccc 18000 tgttctgcct catttccccc tgagagactt gatcccaataaatctttatg ggaggcagag 18060 gaactgatgg tctgtcttct gtaattgctt cgtgcggattagggcagagt ccctacatat 18120 tggggaccac agaactcttg ccctgctctg tctagtggagagagggtgac ttcttgaagg 18180 ctagggctgg catcgtcacc tggaactggc tagaagccctgctgcatgat catttgaagc 18240 ttaatgttct ctaggtgaga agaaataaat ctggttacatgattaaacaa aaatggtcca 18300 aaaatcaatg taagtacaag tattaataat gtgctggctaggggaaggag ccatgaaacc 18360 cagcttagta tccttgacca ggggccccat gacttggacaactgttgtca tattttagag 18420 gcctggtcag ctaattttgg ggcagcatcc cttactaatcctgattggtt gatatgaaaa 18480 cagtgctttc cctctaggaa aagatataag ccacttttttcagcagttag gagatccagt 18540 ccctgtatta gtccattctc acactgctaa tgaagacatacccaagatcg ggtaatttat 18600 aaaggaaaga gttttcattg agtcacagtt ccacatggctaaggaggcct caggaaacta 18660 ccaatcatgg cagaagacac ctcttaacag ggtggcaggagagagaatga gcaccagcag 18720 gagaaatgcc ataaaacctt ataaaaccat tagatcttgtgagactcact cattatcatg 18780 agaacatcat gggggaaact gcccccatga ttcatttacctccacctggt cccacccttg 18840 acacgtgggg attattacaa tccaaggtga gatttgggtggggatacaga gcccaacctt 18900 atcagtcctc ttctgttttg taaagtgact gccaaagagtctacctgatt ttgtaaggca 18960 tactttgggc agtgtcttcc aagccgtctg aaagctccttggacaagcgt tggtaatagg 19020 atagagaagt tggaagccca ctatttcctg tttctacgcctgcagttatt cgtaacccta 19080 cctgaaaggg tatgagttgg gtggcttgtt tgtgcctgatggttgcagtt aaaggtataa 19140 tgagagactg gttattggga gctatattga tctcgggggctaagtaaaca agtgtgcagt 19200 gcaaacaatt ggttccagtc catttggcta gtaaacgtaagtaggaacta gtcccacaca 19260 ggaaaaaggc tgcttgtttt tcaagacaaa aattgttctctatgatgaac atgtaggtta 19320 gcttgttgtt ttccttttcc caagtggtta aggtccctgctacagtggcc ctggttaaag 19380 gctggagggg gccttgggta tcgggggatc ccacccccagtatttcaacg taggttcttt 19440 ctgttttcca taagtgttgg ccagctgaga aataaagagagacagtataa agagaggaat 19500 tttacagctg ggccatcggg ggtgacatca catatcggtaggactgtgat gcctgcttga 19560 gcctcaaacc agcaagtttt tattaagggt ttcaaaaagggggtgtaaga acagggagta 19620 gatacaaaga tcatatgctt caaagggcaa caagcagaactactaataag ggtgtaacaa 19680 agatcacata cttctgaggg aacaggacaa agggcaaaagcagaactact gacaagggtc 19740 caacaaagat cacaaggcaa agggcaaaag cagaactactgataagggtc tatgttcagc 19800 agtgcacata ttatcttgat aaacatctta aacaacagaacacaggattc aagagtagag 19860 aactggtctg accacaaatt tacgagggtg gagtttttcccccaccctag taagcctgag 19920 ggttctgcag gagaccaggg cgtatctcag tccttatctcaactgcacaa gacagacatt 19980 cccagagccc agagcggcca tttatagacc tccgcctaggaacacattcc tttcccaggg 20040 tattaatatt aatattcctt gctaggaaaa gaatttagcgatatgtctcc tacttgcatg 20100 tccatttata ggctctctgc aagaagaaaa atgtgactctttttgcctga ccccacagac 20160 agtcagacct tatggttgtc ttcccttgtt ccttaaaaattgctattatt ccgttctttt 20220 tcaaggtgca ctgatttcat attgttgaaa cacacatgttttacaatcag tttgtacagt 20280 taacacaatt atcacagtgg tcctgaggtg acatacatcctcagcttacg aagataacag 20340 gattaagaga ttaaagtaaa gacaggcata aattataaaagtattatttg ggaactgata 20400 aatgtccata ttaaaatgaa atctcccaat ttatgttcctctgctgcggc tccagccagt 20460 ccctccattc ggggtccctg acttcccgca acacttgggaagtactctga gttgcccaag 20520 tggttttgtt ctctcagttt aggtggttat gcttagtgtctaccagccaa cacccagagc 20580 tatttttgta ctgggggact aaaaggcaac tagatgtctcaggattagta tagccttccc 20640 aggggaaaat gtgcatacag ctagtgggcc taccctgacagtacttagac tgcatatcct 20700 ttaaagtagc cttaactaag ggtggttttc atgaaaaccatacaagtttt ctaaatgatg 20760 cagtctgggt aactgcatag cttacatgat cagataagaggttaatctct agggggtggt 20820 tgcattgaag atatttcaag gtactcaggg cttgaccaaaattttggctt cttttaatac 20880 aaagtggtgc ctggaatttt agttctgtgt gcatcgatattgggccccta atgggttttt 20940 gaggggatgc aactccagaa aggttgattt gataggactggagaaggttt actgcttgtc 21000 ttgtcattgt aacctttgtc atttccgtaa ttttgaagtcaaatatgtca tgcaggttca 21060 ttaaattgaa gggagttctt ctcttatagt tggagatttgggtggggata ttttctcaag 21120 ggcccaagat tgggctggga ttgggatagc agtgtgtttgacttcagctt aattggatgt 21180 tgtttttggt tgggataatg actgggtcct ttaagctgtatgttgactgg cactgccatt 21240 ctagcccttc caggcctccc agtataccat gctagcaggttgacctgttt gttgacatgg 21300 tccagaacgt tgtctgcatc actgaccatt agcacccaggcagtgcttaa attgtagcag 21360 tgcccctatt ttaaccataa aatctcttct gaacaaggggactgggcagc ttggtactat 21420 tagaaacccc tgctggaaaa tttgtttttc aaattggcaggttaaaggag gggtgaaatg 21480 cctgacttta ttttttcctt catttcctat aacagtcattgtcctagtgg agggctttcc 21540 tgcataagca gtaagtacag agtaacttgc ccctgaatcaaaaagaaact gaatttgtgt 21600 acccgttgtg tccagagtta ctcagggatc ctcagtagtaatgatgatgt tcctggacag 21660 gggcagtgag gaaggccctg ggccccttca gtcttcatctagctcctgct tttgcactgc 21720 tagagtctta actgactgag ctcctccgtg ggagctggggcagtcagtcc tccagtgctg 21780 gggttacagg cacctgccat gatgcccagg taattttttaattttttttt tttttcagta 21840 gagacaggtt ttcaccatgt tggccagatg gatctcaaattcctgacctt aaatgatcca 21900 cctgcctcag cctcctgaag tgctgggatt tataggtgtgagctgccaca cccagctagg 21960 agtgacagct tctaagctct ttacatgtca aagcctaaactgatgttcct atgttaattt 22020 tttacctata tagataaaaa acatgcacat atatgtgtatatatgtatat atatatatac 22080 acacacacac gcatacatac atacatactt acatatatttttaaatattt ttaaaattta 22140 tttttcagtg gttgttctgt gttcctttaa ctgatcacaatctacttcag gttaatactg 22200 actcagttcc agtaaaatat agcaacttgt tctaatataactccattttc tactcctccc 22260 tttggtctat tagtgccatt caggtatgtg tatatgcatatatatttgtt gtaatcccaa 22320 caatatgtgt tatgatttta cattaaaaat cattatttcttaaaaaatct taggttttta 22380 aataaataaa gagtagaaag caaaaatata tatattgtctttttaaaaag tttattttct 22440 aattgtggta aaatataact aacatacaac ttaccatctttaagtataca gttccatggc 22500 attaagtata ttgacaacca tcactactaa ccatctccagaactcttttc tttttttatt 22560 ttttttttga gttggagttt cattctgttg cccaggctggagtacagtgg cgtgatctca 22620 gctcactgca acctctgcct cctgggttca agtgattctcctgcctcagc ctcctgagta 22680 gctgggatta caggcgtatg ccaccacgcc cggctaattttttgtatttt tagtagagac 22740 ggggtttcac catgttggcc aggctggtct ttaactcctgacctcaggtg atccacccgc 22800 cttggcctcc caaagttcgg ggattacagg cgtgagccaccatgcctggc cctccagaac 22860 tcatttcgtc ttgcacaatt aaaactctgt acccattaaacaataactct ctattctcta 22920 tcctcccagc ccttgacagc caccattcta ctttttctatgaatttgact attttatgta 22980 aaaaaaaatg acttatttta cttcatgtaa gtggaattatacaatatttg tccttttgtg 23040 actgttttat attttttagc atactttgtc ttcaaggttcatccttgttt tagcttgtgt 23100 cagaatttcc tttcttttta aggctgaatc atgttctattaaaacgtata gaacacattt 23160 aaaaaaatct gtttgtattg tcttttacgc ttacccacatatttaccatt tctcatactc 23220 ttcattcttt cttgtaggta tgaattagtt aatatctggtatcattttcc tttcctttct 23280 cttttaagag ataaggtctc actctattgt acaggttggagtgcagtggt acattcatag 23340 ctcactgtaa cttcaaactc ctggtctcaa gcagtcttcctgccccagcc tcctgagtag 23400 ctgggactac acgcacatgc caccatgcct atctagtaaagatggggata ctctgtgtta 23460 ctcaggatgg tcttgaactc ctggcttcaa gcgatcctcctggcttggca tcccaaatca 23520 cacctgggat tgcaggtgcg agccacctcc ccatgccctgccctttttta aaaaagtgta 23580 tcttatagag caggtctatt agcaacatac tccctcagttttcatttgtc ttggaaggta 23640 ttttgctttc acttgtgaag aatagttttg ctaaatatagaatttgtggt ttatagttct 23700 gtttttttct gtcggtactt tgaacatgtc atttcattgtcttctatcca ttgtttcatg 23760 agagccttaa aaggtgatag ggtcaccatg catccgtagctctctcattt acataatctt 23820 tccattaaat ttctgactgc ttaagcactt atcctaaccaggatctcaac ctcagaccaa 23880 ctgcaaagtt ttcctcttta ttcccaacca agcctagcacttttatccac caaagctaca 23940 ggttttcact gccctacccg gaaatgagcc caccctttttagcaacaaac tgctaggttc 24000 tttttggtag tttcatgttg gtatgggttg agcatttatgatcaaaaaat acaaaatctg 24060 aaatgctcca aaatctgtaa cttttgagca ccaacacaatgctcaaagga agtgttcact 24120 ggagcatttt ggatttcaga tttttggagt aaggatgctcagccagtgtg tattctgcaa 24180 gtattccaaa atctgaaaaa aatccaaaat ctgaaacacttctagttcca agcattttgg 24240 acaagggata ttcagccagt aaaattgcca ggctcatcatcctagctggg agggggtttt 24300 aggagcaacc tcaggccaaa gggcacagct tcttacctttcatacttaga actttagcag 24360 cttttctaga ctaaagactt ttctctttgt agtcttcttttggttaattt ccagtcccct 24420 gaaatggttg tttttgataa ttttatccag ttttatccttaatatttgtg gaggggaatt 24480 gccaacctct tcatgttgcc acaaaatctg catgttgtctttgcagatga attttatatt 24540 tacttatcaa gtttcctaag aagtcctctt ggtattttgattgaatttac attgactttg 24600 taaatttgca gcgcatcaac atacttataa tattgagatttccctccagg aacatggcat 24660 ttatctccat ttatttggat atactttaca tctctcagcaaaattattta acacacatat 24720 atgacttgct tatatatttt ttgtttgttt gttttgtgtttgagacgaag tctgtctctg 24780 tatcccaggc tggcgtgcag tggcgcgatc ttggctcactgcaacctcca cttcccaggt 24840 tcaagtgatt ctccttcctc agcctccaga gtagctgggattacggcgtg cgccactgca 24900 cctggctaac tttttgtatt tttagtagag acgaggtttcaccatgttgg ccaggctggt 24960 cttgaactcc caacctcagg taatccgccc acctcaacctcccaaagtgc taggattaca 25020 ggcatgagcc accgcccctg gccttatgac ttgcttatattttgctaagc ttattcattt 25080 atgtttttct ggtgattgct gatgaaatta acgtttccattgtagtttct aattatttat 25140 tgccagtttg taggaaagta agtttgtttt tataagtttgtataagttga tctttttttt 25200 tcttttgaga tggagcctca cgctgtcgcc caggctggagtgcagtggca taatcttggc 25260 tcactgcaac ctccgtcttc tgggttcacg cgattcttctgcctcagcct cctgagtagc 25320 tgggactaca ggcatgcacc accacgcctg gctaatttttatatttttag tagagacaag 25380 gtttcaacat gttggccagg ctgatcttga actccttacctcatgatctg cccacctcgg 25440 cctcccaaag tgttgagatt ataggcgtga gccatcgcgcccagctagtt gattttatat 25500 gtgactgcct tgctgaactt acttttggtt tgtcagtttattattttggt tattttaagt 25560 agtgtactat tatttgcaaa tgatgcaatt ctatctccttgtaatctata tttgtatttc 25620 ttatttttaa aagtttatca tttaggttct gacctctaggaaaatagtaa aacattaggt 25680 atacttgcct tagtgatttt gctggaaata tttctaatatttcttttatt ttttattttt 25740 atttttttga gacggagtct tgctctgtga cccaggctggagtgtagtgg cgtgatctag 25800 gctcactgca acctccacct cccaggttca agagattctcctgcctcagc ttcccgagta 25860 gctgggacta cagttgtgtg ccaccacgcc cagctaatttttttattttt tgtagagata 25920 ggggttttgc catgttggcc aggctggtct cgaactcctgacctcaggtg atccacctcc 25980 ctcggcctcc caaagtgctg ggattacagg tgtgagccactgcgcccggc tatttctaat 26040 atttcgtcat gaagtataac atagtcttgg tccttctatccagcttataa atttttattt 26100 cttattttta ttcccaatat caactgacat tttggcatacactgacatca taatgctttt 26160 ctctattgat ttcctaatac cttaagtaag aaagaccctatttgatcaag gtgtattata 26220 attttaatat tttcctaggt taagttaccc ctatttgattaaggtgtatt ataattttaa 26280 tattttccta ggttaagtta cccctatttg attaaggtgtattataattt taatattttt 26340 ctaggttaag tttgcatata tatatatata cacacacacatatatataca cacatatata 26400 tacacacata tatatacaca catatataca cacatatatatacacatata tatacacata 26460 tatatacaca tatatacaca tatatataca cacacatatatatatataca cacacacata 26520 tatatatata tatatatata tttttttttt ttaggttttttttttgtttg ttttgaggtg 26580 gcctctcact ctgttaccca ggctggaatg cagtggcgcagtctcggctc actgcaacct 26640 ctgcctcttg ggtttaagcg attctcatgc ctcagcctcccgaatagctg ggattacagg 26700 tgtgcgctac cacacctagc taatttttgt atttttagtagagatgggtt atcaccattt 26760 tggccaggct ggtctctaac tcctgacttc aagtaatttgcctgactcgg cttcccaaag 26820 tgttgggttt acaggcgtga gcctccatgc cgggctgagtttgctaatgt tttatttaca 26880 atttttgcat gtaattcaca agtgggattg gcttataaagaacaatgcct tgttgaccag 26940 acattcattc tagattaaaa gaattataca tttcctcttcttcaaaaatt tagtgtagga 27000 actattcatt attctcgtat tagttttatt tgctgtctgcattaaactaa taacctgtag 27060 taaatggcat ccttttttga acagtacaaa cacctaaaacccaatttgtt tattttattt 27120 tttttgagaa gtctcactgt gtcacccagg ctagagtgcagtggggcgat cttggctcac 27180 tgtaacctct gcctccgaga ttcaagtgat tctcctgcctcagcctccca agtagctggg 27240 attacaggtg tatgctacca cacccaccta atttttgtattattagtata gatggggttt 27300 caccatgttg gccaggttgt tcttgaactc ctgacctcaagtgatcaacc tgcctgggcc 27360 tcccaaagtg ctgggatttc aggcatgagc cactgcccccgggcctccag tcctttatgt 27420 acgatgatta ttattttagc cttctgagtt tttctgttactgcatattcc tccgtgtgtc 27480 ttccctgtat tagatgattt ttctttgaaa gaccttcaaggattgtttaa tatttgtcgg 27540 tgtctgtgtt aaattgtgtg tttcctatat tagatgatttttatttaaaa tatctttaag 27600 agctgggcac ggtggctcac gcctgtaatc cctgcactttgggaggttga ggcgggtgga 27660 tcatttgaag tcaggagttt gacaccagcc tggccaacatgatgaaaccc tgtctctact 27720 aaaaatacaa aaattagacg ggcatggtgg tacacacctgtaatcccagc tactcaggag 27780 gctgaggcag gataattgct tgaacccgag aggcggaggttgcagtgagc gaagatcgtg 27840 ctactgcact ccagcctggg tgacacagca agactccatctcaaaataag taagtaaata 27900 aataacaaaa tatctttaag aattgttggc tgggcgtggtggctcacgcc tgtaatccca 27960 gcactttggg aggccgaggc gggcagatca cgaggtcaggagatcgagac catcctggct 28020 aacacagtga aaccccatct ctactaaaaa tacaaaaaattagccgggcg tggtagtggg 28080 tgcctgtagt cccagctact cgggaggctg aggcaggagaatggcatgaa cccgggaggt 28140 ggagcttgca gtgacccgag atcgtgccgc tgcactccagcctgggcgac agagtgagac 28200 tccatctgag aaaaaaaaaa aaaaagttta acatttgtccatctctttat gacatcataa 28260 aaaatatata tttggtccct gcctcttgtt attagcatagagctcctaaa acccatgtaa 28320 ttttctgagt gatggggtgc taggttcatc ttttgttaaattatttggat tttgacccag 28380 gttcctgaca cagagctcct aatcccttgg aatttcctatgtaataggaa aatcttttgt 28440 tctaatgagg caactcttga tgggctcttg ggtggtggctggccaccaga aagaccaagc 28500 tatgactagt tgtctggaac ttgcagcacc cctccccatcattttgatag gggctggaga 28560 ctgacttaat aatcaatcat gctgggtcca ctggcttacgcctgtaattc cagcactttg 28620 ggaggccgag gtgggaggat cgcttgagcc caggagctcaagaccagcct gggcaacata 28680 gatagtgaga ccctgactct aaaaacaaca acaacaaaattagccattcg tggtgctgcg 28740 ggcctgtggt cccaactact tgagaggctg aggtgagaggatcacatgag cctaggaagt 28800 ggaagctaca gtgagctaag gttgtgccac tgcactctccagcctgagtg acagaacaag 28860 accttgtctc aaaaaaaaaa aaaaaaaaaa aatccgccaggcatagtagc tcatgtctgt 28920 aaatcccagc actttgggag gctgaggtgg gtagatcacttgagcccagg agttcaagac 28980 cagcctgggc agcaagggaa aaccccatct ttacaaaaaaataacataaa aaattagtca 29040 ggcttggtgg catgtgcctg tgtcccagct acctagaaggctgaactgga ggatcgttgg 29100 agcccaggag gttgaggctg cagtgagcca tgattgcgccattgcactcc agcctgggtg 29160 acagagcaag accctgtcta aaaaaaaaaa aaaaacccagtcatgcctgc tagataaaac 29220 ctccataaaa ttcctgtaac tatgaggttt ggagaacttctgggttgctg aacacttgga 29280 gggagaaggc atggaaactc tgtgctcctt ccccggtatctttccctaga catctctttc 29340 atttgcctct tcctgatttg catcttttta ttaaaaatgggtaaatatgg ctgggcgcgg 29400 tggctcacgc ctgtaatccc agcactttgg gaggcctaggcgggtggatc acctgaggtc 29460 aggagttcaa gatcagcctg gccaacatgg tgaaaccctgtctctactaa aaatacaaaa 29520 attagccagg cgtggtggta tgtgcctgta gacccagctactcaggaggc tgaggcagga 29580 caatcacttg aacctgggag gcggaggttg cagtgagccgagatcgtgcc actgcactcc 29640 agcctgggca acggagtgag actccgtctc agaaaaaaaaaaaaaggggt aaatataagc 29700 gaggtattta tctgattcct gtgagccatt gaagcaaatggtcaaacctg aggagggggt 29760 tgtagaaacc cccaacttat agctgattgg ttagaaatatgggagtcctg gacttatgat 29820 tggcatctgt gtggagactg tcttatggaa ttgagcccttaacctgtggg atctaatgct 29880 aactccgggt agataatgac agaactgaat tagaggacacatagctgatg ttagagaatt 29940 ggtaagcata ggccgggcgc agtggctcac gcctgtaatcccagcacttt gggaggtcaa 30000 ggtgggcgga tcacgaggtc aggagatcga gaccatcctggctaacacag tgaaaccccg 30060 tctctactaa aaatataaaa aaaaaataaa ttagccaggtgtggtggcag acacctgtag 30120 ttccagctac tcgggaggct gaggcaggag aatggcatgaacccaggagg cggagcttgc 30180 agtgagccga gattgcgcca ctgcactcca gcctgggcgacagagtgaga ctccgtctca 30240 aaaaaaaaaa aaaaaaaaaa aaaaagaatt ggtaagcataggagaaaccc acaagtttcg 30300 tgatggaagt gacctatgga gtgttgtgag agtatataagaggcataaac agtttgtttt 30360 ttctctgtac actctgtttt tctttttctt tctttctttctttttttttt gagaggagcc 30420 tcgctcttgt cccccaggtt tgagtgcaat ggctttatctcggctcactg caacctccac 30480 ctcccaggtt caaatgattc tcctccctct gcctcccaagtagctgggat taagggcctg 30540 ccaccaagcc cggctaaatt ttgtattttt tagtagagacagggtttcac catgttggcc 30600 aggctggtct cgaactcctg acctcagatg atccacctgcctcagcctcc caaagtgctg 30660 ggatttcagg cgtgagccac cgcgcccggt cactgtacactctgtttttc tttggtacat 30720 gtagtctctt ttctctttat cataagcttt gtgttattttcttcttcatg tttttctctt 30780 cattgtagtt ccttctgtta cctactctgt gaagcctttcttggtttctc ctcttcatca 30840 ctactctctg aagagctgga ctatttctgt ctctaatatagcttattata aattatcatt 30900 atacctatag ttcccttaac tacatcttgg ctataataccagaactttcc tgttattttt 30960 tgttgtaaga acagtctcat ttttggtaat taagacttagtcttatgcat tttaaaaact 31020 tcatgtaaaa ttcattcttc ttgcagggag tatgatgggtgagggtgtct gactctccac 31080 atattctccc tttttcatgt gttggggcag agagtgaaaaaaggcagaca tataattagg 31140 ctgggtgaag tcgtctttta ggttgtggct tcctctctaacatggagtgt tcatcatgcc 31200 ttattgtgag gcatttaaat tttgtttcat tgccatgtgtagattcttcc tggttcaatc 31260 tgttggcagc ttactggcaa ctctctgaac taagaatatatagtaataat tagcatattt 31320 tgtgcttaat ttaagcctga ggtaaaattg ggactacaggaaattttcat tcagtgtccc 31380 gtgaaattta ttttaaagtc agcatctcac aggaaaataatcagtcttct agaagagagt 31440 attatgtcat gtagatatta cagagcacct ttcagtgcacaggtttcata ctcgtaatgt 31500 taaatctcta ttttaaagta atacaacatt tagggaccttcatcctagca tatccatagt 31560 ctagaaccac ttcagatgtc ctatttaaat gtaaattaatttaaatgtac attaatgaaa 31620 cttaaataac attaaaaatt cagttcctga gtctcagtagccacatttga agtacttaat 31680 tagccacctg tggctagtgg ctactatatt ggatagcacagacattttga tcattgaagt 31740 aagtgcttct ctagtggata gaggtaagaa atttttcttaccataggaaa gtcagataca 31800 tggagtcaat catgtacacc aactaggtac tctgtttcacaaggtttttt ttcttgccca 31860 tgtgagggaa gtttgaaagg cagaaaagtt gccacacacctgtacaagat actgctttca 31920 aattcatctg atatttagct ctttgaaagt gtcagacaactactagtgca aacataggtt 31980 ttgcagcagg attaagactt caaatatttc cacccagcagagacagaccg tcttgttcat 32040 ccttcctatt tccttttcta ctgttccctc ttccttcagtccttaggact gaagggttgg 32100 cacaacttcg gttgacaggg taagacttgg gataagttgaaaagcaaatg tttgaatata 32160 tgtgttggga tgtgtgtgtg tgtgtgtgtg tgtgtagattttgagagaag tggcttaact 32220 cctagaataa taaatttcta ttattttttc taccaagcccttaggtatca tctaattgaa 32280 tgcctgccca cattttacat ataagtaaac tgaggttggagaaagtgatt gcctaagacc 32340 atacagctaa tggtagatct gggactaaaa tctttgttccatgactccaa caccaatggt 32400 ttttctcctg aatcatttac ctttcccatt ttaattcataattcactact acctattgtt 32460 acaaatacaa tggcaagagt ttagaggtat gaataactaattattgtaat gaatttctca 32520 tttaaataaa tgttgctttt atgtatttta aagaatttggtaattgcaat tgttatagat 32580 tgaagaagaa gagaggaaaa aaatagaaga tatgaaagaaaatgaacgga taaaagccac 32640 taaagcattg gaagcctgga aagaatatca aagaaaagctgaggagcaaa aaaaaattca 32700 gagagaagag aaattatgtc aaaaagaaaa gcaaattaaagaagaaagaa aaaaaataaa 32760 atataagagt cttactagaa atttggcatc tagaaatcttgctccaaaag gtaaaatgat 32820 taagaatttc ttgagtagtg agtcctgttg gtgaagtatatatgacgctt ttcttttttt 32880 gtaaatctat tcacagcatt aggttactgt tttggcacattgagaataag caattcagta 32940 caaagactaa agtaaagaca tttcttcttt cggggataatgaagttttct aataaaatga 33000 gcaaggattc gttcaaggat tcgaaaagaa gagtgtcttctttgcttgtg tgctttcttt 33060 tgaaatttac aaagatgttg ttaaataagt gcttaactcaggcccaaaaa gacttggagt 33120 ggactagcaa tgtcagaagc attcatttat tccattagagataagaaact aggaatttca 33180 ttaaaagacc ttttcctcac atcacttagg aaaatgagtactataagcag acttactcta 33240 cagcaaataa agattgcttc tagcttttaa tcttggtgtattcaaaaaca gataaattaa 33300 tataattttt ttttttgaga caaggtctgg ccctatcgcccaggctggag tgcaatggtg 33360 tgatctgagc tcactgcagc ctctgcctcc ccagctcaagccatcctgcc ttagcctccc 33420 aagtagctgg gactacaggc atgtgcctca atgtccagctaatgcttttt tgtatttttt 33480 gtagagacga ggttttgcca tgttgcccag gctggtcttgaactcgtgag ctcaagcaat 33540 ctgcctgcct tggcctccca aagtgctgag attgtgtgcatgagccacca tgtccagctg 33600 atacaaatat aattcagttt ttgtatgtgt gtgtttttaaaattattatt tcagtagttt 33660 tggggaaaca ggtggtgttt ggttacatgt ataagttctttagtggtgat ttctgagatt 33720 ttggtggacc catcaaccaa gcagtgtaca ctgcacccaatgtgtagtct tttatccctc 33780 acccctgcac ccttcccccc tagtccccag gcccatatcattcttatgcc ttggcatcct 33840 catagctcag ctcccattta tgagtgagaa catgggccaggagcagtggc tcatgcctgt 33900 aatcctaaca ctttgggagg acaaggcggg cagatcatctgaggttggga gttcgagacc 33960 agtctgacca atatggagaa accccatctt tactaaaattacaaaattaa ccaggtgtgg 34020 tggcacatat ctgtaatccc agctactcag gaggccgaggcaggagaatc gcttgaacct 34080 gggaggcgga ggttatggtg aaccgagatc gtgccattgcattccagcct gggcaacaag 34140 agcaaaactc tgtctcaaaa aaaaaaaaaa aaaaagtgagaacatatggt atttggtttt 34200 ccatttctga gttacttcat gtagcataat cgtctccaactccatccagg ttgccgagaa 34260 tgccattatt ttattccttt ttatggctga gtagcattccatgattgtat gtgtgtctgt 34320 gtgtgtgtgt gtgtgtgtgt gtgtgtatat atacaccatattttctttat cttctcatta 34380 gttgataggc atttaggcta gttctatatt tttgcaattgcaattgtgct gctataaaca 34440 tgagtgtgca agtgtctaat gacttctttt tctctagatagatacccagt agggggattg 34500 ctggatcaaa tggcggttct acttttcgtt ctttaaggcatctatctcca cactgtcttc 34560 catagtagtt gtactagttt acattcccac cagcagtgtaaaagtgtccc ttttcaccac 34620 atctacacca acatctgtta ttttttcatt tttaaattatggtcattctt aacaggagta 34680 aggtggtatc gcattgtggt tttgatttgc atttccctaataattagcgg tgttgagcat 34740 tttttcatgt ttgttggaca tttgtttgtt tgtttatttattttgagatg gaatttcgct 34800 cttgttgccc aggctggagt gcaatggcac gatctcggctcaccacaacc tctgcctccc 34860 aggttcaagc gattctcctg cttcagcctc ccgagtagctaggattacag gcatgtacca 34920 ccatgcctgg ctaatttaga gatggggttt ctccatgttggtcaggctgg tctcgaactc 34980 ttgacctcag gtgatccgcc tgcctcagcc tcgaaaagtgatgggattac aggcatgagc 35040 caccacacct ggcgggacat ttgtatatct tcttttgagaattgtctatt catgtcctta 35100 gcccactttt tgatgggatt gtttgttttg ttcttgctgatttgtttgag ttccctgtac 35160 attgtggata ttagtccttc gtcagatgca tagtttgtgaagattttctt ccattctgtg 35220 ggttgtctgt ttactgtgct gattatttct tttgctgtgcagaagctttt tagtttaatt 35280 aagtcccatc tatttatctt tgtttttgtt tcatttgcttttggattctt ggccatcaag 35340 tctttgccta agccagtgtt agaaggggtt ttccagtgttatcttctaga atttttatga 35400 tttcaggtct tagacttaag tctttgatcc atcttgagttaatttttgtg ttaggggaga 35460 gatgaggatc cagtttcata cccctacatg tggtttgccaattatcccag caccatttgt 35520 tgaataggtt gtcctttccc cactttatgg ttttgtttgctttgtcaaag attggttggc 35580 tgtatttgac tttatgtctg ggttctctat tctgttccattggcctatgt gcctgttttt 35640 ataccagtac tatactgttt tggtaactgt ggccttgtagtatagtttga agtcaggtaa 35700 tatgatcccc tcagatttgt tctttttgct tagtcttgctttggctatat gggctctttt 35760 tttgttctat atgaatttta ggattgtttt ttctagttctgtgaagaatg atgatgatat 35820 tttgatggga attgcactga atttgtagat tgcttttggcagtatggtca ttttcaaaat 35880 actgattcta cccatctgtg agcatgggat gtatttccatttgtttgtgt catctatgat 35940 ttctttcagc agtgttttgt agttttcctt gtgagatctttcacctcttt agttaggtat 36000 attcctaagt attttggttt tttgttttgt tttttgggtttttttgcagc tgttgtaaaa 36060 gaggttgagt tcttgatgtg attctcagcc tggtccttgttggtgtatag tagtgctact 36120 gatttgtgtg cattgatttt gtattctgaa actttacttgaattcatata tcagatctag 36180 gagctttttg gatgaatctt taggattttc taggtatacgatcatatcat tggccaacaa 36240 tgacaacttg acttcctcct tactgattta gatgctctttctttctttct cttgtctgat 36300 cgctctggct aggacttcca gtactctgtt aaatagtgttggtgaaagtg gacatccttg 36360 tcttgttcca gttctcaggg gaaacacttt caacttttcactgtttatta taatattggc 36420 catgggtttg tcaaagatgg cttttattac cttaaggtatgtcccttctg tgcccatttt 36480 gctgagggtt ttagtcataa agggatgctg gattttgtcaaatgctttgt gtgtgtgtgt 36540 gtgtgtgtgt gtgtgtgtgt gtgtgtgaga cagagtctcactgtgttcct taggctggag 36600 tgcagtggca tgatcttggc tcactgcaac ctctgcctcccaaattcaag cagttctcct 36660 gcctcaacct ccccagtatc tgggattaca ggtgtgcaccaccacaccta gctaactttt 36720 tgtatttttt agtagagaca gggtttcgcc atgttggccaggctggcctc aaaactcctg 36780 acctcaaatg atccgtctgc ctcggcttcc cgaagtgctgggattacagg catgagccac 36840 cacactcggc ctcaaatgct ttttctgcat ttattgagatgattgtatga tttttgtttt 36900 gacttctgtt tatgtggtgt attatattta ttgattttttgtgtgtgtat gttaaaccag 36960 ccctgcatcc ctggtatgaa acccacttaa ttatggtgtattaccttttt gatatgctgt 37020 tgcatttggt tagctagtat ttggttgagg agtgttacatctgtgttcat cagggatatt 37080 gttctgtagt tttctttttt ttttttttgt tatgtcctttcctggttttg gtattagggt 37140 agtactggcg ttgtagaatg atttagggag gatttcctccttatcttttg aaatagtttt 37200 aataggattg gtaccagttc tcttagaatg tctgttagaattcagctgtt gggctgggca 37260 catggctcat acctgtaatc ccagcctttg agaggccaaggcaggcaatc tcctgaggtc 37320 aggagttcaa gaccagcctg cccaacgtgg tgaaacctcatctaactaaa aatacaaaaa 37380 ttagcagggt gtggtggcat gtgcctgtaa tcccatctactcgggaagct gaggcaggag 37440 aatcgcttaa acccggagat ggaggttgca atgagccgagatctcaccac tgcattccag 37500 cctgggggca agagaacaag accctgtctt aaaaaaaaaaaaccagctgt gaatccatct 37560 ggtcctggac tttttttagt tggccatttt taaattactgtttcaatctc cctacctgct 37620 attggtcttt tcagagtttc tatttcttcc tggcttaatctgggaggatt gtttaattcc 37680 ttctaggttg aggaatttat ccatctcctg taggttttctagtttgtgtg cacaaaggta 37740 ttcatagtag ctttgaatga tcttttgtat ccctgtggtatttgttgtaa tttctctcat 37800 ttcatttcta atcgagctta tttggatctt attcttttctgggttaatct tactaatggt 37860 ctatcagttt tgtttgtctt ttcaaagaac cagcattttgtttaattttt cttttgtatt 37920 tttttctttc agtttcattt agttctgctc tgatctttgttatttctttt cttgtgctgg 37980 gtttgggttt gatgtgttct tttttctcta gtttcttgatgtgtgagcct agattgtctg 38040 tttatgctct ttcagacttt ttgatgtagg cgtttagtgctatgaacttt cctcttagca 38100 ctgcttttgc tgtatcccag aggttttgac tggttgtgtcactattatcg ttcagttcaa 38160 agaattttaa aatttccgtc ttgatttcat tgttgacccaaagatcattc aggggcaggt 38220 tacgtaattt ccatatattt gtatagtttt gagtgttccttttgaagtca atatccagtt 38280 ttattccact gtggtcttag agagtatttg atataattttgattttctta aatttactga 38340 gatgggctgg gcgtggtggc tcacacctgt aatctcagtactttgggagg cctaggtggg 38400 tggatcacga ggtcaggaga tcgagaccat tctggtctctaaccagagac cagaatctgg 38460 tggctaacac ggtgaaaccc catctctact aaaagtacaaaaaattagcc aggcgtggtg 38520 gggggcacct gtagtcccag ctactcggga ggctgaggcaggagaatggc atgaacccag 38580 gaggcggagt ttgcagtgag ccgagactgc accactgcactccagcctgg gcaacagtgc 38640 aagactctgt ctcaaaaaaa aaaaattatt gagatggctgggcgcagtgg ctcatgcctg 38700 taatcctagc actttgggag gccagggaag gtggatcacctgaggtcagg agtttgagac 38760 cagcctggcc aacatggtga aaccttgtct ttactaaaaatacaaaaatt aggctggtgt 38820 ggtggcgggg gcctgtaatc ccagctgctt gggaggctgaggcagaagaa tcacttgagc 38880 ccaagaggtg gaggttgcgg tgagtcgaga tcacgccactgcactccagc ctgggtgaca 38940 aagcgaggct ctgtctcaaa aaaaaaaaaa aattattgagacttgttttg tgttctatca 39000 tttggtttat cttggaatga atgttccatg tgctgatgaaaagaatgcat attctgcagt 39060 tgttgggtag aatattctgt aaatatctat taagtccatttgttctagga tatagtttaa 39120 atccattatt tctttgttga ctttctgtct tgattacctgtctagtgctg tcagtagagt 39180 actgaagtcc tccactatta ttgtggtgct atctcatttcttaggtctaa taataactgt 39240 tttataaatt tgagaattcc ggccgggcgc ggtggctcatgcctgtaatc tcagcacttt 39300 gggaggccga ggcgggtgga tcacgggtgg tcaggagtttgagaccagcc tgaccaacat 39360 ggtgaaaccc cgtctctact aaaaacacaa aaattagccgggcgtgctgg cacgcacctg 39420 taatcccagc tactcaggag gctgaggcag gagaattgcatgaatctgga ggtggaggtt 39480 gcagtgagcc gagactgcac cacggcactc cagcctgggcgacagagtga gactctgtct 39540 caaaaaaaaa aataaataaa taagtaaata aataaataaataaatttgag agttctagtg 39600 ttaggtgcat aaatatttag gattgtgata ttttcctgttggactaattc ttttatcatt 39660 atataatgtc cttttttatc ttttttaact gttgttgctttaaagtctgc tttgttttgt 39720 ataagaatag ctattcctgg ctaggcgcag tggctcacgcctgtaatccc agcactttgg 39780 gaggccgagg cgggcagatt acgaggtcag gagtttgagaccagccaggc caacatggtg 39840 aaactctgtc tctactaaaa atacaaaaat tagccaggcgtggtggcgcg tgcctgtagt 39900 cccagctact tggaaagcta aggcaggaga atcgcttgaccccaggaggc agaggttgca 39960 gtgagccaag attgcaccac tacactccag cctgggcaacagaaggagac tctgtctcaa 40020 aaaaaaaaag aaagaaagaa agaaagaaaa aagaatagctactcctgctg actttggtgt 40080 tcatttgcat ggaatatctt tttccaccct gtttatgagtccttatatgt taggcaagtc 40140 tgttaaaaga cttacttggt tggttgattt ttatccatttgacattctgt atcttttaag 40200 tggagcattt aggccattta cattcaatat cagtattgagatgtgaggta ctgttctatt 40260 catcatgcta gttgttgctg taccttattt tttttcattgtgttattgtt ttatagatcc 40320 tatgagattt atgttttaag gaggttctat tttggtatattttgaggttt tgtttcaata 40380 tttagaactc cttttagcat ttattgtagt gctggcatggtagtgacaaa ttcagcattt 40440 gtttgtttga aaaagacttt atctcgcctc tggttatgaagcttagtttc actggataca 40500 aaactcttag cggataatta ttttgtttaa ggaggctaaagataggaccc ccatcccttc 40560 tggcttgcag ggcttctgct aagaaatctg ctgttaatctgataggttct cctttataga 40620 ttacctggtg cttttgcctc acagctcttt ttttttttttttttgagaca gagtcttgct 40680 ctgtcaccca ggctagagtg cagtagcgtg atctcggctcactgcaacct ccaactcccg 40740 ggttcaagca attctcctgc ctcagcctcc tgagtagctgggattacagg cacctgccac 40800 cacgcctggc tgatttttgt atttttagta gagatggtgtttcaccatct tggttggcca 40860 ggctggtctc gaactcctga cctcgtgatc cacccgccttggcctcccaa agtgctgaga 40920 ttacagatgt gggccactgt gcctgacctt gcctcacagctcttaagatt ctttctttca 40980 tctttacttt agacaatgtg atgactatgt gcctaggcaatgatcttttt gcaatgaatt 41040 ccccgggtgt tctttgagct tcttgtattt ggatgtctagatctctagca agaccatgga 41100 agtttttctt gattattccc tcaagtatgt tttccaaacttttagatttc ccttcttcct 41160 caggagcacc aattattctt atgtttgctt gtttacataatctcagattt cttggaggct 41220 ttgttcattt tttaaaattc tttttttctt tgtctttgttggattgggtt cgtttgaaag 41280 ccttgtcttt gatctctgaa gttatttctt ctacttgttcaaatctattg ttgaaacttt 41340 ccagtgtatt ttgcatttct ttaagtgtgt ctttcatttccagaagtttt gattattttt 41400 tctttataat atctatttct ctggagactt ttccattcatatcctccttt ttttaaaaat 41460 ttctttaagt tgattttcac cttcctctag tgccttcttgaggagcttaa taatcaacct 41520 tctgaattat ttatctggca attcacagat ttcttcttagtttggatcca ttgctggaga 41580 gctagtatga tcttttgggg gtgttacaga accttgtattgtcatattac tagaattact 41640 tttctggttc cttctcattt gagtagactg tttcagtggtaagatctgga actcaagggc 41700 tactgttcag attcttctgt cccatgggtg ttcccttgatgtggtgccct ccccctgcca 41760 ctagggatgg ggcttcctga gagccagact gcagtgattgttattgccct tctatttcta 41820 gccacccagt tgggccccag gctggtgctg gggaatgtctgcaaagagcc ctgtgatgtg 41880 atccacaggt ctcccagccg tggataccag cacctgttctggtggtggca ggtgagtgaa 41940 gtggattctg ttggagtctt ttgttgtaat tttgtttagtgcacttcaag tactggttat 42000 gtaagcagtg aagttgtcac gtggacagat tcaggacctctggctagaca gggtgttgca 42060 ggaagtggaa ttagctgttg ttttctcctt ctttggagcagggttgttct gttatgagtt 42120 gctatggtgg cttgagttcg ttgggctcca gccaggaggtggcactttca agagggcacc 42180 agctgcagta tagaagagag atataatctt gatgttggccgggacaagta ctcgggtttc 42240 tcaggtgatg ggcagggcca tagagcaggt agagaaaaccttgccccatc aggtgggggc 42300 aaggttagtt gggtctgggc tcaggctccc cttgggtggggcttgctgtg gccacagtgg 42360 gggtggaggg gattctcagg ccaatggaat tatgttcccaggggcattat ggctgcctct 42420 gctgtgctat acaggtcacc agggaggtgg gggaaagctggcagtgacag gcctcaccta 42480 gctcccaggc agccaccaag gccagtctca ctctggccatgccaccccaa ccgcactgcg 42540 tttatatcca ggcagttggt gagcagggct gagatcttgccccagactat aagccttgcc 42600 actgagaaag caagagggct gttaggcctc accagtccctgcctgcccac actattggct 42660 gtggcttctg cactcgcatc tgtacttccc atttgccccctctgccacca atttctgctt 42720 aggaaaattc ctgctcagtc aaaattatta caaagttcagctacaagctt ccttcaccct 42780 gtggtcctgc cccaattcca ctggctgcct tcccgtctccaaggacctct gtgagatcac 42840 gccaggaatg gcttccttgg actccagctg gggatggaagtacctatagg gctcttcctg 42900 ctgcttcttc tactttcata ttttgctcag ctacctaaatctatttcagc tcagggtaaa 42960 gttaaatcct tcccctgtga tctggatttt caggttccccagtggggatg tatgttcaga 43020 gactgacctt ttcttccctc acactttggg aactcacggtttttcagctg tttcatggca 43080 tttgcagcag cgaaccactt ctttcaaagg gtctgtgaattctttcagtt ttcctacagt 43140 gtttcttgcg gtgttcctga agtgattctt ggagtaaaagttcgcattgt gagtctccag 43200 atgctgttct gtccatccag gtggcagctg catgttaatcctgtctccga tctgccattt 43260 tccctcctat ctcccaatga atataattct atactgaaagctacgagttt ggttttatct 43320 aattttagaa tattaaactt tgttttggat gcattttccgccggatgcag tggctcacgc 43380 ctgtaatccc agaactttga gaggctgagg cgggcagatcacctgaagtc gggtgttcaa 43440 gactagcctg accaacatgg agaaaccctg tctctactaaaaatacaaaa ctagccggac 43500 gtggtggtgg gtgcctgtaa tcccagctac tcgggaggcactgaggcagg agaatcgctt 43560 gaacccaggg aggtggaggt tgcagtgaag cgagatcttgccattgcact ccagcctggg 43620 caacaagagt gaaactccat ctcaaaaaaa aaaaaaagaaatatttagta ttttccttac 43680 ataagtcatt attgaattcc tataaattta acattttagtgtaaaatcac atatataata 43740 ataataatta acatttatta ggtgactact atgtgccaggggattttatt gcttgggtca 43800 ctcagtcttc acaacacttc agtctaagtg ctgctattcttattttagag gaaatagatg 43860 ttcagaaaaa aaaaataact atgaataagt aaacttgtgggatttgaacc cagatctggt 43920 ctgcatctga aacctgtgct atttccacca ggtcatatgtctttacaact ttaacagtga 43980 ggcttggcat attgaaaagt catttagagc ctgggcatggtggctaacgc ctataatccc 44040 agtactttgg gaggccgagg tgggcagatc acctgaggttaggagttcca gaccaccctg 44100 ggcaacatgg cgaaaccctg tctctactaa aaatgcaaaaattagccagg tgtggtggca 44160 tgcgcctgta gtcccagtta ctcaggaggc tgaggcaggagaatcacttg aacccaggag 44220 gaagaggctg cagtgagcca agatcgcgcc actgcattccagtgtgggtg acagagtgag 44280 accctgtctc aaaacaacaa aaacaaaaaa aagtcatttagattgaatat atatatatat 44340 atatatatat attcaatttg ctaatatttt ataagcagttgtcacattta tcttcatatt 44400 gaggttcagt tatatttttc tttcctcata ctgttcttgtctagattgta taccaaattg 44460 taccagacct atatactata gagcgttttt ctttttctactatttgaaac aatatagtta 44520 gataagagaa atacctgttg ttttaaggct tagtaaaacttcccctaaaa ctgtctaggt 44580 ctggagtttt tttatggagg tttttttaaa aaaaaaaaaagattcagttt ctataatagt 44640 tattgattat tgaaattttc caaagtcaat tttggtagtttgtcttctaa attgtgcatt 44700 ttatctattc aaattcattt tcataaagtt tttatttacttatctgtact ttatctataa 44760 ttatataatt tattaatttc taatattgtt cttttttttgagacaggatc tcaccctgtc 44820 acccaggatg aagtataatg gatctagctt gatgcttaataaagtaatct atcctttgtt 44880 tctggttgtt ttaaaattct ttcccttggt atattatgggttcattagta taagttcaat 44940 tttatattta tttatctcat aatatcataa cttggagcatactgtcactc agagaacttt 45000 gtcattcatc aattctggga atttcaaaac tattgtcttcaaatattacc ttcttggctg 45060 gtaatttacc ttcttggctc atgcctgtaa tctcagcactttgggaggct gagttgggcg 45120 aattacttga gaccaggagt tcgagacttg cctggctaacatggtgaaac cccatctcta 45180 ctaaaaatac aaaaattagc tggctgtggt ggcacatagctgtaatccca gctacttggg 45240 atactgaggc atgggaattg cttgaacccg ggaggcagaggctgcagtga gccaagatcg 45300 tgccactgca ctctagcctg ggtaacagag tgagactctgtctcaaaaac aaaaacaaaa 45360 acaaacaaat attacattat tgtattctct tgttttcaatatatattttc aaattacaca 45420 gatgtttttc tttttttttg agacagagtc ttgctctgttgtccatgctg gagtgcagtg 45480 gcacgatctc agctcactgc aacctccacc tcctgggttcaagcaattcc cctgcctcag 45540 cctccttagt agctgggact acagatgtgc accaccacaccaagctaatt tttgtatttt 45600 tagaagacac ggggtttcac catattggcc acgctgatcttgaattcctg acctcaagcg 45660 atctacctgt cttggcctcc caaaatcctg ggattacaggcgtgagccac catacctggc 45720 caactttctt gtattctctt tatcttcctc agctattttctgtataatat cctcagatct 45780 atcttctagt ttataaattt tcttcaacca tgactaattttatgttatac ttgtccaaga 45840 tgtttttaat ttcagtgaca atatttttca ttttgaaagttctgtttttt ggccaggcgc 45900 tgtggctcat gcctgtaatc ccagcacttt ggggggccgaggtgggtgga tcacgaggtc 45960 aggagatgga gaccatcctg gctaacccgg tgaaaccccgtctctactaa aagtacaaaa 46020 aattagctgg acgtggtggt gggtgcctgt agtcccagctactcaggagg ctgaggcagg 46080 agaatggcgt gaacccggga ggcagagctt gcagtgagccgagatcgcgc cactacactc 46140 cagcctaggc gacagagcaa gatgctgtct caaaaaaaaaaaaaaaaaaa agaactgttt 46200 ttttttcaca cctctctgtt ctttgtcact agcttcttagttttcattat tgatgttagc 46260 ctgtctttac tggctttaag taagtatgtt taaaatgatcaatctctttc agattgttgt 46320 gctatttcaa agtcttgggg agccagtcgt cttatttgttgtgtctgctg attgttcctc 46380 atactggatt gtttcctctt gtgaattgtg cttttttgcctgaccactaa tcttctgcaa 46440 aaacttctta gtgtgtatgt atgaggaaat atcatatattcttatttgca aaagacttgt 46500 tgatgaggaa tacctggagc ttccatttct tacaagagacattttttcca agcttcactt 46560 tctaagatta gtgagcagag atcgtataag catccttttcactaagagtg atgcccactg 46620 ggcacggtgg ctcatgcctg taatcccagc actttgggaggccaaggtgg gtggctcacg 46680 agatcaggag ttcgagacca gcctggccaa catgatgaaacccgtgtcta ctaaaaatac 46740 aaaaaaatta gctgggcatg gtggtgcacg tctgtaattccagctactca ggaggctgag 46800 gcaggagaat cgcttgaacc cgggaggtcc tacccttctatgattctagt ttcatttcca 46860 cctccccacc tctgtaccta tatcagcatt aaatttccagtctccagcca ttgatattaa 46920 tctatttgca tctaaaatct ttccaaacag ctttgtgtcagcttttgaga tgaccctggc 46980 tttaagttcg atgatgaagc atttccttta cttacttttgaaactgaact atatattgaa 47040 ccttttgttt atttattttt tatcaagaat ttgtatgtgttcataacatt ttaccttttc 47100 ataaaattgc atgtaaaact ttgtagtaaa agttttaacctgtgttgtta caaacagcaa 47160 atttcttttt tatgttttgc aatttgcaaa tggaaaatagaagagtttgt aaattagata 47220 tatgagtttg gaaattatat atcttatttt tactgtaactagtggtcact gtaatatttt 47280 ttataaacac ataaagattt gtttttctgt agcaatatagttttttttag ttatcctcat 47340 gggataatag tgatgatttc ctgcatgttc tatatcgtattaatcattag tattattagt 47400 aatctgaagt aaaatgaagt atgcttgatt tttactttctattctatttt ccttcttttt 47460 ttccttttcc tttttttttt tttttttttt tttttagtgagacatgctct gttgtccagg 47520 ctggagtgca gtggcgtgat cttggctcac tgcagcctctgcctcccagg ttgaagcgat 47580 tctcctgcct cagcttccca aatagctggg attacaggtgcctgccacca cccctgacta 47640 attttttgta attttagtag agatgaggtt tcaccatgttggccaagctg gtctccaact 47700 cctgacctca agtgatccac ccgcctcagc atcccgaagtgctaggatta caggtgtgag 47760 ccgctgcgcc cagacctatt ttccttcttt tgtattactatttaaaaata ttatttacag 47820 gctgggtgtg gtggcttaca cctgtaatct cagcactttgagaggccaag atgggaggat 47880 tgcttgagcc caggagttca agagcagcct gggcaacaaaacaagacccc atctctacaa 47940 aaaagcatac aaacaaaaaa ttagccatgt atggtggtgggcacctgtag tgcctgctct 48000 tgaaaggctg agatgggagg attttttgag ccaaggggttcaaagctgca gtgtgctgtg 48060 attgcatcac tgcactccag cctcggtgac ggtaataaccctgtctcaaa aaaaaaaaaa 48120 gatattattc acaaaatttt tagtgtgttc tccactgctttagaaaaccc attctttttc 48180 attttgctct caaattcccc actcctggtt tcttaatgttatttctctgt gttctggaac 48240 atttatttga gtaatgtatt cacaaaagat gactaggtagtgttggctga gttcttacat 48300 acctagaaat gtcttttgcc attatgagtg agcaacagttaacttggata taaaattatt 48360 gggatcttgt attaggtagg ttcaagccga gcattgtaaaataaagcccc aaatgtacag 48420 atcaaataaa gataaaaatt tagttctctt taatgtaatactttgttatg caacagtgct 48480 caacgactgt gttctacaag gccatcctgg ctgatgggatcacctctgtt atcacattat 48540 ttggctttca tctttgagtc taagagcgct ccttccccccttgccccagt cctttgaaat 48600 gtctagtcaa gaccctttcc tagttttcgt ttgtttgtttgttggagacg gagtctcact 48660 ctgttgccca ggctggagtg tatggcacga tctcggctaactgcaacctc cacctcccag 48720 gttcaagcaa gtctcctgtc ttagcctccc aagtagctgggattataggt atgtgccaca 48780 ggcctggcta atttttatat ttttagtaga gacagggtttcatcatgttg gccaggctgg 48840 tcttgaactc ctgacctcag gtgattggcc cgccttggcctcccaaagtg ctgtgattac 48900 agacatgagc cactgcgccc gtccttgcca gttctcattagttctctttg atggctaaaa 48960 cctcttacac tattataaga aagcatatag gagataaagtatgtaggaga tactgctata 49020 gagtttaagg agatagagat ggtattggca gtggtggttttgcctatgtg cccttctcta 49080 gagttgatgt agagttgcct agagtatcct cccttagagttgatgtgaat taaacactgt 49140 ggttttacaa agagaacccc agaaaagtag ctgaggccattgataaagag caggtaggtc 49200 attagctgct atattatcat tgctaaattt tgcattcttttcttgcagaa aatatatttg 49260 atttatttgt ttaggatttg ggggtgagct ttgatgtgtaattactttat cagttgattg 49320 ttaactagaa aatgagaaat aagtgacttg tttgctaccattgtttttga agggagaaat 49380 tcagaaaata tatttactga gaagttaaag gaagacagtattcctgctcc tcgctctgtt 49440 ggcagtatta aaatcaactt tacccctcga gtattcccaacagctcttcg tgaatcacaa 49500 gtagcagaag aggaggaggt atatatactt actctagttacaattaccac aaatgaaaat 49560 actttatttt tatttcatct attgaaatta gtactggttctgaatttctt aagtatttat 49620 tacactaaag aaataacgtc atgaatatgt tttagaatttccttatgaga aaatatattt 49680 tgcagatgtt tttggctcca gaatagtgat aagagaataccgacttaata tatgtacagt 49740 aggccgggcg cagtggctca tgcctgcaat cccagcactttgggagcccg agatgggtgg 49800 atcacttgag gtcaggagtt caagaccaac ctgactaacatggggaaact ccatctgtac 49860 taaaaataca aaaattagcc tggcgtggtg gcgagcacctgtgatcgcag ctactagcgg 49920 ggctggggca ggagaattgc ttgaacttgg gatgtggaggttgcagtgag ccgagattgc 49980 accattgtac tccagcctgg 50000 8 50000 DNA Homosapiens human DYXC1 chromosomal gene region, nucleotides 100001-150000 8gcaacagagt gagactttga atcaaaaaaa aaaaaaaaaa aaagcggtct ttttgttgtt 60gttgtttgtt ttagagatgg agtttttgct cttgttgccc aggctggagt gcagtgggca 120caatctcagt tcactgcaac ctcctcctcc caggttcaaa caattctcct gcctcagcct 180ccctagtagc tgggattaca ggcatgcgcc agcatgtctg gctaattttt tatattttta 240gtagagatgg ggtttcacca tgttggtcag gctggtctca aactcctgac ctcaggcgat 300ccaccctgct cggcctccca atgtgctggg attataggca tgagccaccg tacccagcca 360agaactgcat ttttttactg cgaggctgaa ttgatgcatc tttgatttga aaaattgtag 420aaataagaag atccttaaga cataatgaca agccgggcgt ggtggctcac gcctgtaatt 480ctagcacttt gggaggccga ggtgggtgga tcacctgagg tcaggagttt gagaccagcc 540tggccaacat ggtgaaaccc catcgctatt aaaaatacaa aaattagtcc agtgtggtgg 600caggcacctg taatcccagc tactcgggag gctgaggcag gagaatcact tgaacccggg 660ggtcagaggt tgcaatgagc caagattgca ccatttcact ccagcctggg tgaaagagtg 720aaactctgtc tcaaaaaaaa aaataaaaaa taaaagacat aatgacaata taaataatta 780tttcatatta ttaaacaagg tattttctat atttgtaaca tttctataat tatacagtta 840taataataat aataattatt attattttgt gggatggagt ctcgctctgt cccctaggct 900ggagtgcagt ggcgcagtct ccgctcactg caagctccac ctcctgggtt catgccattc 960tcttgcctca gcctcccgag tagctgggac tacaggtgcc caccgccacg cccagctaat 1020tttgtgtagt ttttaataga gatggggttt caccatatta gccaggatgg tctcaatctc 1080ctgaacttgt gatccaccca cctcggcctc ccaaagtgct gggattacag gtgtgagcca 1140ctgcgcccgg cccatagaat tatttttgaa ttgtgtttat acacacacac acacacacac 1200acacacacac acacacacac cctttttttt tttttttttg agttgggggt cttgctctgc 1260tgcccaggct ggagtacagt gggacaatca tggctcactg tagccttgaa ctcttgggct 1320caagtgacct tctgcatatt tttcagtaca gaaaaatgaa aatataaaag aattttagat 1380caatatcctg gatgaacatc gatgcaaaaa tcctcaataa aatgctggca aaccgaatgc 1440agcagcacat caaaaagctt atccaccatg atcaaatggg cttcatccct gggatgcaag 1500gctggttcaa catacgcaaa tcagtaaacg taatccagca tataaacaga accaaagata 1560aaaaccgcat gattatctca ccagatgcag aaaaggcctt tgacaaaatt caacagcact 1620tcatgctaaa aactctcagt aagctagata ttgatgggaa gtatctcaaa ataataagag 1680ctatttatga caaacccaca gccaatatca tactgaatgg gcaaaaactg gaagcattct 1740ctttgaaaac tggcacaaga cagggatgcc ctctctcacc actcctattc aacacagcat 1800agtgttggaa gttctggcca gggcagtcag gcaggagaaa gaaataaagg ggctcccctc 1860tcccctctcc cctctcccct ctcccctctg ccctctcccc tctcccctct gccctctccc 1920ctctcccctc tgccctctcc cctctcccct ctcccctctc tctttccacg gtctccctct 1980gttgctgagg ctggactgta ctgccgtgat ctcggctcgc tgccacctcc ctgcctcagg 2040ctcctgtcat tctcctgcct cggcctgccg actgcttggg attgcaggca cgcaccgcca 2100tgcctgactg gtttttgtat ttttggtgga gatggggttt tgctctgttg gcccggctgg 2160tctccagctc ctgacctcca gctcctgatc tgcccgcctc ggcctcccga ggtgctggga 2220ttgcagatgg agtcttgctc actcaatgct caatgttgcc cagactggag tgcagtggca 2280tgatctcggc tcgctacaac ctccacctcc cagccgcctg ccttggcctc ccaaagtgct 2340aagattacag cctctgcctg gccgccaccc catctaggaa gtgaggaaca tttctgcctg 2400gccgcccatc gtctgggatg tgaggagtgc ctctgcccag ccgcccagtc tgggatgtga 2460ggagcacctc tgcccgaccg ccaccccatc tgggaagtgg ggagcgcctc tgcccggctg 2520ccccgtctgg gaagtgagga gcgcctctgc ccggccgccc atcatctggg atgtgaggag 2580cgcctctgcc tggccacccc gtctgggaag tgaggagtgc ctctgcgcag ccgccccatc 2640tgggaagtga ggagcacctc tgcccgtcag ctgccccatc tgggaagtga ggagcgcctc 2700tgcccggctg ccccgtctgg gaagtggaga gcgcctctgc ccagctgccc cgtctgggaa 2760gtggggagcg cctctgcccg gccgcccatc atctgggatg tgaggagcgc ctctgcctgg 2820ccgccacccc gtctgggaag tggggagcac ctctgcccag ccggcccgtc tgggatgtga 2880ggagcacctc tgcccggcca ccccatcagg gatgtgagga gcgcctctgc ccggccgccc 2940catctgggat gtgaggagcg cctctgcctg gccaccaccc tgtctgggat gtgaggagtg 3000tctctgcccg gctgccccgt ctaggaagtg aggagcgcct ctgcccggcc accccgtctg 3060ggatgtgagg agcgcctctg cccggccgcc accccatctg ggaagcaggg tgcgcctctg 3120ctcggccgcc ctgtctggaa ggtgaggagc gcctctgcct ggctgccctt catctgggat 3180gtgaggagcg cctctgcccg gccacccggt ctgggaagtg aggagcacct ctgcctggcc 3240accccgtcta ggatgtgagg agcacctctg cccgaccgcc accccatctg ggaagtgggg 3300agcgcctctg cccggccgcc ccgtctggga agtgaggagc gcctctgccc ggccgcccat 3360catctgggat gtgaggagtg cctctgcctg gccaccccgt ctgggaagtg aggagtgcct 3420ctgcccagct gccccccccc cccgtctggg atgtgaggag cgcctctgcc cggccgcccc 3480gtctaggagg tgaggagcgc ctctgcccag ctgccacccc ttctgggaag tggggagcgc 3540ctctgcccgg ccaccccgtc tgggaggtga ggagcgcctc tgcccggctg ccgcatctgg 3600gaagtgagga gcgcctctgc ctggctgccc tgtctgggat gtgaggagcg cctctgcccg 3660gccgccaccc catctgggaa gcggggagtg cctctgcccg gccaccccgt ctgggaggtg 3720aggagcgcct ctgcccggcc accccgtctg ggatgtgagg agcgcctctg cccggccgcc 3780ccgtctggga ggtgaggagc gcctctgctc ggccgccccg tctgggaggt gaggagcacc 3840tctgcctggc tgccgcatct gggaagtgag gagcgcctct gcccggctgc cccgtctggg 3900atgtgaggag cgcctctgcc cggccgccac cccatctggg aagcggggag cgcctctgcc 3960cggccacccc gtctgggaag tggggagcgc ctcttcccgg ccgccccgtc tgggaggtga 4020ggagtgcctc tgcctggtgc ccttcgtttg ggaggtgagg agcgcctctg cctggccacc 4080ccgtctggga ggtgaggagt gcctctgcct ggccgcccca tctgggaggc gaggagcgcc 4140tctgcctggc cgccccatct gggaggtgta cccaacagct ccgaagagac agcgaccatc 4200gagaacgggc catgatgacg atggcggttt tgtggaaaag aaaatgggga aatttgggga 4260aaagaaagag agatcagatt gttactgtgt ctgtgtagaa agaagtagac ataggagact 4320ccattttgtt ctgtactaag aaaaattctt ctgcatggga tgctgttaat ctataacctt 4380acccccaacc ccgtgcactc tgaaacatgt gctgtgtcaa ctcagggtta aatggattaa 4440gggcggtgca agatgtgctt tgttaaacag acgcttgaag gcagcatgct cgttaagagt 4500catcaccact ccctaatctc aagtacccag ggacacaaac actgtggaag gctgcaggga 4560cctctgccta ggaaaaccag agacctttgt tcatgtgttt atctgctgtc cttctctcca 4620ctattatcct atgaccctgc cacatccccc tctctgagaa acacccaaga atgatcaata 4680aatactaaaa aaaaaaaaaa aaaaaaaggg tattcaatta ggaaaagagg aagtcaaatt 4740gtccctgttt gcagatgaca tgattgtata tttagaaaac cccatcgtct cagcccaaaa 4800tctccttaag ctgataagca acttcagcaa agtctcagga tacaaaatca atgtgcagaa 4860atcacaagca ttcttataca ccaataacag acaaacagag agccgaatca tgagtgaact 4920cccattcaca attgcttcaa agagaaaaaa atacgtagga atccaactta caaggtatgt 4980gaaggacctc ttcaaggaga actacaaacc actgctcaac aaaataaaag aggacacaaa 5040caaatggaag aacattccaa gctcatggat agaaagaatc aatatcgtaa aaatggccgt 5100gctgcccaag gtaatttata gattcaatgc catccccatc aagctaccag tgactttccc 5160caaagaattg gaaaacaaac tactttaaag ttcatatgga accaaaaaag aacccacatt 5220gccaagacaa tcctaagcca aaagaacaaa gctggaggca tcatgccacc tgacttcaaa 5280ctacactaca aggctacagt aaccaaaaca gcatggtact gatactgaaa cagagatata 5340gaccaatgga acagaacaga gccctcagaa ataataccac acatctacaa ccatctgatc 5400tttgacaaac ctgacaaaaa caagaaatgg ggaaaggatt ccctatttaa taaatggtac 5460tgggaaaact ggctagccat atgtagaaag ctgaaactgg atcccttcct tacaccttat 5520acaaaaatta attcaagatg gatgaaagac ttaaatgtta gacctaaaac cataaaaacc 5580ctagaagaaa acctagacaa taccattcag gacataggca tgggcaagga cttcatgtct 5640aaaacaccaa aagcaatggc aacaaaagcc aaaattgaca aatgggatct aattaaacta 5700aagagcctct gcacagcaaa agaaactacc atcagagtga acaggcaacc tacagaatgg 5760gagaaaattt ttgcaatcta ctcatctgac gaagggctaa tatccagaat ctacaaagaa 5820ctcaaacaaa cttacaagaa aaaaacaacc ccatcgaaac atgggtgaag gatatgaaca 5880gacacttctc aaaagaagac atttatgcag ccaacagata catgaaaaaa tgctcatcat 5940cactggccat cagagaaatg caaatcaaaa ccacaatgag ataccatctc acaccagcta 6000gaatggcgat cattaaaaag tcaggaaaca acaggtgctg gagaggatgt ggagaaatag 6060gaatactttt acactgttgg tgggactgta aactagttca accattgtgg aagacagtgt 6120ggcgattcct caaggatcta gacctagaaa taccatttga cccagccatc ccattactgg 6180gtatataccc aaagattatc aatcatgctg ctataaagac acatgcacat gtatgtttat 6240tgcagcacta ttcacaatag caaagacttg gaaccaaccc aaatgtccat caatgataga 6300ctggattaag aaaatgtggc agtaatgtgt gccatccagg gctagagcaa gtgcggcccc 6360acggcctgca cggccctgag ccatgctgag gagctgcgcc aggcgcctcc gcacgctggg 6420ggccctttgc cagccgccac cggtaggcag gcgcctgccg ggtagtgagc cgcaacccgc 6480gctgaggtca ttttcttctg aggaagtcat tcttaaggac tattctgtcc ccaaccccag 6540ctggaacaag gacctaagac tgctctttga ccagtttatg aagaaatgtg aagacggctc 6600ctggaaacgt ttgccttcat ataaacgtac acctactgaa aggattcaag actttaaaac 6660ccattttctt gacccaaagc ttatgaaaga agaacaagtg tcacaggccc agctcttcac 6720cagaagcttt gatgatggcc tgggctttga atacgtgatg ttctacaatg acgttgagaa 6780aaggatggtt tgcttatttc aaggagtccc ttacctagaa ggaccacctg gattgattca 6840tggaggtgcc attgcaacca tgattgatgc tactgttggt atgtgtgcaa tgatggctgg 6900gggaatcgtc atgactgcca atctcaacat cagttgtaaa agacctatcc ctctttgttc 6960tgttgttagg ataaatagcc aacttgataa agttgaagga aagaaatttt ttgtttccag 7020taatgttcag agtgttgatg agaagaccct atattcagag gcgacaagct tacttataaa 7080gctgaatcct gctaaaagtc tgacataaag agctgctggt gaactccatc tcattctctc 7140ccctccagaa gaagcagttg tcccccgaat actctgctcc ctcactgctg aatccctgta 7200gggagaagcc tgccaagagt gaccttccga aacagccttc tgaatacaag gaggattcag 7260tttccatctt cccaactttt taacacagaa acacttcctg cgagcatttc gacaactctc 7320agtcagggcg ctgtggctca cgcctataat cccagcactt taggaggcca aggcgggtgg 7380attgcctgag ctcaggagtt caagatcagt ctggacaaca cgatgaaacc ccgtctctac 7440taaaataaaa aaaattagcc gggcatggtg gcgtgtgcct gtagtcccag ctactcagga 7500ggctgaggca ggagaattgc ttgaacccgg gaagcggagg ttgcagtgag ccaagatcat 7560gccacatcac tccagccttg gcaacagaac gagaacccat ctcaaaacaa aacaaaacaa 7620aaaaaactct gtctccttag gatgtgttac ctgctccact gcggactgga gaaataaatg 7680tgtattgaaa cttttcctgc aaacttgaaa atgctagaaa accaagcatg aagaataaat 7740acatggcagg gaagacacag acatgtgcat atgcatatac attataagtt agtaagttag 7800aaagctagct ttgttgtatc tgaacacatg aatctttttg gtcagagtag gaagcacagc 7860caaattctat aggaatgaat acctcaaatc tgttgtctgg gattctagag attaaaccac 7920tgtgccattt aaaaaagaaa aaagaaaatg tggcacatag acaccatgga atactatgca 7980gccataaaaa aggatgagtt catgtccttt gtagggacat ggatgaagct ggaaaccatc 8040attctcagca aactattgca aggacaaaaa accaaacacc acatgttctc actcataggt 8100gggaattgaa caatgagaac acttggacac aggaagggga acatcacaca ccggggcctg 8160ttgtggggtg gtgggagggg ggagggatag cattaggaga tacacctaat gtaaatgacg 8220agttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa acctgcatgt 8280tttgcacatg taccctagaa cttaaagtat agtaaaaaaa aagaaaaatg aaaatattat 8340aacccagaaa gataaaataa taatcacatg ggctgggcat ggtggctcac gcctgtaatc 8400ccagcacttt gggaggccga ggtgggcaga tcacaaggtc gggagttcga gaccagcctg 8460gccaatatgg tgaaaccccg tctctactaa aaatacaaaa actggccggg catggtggca 8520cacgcctgta atcctagctg ttcaggaggc tgaggcagga gaattgcttg aacccagaag 8580gcggaggttg cggtgagctg agatcatgca actgcactcc agcctggggg acagagtgcg 8640actgtctcag aaaaaaaaaa attaataata tcatatgaac tcccagaaag caagaaattt 8700ggctagaaat tttatctatt gtatttccac cagctattga ggtttaaaaa aaagtttaag 8760gacgggcacg gtggctcaag cctgtaaccc cagcactttg ggaggccaag gtgggtgaat 8820cacaaggtca ggagtttgag accagcctgg cccatatggt gaaaccccat ctctactaaa 8880aatacaaaaa attagctggg catggtggcg tgtgcctgta gtcccagcta tttgggaggc 8940tgaggcagaa gaatcgcttg aacccaggag gcagagggta cagtgaaccg agattgtgct 9000actgtactcc agcctgggca gctgagtgag actctgtctc aaaaagaaaa aaagtttaat 9060aatgtataaa tatggccagg tgcagtggcc caacgcctgt aatcccagca ctttgggagg 9120ccgaggtggg cagatcacaa ggtcaggaga tcgagaccag ggtgaaacct cgtctctact 9180aaaaatacaa aaaattagct gggtgtggtg gtgggtgcct gtagtcccag ctacttggga 9240ggctgaggca ggagaatggt gtgaacctgg gaggcagagc ttgcagtgag ccgagatcgc 9300accactgcac tccagcctga gtgacagagc aagactccgt ctcaaaaata tatatatata 9360aatattgcaa gattaaaatc accatcattg gccaggcgtg gtggctcacg cctataatcc 9420cagcactttg ggattccgag gtgggtggat cacgaggtca tgtgttcaat accagcctgg 9480ccaaaatagt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtggcac 9540acgcctgtaa tcccacctac tcgggaggct gaggcaggag aatcacttga acctgggagg 9600tggaggttac agtgagctga gattgctcca cttgcactcc agcctgggtg acagagcaag 9660ataaaaaaaa aaaattacca ccatcaagta gtacgttaat ctgctctggc tgctataaac 9720aaaataccat agactgggtg gcttaaacaa taaacagtca tttcttatag ttctggaggc 9780tgggaaatcc aagatcaggg tgccagcatg attcttggta ggggtgctca tcataacttg 9840cggacaccca ctttctcact gtgtccacat gggggagctc tgatctcttt ctcttcttaa 9900aaggataaac tcgttttggg agctctcctc tcatgaccta aacctcatta cctctcagag 9960gccccactac caaataccga ttcacattga tggttatggc ttcagtatat caatttggag 10020gagaggtgga gaagacacaa acactcagtg catagcaaat aatatttcaa tccactggag 10080gaagatggaa aatctaaaag gaaatgttaa ttaaaaaaag acctttttat tcttcataag 10140acttctttct cattctagtg gctacacaaa caagctgagg cacgaagagc aatgaatact 10200gacatagctg aactttgcga tttaaaagaa gaagaaaaga acccagaatg gttgaaggat 10260aaaggaaagt aagttgtttg aactctgatc atgagcttta tcatgtatga agacattagc 10320agttatcata ggacgagtat ggtggctcat gcctgtaatc ccagcccttt gggaggccga 10380ggtgggatga taacttgaag ccagaagttt gagaccaacc tgggcaacaa agcgagattt 10440tgtctctaca aaaaaacaaa caaaataaaa cattagcctg gtgtggtggt gagcacctgt 10500agtcccagct actcagaagg ctgcggcggg aggatccccc aagcccagga gttcatggct 10560gcagtgagct atgattgtgc cactgcactc cagtctgggc aacaagagtg agaccctgtc 10620tttgaacaaa caaagtagtt atcacattct ctagatattt tgtctgtttg tgtgttgttg 10680gagaaagata atgcaaataa gcaaataagg tagacagggc atccatattt taaaagtcag 10740ataacaaggc aatgaggctc taattttatt tttttattta aatgtcataa aaatgaaaaa 10800aattacatct tttggaatgc ttattaaaat tccttttaaa atccgtttta catttgacat 10860aagtcctttc tgatgtctcc cataaaaacg ggctttttgc aaagctacag ctgttttgat 10920tattcttatc catttttttt cttttttttt tttgtgagat agtgtctcat tttatcaccc 10980aggctggagt gtagtggtgc aatctcagct cactgcaacc tctacccgcc aggttcaagc 11040agttcttctg cctcagcctc tcaagtagct gggattacag gcatccaccg ccacacctgg 11100cgaatttttt ttgtattttt agtagagacg gggtttcacc atgttggtca agctggtctt 11160gaactcctga cctctagtga ttcatccacc tcagtctccc aaagtgctgg gattacaggc 11220atgagccctg gtgtgggacc tattcaaatc catttctaaa gattaccatc ttactgcctt 11280ccaggtcagt gatgtaaaca caaaaaagat taccatatta tcccagaaat tatcttatat 11340ctgggcagtc attttattca tttgtatatg gatttttttt ttttttttga gacaaagtct 11400cgctcttggt ccccaggctg gcgtgtgatg gcacaatctt ggctcaatgc aaactccacc 11460tcccaggttc aagcgattct cctgcctcag cctcctcagt agctgggatt acaggcgcct 11520gccaccacgc ccaactaatt tttgtttcac catgttggcc aggctggtct caaactcctg 11580acctcaggtg atccgcgcac cttgacctcc caaagtgctg ggattacggg tgtgagccac 11640tgcacccggc cgtgaatatt ttaacatact gatcaaaaac agtgaattct ggcatattct 11700gagtggcaat ttgtgttcat attttgaggc ggctatagat attatttatt gtatttcatc 11760atatacactt ctgtgtttat tttcctatta cttattactt ctataacaaa ctaccaccaa 11820gtggcttaaa acaacacaaa tttattatct tatagttctg taattcagaa gtccaaaatg 11880agtttcactg ggccaaaatt aggtgtcaac tgccttcctt ttgaaggctc taggagaaaa 11940gctgttttct taaatttccg gcttctaagc tgtttgcatt ccttgaattg tggctcccca 12000gccactgatt gcgttattct gacctctgct tccgtgatct ccttttctga ctctcctgcc 12060tccttctacc ttttataagg cctcttgtgt ttatgtaagt cccacctaca tcatccaggg 12120tactctctcc atcaaactct ttaacttatt cacatgtgca aagtcctttt tgccgtgtta 12180ggtaacgttc ataggttctg ggattagaat atggacatct ttttttgggg ggcggggggc 12240attatctgtc taccacaata tctatatttt tcctttcttt ctactttttc ttggtctttt 12300ctcttgtctg ttacaacacc agggattgtt ttgtggcgtt tagctggagt tggcaatttt 12360tctgaaggtt agaagcctgg aactgacagg ttggttcttc taactcccaa gagtaaaacc 12420atatataatc tttcctcctc tttctcttct tcctttcttc cttcctattc atttattcag 12480ccattaaata agcaattatt gattgcttgc tatttgccag actataggca cttaacaaca 12540gaaatcagga ggagagagac gtacacaaat atttaaaaca ctgtgtggga agtacaataa 12600catggataag aacaaggtaa tagagccagg tgcggtggct cacgcctgta atcccagcac 12660tttgggaggc tgaggcgggc ggatcacctg aggttgggag ttcaccagac tgaacagcaa 12720ggagaaaccc tgtctttact aaaagtacaa aattagctgg gtgtggtggc gcatacctgt 12780aatcccagct actcgggagg ctgaggcagg agaattgctt gaacctggga ggtggaggtt 12840gcggtgaatc gagatcgtgc cactgcactc cagcctgggc gacagagtga gactccatct 12900caagataaaa agaaaatttc tggccaggca cagtggctca cgcctgtaat cccagcactt 12960tgagaggcca agatgggtag atacttgagt tcaggatttt gagacaagcc tggccaatat 13020ggtgaaaccc aatttctact aaaaatgtaa aaattggctg ggcacggtgg ctcactccta 13080taatcccagc actctgggag gccaaggtgg gtggattacc tgaggccagg agtttgagac 13140cagcctggcc atcatggtga aaccctgtct ctactaaaaa tacaaaaact agtcaggcat 13200tgtggcgcac acctgtaatc ccagctaatc tgagtctcag aggcatgaga atcacttaaa 13260cctgggaggt agaggttgca gtgagctgag atggcaccac tgaactccat tctgggcaat 13320ttagcaagac tgctcaaaaa aataataata attaaaaaaa taataataat gggcaaagaa 13380cttaaatagg catttctcca agaagagaga caaatggcta gtaaatataa aaagatgttt 13440aacatcacta accatttggg aaatgtctta tcaaaaccac tatgagatgc cacttcacac 13500ccattaggat ggctactcag aaaaaaaaca gaaaataaca agtgttagtg aggatgtgga 13560gaaattagaa tcctgtgcac tgttggtaga ggtgttgaat gatccagctg ctatggaaaa 13620cactattgtg gttcccaaaa aagtaaaaat agggccgggc gcaatggctc acgcctgtaa 13680tcccagcgct ttgggaggcc gaagcgggca gatcacctga gatcgggagt tcgagaccag 13740tctgaccaac atggagaaac cccatctcta gtaaaaatac aaaattagcc aggcgtggtg 13800gtacatgcct gtaatcccag ctactcagga ggctgacgca ggagaatcgt ttgaacctgg 13860gaggcagagg ttgcggtgag ccaagatcgc accattgcac tccagcctgg gcaacaagag 13920tgaaactctg tctcaaaaaa caaacaaaca aaaaaaagca aagactttgc attttgaaga 13980aatcctttaa tcgtgtacat ctctttattt gaagagaatt ttggaacatt taaactgaaa 14040gagtatatcc attgcaagta accaaaaaac ccaatttttt tatattgaaa ggaatttatt 14100gtcttatata actaaacagc taaaggtgtt ttctatttca agtaaagctt gatccagcag 14160cttaactgta tcatgaaggg ctcggtttct ttctgccttt ttattccttt catatttcca 14220tagtatcagc tttattctaa tgccagctct tcccacggtc ttaaaaacgg tcagcaacaa 14280tgtgggctat gtgacttctt cacttatatc cagcaggggg agaaatttgc ccaacttttc 14340attcttcaac tttgaaacca acccacaggc ttcatcctaa gtagaacaat ataggtcaca 14400ctagcccatc cctgagtcaa ttactggagc aaaaataatg caaatatgcc ctactggctt 14460aaattactaa tgtctaccct tggaggtggg agtgaggtcc attccattca aatgacaggc 14520tggtatatgt gaaaagagat ggattcagtg caggcaacgt ttaccctaaa gagaatgcaa 14580aaagaggtaa gccatcctct ttgtcaaata caattagata ttatttctgt gtttctgttt 14640caatgttaaa ttgtttttct tctctgtttt tgtctcatta gcaaattgtt tgcaacggaa 14700aactatttgg cagctatcaa tgcatataat ttagccataa gactaaataa taagatgcca 14760ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa aaaacttaca caaggctatt 14820gaagattctt ctaaggtatg gatatctatg tatgatatat ggtgctttaa atatatcctt 14880ctattaattg gtttaaatga tgatcttttt ctgttcagtt gaaataattg agatgcaaag 14940attttaaaga ttgtctttct tattgaatct tttttttttt aactgatttt ttactaatgg 15000acaaggaact ggtgtttttt tgtgacttct atgaatagtt agttagatta aaaatcagct 15060gttactggcc gggcgcagtg ggtctcgcta tattgcacag gcaggtctcg aactcctggg 15120ctcaagctat cctcccgcct ctgcctccct gagagctggg attacagaca tgagccaccg 15180cgcccggcac ccagcccaga tatctctaca atcattttct catttgcagg gtaacttagt 15240atattctact ttccattact aatatttact gtgtatgtct tgaacttcta cagctttttc 15300ttttttccat gtcaagataa cttgttttaa gggcatatca tgtgcaaaat ctcttaggta 15360gcttcttgag attgaggata tggaggacac aaccaagtct tcatcacttt gatatcatac 15420tacttttatg atccagtttt tctttgactc tcacaatgca aacaaatatt tgttgaatga 15480atgaataagc tgaatcaccc aatctgaata caaaagccca caaatgctat ttaataattc 15540ctactggtaa aaataaagct gtggagatgt gaaatgataa gctgaataat aaccttggag 15600gggtatgaat cccatatagg aacaactgaa aaattcctta agttgttcaa catatctctt 15660ctggaaaacc tgataataat tatttgtttt atatatatat ataatatata ttatatataa 15720gaatatatat aatatatata atattatata tattatatat aatatataaa atatattata 15780tatattatat atattatata tattttatat aatataatat atataattat atataatata 15840tataatatat atataatata tgtaatatat ataatatata ttataatata tataatatat 15900aatatatgta atatatataa tatatattat atatataaaa caaatatata tatttgtttt 15960ataaaaacaa ttatatatat ttatatataa aaaacaaata attatatata tatttgtttt 16020atatatataa tatatttata tttgctaaat tcctgtacca gctaagctaa aaatttaggt 16080gagtgcttga ggccattttt tttttttttt ttttgagacg aggtcttgct ctgttgccca 16140ggctggagta caggggcaca atttcggctc actgcaagct ccgcctcccc ggttcacgcc 16200attctcctgc ctcagcgtcc ggagtagctg ggactgaagg cgcccgccat catacccggc 16260taattttttg tatttttagt agagacgggg tttcaccgtg ttagccagga tggtctcgat 16320ctcctgactt cgtaatccgc ccgcctgggc ctccgcccgc ctgggcctcc caaagtgctg 16380ggattacagg catgagccac cacacccggc cgaggccttt tgtgtgtgtg tgtgtttgtg 16440tgagacaaag tctcactctg tcaccaggct ggagtgcagt ggtgcgttct tggcttattg 16500caacccctgc ctcccggatt caagtgattc tcctgcctca gcctcctgag tagctgggat 16560tacaggtgcc cgctaccaca tctggctagt ttaagtattt ttagtagaga cagggttttg 16620ccatgttggc caggctggcc tcaagctcct gactttgggt gatctgccca cctcagcctc 16680cgaaagtgct ggaattacag gcgtgagcca ccaggcccac ccgaggctta ttttaaaatt 16740agaattttta ccatgttttt gcttgtttgt tttttgtttt tgtttttttt gagacggatt 16800ctcgctctgt cacccaggct ggagttcagt ggcgcgatct cggctctctg caagctctgc 16860ctccctggtt caagcaattc tcccgcctca gcctcccaag tagctaggac tacaggtgtg 16920caccaccaca gccagataat ttttgtattt ttttttagta gagacggggt ttcgccatgt 16980tggccaggct ggtctcaaaa tcctgacttc aggtgatcca cctacctcgg cctccccaag 17040tgttgggatt acaggcgtga gccaccatgc ccagcctttt gcttgtttaa attaagaaac 17100tataactttc ttgtaataat tatatatatt ttgtaaggca ctggaattat tgatgccacc 17160tgttacagac aatgctaatg caagaatgaa ggcacatgta cgacgtggaa cagcattctg 17220tcaactagaa ttgtatgtag aaggtaagga attgatagaa atggtttaag tcccaagtta 17280tactctgaaa aaaatgtcat tggaattatt taagatcgtg acttttaagg actccatttt 17340taaatatttt tagcatttaa tttattctta gtaatgtctg cagtatatct gacaatacat 17400gatttctaaa ttatatttaa aaaattcatt gtagaagaga attaaaataa gtgtaaacaa 17460caagtttcag tctagaaaaa tgctatatta gctgggtgca gatgctcatg cctgtaatcc 17520cagcactttg ggaggcagag gcgggtggat cacctgaggt cgggagttcg agaccagcct 17580gaccaacatg gagaaaccct ctactaaaaa cacaaaatta gcttggcgta gtggcacatg 17640cctgtaatcc cagctacttg ggaggctaag gcaggagaat cccttgaacc cgggaggcgg 17700agattgtggt gagccgagat catgtcattg cactccagcc tgggcaacaa cagcgaaact 17760ccttctcaaa aaaaaaaaaa atgctatatt accagacaac tcttcataga aacgtgtgat 17820aaatgctggg tgtggtgctt cacgcctata atcccaggaa ctggggaggc tgaggtggaa 17880ggatggcttg aggccaggag tttgagacca gcttgggcaa catagtgaga ccctgtctct 17940taaaaaaaaa aaatacatga taggctgggt gtggtggctt atgcctgtaa tctcagcact 18000ttgggaggcc gaagcaggtg gatcacaagg tcaggagatc aagaccatcc gggctaacac 18060ggtgaaaccc cgtctctact aaaaatacaa aaacaaaatt agccaggtgt ggtggcgggc 18120gcctgtagtc ccagctactc aggagactga ggccagagaa tggcgtgaac ccggaaggca 18180gagcttgcag tgagccaaga tcacgccact gcgctacagc ctgggtgaca gagcaagact 18240ctgtctccaa aaaaaaaaaa aaaaagataa aatatataaa tgatttgaga tatcatggat 18300atttatctca gagagcttct tcggtcatcc ctgtatgtat gtatgtattt gtgtgtgtgt 18360gtgtgtgtgt gtgtgtgtgt atacacacac ctaagctcgg aaataactga tccaccatag 18420tgcatgcaca ttgcttatat ttgttagatt gtattaagtt ctgtaattta gctctatgta 18480tacagaaaat atagcattta ttttatttta ttttagatag atttaggggc cgggcacggt 18540ggctcacacc tgtaatccca gcactttggg aggccaaggt gggtggatca tgaggtcagg 18600agatcgaggc cctactggct aacacggtga aaccccatct ctactaaaaa tacaaaaaat 18660tagccaggtg tggtggcagg tgcctgtagt cccagctact caggaggctg aggcagaaga 18720atggtgtgaa cccaggaggc agagcttgca gtgagccgag atcatgccac tgcactcccg 18780cctgggcaac agaaggagac tctgtctcaa aaaaaaaaga tgggaatcta atttaaaact 18840tggtacttgt tctgaaccat gctactagtg attattttta ttttaaacaa ctattgtcta 18900gataaaagaa gtgctaataa aatatttatt gtattaatca tcattgctat ataaacacag 18960gcctacagga ttatgaagcg gcacttaaga ttgatccatc caacaaaatt gtacaaattg 19020atgctgagaa gattcggaat gtaattcaag gaacagaact aaaatcttaa tgactattag 19080aagtaactaa gtattgttat aagtttttta aaaacaactg gaggcatctt tgtacatatt 19140atggccagtt gtacagaatc gctttctgtt tagtacttta gttctgttga gggcaaaata 19200ttataaatct atagaaaata aactgtttga cttgaatcat ttctgaataa gtaaatctaa 19260ataagaatct attttaattc cttatttctt catattaata catatgtata cttttttgtg 19320ttactgaatt aagcttgccc ttgtaacaaa atatgttttg gtatagttac caggacactt 19380actgattaat ttttaacaag gtagaatttt aaaataaaag atttataaat aacttttgtt 19440tgtattaata taccatttaa ttgactgaat ggttgacttt ggtataataa atattgacag 19500gttgtccgtt agtttccaac tgcacagaac cttatttttt tgtttaatac ttctctaatg 19560cttgttgttc aagattagac cagttcagcc tagtataaaa caactgttta gaaaacctta 19620tattcaactt catttatagg ctgtgcacct gaaaactgat catatttcat aacactatct 19680ggtgaagata aatttttgag tgaaatagtt ttctagtacc tccaagtaga caagggggag 19740aaaagacagc aaagtgtaag atattaacct ggaatattat ggtattggta ttggactgca 19800ccatcatttg tgttgtatca ctgggattat gcaagtgtta agcacaatag cacagcttcc 19860cttttgcttg tagttactgt aattctctaa ttaaatttta aaggtttttt tttttttttg 19920agacggagga agtctccctt tgttgcccag gctggagtgc aatggcgcga tcttggctca 19980ctgcaagctc tgcctcctgg gttcaggcca ttctcctgcc ttagcctccc gagtagatgg 20040gactacaggc gcctgccacc acgcctgact aattttttgc atttttagta gagatggggt 20100ttcaccatgt tagccaggat ggtctcaatc tcctgatttc gtgatccacc caccttggcc 20160tcccaaagtg ctggattaca ggtgtgagcc accgcgccca gccttttttt ttttttttct 20220tgagacacag tttcactctt gttgcccaga ctggagagca gtggcctgat catagctcgc 20280tgcatcctcc acctcccagg tttaagggat tctcctgcct caggcctcct gagtagctga 20340gattacaggc accaccacgc ctgattaatt ttttgtattt ttagtaaaga cagggtttca 20400tcatgttggc caggttggtc tcgaactgct gacctcaggt gatccacccg cctcggcctc 20460ccaaagtgca gggattacag gcatgagcca ccgcgcccgg ccttatttat ttatttttga 20520gatgtagtct ggctctgtaa cccaggcttt agtgcagtgg tgcaatctcg gctcactgca 20580acctccgtct cctgggttca agcaattctc ctgcctcagc cttccaagta gctgggatta 20640caggtgcgtg ccaccacatc tggctaattt ttgtattttt agtagagacg gggttttacc 20700atgttggcca ggctggtctc gaactcctga cctcaagtgg tctgcctgcc tcagcctccc 20760aaagtgctgg gattataggc aagacccccc gcgcctggcc taacaaattt agtttaaagg 20820tctaattggc ctttatcagt gactcatgaa tcaagcagca tcttatataa agatttagaa 20880gagacactgc tagaggtggc agaataaaat ggcctttgca aaattatgat taagacagtg 20940aaagaggctg ggcgcagtgg ctcaagcctg taatcccagc actttgggag gctgaggcag 21000gcagatcaca aggtcaggag atcgagacta tcctggctaa catggtgaaa cccccctctc 21060cactaaaaat acaaaaattt agccaggcgt ggtggcaggc gcctgtagtc ccacctactc 21120gggaggctga ggcaggagaa tggcgagaac tcgggaggcg gaggttgcag tgagccgaga 21180ttgtgccact gtactccaac ctgggtgaaa gagcaagact ccatctcaaa aaaaaaaaaa 21240aaaaaaaaaa aaaaagaaaa aaaagacagt gagagagatt taacttaact gaatttatct 21300tgcttttaac ctccaagctg tccttgttca ttcctgggtg taggctgaac taactttaaa 21360aaacttagtg tatagtttaa acaaagacag tgacagtcct ttcccaaagc cgacctcctt 21420cttgcctggg gacggaattg cctttgtagg actaacatta gccacaagat taaaaattat 21480agtttatgct gggcatggtg gctcatgccc ataatcccag cactttggga cactgaggca 21540ggtgggtcac ttgaggtcag gagttagaga gcagcctggc caacatggtg aaaccctgtg 21600tctactaaaa atacaaaaat tagccgggca tggtggcagg tgcttgtaat ccctagctac 21660ttgggaggct gaggcaggag aatcacttaa aactgggagg tgaaggttgc agtgagcgga 21720gattgggcca ttgcactacg gcctgggtga caggagtgaa actccatctc caaaaaaatt 21780acggtttaga agtcatactg ctggaggcca ggcgcggtgg ctcatgcctg caatcccagc 21840actttgggag gccgaggcgg gtggatcacc tgaggtcggg agttcgagac cagcctgacc 21900aacatggaga caccctgtct gtactaaaaa tacaaaatta gctggacctg gtggcgcttt 21960cctgtaatcc cagctactcg ggatgctgag gcaggagaat cccttgaacc cgggaggcgg 22020aggttgcggt gagctgaggt ggcgccattg cactccagcc tggacaagaa gagcgaaact 22080ccatctcaaa aaaaaaaaga agtcatactg ctggaggcta caaaattctg accctcccta 22140aactgctcct aagatcagtg tttacaatat tttgcagacc ctgcacttaa tgaatcagct 22200ggcaccaccc agatcaataa actgactcat ctaatcttgt ggccccccca accaggaact 22260aacttagcac aagaaaacag ctccaatctt taatttcatc tctaaccaat gagccactcc 22320tggctcacca gcttcacctc acccaccaag ttgtctttaa aaactctgct ccctggctgg 22380gcgcggtggc tcacgcctgt aatcccagca ctttgggagg cttaggcgag tggatcacga 22440ggccaggagt tcaagaacag cctggccaag atggtgaaac cccgtctcta ctaaaaaaac 22500aaaaaaatca gccgggtgtg gtggcgggca cctgtaatcc cagccactcg ggaggctgag 22560gcagagaatt gcttgaaccc aggaggcgga ggttgcagtg agctgagatc gggccactgc 22620actccagcct gggcgacaga gcgagactgt ctcaaaacaa acaaacaaac aaaaaaaaac 22680aaaaaaactc tggtcttctg cacagctggt tctgtgtgaa ttactctttc tctgttgcaa 22740tttccgtgtc ttaataaatt ggctctgtct aggcagcagg cagagtaaac ccctttgggg 22800gttacaaaaa caattggtat ttatagggta gctgaagcag gaacaagaaa cagcataata 22860caaaaagtgg gttggttgat gtaacttcag atcactttcc ttgcaagagt taaaacagtg 22920aggacttccc tatcctgcca gctaaaaggg gcctgtttgg gtatttggct atcttctctc 22980tcatgattta tcagaagatc agataaacaa ctaaattttg ggccaggctc agtggctcat 23040gcctgtaatt ccagcacttt gggaggctga gatgggcgga tcacctgagg tcaggggttc 23100gagaccagcc tggccaatcc cagctccact aaaaatacaa aaattagccg gacatggtgg 23160caagcacctg taatcccagc tactcaggag tctgaggcag gacaatgact gagacagtga 23220aagagagcta acctaacaga ctccatcttg gttctaacct ttaagctgtc cttgttcctt 23280cctgtgcata ggctgaacta actttgggag gaacttagtt tatagattat agttggaaac 23340aaagatgtta acaacctttc tccaaaacct tttccttcct gcctggggat tagactgcct 23400ttgtaggact aagaaattag ccacaagatt agaaattatg gtttaggagt catgccgttg 23460gaagttacaa gattctgacc ctcactaaac tgctcctaag atcagtgctt gagatatttt 23520gcagaccctg cacttgctgg atcagctggc accacctagc tcaataaact ggctcatccc 23580atcttgtgac ttccacccag gaactgactc agtgtaagag gacagcttca attcctattg 23640atttcatcta cctaaccaat cagcactcct ggctcactgg cttcccccca cccaccaagt 23700tgtccttaaa aactctgatt cccaaatgct tgggcagtct gatttgatta gtaataaaac 23760gctggtctcc tgcatagctg gctctgtgtg aattactctg tctctgttgc agttcccctg 23820tcttgataaa ttggctctgt ctaggcagca ggcaaggtca acccattggg cagttacact 23880agcgcaagag gttcagtcca aatcagtggc cttccataca ttttatttaa cacatcccag 23940aaagaggttg tgaattacat caagcaaaag ggttctgtcc tacaccaggt ttgggatgat 24000ttttattttc cacacgttag ctctttgctg acagaggtca aaatattagt cctaatacag 24060agatattgtc taatagttta gtgttatata aacctattct gtcttggttc cctagtgtag 24120aagaaaatca gagttgaaca gtaaagtgaa aaaaaaaatg cttttactca gtaacttata 24180ataaggaaaa agagacctca gcatggaacg aggcttagtt cttttcattc ctgtgaggcc 24240tgagaataaa aaatgaaaaa gaactaggct cagttccaaa tatggcatgg acaagtaggg 24300gtttatagcc aaggagtagg ttgggtaatg aaggtggtca gtggatggaa aattaccaag 24360agaaaacatt aggggttaga ggaattctgg ttaaattgac ctaacaggat tcttgctgaa 24420gacaggccag gttgatcagt tatcaccggg gggatggtag ggaatgagga atctggtcaa 24480atatcaaggg tgatcagata ttgatggtgg ggattctggc taaaggaact tggcaggatt 24540cttgccatga ctgggctctt aagagcaaag tatgtggctg agcgtgatgg ctcacgcctg 24600taatcccagc actttgggag gccgaggtgg gcggatcaac tgaggtcagg agttcaagat 24660cagcctgacc aacatggaga aaccccatct ctactaacaa tacaaaatta gccaggtgtg 24720gtggcacatg cctgtaatcc cagctactca ggaggctgag gcaggagaat tgcttgaacc 24780tgggaggtga cggttgtggt gagccgagaa tgcgccattg cactccagca gcctgggcaa 24840caagagcaaa actccatctc caaaaaaaaa gcaaggtaca gccgggcacg gggtctcacg 24900cctgtattcc cagcactttg ggaggctgag gcaggtggat gatgaggtca ggagttggag 24960accagcctga ccaacatggt gaaaccctgt ctctactaaa aatacaaaac ttagctgggc 25020atggtggcgc atgcctgtaa tcccaggtac tcaggaagct gaggcaggag aatcgcttga 25080acctgggaga cagaggttgc agtgagctga gatcgtgcca ctgcactcta gcctggataa 25140agagcaaggt gcaaggatgg ggcctagtca aaaaagtggt tcacaggagc ctatctagag 25200tttggtcaag gagagacctc ttaatcacta gcaagccaac tgctttccaa caaatttcat 25260ccatgtggga aataagggca aaggattttg cacatgccat ctagggaaaa agtaggtgcc 25320ttacttcatt ttccactgct gtatcagaat accacagact aggtaattta taaaggacag 25380agatttattt ggttcatggt tctgcatgct gggcagtcaa gattaaggga ctacatgcat 25440ctggtgaaga ccttcttgct atatgataac atggcagaat gtatcacata gtaagacagc 25500atgcaagaag aaaggaaagg aaaagggggc tgaactcccc tcttttataa ctaaacccag 25560tcctgcaata actaactcac ttctgtatta acaactttaa tttattcaag agtatggtgt 25620ccccatgacc taatagtctc ttttgtgtgt gtgacagagt cttgctttgt cacccaggct 25680agagtgcagt agtgtgatgt aggcttactg caacctccac ctcctgggtt caagtgattc 25740tcctgcctca gcctcccaag tagctgagat tacaggcatg cgccaccatg cccggctaat 25800tttggtattt ttagtagaga tggcttttca ccatgttgcc caggctggtc tcaaaactcc 25860cgacctctgg cgatttgccc accttggcct cccaaaatgc tgggattaca ggtgtgagac 25920actgtgcctg gcctattttt gtatttttta atagagacag catttcacca tattggccag 25980cctggtctcg cactccttat cttaagtgat ccaccggcct tagcctccca aagtgctgag 26040attgcaggtg tgagccaccg cgctggcttt actttagctt ttttagtcca tattaaggac 26100taacatgact ctctagttat cttcagctat atttacatct gattgctgta ggtcagcagt 26160tctcaaaatg tgttctaatc agaatacaaa tactctggtc agcatggtgg ctcacaccca 26220taatcccaac actttgggag gtggtgggtt atgcctataa tcccagcact tgggaggagg 26280tgggaggata acttgagccc aggagtccaa gactaaccta agcaacatag cgagaccccc 26340atctctacaa aaaatagaaa aaaagttagc caggcatggt ggtgcatgac tgtagtccta 26400gctacttggg aggctgaggt tggaaaatcg cttgagccgg ggaagtcgag gttgaggtta 26460cagtgagctg tgcttgtgtc attgcgctcc agcctgggtg acagagggag accctgactc 26520aaaaagaata caaaatatgc tatattatat catatcttaa aaaaaaaaaa acttttggct 26580ctacatctag ctattgcccc atttatctgt tcagtgtgca gcaaaactac ttaaaattag 26640ttttgagttt ttctgttctt tcttattcca ataaagtttt cctctctacc gcttcttctt 26700gtagagagga atacatttat ttatttattt atttatttat ttttgagacg gagttttgct 26760tgtcacccag gctggagtgc aatgtcgtga tcttggctca ttgcaaactc tgcctcctgg 26820gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggc ttccaccatc 26880acacctggct aatttttgta tttttagtag agatggagtt tcaccatgtt ggccaggttg 26940gtctcaaacg cctgacctca ggcgatctgc ccacctcagc ctcccaaagt tctgggatta 27000caggtgtgag ccttcgagcc tggccttgtt gaaataattc tgtttgaagt catccatgac 27060ctctgatttg cctaatcaaa ggtcagttct caattcatat gctatatctc ccaagataat 27120ttcacactgc tgggtcattc cctctccttg aaacaagctg ggcttccagg cctcacagtc 27180ttctaatttc ctctttcttc agtagtcact ccttcttggt ctcatttgtt tcttcttgtt 27240ctttgccttg acctctaaat ggtggttttc cctaaagcat agtcctcagg tctgttttct 27300acctacactt tgtagtctta tctggtttaa tcattttaaa taacatgttc caagtgataa 27360tcttcaattt gggctactcc cttgaattca agttgtatat tcagttgcct tacatcaact 27420tgactttcct cagatgttct cttaacctcc tttagagggt gtggtcagac atctccttat 27480cagaaacctt ccctttccac ctacctaaag taactccttg ctgaagtact cactttcctc 27540ctaactctat tttatgtttt ttcccgtaac acttatcact tggcatgttc tatacatcta 27600gccatatata tttacatagt tacctatgta tgttatcatg ttatttatgc atatattcat 27660gtgtattttt atttgtaaat atataaaaat atgtatttat acatgctttt tggtctgttt 27720tctcctgctg ggattcatta gaatctaaac tccattagga ctagcttcta gtgcctagta 27780tagtcctggg acctttatta ttattattat tattattatt attattatta ttattattat 27840acattttttt gagacggagt ttccctcttg ttgcccaggc tggagtgcaa tggtgtgata 27900tcggctcacc gcaacctccg cctctggggt tcaagagatt cttctgcctc agactcccaa 27960gtagctggga ttacaggcat gcgccaccat gccagctaat tttttttgta tttttagtgg 28020agatggggtt tctccatatt ggtcaggctg gtcttgaact cctgacctta ggtgatctgc 28080ctgcctcagc ctcccgaagt actgggatta caggcgtgag ccaccatgcc cagccagtcc 28140tgggacttta ataggcactg aatgactgtg tatataatga aattccagat gatatgcttg 28200attttcagct acttatcctg ataattttat tattttttag atgaagtctc cctctgtcac 28260tcaggttgga gtgcagtggc atgatctcag ctcactgcaa cctccacctc ccaggttaaa 28320gagattcttg tgcctcagcc tctggagtag ctgggattac aggcatgcac caccatgcct 28380ggctaagcat tttgtatttt tagtagagat gtggtctcac catgttgccc aggcttgcct 28440tgaactcctg gcttcctgta atcggaccac ctcggcctct caaaagtgct gggattttaa 28500gtgtgagcca ctgtgcctgg agtatcctga gaattttttt tttttttttt ttgagatagt 28560ctcactctgt tgcccaggct gcagtgcagt ggtgtgatct tggctcactg caacctctgc 28620ctcctgggtt caagcgattc tcctgccgca gcctcctaag tagctgggac tataggcaca 28680caccaccacg cctggctaat tttttgtatt tttagtagag acggggtttt gtcatgttgg 28740ctaggctggt ctcgacctgc tgacctcaag tgatctgccc gtctcggcct cccaaaatgc 28800tgggattaca ggtgtaagcc accgtgcccg gccaatcctg agaatttagc aacaacaaaa 28860atgaccgaac agtgcaccac tgccataggt aggaatttta ggttagtatc tagattctac 28920atataaaaag gtaaattcac ttgccatgaa ttgggcacct gcagtgaagg gggaaaatgg 28980tttgtatggt ttatactgca agaacaggct aataaactaa aatgttattg cataattcac 29040ttggacatct tgtgcagtgc cccactattt gatgttttga ggaagtgaaa aaaattaatt 29100tttcttcttg cttgtgccat tactaaatat cagttttggg ggggtatttg gaagaagttg 29160atgagtctgc agagtttgag ctgtttcctt acatcaagca aattttatga ttagaagatt 29220caacttttat aatcccctta tgactcacaa atttattctt tctaattgat ggtaatatcc 29280tgaactgaaa ccaacagggg aaaataacaa tgattttttt tttttccaga aagatactca 29340gacccaatta tcaacatatg gtttaaacag atggcagctg aaataaatct gtgtgtagta 29400gaatcaaaga ttttaaagaa ttgtgtagcc tgtcacctgc cactgctcac actgtgttga 29460agatatataa aattaattgc atttataaaa atataccaca ttgtctcaca tctttgtact 29520tttatccata tagtttcctc tccctagaat agccttcttt tgatttagct ttatcttctc 29580caggacactt ctcctgatct ctctggtctc aatttgagca attctgtgtc tgtctgaaag 29640gcctgtgcat actgcctact ttacattaca aaaattatca catattaatt tgctaatctc 29700attctcccaa aatacttttt tttattcttt ttttttgaga cagagttttg ctcttgttgc 29760ccaggttgga gtgcaatggc gtgatcttgg ctcactgcaa cctccacctc ccaggttcaa 29820gtgattctcc tgcctcagcc tcccaaagta gctgggatta caggcacccg ccgccatgcc 29880cagctaattt ttttgtatct tagttgagat ggggtttcac cattttggcc aggccggtcg 29940gtcttaaact cctgacctca ggtgatccac cagccccggg ctcccaatgt gctgggatta 30000caggtgtgag ccaccgcacc cggccaatat tgttaattaa aacaaaaatc actgtctttt 30060atttctgtat ctctatttgc atagtacagt ctgccatcag tcggggttca aaaaatattt 30120gctcaatcta tcaataaatt acaagttctc tcttccacca gcctagcagt gggaactaac 30180acaatgttaa aagtgggaaa ttggctgggc agtgtggctc actcctgtaa tcccaacact 30240ttgggaggcc gaggcaggat gactgcttga ggacaggagt ttgagatcag cctgggcaac 30300acagtgagac tccatctaca cacacacaca cacacacacc ccacaaatta gctaggggca 30360tggttgttgg tgcctgtagt cccagctagt cgagaggctg aggtggggga tagtttgagc 30420ccaggagtcc aaggttgcag tgaaccatga tcatgccact gcattccagc ttgggtgaga 30480taaggtgaaa ccatttctcc aaaaataaaa aatataagtg tgttggctgg gcacagtgac 30540tcacacctgt aatctcagca ctttgggtgg ccgaggcagg cggatcacca ggtcaggaaa 30600ttgagaccat cctagctaac agggtgaaac cccgtctcta ctaaaaatac aaaaaattag 30660ctgggtgtag tggcgagtgc ctgtaatccc agctactcag gaggctgagg caggaaaatc 30720gcttgaacct gggaggcgga ggtcgcagtg agcaaccact gcactctaac ctgggcgaca 30780gagcgagact ccaactcact caaaaaaaaa aaaaaaagtg tgaaattgtt ggtcagaagc 30840ttccttaaat caattttttt ttccttacag ctcctgtgtt cctttgtctt gataagtata 30900ctcaatagat aagtaaataa aatatgaaag gcttttgaag cttttggatt acatggacta 30960aaacactttc taccttttat tttgctattt tgaacatatt ttcatttaaa aagtcactgt 31020catgtagtta tcagttgaaa tactttattt aacttatttt aaaaattgat tcaaaacttt 31080ttatcttctt tattaggtat tctaccctta gatttaacac tcatttttcc cgagtatatt 31140ttctcttcaa tatacaaagg aatatatttt catagagtgt gttgaatatt aggaaaatca 31200agagttctgg ttctgtcagg tgcagtattt agagtgttat tttgataaaa tccagttgct 31260ctgatatggc ttgaaaatac ttgctccttt ggagtataat tgcaggggaa aaactgtgga 31320ataggtagaa attcaccata atgacttgaa ttggttttat acataatcat ttgaggtttt 31380gatagtgagg tggctgtctg gagtgtcttt ggatccaaca tacatgaaaa cacaggattg 31440ccagggttca cacaaggagg cagttgttca gatttcattt ctgtgtctga atttgaaggt 31500gaagtacttt tcttatccta aaagataaac acataaaatc attctccatt ataaagttct 31560gaaaaaaaaa aaatttaatt cagtcccacc cacttccctt tttcaggaat tctgttctct 31620tgagggcatt gaatgtcagg cctctgagcc caagctaagc catcatatcc ctagtgacct 31680gcacgtatac atccagatgg cctgaagcaa gtgaagaatc acaaaagaag tgaaaatggc 31740cggttcctgc cttaactgat gacattacct tgtgaaattc cttctcctgg ctcagaacct 31800cccccactga gcaccttgtg acccctgccc ctgcccgcca cagaataacc ccctttgact 31860gtaattttcc attacctacc caaatcctat aaaacggccc cacccctatc tcccttcgct 31920gactgtcttt tcggactcag cccgcctcca cccaggtgat taaaaagctt tattgctcac 31980acaaagcctg tttggtggtc tcttctcttg acgttgaaga ctacccttaa aatcacatac 32040acctgtacac agagcaaagt tgtcaaaaat atgctaagtt acctttttaa acattctgta 32100ctagaactat gagaatttat ttaaaaatct gtaaatcata gggaaaaatc tgtaaaagtc 32160atagttagaa gaggaagtac agcttgattt tagagtgaga aaggaacaag ataaacatcc 32220agggttagcc tgggtatgtg ggcagccatt aaataactaa ttacatagct aactgaataa 32280ttacaattgt gataactgct atgaagaaaa aaaaatacaa gatattaatg aagacagaat 32340gggggttctt atctagtgtt gggggttagg gaaagccatt ccactgaagt accattcaat 32400ctaagattga ctataaggca aggaagtaaa agatagaagt ggggacaaag tatggcaaaa 32460gtcaagtaaa ttagggtgaa aatatcatga gatcagaata gagagccagg ggttagatct 32520cttagggttt tgttgactgt gtttaaaatc tgaatcttta ttgtaaaagc aatgaaaaac 32580tattgaaggg ttttaaggag aggagtgaca tgaggtaata taattctagt aaaattactt 32640tggctgttgt tagggcctgt gtgaatgtgg tgaggagctg cagtagtcca tgtgagtaat 32700gatgacaata tatagtaggt ggtagcatgg agatggagca aatttgtttg ttttgttttg 32760ttttgtgtgt ttgttttttg agacagagtc tcgctctgtc atccaggctg gactgcaatg 32820gtgcagtctc ggcttactgc aacctccgcc tcccgggttc aagcaattct cctgcctcag 32880cctcccaact agctgggatt atgggagctc accacgacaa ccagctaatt tttttttatt 32940tttagtagag acagggtttc accatgttgg ccagactggt ctcgaactcc tgacctcagg 33000tgatccacct accttggcct cacaaagtgt tgggattaca ggtgtgagcc accgcgccca 33060gcctatggag caaatttgaa atatattttg gaagtagaat tcacaggatc tcatgattga 33120ttggaggtgg gtggtgaggg aaaaggacag atctaggata acttccaggt ttctggacaa 33180acacttgggc ggatggtggt gccatttact acaatgtact acaatgtaat atgtaaatta 33240aatatatata tgtagtttta tatatagatg atacataatt ttggcactga aaagcacttt 33300gcattgatga tggcttgata aattaatata acaagtttcg tccaggcgca atggctcaca 33360cctgtaaatc ccagcacttt gggaggccaa ggtgggcgga tcacgaggtc aagagattga 33420gaccatcctg gacaacatgg tgaaaccccg tctctactaa aaatacaaaa attagctggt 33480tgtggtggga tgtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaggatccct 33540tggacccatg aggcagaggt tgcagtgagc caagatcacg ccactgcact ccagcctggt 33600gacagagcaa aagactctat ctctctctct ctctatatat ataacaatgt ttaaaaaaac 33660caacaaactg catgaaaaac tctaaaaaat gtcatgactg aatcctgaaa ttctgattgt 33720gaattctatc ctaagaaact ttattgtaga aaaatttaat tcacagcatt acttacaaaa 33780gaactgaaat gtgtactgat ttagatggaa gttaatttta attctaatgc taatgccaaa 33840aatactaagg gagaagacca cccctcatat tgtcttatgc ccaatttctg cctccaaaga 33900aagaagaggt aaaaactaaa aggcagaaat gaaatccaca ggcagacagc ccggcactac 33960accctgggcc tggtagttaa agatcgaccc ctgacctaat cggttatgtt atctgtagaa 34020tacagacatt ttatggaaaa gcattgtgaa aatccctgtc ctgttcggtt ccattctaat 34080tactggtgca tgcagccccc agtcacgtac ccgctgcttg ctcaatcgat caggactctc 34140tcacgcggac ccccttagag ttgtaagccc ttaagaggga cgggaattgc tcactcaggg 34200agctaggttg ttggagacgg gattcttgcc gaatggccga ataaagccct tccttccctt 34260ccctcttttt tttttttttt tttgagacga agtttcactc tcgtccccca ggctggagtg 34320caatggcagg atctcagctc actgcaacct ccgccttcca ggttcaagcg attgtcctgc 34380ctcagcctcc cgagtagatg ggattacagg cacctggcta atttttgtat ttttagtgga 34440gacagggttt caccatgttg gccaggctgg tctccaactc ctgaccttag gtgatccacc 34500tgcctcggcc tcccaaagtg ccgggattac aggcgtgagc caccacgccc ggccaagccc 34560ttccttcttt aactcggtgt ctgaggggtt ttgtctgcgg cttgtcctgc tacaatacta 34620atagaagtac ttgaaaatag cttattttct taaatagtta agtttcttct gcaaccttac 34680attgatgtaa gataaacgtt cacccagccc tggtataatt atgtcagaat aattacaaac 34740tgggtattct ctaaagtgct gttagtataa atagactttt tgtttaataa atttcacttt 34800gagatggttc acctattaaa agttaataga tgaacaatca atgttttgtt tttctttttt 34860ttgagatgga gtctcactct gttgcccagg ctggagtgta gtggcgccat ctcggctcac 34920tgcaacctcc ccatcttggg ttcaagcaat tctcatgcct cagcctccca agcagctggg 34980attacaggcg tgcgccacca tgcccagcta atttttgtat tttagtagag atggggtttc 35040accatgttgg ccaggctggc ctcggacttc tgacctgagg tgatccaccc gcctcaacct 35100ccaaaaatga tgggattaca ggcgtgagcc accatgccca gctggaaaat ctattaaaag 35160ttaatgactt cacttactaa cttttttgga agacttacaa tgactaatcc tttataaatt 35220taatttcatt tgcatttcta gttgggaaaa ttacaaatat aagaacattt ctaggccgag 35280tgcggtggat cacctgaggt caggagtctg agatcagcct ggccaacatg gtgaaaccct 35340gcctctacta aaaatacaaa aaattagcca agcgtggtgg cacacacctg taatcccagc 35400tactcgggag gctgaggcag gggaattgct tcaacccggg aggccaaggt tgcagtgatc 35460cgagattatg ccactcactg actccagccg gggcaacaag agtgaaactc tgtctcaaaa 35520aaaaaaaaaa caaaaaaaaa ccaggcctgg cgcggtggct cacgcttgta atcccagcac 35580tttgggaagc tgaggcgggc agatcacagg gtcaggagat ccagaccatc ctggctaacg 35640cggtgaaacc ctgtctctac taaaaataca aagaattagc cgggcgtggt ggcgggcgcc 35700tgtagtccca gctactcggg aggctgaggc aggagaatgg cgtgaacctg ggagatggag 35760cttgccttga gccgagatcc tgccactgca ctccagcctg ggcgacagag cgagactccg 35820tctcaaaaaa aaaaaagcat ttctctatgt aatatcttat atctactcat attttaaatg 35880tacttagagc tgaaaaataa aaaaagtcct aatgagttga aatgaagctg atttaaaatg 35940ctttccccat aaaaacagtc tttttttttt tttttttttg aaacggagtt ttgctcttgt 36000tgcccaggct ggagtgcaat ggcgcgatct tggctcactg caacctctgc ctcccaggtt 36060caagcgattc tcctgcctca gcctcccgag tagctgggat tacaggcatg tgccacacca 36120ggcccagcta attttgtatt tttagtagag acagggtttc tccatgttgg tcaggctggt 36180ctcaaactcc cgacctcaag tgatctgcct gccttggcct cccaaagtgc tgggattaca 36240ggcgtgagac accacggccg gcccttaaaa acattcttaa agggcagctt ttaattaact 36300gttttggtgt ggagaaggga gaaagttttt ctctgtcact caggctagag tgcagtagtg 36360atcgtagttc actgcagcct caaactcctg gattccagtg accctcccaa gtagctagga 36420ctacatgcac accaccatac ccagctaatt tttataattt tttttttttt ttgagacgga 36480gtctcactct tttgcccagg ccggagtgca gtggcgcgat cttggctcac tgcaagctcc 36540acctcctggg tttacgccat tctcctgcct cagcctcccg agtagctgga actacaggcg 36600ccagccaccg tgcccggcta attttttgta tttttagtag agatggggtt tcaccgtgtt 36660agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct cccaaagtgc 36720tgggattata ggtgcgcacc accgcgccca gccttaattt ttataatttt tttgtaggga 36780tgaggtcttg ctatgttgcc caggctggtc ttgaactcct ggtctcaagc aatcctcctg 36840ccttggcttc ccacagcact gggattacag gcataagcta ccatatcaat ccccagcttt 36900taacttaaaa gtactataaa accatattca atctactctt catcaacttt ttcttttttt 36960tgagacagag atctcacttt gttgcccagg ctggagtgca ctggctgttc acaaatggga 37020taatagtgca ctgcaacctg gaactcctgg gctgaagtga tcctcaggcc ttggcttctc 37080aaggtgggac ttcaggtaca tgccacagtg tccagctttc agtcaattat taatgttcta 37140cctgaatagt gtccctacta aagtttttga aagtattttt ccatgaataa ggggactgaa 37200aatatgaatc aaatataaag caatttaaac ttggacaagt cacttagatt ctctgtgcct 37260aaaatttgtt tgtaaaacag tggagcctgg attatttgac ctctcagatc tcttctacca 37320actccacaga atttattaac cttataaact tgaggcagaa tcacagtgta gtatactatg 37380ttttcatgtt ttgctttatt ttaatgagaa tcataagcga aagagggctg gatgtgatat 37440attggaagag tagcacaagg cagcaactat gacctaggtt ctcatacttt atcatttcac 37500ctttatttgt atattatctg taaaactggt aaataaaaat ctgccatagt tcctatggtt 37560gtggagatta aatgaaagaa aatttgatgt aaatggtgaa tcactatatg aatgggatca 37620attttttttt tttttttttt ttttttgtgg agacaaagtc tcactctgtt gcccagtctg 37680gagtgcaatg gtgtgatctt ggctcactgc aacctctgcc tcctgggttc aagcaattct 37740cctgccttag cctcccaaat cgctgggctt aaaggcgtgc gccaccacgc tcagctaaat 37800ttatttattt ttttttgtga gaaggagttt tgctcttgtt gcccaggctg gagggcaatg 37860gtgcaatctc agctcaccgc aacctccgcc ttctgggttc aagccattct cctgcctcag 37920actcccgagt agctgtgatt acaggcatgc accaccatgc ctggctaatt gtgtattttt 37980agtagagatg gggtttctcc atgttagtca ggttggtctc gaactcccaa cctcaggtga 38040tccgcccgcc tcggcctccc aaagtgctgg aattacaagc gtgagccacc gtgcctagcc 38100taatttttgt atttttagta gagatggggt ttcaccatga tggccaggct ggttttggac 38160tcctgacctc aagtgatcca cctgcctcgg cttcccaaag tgttgggatt acaggtgtga 38220gccactgcgc ctggccaaat ggaatcaatt tttatcacta ttttatttta ttttttgaga 38280tggagttttg ctctgtcacc taagctggag tgcagtggcg cagtcgcagc tcattgtaac 38340ctctgcgtcc caggttcaag tgattcccct gcctcagctt ccagagtagc tgggactaca 38400ggtgcctgcc aacacacctg gctaattttt gtgtttttag tagaaatggg gtttcaccat 38460gttggccagg ctgttcccaa actcctgacc tctgatgatc cgcctacctc agctttccaa 38520agtgctggga ctacagtcgt gagccaccat gcctcaccaa attttattat tttctttttt 38580gcaggtttac ctcaatgtat gatcttccag aaacagttct gaaacctaca ggttaatgac 38640cttgtattag cataatatgg tttgctaata ttcacttaat actcataagt ttgtagttgg 38700caaagctgga aatagaactc aggttcactg agtgtcatca atgttattct catcagatct 38760tgctgtttat tctttttgaa actgcttatt aatttgcttt aaatattaac aacacagata 38820ctggataata gtaaatcata agaattttaa aattttgatg gtatctcaac tgatcagctt 38880ttcttaaatt ttctaggttt cctcagcaca ggggaaagct ttataggtgg aaggtggagg 38940ccctgtgact tgcgcagaaa agtaccactg taatttactt ttatgggcac ctaagcaggt 39000tgcccagggc aacttgtaga ttttgttgtt gttgttgtta atactatctc cttcagtcac 39060tgagaactct tttttatttt tttatttttt gagatggagt tttgctcttg ttgcctaggc 39120tggagtgcag tggcgtgatc ttggctcact gcaacctccg cctcccggat tcaagcgatt 39180ctcttgcctc agccacccga gtagctggga ttataggcat gcgtcaccac gcccggctaa 39240ttttgtgttt ttagtagaga tagtgtttct ccatgttggt caggctggtc tcgaactctt 39300gaactcaggc gattcgcctg cctcggcctc ccagagtact gggccttaaa tgctggaatt 39360ataggcatga gccaccgcgc ccagctgaga actcttcttg ttatcaaatg accctcttta 39420ctactggttc tagaatttcg ttcagctttg gctcaaaaca taatgcagaa aacgaaatct 39480agtaaaaaca gaagacaaat tagctgataa actttgttgg cataattagt accataaaat 39540ctggaaaagc taaatcttaa attaaaaatt ttttagattt ccaggataat tcacaaatgt 39600ttatagattc agaaacaaaa ggtccattgc tttatacttt acatcataga caaccactgc 39660agttttctaa tatgggtttc accttcttca aacctgatat tcttaaaatg tggagttcaa 39720actgactata gttaagaacg aaacaaatag ccaatacaaa gaataataaa aggatgagtt 39780caaattatct gccacatgtc atcaactttt attaaatgat aaaaaggtta attaaaattg 39840taaatgattt ttcagaagaa attacatctt aaaattggcc tgtgaaagtg gcttgaaagg 39900tataaaaatc taccagtagc tggtattagc tttcttagta atttaatttt cagttagaga 39960aagccagacc actttgacct ttcgaagtcc tttggtatag atacatatac atttaaaaag 40020ataaatgaaa acaagccatt gattaataat gcccatcgca gaagctgtaa ttataaaatt 40080aagatttttt gatgtcactg ttgatgttga atatagttaa tagaaaagca aaaataaaaa 40140ataaaaaagg tctaattttg aggcactctt ttgtctctgc tcaggtccac cgtcttcctt 40200gctaatgttt acgtttatta ttaatttttc catttattta tttactttta ccacaattag 40260gggacagaga atgaaaccta aactttttat tgcttctgta aagagtgaat ataaatgtaa 40320gatttttttt ttttgagacg gagttttgct cttgttgccc aggctgcagt tcagtggcgc 40380aatctcggct cactgcaacc tctgcctccc aggttcaagc aattctgctg tctcagcctc 40440ccaagtagct gggattacag gcccgcgcca cctctcctgg ctaatttttt gtatttagta 40500gagacggagt ttcaccatgt aggtcaggct ggtctcgaac tcctgacctc aggtgatcca 40560cccgcttcgg cctcccaaat tgctgggatt acaggcgttg agccccggcg cccggccacc 40620aaatcctttt tcaaaacaac tcccttcttt gacacagtgc aatttaaata agtatacaat 40680taacaaagta cgtttttctt gttcaaaacc atcactgaac agtttgcaac agtagggtat 40740gaatgcatac aatctcgatg gtctttacac cttcagaggc tattcggact taaggaaacg 40800tgcatttaca agtgtaaatg taaaagctca gtagttgcct tgtaaagtgc ttttcggggt 40860tgtggggttg ggggtggtag gagtaggtgg tgcctcaaat tatactagcg aataccaaca 40920ttcccaaaca tctagccctc tgcctaaact cacccggttg cggtctgtca ttttcgctct 40980tctttgttaa ttttttcggc aaagtcagtt ttcatgcagc agatggcaag aaagccggtg 41040aacgcctagg gacgtggcct tttaaccgca cccaattaaa gcagcaaaca gaagatgaat 41100agctgggtgg atcagtatgt gtaaacctat ccgtttaatc cggggagctg ttttcccggg 41160tgaaaccacg aattctttct ggaggttgca actcgtaacc atagcaactg gaagtggtcg 41220ccggctcccg gatgttgtgg ggatctgcgg ccgcctggcc cagcttcccg cagccgcccg 41280gcggcggcct gcgctccact tcgggagtgg tagttcttct cttcaccgct gccgggcagg 41340aggcgcaggc gggactacgc gtcacggcat gcactgcggc gcccagccgg tcaccgcctg 41400ccggctgcag acgcctgcga gcaggttgtt tttataagag gcgtcattgg cgcccgagct 41460gtgaccgccg ccactggggc agccagcaca atcgggcgga ggtggcgctg ccccttcagg 41520tactgtacta ggcgggctta gaccccggga gggggtttgt gccgactgtc tgagtccctg 41580gccgacacgc tcggctcagt agaggagcag tggcggggtc cgcctcctag gctggggctg 41640ctcgggcggg gacttgacgc ctggtgtcag cggccgcacg ggcgacctcc tcgggccgtg 41700cgcgagtgca cagctccgga ggcccgagcc gaccctgggg cgtccggtcc ggtggtcttg 41760cagcctccaa accccgagtg ctataccgaa ctgcgcgcca agggtgggag agctgacggc 41820ctgggccacc cttcttcctt cactgggcag gctttgaggt gcttgtcggt ctggactgat 41880gaaaatccat atggtaagat gttatgtgcg tcaccctgcc gggtttaatg ccagcctgtc 41940ttttgatgac atttgagccc ccgtgatgtc aggaatagaa agattaaata ttaaataatg 42000cccggagact tccgctagca cgccagcctg atgatgatca aatacctctc catatccttc 42060tccagttcca gtggcctcct ttagctttgg tctccctaat cgatttgtcc tcattagcag 42120ctgtcccatg cagtgccttg tacgcgttgt ttatgtttag cactattggg agcgccaagt 42180aaggtatttt attgagtggt gaagtttgca ctgttctgct ctacttttat tgaaaaacac 42240agttgggcat tcttgtagtt agaatagcta actatatagt actatgaatt ttagatttgt 42300ctcctccaat ctacaggata gtgcttgaaa tatcgctatt actgcatcgt atcttttaag 42360attagaatca tattgggtcc cacacgtctc aggggatatt tatcacacac atccagtgtg 42420aatggtttac ttttattttc tgagttcagg tcatatagca gaagatggag atggtgaggg 42480tattatttta attcatattt tttttttttt tgagagaggg tttcgctctt gttgcccagg 42540ctggagtgca gtggcgcgat ctcggctcac tgcaacctct gccttccagt ttcaaacgat 42600tctcctgcct cagcctcccg agtatctggg attacaggcg cccgccacca cgcccagcta 42660aattttgtat ttttagtaga gacggcgggg cggggggggg ggtctcaacg tgtcggccag 42720gctggtcttg gactcctgac ctcgtgatcc gcccacttcg gcctcccaga gtgctgggat 42780tacaggcgtg acccaccgcg cgggcgttaa ttcataattt ttaacctttt acgctgaggg 42840cggaatttca gtcaaaaaag ctgattaaaa atcagcccaa atacaattta aaggtgtggg 42900aaatactcct tcttagatga aaacagttta gaaaatagtg taattgcaat tttgtaaacc 42960atggaacaaa aagtgaacat aacttctttt agaaatgact taaagggtcc agagcggtgg 43020ctcaggcttg taatcccagc actttgggag gcccatgcag gtggatcacc tgaggtcagg 43080agttcgagac cagcctggcc gacacggtga aaccccgtct ctactaaaaa tacaaaaatt 43140agcctgtaaa cccagctact tgggaggctg aagcaggaga attacttgaa cccgggaggc 43200ggaggttgca gtgagccaca agatctggcc accgcactcc aacctgggtg acagagtgag 43260attatctcaa aaaaacaaaa aaaaaaaaac aaaaaaaaaa aaagagaaaa agaaagaaaa 43320gaaataaagg atattcacag ttataaaagt gtagatagtg aaactagaaa tgatttttct 43380tgtactttcc tgtatttttc aagttttctg tagaaaaaac ttttaaaaaa ggatgcaagt 43440attaacagca ctttgagagt ttctatatca tttttttcac tttctagtgg aaagccccac 43500ccttatgcaa aaaaaaaaaa aaagcagcaa ttccagttat ggactctatg aacattactt 43560taaaaagaaa ataaaggcct agagcagtgg ctcatgcctg taatcccagg actttgggaa 43620gccaaggcag gcggatcact tgaggtcagg acttcaaggc cagcctggcc aacgtggcaa 43680aaccccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcggat gcctgttatc 43740tcagctattc aggaggctga ggcaggagaa tcgcttgaac ccgggaggca gaagttgcag 43800tgagccgaga tcatgccact gtactctagc ctgggtgaca gagtgagact gtctcaaaaa 43860caccaaataa gcaacaacag taaaaaacac aggcaaagtc cctgttgctg catctgtaga 43920ctatatgaat ttaagtgtaa attatttgga gagtagggac aataaatgaa atagttggac 43980tcgaagaaaa taacagatcc gacaatttgt agcatttgta gatctcattt tattttttgg 44040agatgatgtc ttgctctgtc acctagtctg gagtgcagtg gcctggacac gacttactgc 44100agcctcctgg gctcaagtga tcccaacaca gcctcccaca tagctggggc tacaggcaca 44160tgtcaccagg cctaggcctg gctattactt tttttgagac agagtcttgc tctattgtat 44220ggtggttcag tctcggctca ctgcaacctc tgcttcctag tagctgggat tacagtgtga 44280ttcaagctga gttcaagtgt gattctcctg cctcagcctc ccagtagctg tcacatgtca 44340cagacatgtg acaccatgcc ccactaaatt tttttttgag acggagtttc gctcttgttg 44400cctagactgg agtgctatgg caagatctca gctcaccaca acctccgcct cctggtttca 44460agtggttctc ccgcctcacc ctcccgagta gctgggatta caggcatgtg ccaccatgcc 44520cggctaattt tgcatttttt agtagagaca gagttttttc catgttggtc aggctggtct 44580caaactcccg acctcaggtg gtccgcctgc ctcagccttc taaagtgctg ggattacaga 44640cgtgacccac tgcccctgac ctaatttttg tatttttagt agagactggg ttttgccatg 44700ttagccgggc tggtcatgaa ctcctggcct caagtgatct gtccgccttg gcctcccaaa 44760gtgctgggat tacaggcacg tagctgggat tacaggcaca caccaccatg cccggctaat 44820ttttgtattt ttagtagaga tggggtttca ccataatggc caggatggtc tcgatctcct 44880gaatgcgtga tccggttgcc tgggcctccc gaagtgctgg cattacaggc gtgagccacc 44940gcacctggcc ctaattttaa aattttatgt agaggcaggg tctcgctatg tttcccaggc 45000tggtctcttt gaactcctgg gttcaagcga ttttcctgcc ttagcctccc agagtgctgg 45060atacaggcat gagagctcca tgtctggcct gtacatccca tcttttgatc tggtttcttt 45120tcactttgta cagttaaatc agaggtgaaa gtacttagct tttcttcact taagcctgga 45180aaatcttaaa cttgtcaaca ttgaatcacg ttcagaacca tgttttatat gtctgatatt 45240ttggcttatg tctatttttg tttttatttt ttgttatggt tatgttggat atggactggt 45300aagtagtata atcaatcatt agcccacatt ttgctttctg ttgtaaaggg ctacattgtt 45360cttccacagt aatatacagt acatttttct tttttttggc tactatcagc ccttaaaaat 45420taagggggtt taccttaaca ccaagtgtcc attaacactg gataaaatat ctattctaaa 45480gtgttttaca aaaaacactg gtaacacgtt gtttttcagg ttgtggtgtt catactttat 45540tttcttaggt tgtcttcttt ggagcttgcc tactccaaat gtcaatttct tttcaatatt 45600ttttacctta taattttgta tattctgtgt actgagttgg ctcaatatgt tattaggctt 45660tgggtctatt cacagggcat aagaaaaatt cataattgat taacatgtct gatttactaa 45720ctcattccac agtattattg tatgggttgt ataattatat tcttatgcaa gttaaagaaa 45780gacttttaaa aattaggtgc atatgaactg ctaaaatcat ggaagtagta gtttttgaac 45840atgttaagaa catgaacaca gcagcaaggc ctgttaagtc caaggtactt taaacaaaaa 45900atgcagactc atctaacagt gcagaactgc tggaggctga attatgtttg tgtttctttg 45960tggtgaagat gaggaagttg cagtattgta agtgataaag gattacattt tcacaaattt 46020ccttcctgac agttccataa ttgtaactag actaaaacac ttggtttcaa aggtcatttg 46080caatgtattg catcagataa acttggccat attttctctc aatttgagtt ctaagatgaa 46140attcagccct atgatatggg aaggattgta attaagtgat aaataaaggg attttttccc 46200ccaaagggta tttaatgtgt ggaaacctct ttaagggtct atagaattac ctgaggaagt 46260attagaaaat aagaagtggg agttaagtat ttttttctgt catcacagga agcctgaaat 46320cttttttttt ttttaagtac ttatccaaat cactattctt ttaaaatctt acaaaatctt 46380acttctggtt catattgcca gcatgttgaa atgtaaaaag agcattaggt tggaaatcag 46440aggattttta atgatgttga ggaagttatt atttataatt ttctgttcgt tttcatttgg 46500aatttgtaaa taatagcaag ctgcctttat gggggtattt gtgaagatta aatcagatat 46560gaaaatgaaa ttgctttgta agtggtggag ttatctactc atatgaagta ttattgtact 46620aagtgcattt acataaagca cttatatgtt tgaagtgtga tgccttgatg tgataaatac 46680tttttgactg ggaagtttga tgaagaaaaa aagtcaaatg ggttattcat ttgatttctt 46740ggtagagatt ggtggctttt tccagactga aggaaacctg gctcctctcc tgactgtgac 46800tttgcactct gttgcatcaa atgtcctgaa actgcagtgt acttctgtgg ttgagctttt 46860aattttggtt ttgatttgtt ttaatctcac ttctataagt gtaagaatgg tcatcagtct 46920agtttgacaa taggaagtag ctattgtttt taatattctc aaatggatct ttaagttatt 46980tcatgaacaa tgagactaca ttgaatgtga aatctcaggt cctctgagaa atacatttca 47040tgtttaaagc attagtcttt gagccaaaga aataatggag tttagatttt tccttctggg 47100gaagttatct ctggctatga gaggatctga cccttgagat taacttcaag ttaggttgat 47160atatagaata tttacgataa agaaaaagta ttttagaaac aagtacatat tggctgggtg 47220tggtggctca tgcctgtaat cccagcactt tggaaggtcg aggagagtgg atcacctgag 47280gtcaggagtt tgagaccagt ctggcccaac atggtgaaac cccgtctcta ctaaaaatac 47340aaaaattagc ctgacttggt ggtgtgtacc tgtagtccca attactcagg aggctgaggt 47400gggaggatcg cttgagccaa ggagtttgag gttacagtga gctgtgatgg tgccactgta 47460ctcccgcctg ggtgagtgac agagcgagat cctgtctcta aaaataaagc tataataaag 47520acattaacaa ataaaattgg agctatttat caaaactttg aacttaatac taattaataa 47580agtagctcaa ggaaaaaagt aagtagtgta agctaccatt aggcaaatta tgctgagaag 47640tatagtaagt gctatagatt caggggaaaa tgaaatctgt atgtcagaaa cagtgatcta 47700ggaaaatttc atgggagaag acagctttaa atacagaaat cagaatgaag gaagaaaagc 47760atttcaggaa gtgaagacat ggagttaggg ttgtccattt tgtgttcaga agacagcaat 47820taaattactt cagccatatg acgaggaaag ctaatcagat tagttgcaaa ttaggtgaga 47880accagatagt gggagttttt cagtgtcaca ctaaggagtg tgtctttatt gtacagaata 47940cttactctta aagttgggca gactctgagt gggaagaaaa atattttagc actgggtata 48000agtgtatgta acctgcagtc tctttcatct ttgcctctat gtttataggg tagtagtggt 48060tttttttttt ttttgagacg gagtttcatt cttacgccca ggctggagtg aaatggcgtg 48120gtctcggctc actgcaacct ccacctcctg gttcaagtga ttctcctgcc tcagcctccc 48180gaatagctgg gattacaggc atgggccacc atgcctggct aatttttgta tttttagtag 48240agacggagtt tcgccatatt ggccaggcta gtcttgaact cctgacctca ggtgattcac 48300ccgcctcggc ctcccaaaat gctgggatta taggcatgag ccactgcgcc cagcagtagt 48360gtgtttttag ggagggacag ggaaggttga aaaatggcac tgtagaaagc catcagtacc 48420atagcaatta aaccagcgtt gtagtggttc aggaatagaa aatagatcag tggaacagaa 48480tagagaacac agaaatggat taataaatgt gtgggacttt atatgacaaa aggtggcatt 48540tcaaattata gaaaaagtgt ggaatattca atatttggtt taatttccac ttcacaccaa 48600aagaaaaaaa atccaaatgc atgaattaaa cagctaaatg taaaagccaa aaactgtgga 48660agtattagta gaaaatacag gagaataatt ttatagtctt gggagcagga aaaactttct 48720aaaacaagat acaaaatcta gatactataa aggacaccct gttttccagc ctctacattg 48780actgtataaa atttgaaaca taataaagat actttaaaaa tgtttgaggc atgctagaac 48840attaattcat gacccaactt ataaggaact acaaatcagt aatgacaatc taataggaaa 48900gtgaacatat gaatatagat gcttcacaga aaaggagatg aggatagcca gtaaacacaa 48960gatgcacagc cccactgaag tcttcctgga agtgcagatt aaggaattta ttattttgct 49020catgagatga gcggaaatta aagatggttg ttactctgtt ggtgggattg tggagaaata 49080ggtactttca tatgttgttg gcagcaactt tgtactacct ttgggagagc aatttagcaa 49140tatctataat tttttttgtt tgttttgttt tgtttttgtt tttttgagat ggagtttcac 49200tggagtgtgc ctggcctttt taatttattt ttgagatgga gtctggctct gtaacccagg 49260ccttagtgca gtggtgtgat ctcggctcac tgcaaccccc acctcctggg ctcaagcgat 49320tcttctgcct cagcctccca agtagctggg attacaggca cgcaccatca tgcctggcta 49380atttttctat tttagtacag gtggggtttc accatgttga ccaggctggt ctcgaactca 49440tgacctcgtg atccgcccac ttcggcctcc caaagtgctg ggattacagg tgtgactcac 49500cacccctggc cttttttttt tttttttttt ttttttgagg tagagtatct tgtccaggct 49560ggagtgcagt ggtattatct cggctcagtg caacctccac ttcctgggtt caagcagcaa 49620ttcttgtgcc tcagcctccc gagtagctgg gattaaaggc tcctgccact atgtgggcct 49680agctaatttt tttgtatttt tagtagagat ggggttttgc cacgggccag gctggtctca 49740agtgatcctc ccaaagtgct gggattatag gtgtgagcca ccacgcccta ctaatttgtt 49800gtatttttag tagagatggg tcttcaccat gttgcccagg ctggtctcaa actcgtgagt 49860tcaagcgatt tgcctgcctt ggcctcccaa agtattggaa ttacagacgt gagccaacgg 49920gcccggcctg tggcttttcg tggagttctt agaacgtaag ttttctgtgc tgttgtgcct 49980tctactttct ctaccttttg 50000 9 50000 DNA Homo sapiens human DYXC1chromosomal gene region, nucleotides 150001-200000 9 gaatgtcttcactttccagt cccttttacc tagataattt gaattactct ctgaaggctc 60 aacctacttttcatgagtta cagatatttg cttcttaagg atcttttttt atcagtttca 120 ttttgatattttagatgtga attcaatttg gttgacagag tcttgctctg tcacccaggc 180 tggagtgcagtggcacaatc ttggctcact ttaatctctg cctcctggat tcaagccatt 240 cttctgcctcagcctcccaa gtagctggga ctacaggtgc ccaccaccat gcccggctag 300 tttttttttttttttttttt ttgtattttt agtggagatg aggtttgcac catgttggcc 360 aggctaatctggaactgtac ccgacctgac agttgatctt tttaatattt agcttagctt 420 atctctaggtgtttcatcca tagaactaaa tctcagttgt gttcaggtac aaaaaagatg 480 gaaaactactcattcattct tcagaactgt tttcaggact tcaaggaggc cttccctaac 540 caccctatttaacattccag ttcttgcacc atccccaccc ctactctgcc ctcacttttt 600 tctccatggcactgggcacc agctggctaa ctctgtcttc aaaaagtact tttctttggg 660 ggaggtttttcttttgtttt tgttttcttt ctttcagtcc tgtatcttca gcacttagaa 720 gagttcatggcacacagtag gtactcaata agcatatgtt gaaagaatga atgcagtttc 780 atgttccggatgaggatagg ctcatttaaa atattttcat atgtttatta gacaaaaagt 840 agccttcaaaaaagttttca tgctgggcgc agtggctcac acctgtaatc ccagcacttt 900 gggaggccaaggcaggcgga tcatgaggtc aagagatcga gaccatcctg gccaacatgg 960 tgaaaccgcatctctactaa aaatacaaaa attagctcgg catggtggtg cgcacctgta 1020 atcccagttacttgggaggc tgaggcagga gaatctcttg aacccggaaa gcagaggttg 1080 cagtgagccgagatcgcgcc actgctctcc agcctggaga cagagtgaga ctctgtctca 1140 aaaaaaaaaaagttttcatt agttgggatc ttgtatcctc ttccctttct caagtgatgt 1200 gttttaaagcagacattttc atatcctttg gcggaggtga aagacccaga ccttttgaaa 1260 agtattttacaaatacgttc ttgaaagcac tccagactga ctcgcttatc tttggtcaca 1320 tgacagtacagctgcacttt gaggcctttg cctatagcct attggttgcc ttacttcgga 1380 attgtagacgtgtgggagaa taatgctccc attcttctcc atcttatcta gttctagaag 1440 atataatggtaatggaaacc tcaccttttt catagtaaaa tgtagctacc caggaatgat 1500 gaggggcaccatcatatcag gtaatattca ttccagttat attttatgag gtaaaattga 1560 tactgttgttgtgttgttct tacagatttt gacaggctcc accaaagtgt ttttaaatga 1620 cttatttagcctctaactct cccctgaatt cagtctccag acgcctactt tatgtttcct 1680 cttggatgtgataataacta tctcagattt aaaatgcccc aaaccaattt gctggtttcc 1740 ttttcttcttcttttttttt cttgagatgg agtcttgttc tgtctcccag gctggagtgc 1800 cgtggcatagtctcggctca ctgcaacctc cacctcccga gttcaggcga ttctcctgcc 1860 tcagcctcccgagtagctgg gactacaggc atccaccaga ccacctggcc aatttttgta 1920 tttttaatagagacagggtt tcaccatgtt ggtcaggctg gtcatgaact ccttacgtca 1980 agtgatctgcccacctcggc ctcccaaagt gctgggatta caggtgtgag ccaccatgcc 2040 cggcccaatttactgatttt cttctcataa cctgctcttt ttgaagtctt tctgcctcag 2100 tagctattccattctagtac tcggtgaggc caggagtcat cctttatacc ccatattcaa 2160 tacatcaggaagtcctgttg gctgctgtac ctttgaaatc cgtgtataat ctgtccattt 2220 ctcactgtcttcactgccac cattctagtc caaaccacca tcatgtctca cctggattat 2280 catagtagccatgcaaatga acttcttgct tctgcctttg ctcccccaca atgctgtccc 2340 agtaggtagccagagtgatc ttttattcct tttctcaaaa cgcttctgtg acttttagtt 2400 ctcagagtgtaaagctaaaa cgctttttaa aaggagtctt aggatctgta agccctactc 2460 agtctgtccccttgccacca ctctgtttat tatcttgtgg gttttttttt ttgtttgttt 2520 ttttttgagacggagtctcg ctctgtcgcc caggctggag tgcagtggcg ccatctcggc 2580 tcactgcaagctccgcctcc cgggttcacg ccattctact gcctcagcgt ccgaagtagc 2640 tggaactacaggcgcccgct accacgcccg gctaatcgcc cggctaattt tttgtgtttt 2700 tttgtagagacagagtttca ctgtgttagc caggatggtc tcgatctcct gacctcgtga 2760 tccgcccacctcggcctgga gtgctgggat tacaggcgtg agccaccgcg cccggcttat 2820 cttgtgtttaatcttttcct cctctctcct gctaggcgat ccacacaggc ctccttgctg 2880 tttctcagaggtagagctct gatctcagct ttatagctac tatttcttaa atgctcttcc 2940 tccagttaactgtatataat ggtgcctcac tcattcaaat ctttgctcac atatacttca 3000 gcaatgaagcttgccctgac catcgttttt agagttaagc ttctctatcc cagcataaat 3060 ctatcccagaataaatctcc tcaaatattt tacagggttt gactgttttt gtcgacataa 3120 gtctaaggtttttgacctga atgtgtggtg actcttgctt gtaatggctg tattgttttt 3180 ggctactgcaattctgtgag ttagcagaaa taggagcagc aggaagatga tttcagtatt 3240 gtagctgttgtgtgttaaac acttgagaaa cctgcaaggg gacatcaaaa gcaattggaa 3300 atatatgactagagatcgag ttaaagaaac tactctgagg aataaaagga agcctgagcc 3360 taaacagagcttcaagttta ttgtcttcac aaagtattct tctttttata accgtatgat 3420 ttcttagcctttgtaactgt cctgtaaatt ctgcttattt ctaaattact attagtaaag 3480 ctcttaaaatggggagggtt tatacattta ccaatggtca gattaatggg agaggaagct 3540 catggatttctccagaattt tgagttcttt tttttttttt tttttggagg tggagtcttg 3600 ctctgttgcccaggctggag tgcagtggtg cgatcttggc tcactgcaac ctccacctcc 3660 tggtttcaagcaattctcct gactcaggct cctgagtagc tgagactaca ggcgcacgcc 3720 agcatgcccgactaattttt gtatttttag tagagatggg gtttcactat gttggccagg 3780 ttggtctttaactcctgacc tcctgatctg cctgccttgg cctcccaaag tgctgggatt 3840 acaggtgtgagccaccgcac ccagcctaat tttgagttct gtaaagaaca attaactgca 3900 ctatcacccagacgtggtta cctttcttgt ttattgattg cttaatatgt atttagcatt 3960 cattcaatatgtgttgggaa tacattatag gctggtaaac aagcaattac agcacaatat 4020 tctatattaagtgccagatg cagaaaataa taagagtctt agggatgggg tcaagggatg 4080 gttctcaaaggaaatgaacc gttagctgag acaagcagag gagtttcggt ggaggtaaag 4140 gggatgggcaactgatcaga atatgtaaag ccctggagta aagacaaagc caagcatttt 4200 gaggggaactgagaaggttg ggcaaagcgg gaatgaatta aaagagatga gagctagaga 4260 taaaatacttgatattcaag gctttggggc attatcttga agaaaatctt aacattttaa 4320 aggaattacataatgagatt atcatttgaa gatctctagc tataatgggg aggttcaaac 4380 tgccagggggctttcatatt cactgtgtct aggatagggc ttaaaaagtt actttttttt 4440 ttttcctttgattgtagtac acgcccaaca ttttgagaac agttgaatta atagggttct 4500 ttagtaagcctgttagtttt gcttatccaa attgtcatgg tggtgttagg gccagcggga 4560 aatctttttctcttttgggc tggatggtgt taccaaaaca ccaggggttt ggtctaggtc 4620 ctgctgcttgccgcacagaa agccaatcac agagacgggt attgccaggg aagaaggctt 4680 taattgggtgctgcagccaa ggacatggga gatcagtctc aaatccatct cagtctcaaa 4740 tccatctctgactgactaaa attagaggtc tatatagcag agaagaaatg taaccatgtg 4800 tgggcaaacaggaattagag aggggtgagg aagagaagtt ggtcaacagg cagcaggtgg 4860 tcagttaagcaatcatgcag gctctggctt ctcattgtcc agttgcagtg atctgttaag 4920 taagtttcagcttcttaata ctatctagga ggcctgatgg tttgtttcct aagaaaggag 4980 cttagataacacaaatagaa ctttctcaag ttttaagact gtgaggatca atttctgtat 5040 ttattcagagaaaccataaa gatcagttct gtgggataat tggctggttt caatgttatc 5100 tttccttgaaggaagtaaac aaagcattaa actggggcct gattaaagtg ggcttattga 5160 tttgagaaattcaagtatgg taagttgtcc caagtcagta atgtatttta cttttttttg 5220 taatctgttagaagatggga gcaggcaaag ggaaggaggg aagctttcac acagtggaga 5280 aagaatgctttttaggcttc agccagtttt tcttatcaca aagccctcac ctacttcttg 5340 tttcatatagaattcttcca gttacccagt cacttaaacc agaaacctgt gagctatcct 5400 acactttctcccttatatag ttggttattc agtcctttaa taaaataatc tttaggctgt 5460 gtacagtggctcacacctgt aatcccagca ctttgggagg ccgaggtggg tggatcactt 5520 gagcccagaagtttgagacc agcctaccaa actagcaaga ccccgactct taaaaagaaa 5580 ttagctgggcagggtggcac atacctgtat agtcctagct acttgggagg ctgagatggg 5640 agcatctacttgaacctggg agtttgaggc tgtgttactg gtggagggtg tccaggttct 5700 tggcatcttgaacaaagaac tggacaaaac acacagacaa agcaaggaag ggatgaagtc 5760 agagatttattgaaaatgaa agtacactcc acagtgtggt ggcgggccct agcgtagggg 5820 ctcaagggcaccgttataga atttgtgggg gtttcaatac cctctagagg cttccattgg 5880 ttacttggtgtataccctat gtgaatggag aggtgaagta aagttacaaa gtcatttact 5940 tggtgtatgccctatggaga ggatatttcc tgtcatagct gaagtgtgaa tcggcctaat 6000 gttccctgcctccagaccct attttcccat ctcagcaagc cgtgttcata ctactgtact 6060 ccagcctgagtgacagagtg agaccttgca tccaaataat gataaaaata ataaaataac 6120 ctttcatgtcttctcagatc tcttcaaaac ccttcccgct atcttctaaa ccctttccct 6180 catcaacactggttaagttc agatgctcat atttttcatg gaatattatg ttgcttcctt 6240 gcatcccacaggtctagggt tgttgagttg cttccctatc ttgaaaaaaa acattttttt 6300 gagacagggtcttgctctgt tacccaggct ggagtgcagt catgcagtca tagctcactg 6360 caactttgaactcctgagct caaatgatcc tcctgcctcg gcttcccaag tagctaggac 6420 aacaggtgtgggccaccatg tcctgctgat taaaaaattt tttttggtag agatggggag 6480 tctcactatgttgcccagcc tggtcttgaa cgcctggcct caagtgatcc tcccacctca 6540 gcctccgaaagtgctgttac aggtgcaagc cgccactctt ggccctgcca tcttaatata 6600 tgctatttaatttaattaat taatttattt attttgagac ggagtttccc tcttgttgcc 6660 caggctggagtgcaatggcg ccatcttggc tcaccgcaac atccgcctcc tgggttcaag 6720 caattctcctgcctcagcct ctcgagtagc tgggattaca ggtgcttgcc accatgcccg 6780 gctaattttttgtattttta gtagagacag ggtttcatca tctttgccag gctggtgttg 6840 aactcctgcccttatgatct acccgccttg gcctcccaaa gtgctgggat tataggcgtg 6900 agccactgcacctggccaaa tctgaccaga tacaaccgct tatgcctgtc atcctagtac 6960 tttgagaggccaagaaaggt ggatcacttg agctcaggag tgtgaaacca acctgggcaa 7020 catggcaaaaccctgtcttt acaaaaaata caaatattag gcatggtggc gcacacctgt 7080 agttccagctactcaggagg ctgaggtggg agggtagctt gagcctggga ggtcaaggct 7140 gcaatgaactgtgttcatgt cactgccctc cagcctgggt gacaaagcga aatcctgtct 7200 caaaaattaaaaaaaaaatc atggccaggt gcggtggctt catgcttgta atcccagcac 7260 tttgggaggctgagttgggt ggatcatgat gtcaggagat ggagaatctc ctggccttta 7320 gtagagatggtgaaaccccg tctctactaa aagtacaaaa attagctggg catggtggcg 7380 cgtgcctgtaatccccgcta ctcgggaggc tgaggcagga gaatcgcttg aaccagggag 7440 tcagaggttgtggtgagccg agatgacgcc actgcactcc agcctggtga cagagtgaga 7500 ctccgtctcaaaaaaaaaaa aaaaaaaaat caaatctgat cttttaaact atatttgtac 7560 tagattgtcttttttatttt ttattttttt aaagaacttt catattcttt tacatttttc 7620 tgcctttgtttttcctgtgt gatgcttttt cctttttcac tgggacatct ttccttgtca 7680 tcagatcttttgattttttt tttttttttt taggaatcag aaatcgtttt gtttgttttt 7740 tgcaatgttgcccaggctga tcttgaactc ttggacttga gcggtccttc cgtcttggcc 7800 tctccgtgttggggttacag acgtgagcta ccacacctag cccccccccc cctttttttt 7860 tttttttaaagagtcaaggt ttcactgtat tacccagtct ggagtgcaat ggcagttcac 7920 aggcatgatcattatggctc ttaacagcct tgaactcctg gcctcaaggg atcttccttc 7980 ctcagtctcccaggtagctg ggattaatag gcactctcca ctgcttccgg ctccagaaat 8040 cttcattttaatgtagtatc tcaattttta aattttgaca actgttaatt tactttaaaa 8100 aatgctatcaaatttgcagc ctcatttata gagatttcct tgatcattct cctttccccc 8160 tgcaaatttaattgctcagt ctttgtgtat ttctgtcatt gcataatttt caagctatta 8220 taaacatgattctcatacaa atagacattg atacatatca taaacttttt tgaaagtcct 8280 gaaaaatagtggaatgagaa attgggattt atatagtcag tttaggccag gtgcagtggc 8340 tcacgcctgtaatcccagcg ctttgggaag ctgaggaggg cggattgctt gaggccaggc 8400 cttccagaccagcctggcca acatggccaa acgttgtctc tacaaaaaat acaaaaaatt 8460 agctgggcatagtggcacat gcccatctac ttatggggct gaggcaggag gatcgattga 8520 gcttgggaggtcagggttgt ggtgagccat gattacgcca ttgcactcaa gcctgtatga 8580 cagaacgggaccctgtcaca ctcaaaataa agaaaagaaa tatagtcagt ttaataaaga 8640 atgctgaaataaaattgcta agatataaac gtggttaata tcctacaggg tatttaaact 8700 gtagctttttggataacctc tactgactgg acagaaaaaa tttattttac cgtagtagtt 8760 ttctgtaagtttacttttaa atttgtagag ttataaactg cctgggcctt aattgaaatt 8820 agaaataaaacaattagatg acctcaggtg agcctattac aaaatgctct tgtcataaca 8880 ttaaaagtcatacaattgat accttatttc aggttttgaa taattcattt gaaacatgtt 8940 aatttttatactattagcga ccaacctttt tgtatcctct ctttttgaaa tattaatgta 9000 caggagttttcagaataatt aacagattat atagatctga cttgaggcta ggagtttgag 9060 accagcctggccaacattcg caacgagtga aacctcgtct ctactaaaaa taccaaaaaa 9120 caaaacaaaacccccaaaaa cagattatat agatctgtat ttttgccctg ttctcatttg 9180 agcactagttccatattgtc ttcagtagag ttctattaga acttggatct aatgtgttca 9240 cagtatatgtccaataacag aagcataaga cacatgtaga ataaatcagt aggagtacta 9300 tttgctttactaagttgggt tttgaagttt aaaggagttt cagatacaaa aagaaaaaac 9360 caggtggagtgaccattgta tgctggctta gggcttgagt ccaggttgtt gccagtgacc 9420 agatgtttgtaaccaacctc tggtgtcttc ccccctgccc caactttaac acaactgaag 9480 tattgctgacacagttattt tcataaaaac agtttgattg ccgggcgcag tggttcacgc 9540 ctgtaatcccagcactttgg gaggctgagg caggcggatc acgaggtcag gagttcgcga 9600 ccagcctggccaacatagtg aaaccccgtc tctactaaaa atacaaaaat tagtggggcg 9660 tggtggcacgcgcctgtagt cccagctact cgggaggctg aggcaggaga atcacttgaa 9720 cccgggaggcggaggttgca gcaagtcgag atcgtgccac cgcactccaa ccggtcgaca 9780 gctcgagactccgtctcaaa acagtttcat catgtttctt ctatgtttga aaatgtaaat 9840 tacttcatgttgccaacata cagacttcat tttcttggca taggagcttt tcagtttccc 9900 tgtgcttctcagtttctgca gtcatgtttt tcacacctta ctgttcattg aaaatagagt 9960 cctttactgttgctgcctgc tccccattca cgattatcct tttccttcac ctctgtctgg 10020 ccaaatgctacattttcttt tagacataac tttctccttc attccaacaa tataactgtt 10080 gagactgttctagtccagga gggtctcctt atcttagaag tttgcttcta tctgttcata 10140 caggtatgcagtcctgtcat gttctgtatg gtaaatctat gggtggcttg tctctgtttc 10200 acctggaagacagtaaacca cttttcaaac ttagtgtcac atatagtgct tcctatagaa 10260 ttaaaaaaaatgtgtctcat gagtcaatat gtttttgtat ttgtagacct gaaagatgtc 10320 tgaaaattccagtgacagtg attcatcttg tggttggact gtcatcagtc atgaggtatg 10380 atatttaatactttttataa ggtaatttgt aatattaatg ttaccagtga tgtaaactgt 10440 gttctttgaagatcagtctt tttctacctt taagcaaaaa gttccaatgg acattttccc 10500 tctcatattaaacttcactg ctgaaaacgc ttcatgagcc agcatcttct acattattgt 10560 acatagctttgagacattag gcaaatattt attgaaggtt tgttattgtt caggccctgt 10620 gctttactttcattttcata taattttgtc tttttttttt tttttttttt tgagacagag 10680 tctcactctgttgcccaggc tggagtgcag tggcgtgatc tcagctcact gcaacctccg 10740 ccccactggactgaaatgat tctcctgcct cagcctcctg agtagctgga attacaggtg 10800 cctgctaccatgcccagcta atttttgtat tttcagtaga gacgagtttc accatcttgg 10860 ccaggctgatcgtaaactcc tgacctcgtg atccatctgc ctcggcttcc caacatgctg 10920 ggcttacagatgtgagccac tgtgcctggc caattttgtc tttttttttt tttaaaggga 10980 caggatcttgctctgttgcc caggctagag tgcagtggct gttcacatgt gcaatcatag 11040 taccatgtaacctttaactc cttgggctca agtgatcctc ccaagtagct gggactatag 11100 gcatatgccaccataccctg ttcttaaata attttgaata tttcactgtg atacatactg 11160 ttttcattcttattttatag ttgagaaaac taaagcttag agaggttaag taatttggtc 11220 aagattatgcagctagaaaa tagatcctgg atttgaacag atcagaaagg agaatggaga 11280 acatgtgttccatttacgtt atagcagaac ttcacaggga aaaggccaga accctatcac 11340 aaaatgaattttataataga agattgatat acatacaaca agtatacata acttgtacat 11400 tttgtttattttttcatacc agtaatatat gttcactgta gaaaaatggc agtatattga 11460 taaacagaaatatacttact ccaggtttta ctccaggttt taatggacat ctataatttt 11520 cccatttgtttttagggtat tgtaagcctc acttgttttc tttttttctt ttttgagatg 11580 gagttttgctcttgttgtcc aggctgtcgc tcttgttgtc ttgtacagtg acgcaatctc 11640 ggctcacagcaaccttcgcc tcctgggttc aagccattct cctgcctcag cctctggagt 11700 agctgggattacaggcatgt gccaccacgc ccgactaatt ttgtattttt agtagagacg 11760 gggtttctccatgttggtca ggctggtctc gaactcccga cgccaggtga tccgcccgcc 11820 tcggcctcccaaagtactgg gattacaggc gtgagccacc gtgcccggcc acttgttttt 11880 ttaataaaaattataggccg ggcgtggtgc tcacgcctgt aattccagca ctttgggagg 11940 ccgaggtcggggcagatcac tgaggtcggg agttcgacac cagcctgacc aacatggaag 12000 aaacccggtctctactaaaa atacaaaatt agccaggcgt ggtcgcacat gcctgtaatc 12060 ccagctatttgggaggttga ggcaggacaa tcgcttgaac ctgggaggcg gaggttgcgg 12120 tgagcagagttcgtgccatt gcactccagc ctgggcaaca agagtgaaac tgtctcaaaa 12180 aaagaaaaaaaaaattaaaa aatttttgtt ttttaaacta ttagttaagg ttcaggtagt 12240 tatgtttagaaaacattaac agaaaaaaac aagattgcct tttctgcatt aaaatttcaa 12300 aatttaaaagcatctatcat ttgagattga gatgattctt ctttttaaaa tcttcagtga 12360 cttttctatttttagcttgt tttcttcaaa ggattagatc aactcccata gcaacttctc 12420 cttcaaggataattaacaat ataggagcaa ggcagctatg ggagtcttac ctgttagtct 12480 gcagggtggagtatgacagc agacctctgt ctggcactca gtcaagtgtg tcattagggt 12540 gttctgtactggatgttatg tcccagattg aatcatattt gtacttttat ctctcttctt 12600 ctatatctgctttccaggtt ctactctttc ttgctaattt ctcttacatg tgtctccttt 12660 tcctctcccattactgccat tctcatttgg gccagaattg gtttccccag caattcctaa 12720 tacataaccttgctttagcc tctaccattc tcctgccact atagacaacc tcggagtctt 12780 gcattccgaattctcattag ggctcaactt aaacgctact tttttcttta cttttttttt 12840 tttgagatggagtcttgctc tgtcgcccag gctggagtgc agtggcagga tctctgctca 12900 ctgcaagctccgccccatcg gttcacgcca ttctcctgcc tcagcctctg gagtagctgg 12960 gactacaggcgcccgccacc acgctcggct attttttttt tgtattttta gtagagatgg 13020 ggtttcaccgtgttagccag gatggtctcg atctcctgac ctcgtgatcc gcccgcctca 13080 ggctcccaaggtgctgggat tacaggcgtg agccactgcc ccggccctac ttttttcatg 13140 aattcttttaatttttgctg tcttgagtta tgtatacgca agagaatgca gacctttcga 13200 ttccatgtgtcagcagacta tagtggggac atagggaaag acggaatcac cttagtggtt 13260 aactttgttttacaattaag acacaaagaa aaattgtatg atccgctatt attaatgaaa 13320 agacagtctgacatcaaagt aggaaagata acctcagaat aaaaagatag tctaaaattg 13380 tgtgaggagagtattcatta accctatagg tttatttaat ccatgtcatt aaagctttag 13440 ccatttttagtttatagtgc cataataagt agttatttgc atatgggtgt ttctctgaat 13500 atgttgtaaaattgaatttt ggatttcatt tttttttttt ttttttgaga cggaattttg 13560 ctttttttgtgatccaccgg cctcagcctc ccaaagtgct gggattacag gcgtgagcca 13620 ccgtgcccagccagatttga attttttata tcccacagca tctagcgaag tgccttgtct 13680 agagtagttccataaatgtt aagtagaaac aaattattat agaaataacc aaatttagac 13740 ccttattctctggaattcaa atttattgct tgagctcata aaatagagca ttccactttt 13800 gggctgacctgacttagaat ttaaacctga gactccattg tgccattttc ctgccatagg 13860 cctttgtggactaaattgaa caaaagcttg tctaattaga tactgttcct ttggagtatg 13920 gcagcatctgagacttttaa taatggaaga agcatttaca tgtagtcaaa tctagctttg 13980 aggagctaataggcaaataa ctgaaagatt atcacttttc cttaggggtc agatatagaa 14040 atgttgaattctgtgacccc cactgacagc tgtgagcccg ccccagaatg ttcatcttta 14100 gagcaagaggagcttcaagc attgcagata gagcaaggag gtaagttgtt cacaaattct 14160 aattttttttttaatatgat atatgagtga tattatgagt cttgccttct ttccaggtgg 14220 gtggcctttctggctaatct aaggggtcgt tggaggatta gaacttcagt gtaggttggg 14280 cacagtagctcacacctgta atcccagcat tctgggaggc tgaggtgggc ggatcatttg 14340 aggtcaggagttcaagagca gtctggccaa catggtgaaa ccctgtctct actaaaaata 14400 caaaaaattagccgggtgta ttggcaggtg cctgtaatcc cagctactca gaaggctgag 14460 gcaggagaatcgcttgaacc tgggaggcgg agtttgcagt gagccgagat tgtgccattg 14520 cactccagcctgggcaacag agtgagactc catttaaaac aaacaaacaa agaaaaactt 14580 cagtgtggatttggtgaagg cccacagaac ccagagtcat cagcctgccc caggggttta 14640 tttgcagctgtagtatattt ttgggttttc agatacactt tgttgctaca gaggtaacca 14700 gtgacaaaaaaagtgtttca tggtttaatc tgaatttgtt tggtagtttc tatttccttg 14760 tcatttgtttggtagtttgt atttacttgt cattattaaa gttaagaaaa aaattattca 14820 ttgatcacaagagatttact aacctgtttt ccagttatta tcatgttgat ggagttacag 14880 acatgcctctcattttattc tgctttgctt tattgtactt cgcagatact acatttttta 14940 caaattgaaagtttgtggca accctgtgtt gagcaagtct attaatgcca tttttccgat 15000 agcatatgcccacttcatgt ctctgtgtct catttttata attataatat ttcatttatt 15060 tttattttattttattgaat tgaattggcg gagtttcgct cttgtttccc atgctggagt 15120 gcaatggtatgatcttggct cactgcagcc tctgcctctt gggttcaagt tatcctcctg 15180 cctcagcctctcagctggga ttacaggcat gcgccaccgt gcccagctaa ttttgtgttt 15240 ttaatagagacggagtatca tcatgttggt tagcctggtc tcgaactcct gacctcaggt 15300 gatccacctgtgtcaacctc ccaaagtgct gggattacag gcgtgagcca ctgcgcctgg 15360 cctgtaattgtcatatttca aactttttca ttattattac atcagttatg gtgatctgtg 15420 atcagagatctttgatttta ctattgtaat tcctttggga caccatgaac cgtgcctatg 15480 aaagacagtgaacttaataa atgtgtgtgt tctgactgct ctactgactt gccattcccc 15540 catctctctccctctccttt ggcctccctg ttcctggaga caacaacaat attgaaatca 15600 ggccaattaataaccctaca gtggcctcca ggtgttcagg tgaaaggaag agttgtgtgt 15660 ctctcacttcaaatcaaaag ctaaaaatga ttaagcttat ttgaggaagg catgtcaaaa 15720 gctaagtctcttgggccaga tagttagcca agttgtgaat gcaaaggaaa agttcttgaa 15780 ggaaattaaaagtccttctt agtgaacaca tgaatgataa ggaagccata tagccttatt 15840 gctgacatggagaaaatttt agtggtcttg gtagaagatt gaaccagcca caaaattccc 15900 ttaagccatagcctaatcca gaacaagtcc ttcctaactt gcttcaagtc tatgaaggct 15960 aagagtggttaagaagctgt agaaagaaag gcggaagcta gctgaggttg gttcatgagg 16020 tttaaggaaagaagctatgt ccgtaacata aaagtgcaag gtgaagtagc aagtgctgat 16080 gtagaaggcgcaccaagtta tccaggagat ctaactgaga taatggatga aggtggctac 16140 cccaaccagcagattttcag tatagatgac acaactttct attggaagaa gatgccatct 16200 aggactttcctaactacaga gaagtcaata tctgcttcta ggcttcaaag aacaagctca 16260 ctttcttgttagaggcaaat gtagctggtg actttaagtt gaagccagtg tttacttacc 16320 atgccttgagaaatcctagg acccttaaaa aatatgctac atctactctg cctgtgctct 16380 gtaaatggaacaacaaagcc taggtgacag ccatgtgttt acaacatggt ttactgaata 16440 ttttaagctcagtgttgaga cctgctgctc agaacaaaaa gattcctttc aaaatactag 16500 acattgtatagcaatacctg gtcaatcacc gaagggctct gatggagatg tacaaggaga 16560 ttcatgttactttgtttcct gctaacacaa catccagtct gtagtccatg gatcaaagag 16620 tagttttgactttcaggttg tattatttaa taaatacatt ttgtaaggct gtagctgcta 16680 tagatagtgattgttctgat ggatctgggc aatgtgtgtg aattgaaaat cttcaggaaa 16740 ggattcaccattctagatgc ctttaagaac aattgtgatt tgtgggaaaa ggtcaaaata 16800 tcaacattaacaggagtttg gaagaagttg atttcaacct tcatgacttt gagtggttca 16860 agactttaatggaggaagga actgcagatg tggtagaagt agcaagagaa ttagaattag 16920 aagtggatcctggtcgggtg cggtggctca tgcctataat cccagcactt tgggaggctg 16980 aggtgggcggatcatgaggt caggagatcg agaccatcct ggctcacacg gtgaaatccc 17040 atctctactaaaaatacaaa caattagctg ggcgtggtgg caggcgcctg tagtcccagc 17100 tactcgggaggctgaggcag gagaatggcg tgaacctggg aggcggagct tgcagtgagc 17160 caagatcgcgccactgcact ctagcctggg caacagagcg agactctgtc tcaaaaaaaa 17220 aaaaaaaagaagtggatcct gaaaatgtga tccaattgtt gtaatctcat gataaacttg 17280 aacagataaggagttgcttc ttatggatga gcaaagaaag tagtttcttg agatgcaatc 17340 tactcttggtgaagatgctg tgaatattat tgaaatgaca acagaggatt tagaatatta 17400 cacaaacttagttaataaag cagtggcagg gtttgagaag attgactcca attttgaaag 17460 ttgttctactgtgggcaaag tgctatcaaa cagcattgca tgctacagag aaatctttca 17520 tgaaaggagagtcaatccat gtgggaaact tcagtgttgt catacttcaa gaaattgccc 17580 cagctactccacccttcagc agctaccaca gtggtcagtc agcagccatc atctttgaag 17640 taagactctccaccagcaaa aatattacaa ttcactgaag gctcagatga tcactagcac 17700 tttttagcaataatgtattt ttaaattaag atatgtacag ttttttagac atgatgttat 17760 tgcacacttaatagattaca gcatagtgta aacctaactt ttacatggac agggaaacca 17820 aaaaattcatgtgacttgct ttattacatt ggtttggaac tgaacttgca gatatctgag 17880 atatgcctgtactctggttc caatctggta aaatggaatt tgactactgt attgcatctg 17940 tattatgtatacttcacatg ggatttgatg cacacattat ttatatagag aaataggact 18000 cctgaacaattactgcatac acttatgttc gtatttaaat tacttcatta actttttaaa 18060 aaaattacagtaaaatgcat acagaacatt tcccctcagg agaaaaaagt ggatgtgtca 18120 aggccagaaatagaagagat tatagctgtt aattttttta agcctacacg ttgattatta 18180 ctactctcatttgaaaagtg attctcatct tttttgtgtc agagatcctt ttgagaatct 18240 gaaagctatggacagtttct tccaagaaat gcatttactt gcatatgtta aagaaaattt 18300 tcttttttttctttttcttt atgagacaga gtctcgcact gttgcccagg ctggagtgca 18360 gtggcacaatgatctcagct cactgtaacc tccgcctccc tggttcaagt ctcagcctcc 18420 tgtgtagcttggattacagg tgcctgccac tatgcccagc tatttttttt ttatttttta 18480 tttttagtagagacgggggt ttcaccatgt tggccactct ggtctcgaac tcctgacctc 18540 ctgatcagtctgcctcggcc tcccaaagtg ctgtgattac aagcatgagc cactgtgccc 18600 ggcctaatttttttgttttt tgagatggtg tcttgctctg ttgcccaggc tggagtgcag 18660 tggcgggatctcggctcgct gcaagctccg cctcccgggt tcacgccatt ctcctgcctc 18720 agcctcccaagtagctggga ctacaggtgc ccaccaccac gctcggctaa ttttttgtat 18780 ttttagtagagacggggttt cactgtgtta gccaggatgg tcttgatctc ctgacctcgt 18840 ggtctgtccgccttggcctc ccaaagtgct gagattacag gcgtgagccg ccgcgcccgg 18900 ccattttaatagcgacggga tttcactatg ttggtcaggc tggtcttgaa ctcctgacct 18960 cgtggtctgcctgcctcagc cgctcaaagt gctgggatta caggcatgag tcaccgcgcc 19020 tggccccagcaccccggccg agtactgtgg cggaatctca cctctaaatt aattaatttt 19080 ctgttagagggtatataatg ctgaaaaata tttttttttc cctgttcttt gcaggactta 19140 aattacataagaaatgcatg atcgaccggg cgcggtagct catgcctata atcccagcac 19200 tttgggtggccgaggcgggc ggcttacggg gtcaggagat caagaccatc ctggctaaca 19260 cggtgaaaccccgtctgtac taaaaataca aaaaattagc cgggcgtggt ggtgggcgcc 19320 tgtagtcccagctacttggg agcctgaggc aggaggatgg cgtgaacccg ggaggcggag 19380 cttgcagtgagccgagacgg cgccactgca ctccagcctg ggcgacagag ggggactccg 19440 tctcaaaacaaaacaaaaca aaaaaaaaac aaaaagaaat gcatgttcat gatagggaaa 19500 aaaaaatagtaagcaaaaga aatttaaaat ggtctataat tcttttatct agaaataatt 19560 actgttgatatttggtgtac tttgctcata aatttatatg ttatattatt tttaactttt 19620 cttaatattttatgctcttt tctttttttt tttttttaag acagagtttc actcttgttg 19680 cccaagctgtagtgcaatgg catgatctcg gctcactgca accttcgcct cctgggttca 19740 agcaattctcctgcctcagc ctctggagta gctgggatta caggcgcgca ccaccacacc 19800 tggctaattttttgtatttt tagtagaaac ggggtttcac cgtgttagcc aggctggtct 19860 caaactcctgacctcaggtg attcacctgc attggcctcc caaactgctg ggattacagg 19920 tttgagccactgtgcccggc ctttatgctc tttttcatta aaaatatatt gtgaagtcat 19980 cattctgtttgtacacattt tctttgagga ggttcttata aaatatatct tctgtagtga 20040 catttagtttttctgtgttt tgagttcttt cttttttaaa aaaaattatt ggtagaactg 20100 gtctcgctatgttgcctagg ctggttttga actcctggct ttaagtgatt ctcacacatt 20160 ggcctaccaaagtcctggga ttacaagcat gagccactgt gcctggactg ccctctctct 20220 gacttttttttgagacatag tcacactctc ttgtccaggc tggagtgcag tggcatgatc 20280 atggctcactgcagcctcaa ctcctaggct caagtaatcc tcctgcctca gctttctgag 20340 tagctagtactataggcaca taccaccatg cccaaataat tttttaattt ttatttttgt 20400 agagacagggtcttgctgtg ttgcccaggc tggtcttgaa cttgtagcgt caagcagtcc 20460 tccagccttggcctcccaaa agtgctaggg tgacaggtat gagtcactgc accccgcctg 20520 agtccttgttttttatagtt tatgttttct tataaggcat ttagacacac acacacacac 20580 acacacacacacacacgtac atatacatac atactttcat aaatcatagt ttgaagccac 20640 ggtttttattcttacggtac caggcattga cagccattag aatggtcttt agaaacttcg 20700 aataaacttttaagaattca ggaaatgtat cactaggtat ctaatgatag attttttcat 20760 attaggtattaatgaacata ctggatcaag taatttggta atgtaaggta gaggttttat 20820 ttacttagtcaaggtagctt tgagttctta ataaatcttg tggctgggca cgatggctca 20880 tacctgtaatcccagcactt tgggaggcca aggtgggcgg atcgcttgaa gtcaggagtt 20940 cgagaccagcctgggcaaca tggtaaaacc ctatctctag tagaaataca aaaattagcc 21000 gtggcgtatgtctgtaatcc cagttgctta ggaggctgag gcaggagaat cacttgaacc 21060 caggaggcagaggttgcagc gagccaagat agtgccactg cactccagcc tgggcaacag 21120 agcaagactccatctccaaa aaaaaaaaaa atcttaaatg attgcatttt cttatccaaa 21180 attatcacctgacagtttca aataaatgaa gttcattagc aacagtggag tgacttctat 21240 aattgtatgtgacatttcat taaatctatc ctaacatatt aggaagagat ttttatctac 21300 ccagattatatgttggctgc agaaagtcaa cagagagttt taaattaaga aataattata 21360 ttgatctttgctttatatca gaaagcagcc aaaatggcac agtgcttatg gaagaaactg 21420 cttatccagctttggaggaa accagctcaa caattgaggt aaacttgtat tttacactgt 21480 ggatatatgttaaatagtat ccttagaata ctatttaaag cctctaattc tatttatgca 21540 ttctattcctattttgaatt ataagcaatt ttgacttcta agttagatgt cttagaggac 21600 atctaagcaaagtattttat tggtattgtg ttaaagatct atcttttcac ctctaatata 21660 attctttttggaagtagatt gcattcttga attatattga aaaattaaac tgttaggttt 21720 catgtctaaaatggtggttc attttaaaat ttggtaacaa cctgagactt atgctttggg 21780 gttttacttgacttctgtat aaaactagat agctagatga tcattttaca tggtgtttta 21840 gtctgtttgtactgatctga caaaatacct gatactgggt gatttataac aaacagaaat 21900 ttatttctcacagttataga ggctgggaag tttaagatca aagtgtggac aagttcagtg 21960 tttgctgatgacatgctgtc ttgtttccaa atggcatttt gttgctacat ctttaagagg 22020 agatgggcaaaaaaaggctg gatgctgcat gaagcctgtt ttataaagac cttaatcata 22080 ttcctaggggaggatccctt ataactcagt cacctcctaa aggtcccact tcttagtact 22140 atcacattggcgattacatt ccagcgtaga aatttttggg gacaccttca gatacattca 22200 gtacaagatacagctgttga agtttattac gtacataacc taaaaagttc agtgagtctt 22260 ttttgggcttccacactaca gagttgtgct cgaatagaac catggaactc gtgagagaag 22320 tgagctcttttttctgtggt tattgagggg gcaaagatgg gcttctcagc ttctgcagcc 22380 cactaggagaatgcagtggt ttgatctaat tctgagagtt gtcaagggat ctgatggtgt 22440 tctcaagctatatgatgagc ctgctattgc ataattcttt actaatagta ggaatcatat 22500 cttttattttaactcagatg actataatac ttactactgt tgtattctaa gaaaatgtaa 22560 gacccttaaatgattgttga acttaccatc tctaaaatta tgattcttca ggcagaggaa 22620 caaaagatacccgaagacag tatctatatt ggaactgcca gtgatgattc tgatattgtt 22680 acccttgagccacctaagtt agaagaaatt ggaaatcaag aagttgtcat tgttgaagaa 22740 gcacagagttcagaagactt taacatgggc tcttcctcta gcagccagta tactttctgt 22800 cagccagaaactggtaagaa tacactgata agagacttaa agacatgtac gaccacattt 22860 tatataaaggcttgttttct acccctaata atttagtctc tagttttgaa tatgtttggg 22920 taaaactcaagacaagacta tttttgtgtg tgaaatctat taatacctag tgtttcgcta 22980 gactgttctggagcatagca atcttttact gtaacagtaa ccatcttttg ccattaaata 23040 gaagacaaaattgcttcagt gagatttgtt aaaatcacaa atgctccaaa attcttttgg 23100 tgctttttagatctttaaga gtgggagatt ggggatgtta atatttttgc ttgcagtagt 23160 gtacattttgtaatatagaa atagtgaaaa aaattgttat taaagtctct tcagatatat 23220 tcaattattaatcatgcaac aaacatttat tgagtaccta ccatatgtga aacagagttc 23280 aaggtgctatcaatacagct agtcttccaa agctcgtgac cttcagatct tttgttttag 23340 attctgttatgaaaatgtca ctagtgtaag ccacattttt aatgcaatca atgcccgttg 23400 tacagacagactcattcaga gattaaagtg tgagttgctt gatttctttc tgctatgctt 23460 cagctcagttttagcagtat gtataacatc ttttaatgtg atgtaagtat gtaggtataa 23520 agttcctggatatatcagtt attaacccac aattataact aagcgtgagt tatggcagag 23580 acaacttgaaacactgctag tgattctaaa aatttcctaa tttgacgaag aaacaggaaa 23640 caggtagtatctattttaga taattttttt agattttacc attctttaat atttacattt 23700 gccaaccagaatcagacaat agaatttctg tcattccagt ttaagctaat aaaatgtcaa 23760 gtagaggttcttggctgggc atagtggctc atgccagtaa ttccagcact ttgtaaagct 23820 gaggcaggtggattacctga acccaggatt tcgagaccag cctgggcaac atagcgagac 23880 ctcatctctacaaataataa aaagccaggc atgatggcgt gcgcatgtgg tcccagccac 23940 ttgggaggctgaggtgggag gattgcttga gcctgggagg ttgaggctgt agtgagctga 24000 gattgcgccactgcacccag attgccaacc tgggtgacag agcaggatcc tgtctcaaaa 24060 aaaaaaaaaaaaagtagaga ttcttggcta tctcatttaa tgagaagtta ttttcagtta 24120 gtatatcagtggtttgccta taaacatgaa cgtgaaaaca ctttttccag ctatttgaat 24180 attcatgtgacattcttgat gttcagagga aaacttcagg ctttgttaga atagcattca 24240 tagtatctttatttatggag gggtattgta attgatttta gaatccttgt tagtcatcaa 24300 attttattattattttttta aactccagga tttgtgttgt attcaggtag tttccccacc 24360 cccgcttcctttcctgcctc tggtttaatt agagaatatt catggcccag aaaagtcaaa 24420 ttgaagccagagtattatag aatggtcaga tatataagaa actgacatag acgtaaaagg 24480 aactacatactgttgctggg cgtggtggct cacgcctgta atcccagcac catctcaaaa 24540 aaagaaagaaattacatatt aacttttttc aggaagttgt atagttctaa gaccattctt 24600 ctaatatttatcttctttct gaattctgac ttcttgagat ttttgtggac taagaggaat 24660 atttgattaactgtattttt acccattgtt attcctccta aagatattgt ttcaataaac 24720 caaatgtttaaagacgaaat tttggactat actgaaaaca ctgcatataa accagttgcc 24780 aaaagtttttgttttggggc cgggcacttt ggctcatgcc tgtaatccct gcactttggg 24840 agactgaggcaggcagatta cctgaggtaa ggagtttgag accagcctga ccaacacggc 24900 aaaaacccttctctactgaa aatacaaaat ttagccaggt gcctgtaatc ccagctactt 24960 gggattagctgcctgtggta gcgcaggcct gtaatcccag ctactctgga ggctgaggca 25020 ggagaatctcttgaacccag gaggcggagg ttgcagtgag ccaagattgc gccactgcac 25080 tccagcctgggcaatagagg gagaccccgt ctcaaaaaaa taaaaaagat ggtttttgtt 25140 tttcccttttagtttgttaa ttttgtgcta gccattgctt aattttgttt tttcctttcc 25200 ctttcttcatccttaaggat ttcaacttca attttttctt ctcctgactt atattcttgt 25260 ggcagtgtacgttttgttgg gttaagaaca ctgcctgctt cctctttatg aactctcttc 25320 cctgacaaaaagcaaagttg gtagtgtaga gaagtttgta ttgtgtgttt ttaagaaggc 25380 atggttattacgttttaatt ttgtacggat aacaatgtta agtgataatt aagtattttt 25440 aattcttttttttcttttta gtctttataa tatagcttta tgcctctttt tttcctgttt 25500 attcacaaaagaaaggtggt gggagaagct gtggaagatt cctgagtgca tatggggatg 25560 ggatgatcagctgaaacacc atgttcctag ccaactcgct ttccaaggtg gtgtgactaa 25620 atctgaccagcttctctaga gctgagtgtg cctagtcaca tttactattt accgagtgct 25680 ttaaagatacctgttgtcat ccgcaatact ctaaacaggt gttcagaatc tcttgtaaag 25740 gagctggccaagcttattgc atgcctttgc attgcttgca tctatgggcc aaattaagct 25800 tttttaaaagaagttaaaaa tcaaaatatt tcagctatta tatgtatggg ttaaaaaagt 25860 tggaagcattagataaggac atgaatatat taatgtgggt taggctgttt tgttagaata 25920 tataatgaaggtaatgttaa tgtagaattg aacaattatt taaataagtt ttacaaatgg 25980 tttgtttttacatttaccta tcttaatttt atgtcagaaa gcctgactta aatactctaa 26040 ccatgatcatgaatgccttt gtattatgta atgctttgtt taagtcttcc tttctttctc 26100 tttgtccaagaaatataatc tcacacctga ggcgacggca tctttgaaaa actagtgatc 26160 aagaataaccagataaacat gatgggcata agggtcatga ccaaaaagat ctctcagtgg 26220 catctgtatcactaaatatt aggaatattc attcatttca gtagtgcctt ctgtctttgt 26280 gtttattgttgtaagtgtga aagtgaactg aatactccat gatccatctc tgaaaaatat 26340 tgcctaacctaaatcaccag ctttcctgtg gcatggatat cctgtcttct gaagaactgt 26400 ttttgcttttctggagcatg aatgtttgtt gttttagagc tctttgtatt cgagttcata 26460 ttttatccttatttttagtg cttttcctct aagtagcttg tggaaattat ttctgagtaa 26520 ttgaagcttctgtgtcaaca taatagtttg ttgacataag aaacagtgtt aagaaattat 26580 gcatttggaaaaaactgaag gtgatttttt ccagggaatt tgtttcctgg acttgggatt 26640 tcttgtgcaaattttcccca ctagtttgtt tttctctact attattttca taaaggagca 26700 gcaccagaatagtccttaat atcggagata gctgttgtgt cacttcctca tgctgacata 26760 tttactagagggtaaaatta ataaccttct agtaagagtg gcagtcgaag ggaagggctc 26820 atctgacttctggaaaccta tgttaaaata cagtgctttg aaccttgatc atgggctaat 26880 taggttggaaatgaaactag agaccagata cacccaagga aacttttggt agttatttta 26940 ctttataagtcacaggaaat gcttgtgtac tttcctgtgt tccttaaata gttgcactta 27000 aattacctctttgaaactga atgaagagac agagagtatt ttttttcttt ccagaaataa 27060 tacttgtttatacctgtaat agcaatgaaa ttttgtttct tttgagacag agttttgctc 27120 tgtctcccagtctggagtat agtggcagga tctcagctca ctgcaacctc cacctcccag 27180 gttcaagtgattctcctgcc tcagcctccc aagtagctgg gactataggt gcactaccat 27240 gcccggctaatttttgtatt tttagtagag aaggggtttc gccatgttgg ccaggctgat 27300 ctcgaactcctgacctcagg tgatctgccc gcctcggcct cccaaagtgc tgggattaca 27360 ggtgtgagccactgctcctg gccagcaatg aaacttgagg ctatgcgaat gaaggattgt 27420 tctaagagtgtaaactataa ggcgaggagg attaaataaa aaaacagaga taggctctca 27480 aagcaccaaatagtatgatt aacagattct tgtgtatcac atttgaaatg ctttatgttt 27540 tggctttatgttgatgagtt gaaaacccgt gtttttgttt atgttgtttg gtttttgttt 27600 ttggctatcttatgtagaaa ggcatgtaag ggatggcatt gattattcta aataattttt 27660 actgggaaagcttttccaag attttgaata gctaaatgtc aacttttttc ttaatagtat 27720 tttcatctcagcctagtgac gatgaatcaa gtagtgatga aaccagtaat cagcccagtc 27780 ctgcctttagacgacgccgt gctaggaaga agaccgtttc tgcttcagaa tctgaagacc 27840 ggctagttgctgaacaagaa actgaacctt ctaaggagtt gagtaaacgt cagttcagta 27900 gtggtctcaataagtgtgtt atacttgctt tggtgattgc aatcagcatg ggatttggcc 27960 atttctatggtaagtactca aaaatgtgtt atacataacc tgatgggata gtgtagagga 28020 acttaagagtgaggactctt gggatctgtt ttcagtgcca ttattaaatg tgtggccttg 28080 aaaacttgaagcctgtttga gcctcagttt tctcattcgg gaagtgggtg ctgcctatct 28140 cacaaagctttttatttaaa taaggtagta gttattaaga aatgtaagga taataaccat 28200 atatgtttgtgactctttta aagttaaaag attggaagat taaaaatctg aaatgctcac 28260 catgaggcaaatcatttaca tttagaatca cacttaaact aagttgaagt gtgactttat 28320 taggaagattatttaaatcc cagttgaaat agttacattt gaaatgtgta aataataagt 28380 gttcattatttctactttga ggtttcatgt aagtatcata ctttgtaact ttcattgttg 28440 cttctgtgattcacatgaat tgagagtttg tcatctttgt tcttatactt tgctctttat 28500 tatgattgatactgtttata tatgttgatt atcttatcaa ttcaaagctt ttaaatgcct 28560 tttgggtgagaagaggaagg tattctattg gtgttacttt actttttcat ttaggagcct 28620 cacccattgactctctcctt tgttttttgg agacggagtc ccactctgtc gcccaggctg 28680 gagtgcagtggcacaatctc agctcaatgc aaactccacc cccagggttc tagcaattct 28740 cctacctcagcctccggagt aactgggata acaggcgccc gccaccatgc ctggctaatt 28800 tttttatatttgtagtagag acggggtttt gccatgttgg ccaggctggt ctcgaagtct 28860 ttttttttttttttcttttt ttttgagacg gagtctcact ctgtcgccca ggctggagtc 28920 cagtggtgcgacctcggctc aatgcagcct ctgcctctgg gttcaagtga ttctcctgcc 28980 tcagcctcctgagtagctgg gactacaggc gcctgccacc acgcccagct aatttttttg 29040 tatttttagtagagacgggg tttcaccatc ttggccaggc tggtctcaat ctcctgacct 29100 tgtgatccacccgcctcggc ctcccaaagt gttgggatta caggcgtgag ccaccgcacc 29160 cagccagtcttgaactcttg acctaaggtg atccacccca ctcagcctcc cagagtgctg 29220 ggattataggcatgagccac cgtgcctggc ctgagtctct tatttaaggt atgtgtttgt 29280 acaatgactggagtatttga aacctgaact ttgactctct ttgctatatt ggaatttggg 29340 gtagagacactttaaaagga aatgtcttag atcttgtcaa cttcccaaat tttagcttgc 29400 tttacattaactacttttag atttttttgc ctgcataatc cacagtctta acttttcgtt 29460 ttgctagttcattcgaaaaa tgtatttctt atgcaaagat tgaagaatta catgtaccct 29520 atgtggatttgtggaaaagg tatattattc aacatagcgt aatgttagaa taaacttaat 29580 gaagacaatacctgtttaaa gtcagagctt gcaagatgtt tcttgtattt atattaataa 29640 aaatatgtatttagatttct gatggatacc tgcttgaatt taatactgag atactattat 29700 ttgtatcctttcttgaaatt tgttgtaata agatttgatt tgaaatatat atttaccttt 29760 atagactatctagctgaaac aatcaataag tatttgagta tgattttccc tccacaagta 29820 aacatgagggtaacaatgga gaagatctta tcttaatctt tttttcttac ttcaaaaaaa 29880 attggatagtgatttaaagt gttaatccaa attgcattaa aacttcacca tttacatgac 29940 ctttgaatattttgtagaaa aataatttta cagaagtgct ttcaaaatga gaagttactt 30000 ctctgttatgtaggattttg gttattagta aaatttacct taatagttaa ttaataaaac 30060 attgtcctttacttgatatt agccttttca ggctatgaaa agcctggata acatattatg 30120 aagtaggcctacatagtaat gagattagtt gaattaacat acaagacctg acctaaatga 30180 cttttccaagtcactactta aaagacatca cttttttttt ttttgagaca gagttttgct 30240 cttgttgcccaggctggagt gcagtgcgtg atctcggctc accgcaacct tcgcctcccg 30300 ggttcaagcaattctcctgc ctcagcctcc cgagtatcta ggattacagg catgcaccac 30360 catgtccagctaattttgta tttttagtag agatggggtt tctccatgtt ggtcaggctg 30420 gtctcgaactcctgacctca ggtgatctgt ccacctcggc ctcccaaagt gctgggatta 30480 caggcgtgagccaccgcacc tggcaagaca tcacattttt taatttcagc actgatctca 30540 acattctttggagttgattt cagagccgtt ttgaattttc tattcaccgt aaagtcggtc 30600 attgcatcccatagtcattc attcacttta taattttatt tttttttgag acagagtctt 30660 gctctgttccccaggctgga gtgcagtggt atgatcttgg ctcactgcca cctccgtctc 30720 ccaggttcaagcgatccttc tgtctcaccc tcctgagtag ctaggattac aggcatccgc 30780 cagcacgcctggctactttt tgtattttta gaagagatga ggtttcgccc tgttggccag 30840 gttggtctcgaactcctgac cttaagtgat ccgcctgcct cggcctccca aagtgctggg 30900 attataggcgtgagccaccg tgcctggccc gctttataat aatttaacaa taccatatta 30960 ctaattgaatcattctgcgt ttgccagccc tggtgccata cagatttgaa ttggcagatc 31020 tatactgcagggaagagaaa gctagcatga ctaaggatag tgaggcagtg tactccaggt 31080 atttggttctgaaaatgctt ccagaagttt tattaaaaag tttcatgaga aagcagtctt 31140 tcttattcttacatttgctt gtgactatca acattccaaa tcatcaatgg agttcaattg 31200 atttggttttctcctcgagt tgctttaagt attgatagac tacccggctc ttcggcagac 31260 tattatataacaagatatct agatgctaag ttatagagca cagaatgaat tacagctcaa 31320 agggtacacttactgaatta tcctggaggt ggtaagattt aagttgtgtc taatcatagt 31380 aagtttatgatagactcaag ggaaggtgga acattccagc gacagagaat ctgataacct 31440 gaggaagacgtaatcttggg tttgggagca gtgaaaagac tgcttggact acagcagagt 31500 gtaggtatttagaaataatg gaataggtgg ggtgctatta tagtcatccc ttgatataca 31560 tgagggatgggttccaggat gcacccccat accaaaatcc atacgtacta aagtcccttg 31620 actgcggacctcacatatat gaaaagtcac ctctccatat acctggattt tgcatcctgc 31680 catgtagttcaaactcatgt tgctcaaggg tcaactgtgt attgtaaaac gtcttggaat 31740 ctagataggaaagtttgatt tattgagtaa cctgctatca ggttagagaa aaaagtgccg 31800 gaactttttgctggtgtgga aaaggtggta tggaaaaatg tagaatagtc agtcagttaa 31860 gagttctgtaatctggatat ttggtgagga ggaccttgac aattggaata acagtgggaa 31920 tggaataagggacattgaag gaataatgga aaataatggc aatttattaa attgtagaaa 31980 atgtgctagctgcttcactt ttggagttgg ggttactggg gaagttttgc cagatgataa 32040 atagatggtaagcacagttt ggtttggttt tacccaaatt tgttctagac aaatttggtt 32100 tggggcaggtgttgaggttt gatttttttt ttttttccac cctacaaaca ggccccctac 32160 acagctggatgtgttggcta gaagctctga tgagaagtta ggacaagatc tgtagcttgg 32220 aattcttaataggagtgata gcaaaatctg acagcgctgc aacatggtaa aataggcagc 32280 atttgtagacatgactaggc caaagattgt atcttgagga taagacttta ggtagctgaa 32340 ggtgcaggaaaaacccccaa gtgattagtc agtaatattg taaaaggcca cattaagaca 32400 gtaatcaagcatatgctata ttatactatc ttgaattcag acctcaacac agttttagat 32460 tattttccagtgggcaaagg aattaatctc agcagtttga aatagaaatt gcagaagttt 32520 tctgttactctgggaactat agataaattt caacatttga aaaaaatctg ggattctgct 32580 gagtaattttgaaacaagct tgccgtgctt ctataaattg agaaatctaa agagaggaaa 32640 tgaattctaacacagaatat catagctaga ctatgtaaca gttacctgta aattggcaaa 32700 agttgtttttggtgtttttc aagatgtatt gaagacattt aaaataattt ttatagcagt 32760 aagggaagaaatagtgatca ctgcatcctt tctttgtaaa attctatagt atctatactc 32820 agtagatgtaatgttaaggt tgctaactgc attttgcctt atttttgatt tcgtggtttt 32880 ttccccccatacatgacgca tgtgaatagc atgtctgagt aaagtaacat tttgattttt 32940 aggatgaaaatatgaagaat cctagttggt ttaagattct ttttttgaga cggagtttcg 33000 ctcttgttgcccaggctgga gtgcagtggc gcgatcttgg ctcaccacaa cctccacctc 33060 ccgggtttaagcgattctcc tgccgcagcc tcccgagtag ctgggattac aggcacatgc 33120 caccactccctggctaatat tgtattttta gtagagacag ggtttctcca tgttggtcag 33180 gctggtctcgaactcctgac ctcaggtgat ccatctgctt tggcctccca aagtgctggg 33240 attacaggcgtgagctactg tgcctgtcca attcttttat cactgttggg ataaggacag 33300 tgctactccagtacagattt aaccattgca gaattcttaa caaatttggc cttgagaatg 33360 gtgcacaatcaccattagcc aattattttc tgtgctgtac tttttgggct ttgttgtatc 33420 cttaaggcaaaatagtaaaa aaaaaaaaaa ttttcatttt tccttattga cttacgacct 33480 gtgaaaaaataccagggttt gttcatttct ctgtataagg gaggctgaaa cactttttgt 33540 acttaaaagataaccccaaa acaacaaagc tgagtgcctt caatatagta agataagaac 33600 attacataaattgttctctt ggttagagcc atatgggctg gcctgtgtgt tttaatacaa 33660 aagatagtgaactgcttaaa tgttcctggg tgtatgtaaa taaatgtttt taagaactag 33720 cctacttggccttacttata ttacgttaac gttcaccacc atttgatgaa tgattgatca 33780 tgggctttcatttacttttc tttttttatt ttattttatt tttattttta gtagagacag 33840 ggtttcaccatgttggccag gctggtcttg aactcctgac ctcaaatgat ctacctgcct 33900 tggcctcccaatgtgctggg attacaggcg tgagccactg tgcccagcct cagttactta 33960 ttctctatttatgtaatcag aatttttaaa gaacggtgaa atgctgatac tctgaatgaa 34020 atgattgtcaagattacata ggttatggcc aggcacagtg gctcacacat gtaatcccag 34080 cactctgagaagccaaggtg ggtggatcac ttgaggccgg gagtttgaga ccagcctggc 34140 caacatggcaaaaccctgtc tctataaaaa attagttggg cctggtggcg cttccctgta 34200 gtcccagacactcgggaagc tgagtcacga gaattgcttg aaccagggag gcagaggttg 34260 cagtgagctgagatcatacc agcctgggca atggagcaag actcttctca aaaaacaaaa 34320 aaaaaacaaaaaaaagacta catagcttat atgcagatta ccaatattaa aaaatacata 34380 aaacatttaatgataatatt tttgttacat acctttaata aaaatattta ttttaggcac 34440 aattcagattcagaagcgtc aacagttagt cagaaagata catgaagatg aattgaatga 34500 tatgaaggattatctttccc agtgtcaaca ggaacaagaa tcttttatag attataaggt 34560 atgtaccactaacagtattt aaaataattg ttagtaatta ttttgcttat tagttagagc 34620 ttattgtgcttattagtgca gattagtaaa tcagtaataa tgctgatcat tgttgaattg 34680 agtacgggtatttagtgtgt cctagtcatt gtcatgagtg taccatatag agtatttctc 34740 ttattctcacaatatgtgaa ttaagcaatt actaactttt ataggtggaa aagaggttta 34800 gaaaagttaagtgactttct caaggtagca actggcagag ctagtttgtt tttgtttgtt 34860 tgtttatttatttgagatgg agtctcgctc tgttgcccag gctggagtgc agtggtgcaa 34920 cctcaggttgctgcaacttc cacctcctgg gttcaagcga ttcttgtgcc tcagcctccc 34980 aagtagctgggattacaggt gtgcacctct atgcccggca aatttttttg tatttttagt 35040 agagacggggtttcactatg ttggccacgc tggtcttgaa ctcctgacct ccgtctaccc 35100 acctcagtctcctaaagtgc tgggattaca ggtgtcagcc accatgctcg gccatggcct 35160 ttttttgttttgttttgttt tgtttgggag agctaattaa ttgattctaa ggatttgact 35220 taagaactcttatccctagc tgctatttta tagttaacat cttttataag tgacatttta 35280 tatgtgtatatagacatttt tattaacatt attttcacag agcgaagcaa acattttcag 35340 ttggcaggagggaaagagga gagttttggt tttatagcct ctctaagatc ttctcttgat 35400 caggggacatagctattcct ttccattgtt tttttttatt ctgatggaag ggagagcatg 35460 ttatctttttctgcctataa ctcacctaga tctcgtctca caggactgta ctgtccattc 35520 tgtcattacctaacacctct gtgggtttat gaggatcagc aaaatagctg gtctcttatc 35580 tagttttttcctaagaaggt tgtagagaga aatgcagggt agaaaaataa gctatgtctg 35640 ggtgtggtggcaacctctca aattcccaaa gttggtaacc ttgggaagcc aaggtaggtg 35700 gattgcttgagcccaggagt tcaagaccag cctggccaat atggtgaaac cttgtctcta 35760 ctaaaaatacaaaaatcagc cgggtgtggt ggcacatacc tgtaatccca gctttttggg 35820 aggcttaggcacaagaattg cttcaatcta ggaggcagag gttatagtaa gctgagatca 35880 cactattgcactccggcctg ggccacagag gaagactgtc tcaaaaaaaa aaaaaaaaaa 35940 aaaaaaaaaaggaaaaggaa agaaaagtaa gctattgttt tttccttcat ttttccaccc 36000 ccaattctcacacttaattt atgtatgctt cccttacagg ttatatttct tgaaaagaca 36060 aaaatactactttgtaacta aattgtatct ttcagggagg tacttctccc atccaagtac 36120 taaccaggccagaccctgcc tagcttctgc catcagagga gactggcggc atttagggtg 36180 ttatggctgtagacacaggg aggtacttct gaagttaatt ataaatagtt cagtttttcc 36240 tacctgtattagaagatgcc attttcttct tcaccacagt gttttctggt tccataggat 36300 aacattggcttttggaaaac tcaccacgca ttaacctcta gagagagttt gtagtttggt 36360 ttgggtttgggttttttttt tgttttgttt gttttttttc tgagatggag cctcgctctg 36420 ttgcccaggctggagtgcag tggcatgatc tcagctcact ggaacctctg cctcctgggt 36480 tcaagtgattctcctgcctc agtctcccaa gtagctggga ttacaggctc cctccaccat 36540 gcccggttcattttttgcat tttcagtaga gatggggttt cactatgttg gccagggtgg 36600 tcttgaactcctgacctcag gtaatctgcc tgcctcggcc tcccaaagtg ctgggattac 36660 aggcgtgagtcactgcgcct ggcctgtttt ttttgttttt gttttttaag agacagggtt 36720 tcattcttattgcccaggct ggagtgcagt ggtgtgatca tggctcactg ctgccttaac 36780 ttctgggctcaagcaatcct cctggcttag cctctcaagt agctgcgacc acaagcacac 36840 gccaccatgtccaacttggt ttttaaattt ttcatagaga tggggtctca ctatgttgcc 36900 caggctattctggaacttct gggttcaagt gatcctccca ccttggcctc aaaatactgg 36960 gattaaaggattgagccact gtgcccagct agagagtcag tttttacaga tctcttattt 37020 ctggctgttaagtgtggatc agatagattt tgaagctctt tggaagacct ggtcaggatc 37080 tgcttatcaatcacttatgt caacatcata tttactgcac gaggaatgct gtactcttct 37140 ttcatcctgtggcttcctgg gcttgtgcat ttcaagatta tgccacacca gtgcatcagt 37200 ctcttctactccacagtcca ctgctgttgg gtagaagaaa tttcttttct ctcatacagg 37260 tagagcagatgaaatgactg tgattaaatt ttaaatcttt atttgttctc tgaagattaa 37320 tgagccagaacgtgaagcag tcatttcaga tagttatttt tcaagtgtat attagtgtca 37380 ttctcttaaaggacttgtat ttttttttcc tttttttttt ttcttatttc tgaatccagg 37440 taattgactgctctgactca aatggggtaa ccataacgtt tgtgataaat taagccaaat 37500 ttaagtatcattttgcagat ttatacatag gatattttta actcgatgta taatgcttta 37560 agaacctgttgaaccatatt gtttaagttt tgactgtttt tggttagatt ttgttactaa 37620 tgcatatgtgtaaaagaaaa ttcaaatcag tcaaggatac ccttattgaa gcagtaaaat 37680 tctataagccgaattgacca tgatttctac cacgggtgct gactttcagt tatagtaatc 37740 tatagattaatcttcagagt tatattaatc tgtacagatt acagaacttc aaaaatttac 37800 cataaaattggataagttag ttataaatgt tcaagattca gtctgtcttc taacatggtt 37860 atagaatttatggcttatct gtacttactt agaaatgtta attgcatagg actaaaatgt 37920 ttcaaataggactaagattg ttagaatttc atcctttgaa gggtacactg agtacaaaca 37980 atttttgaagccgtaagtca gctctcgatg taattttact tttatttttt atttgttttt 38040 tttttgagacagagtctcgc tctgtcgcca ggctggagtg cagtggtgcg atctcggctc 38100 actgcaacattcgcctcccg ggttcaagcg attcccctgc ctcatcctcc caagtagctg 38160 ggactacaggtgcatgccac catgcccagc taatttttgt atttttagta gagatggggt 38220 ttcaccacgtaggccaggat ggtcttgatc tcttgatctc gtgatccacc cacctcagcc 38280 tcccaaagtgctgggattac aggcatgagc caccgcgccc agctaataat tttacctttt 38340 ataaaaggtaatctcttttc ctgattcaga aaagccttta gtcctgcaag ctctagctaa 38400 ctttctgtcttttaaattct tccagccagg cgcggtggtt catgcctata atgccagcac 38460 tttgggaggctggagagtcg cttgaactca agaggcagag gttatagtga gccgagattg 38520 cgccactgcactctagtctg gacgacagag tgagactcca tctcaaaaaa aaaaaaattc 38580 ttacaccatgctgtagttct caatttgatg tagctctctg ctctgcgttt tcttgcatat 38640 gaaccttgtatttcccaatg tttatactat tgaaaatact acccgggggg ttgtatctgt 38700 agaagtaaagacacaaaagc ttatggggta ttatatcttg aagatttaaa ttcagctttt 38760 aaagcatttgacattttatt tcttctcttt caaaaaaaat gtagtcattg aaagaaaatc 38820 ttgcaaggtgttggacactt actgaagcag agaagatgtc ctttgaaact cagaaaacga 38880 accttgctacagaaaatcag tatttaagag tatccctgga gaaggaagaa aaagccttat 38940 cctcattacaggaagagtta aacaaactaa gagaacagat tagaatattg gaagataaag 39000 ggacaagtactgaattagtt aaagaaaatc agaaacttaa gcagcatttg gaagaggaaa 39060 agcagaaaaaacacagcttt cttagtcaaa gggagactct gttgacagaa gcaaagatgc 39120 taaagagagaactggagaga gaacgactag taactacggc tttaaggggg gaactccagc 39180 agttaagtggtagtcagtta catggcaagt cagattctcc caatgtatat actgaaaaaa 39240 aggaaatagcaatcttacgg gaaagactca ctgagctgga acggaagcta accttcgaac 39300 agcagcgttctgatttgtgg gaaagattgt atgttgaggc aaaagatcaa aatggaaaac 39360 aaggaacagatggaaaaaag aaagggggca gaggaagcca cagggctaaa aataagtcaa 39420 aggaaacatttttgggttca gttaaggaaa catttgatgc catgaagaat tctaccaagg 39480 agtttgtaaggcatcataaa gagaaaatta agcaggctaa agaagctgtg aaggaaaatc 39540 tgaaaaaattctcagattca gttaaatcca ctttcagaca ctttaaagat accaccaaga 39600 atatctttgatgaaaagggt aataaaagat ttggtgctac aaaagaagca gctgaaaaac 39660 caagaacagtttttagtgac tatttacatc cacagtataa ggcacctaca gaaaaccatc 39720 ataatagaggccctactatg caaaatgatg gaaggaaaga aaagccagtt cactttaaag 39780 aattcagaaaaaatacaaat tcaaagaaat gcagtcctgg gcatgattgt agagaaaatt 39840 ctcattctttcagaaaggct tgttctggtg tatttgattg tgctcaacaa gagtccatga 39900 gcctttttaacacagtggtg aatcctataa ggatggatga atttagacag ataattcaaa 39960 ggtacatgttaaaagaactg gatacttttt gtcactggaa cgaacttgat cagttcatca 40020 ataagtttttcctaaacggt gtctttatac atgatcagaa gctcttcact gactttgtta 40080 atgatgttaaagattatctt agaaacatga aggaatatga agtagataat gatggagtat 40140 ttgagaagttggatgaatat atatatagac acttctttgg tcacactttt tcccctccat 40200 atggacccaggtcggtttac ataaaaccgt gtcattacag tagtttgtaa catttgtaga 40260 ttggatagcatttttatgat ttgatgagtt tcttgtaagg ttaccgtttc taagagttgt 40320 gctttatggccactgagaga attcagaata aattgaaaga tggagtctaa aaattattag 40380 ctgttacaaatggaacattt cattataacg tgatcacttt gacttgagca aatggtttaa 40440 tttttatcttaaaaatcagt taagaatata taaaatccta ctttggccaa gtttgtttct 40500 tttcattatagtttatatga aaagatcacc ttaagtgaaa ttattttcct ttaatctttt 40560 atgtatttattcacttttgg aagctaggaa tgagcaacac aaattttact ctgaagtcag 40620 aagagctcatatataataat tctaatgtcc cacctatttt cacttgtcca ttccatgtac 40680 cagcttagttatgatactta gtcacataat tatctttgat aaaggtagag gcacaaagag 40740 gcaaactaagcaagtcaaat tctaatgtgt gtacttcata ataatttttt atccattttc 40800 atctttatattctgtaacat gaaacttacc taatcttcaa atgttagctt cattttttac 40860 ctttgaaatacttaatcttt ctgaataaat ataatgtgtc tataaaataa tgagactgat 40920 tctggtgtctttagtcatta agctggtatc tagtcctata atgaacaaag gtgaagctgc 40980 cttgaggagacaagtgaaaa atttttgctt caaaggagct cacaagctaa gtaaataaat 41040 gaaattaaggtatggggcat ggtggcctca ggctgtctgg aggtgtttgg aaaggcttct 41100 tgagtgaggtggcctttgaa ctgaacttag tttttaaagt agcttttgga agagaaatga 41160 ggatttgctatgcagacagg gaagggaatt tcacttaaaa ggaaggtcat ttggagatgt 41220 gaagatacactgctttaagg aagcagggta gagctggagg ataagagatg cagaccatga 41280 agggccccattttatgctaa aggttttgtc ctgtaggaca tggagaactt ctgaagaatt 41340 ttcaaggcgggtgggataag attatattgt attttagatt acagtagtcc ccccttatct 41400 tcaggatatatgttccaaga cccccagtgg atgctggaaa ccagggatag aacataattc 41460 tatatatactatgcatgaat ttctttttcc ttctttacaa tctcacacat aggtttgttc 41520 ttactatagatcttaccaat ctcagcatac ttttatttct cttgagaacc ttcacccttt 41580 cacttaaaggaggcgcttta tagcttctct ttggcatatc caaatgccag catcactgtt 41640 gtattttggggtcattatta agttacttaa tcatccttaa tccttatctt agggatactt 41700 gaacacaaacactgtggtag gataacagta tatctgatta acagactgct actaggtgat 41760 taatgggtgggtagtgtaaa tacacaagaa aaggatgatt cacatcccat gtgggatgga 41820 gcagaactgcattatttcat tacattactc agaacaggca tataattgaa aacttatgaa 41880 tttttttttttaattatttg agatggaatc ttgctttgtc agccaggctg gagtgcagtg 41940 acacgatctcagctcactgc aacctctgtc tcctgggttc aggtgattct cctccctagt 42000 ctcccaagtagctgggacta taggcacgtg ccaccacacc cggctaattt tcatattttt 42060 agtagagatggggtttcacc atgttggcca ggctgttctt gaaatcctga cctcaagtga 42120 tccacacatgtctacctccc aaagtgctgg gattacagtc gtgagccact gtaccccgcc 42180 taaaactgatgaattatttc tgaaattttc tatttaacat tttcagacca cagttgacca 42240 caggtaacggaaacctcaat cacagaaagt aaagccgtgg atacggtggg actaatgtat 42300 tggtagcagcctagaggatt gatgggaaag gtatgaagct agaaggtggt caatataata 42360 cagacatgagctgatgaaca tctaaactgg gactatacta gtaggagagg aaaggaaaaa 42420 acatttggaaaatagtaaca ttgatatttc ttgtgaagga gaagtagaaa gtaacagtga 42480 cttctagatttctgggttgg gtcatctgtt gttggatagt agtaccactg agatagggaa 42540 ttcaaggtttggggcaaggg taattggaga tgagaattgt gtttggaggt aactactgac 42600 attcaagtggagagggttag ttggcagtta gttctatggt catctctttt gccgagactg 42660 tatatttatcagactcctgg gagaacacca acatccatgg ggttgtaggg aaggctaagg 42720 acaagagtggggagtggtac cttgaaaatc caaaagccat ctcaagtaaa aggaataaat 42780 gtgtcatgctttttaaaaag ttgatgtgcg gaaaatgttt tcttggcttg gaaactgggc 42840 ggccaggggatgacagtatg gacttccagt gaagtagtga cggaagcctg atcatagaca 42900 ttaaggaaagcggtgtaggt gttgtgagct tttgctgtaa gaaaaagttg agacttttgt 42960 tttgctttgtttgtgagaga tgtgtatgta tttctgctga gtgataaagc cagcggggag 43020 ggactgatttttataggaaa ggaggaaaaa taatggaaac acatctcatt attttattgt 43080 cacatttcttttctttgtta tcttttgagt gtttcccttt tttgccagta gagttattgt 43140 ctattttttctttctatagg acaaaaaaac taatacagac tcctttattt ttatatggat 43200 atactaggattgtaattcag atatttaata tcttttatca gtgttcagat catagattaa 43260 tggagaaaacatttaaaatt gttttaaatt taaatacatt gaactctaac atagatgaaa 43320 aatgtgtttactgctttcag tcgacctgat aaaaagcaac gtatggtaaa tattgaaaac 43380 tccaggcatcgaaaacaaga gcagaagcac cttcagccac agccttataa aagggaaggt 43440 aaatggcataaatatggtcg cactaatgga agacaaatgg caaatcttga aatagaattg 43500 gggcaattaccttttgatcc tcaatactga ttcacaattg agttaaatta gacaactgta 43560 agagaaaaatttatgctttg tataatgttt ggtattgaaa ctaatgaaat taccaagatg 43620 acaatgtcttttcttttgtt tctaagtatc agtttgataa ctttatatta ttcctcagaa 43680 gcattagttaaaagtctact aacctgcatt ttcctgtagt ttagcttcgt tgaatttttt 43740 ttgacactggaaatgttcaa ctgtagtttt attaaggaag ccaggcatgc aacagatttt 43800 gtgcatgaaatgagacttcc tttcagtgta agagcttaaa gcaagctcag tcatacatga 43860 caaagtgtaattaacactga tgtttgtgtt aaatttgcag cagagcttga gaaaagtaca 43920 ttgttctggaatttcatcat taacatttta taatcttaca ctcacttctt gtctttttgt 43980 gggttcaagagccctctgac ttgtgaagaa tttgctgccc tcttaagagc ttgctgactt 44040 gttttcttgtgaaatttttt gcacatctga atatcgtgga agaaacaata aaactacacc 44100 atgaggaaaactaaaggtct ttatttaaaa tctggcattg tattaacatg taattttata 44160 ctatgtggtattttatacat ttcctcagta gtgatatttg gtaaagcagt tcatacagct 44220 tttttctaagttccatgaat cttacccagt gtttaccgaa gtatttaagc agcatctgaa 44280 tatttccacccagcaatgtt aatttatcta ggaaagttca gaatttcatc gtcatgttga 44340 atttcccttttaacttccgt tcatagacat atatgtgact tccaattcga ccctctggca 44400 agtgagtgtggaagaaaaca gcagttcttt tataattgct tgaaattagg aaagcgctta 44460 tttcctagaagcaaataaat gtttgagtaa ataaaggcta cattttgctg agtactgttt 44520 cagtcaattttagaattgcc tattctaatt gctgtctaca actttttgct taataaaaga 44580 attaacttataggaagtaaa atactttgat agttacagaa ctggggctaa ttttgactgg 44640 agaaaagactaattatgaaa tgtgggttga aacagaccat aaaaaggtta tattatctat 44700 ttacctgagggtttcctaaa cctggggtaa aattaaaata ctgagttttc ctctttttca 44760 tgtttacttacctcttccaa aatgccgaag gtgatcaagt gagtaggcaa tgatgcatca 44820 tcatgaaactctctatgtaa ccagtttaag ggatttaggt aaaatacatc tgcttcatca 44880 agataatgactttttccagt caggtctggc gggcactgga gaaatctcat gggaagtggg 44940 cagtgaacatggctatgaaa agaaaagtta ccataataaa tacaagtaaa acatgaaagt 45000 tttcattagtcttaagatat gtcatttata cttagcaaaa tgtgaaatct gaatctgtaa 45060 actgtgttgcagttaagtga agaagcaagc ctttaactca ttttctcaaa gataaaaaaa 45120 acatgattcttataccatgt acctatgcag cagcagcagt ataacctata agcccaaact 45180 agtgcatagaagtccatttc aaggagggaa gtaggtcagt agggggactc aacattctgt 45240 agcattggtattctgttccg gaaacataaa tggtcctcag gaccaggtaa gttaacttgt 45300 taataggagagtaattctcc ataggtgtat ttgataaagt aggaaactgt gatcataatc 45360 agaaaggattctttctctct tccctttctg ctctgatagg ggatggatca catacttata 45420 tggcaagttttttttttttg aagacaagag tttcgctctc gtcacccagg ctggagtgca 45480 atggcgcaatctcagctcac tgcaacctcc acctcccagc aattctcctg tctcagcctc 45540 ccaagtagctgggattacag gcgcccgcca accacgcctg gctgattttt gtattttttt 45600 agtagagatggggtttcacc atgttggcca ggctggtcct gaactcctaa cctcaggtga 45660 tccacccgcctcagccttcc aaagtgctgg gattacaggt gtgagccacc acgcccagcc 45720 acatggcaagtttgaagtgt tttttttttt tatttaagat gattgagaag tagagagcaa 45780 catatgtccactgattaaca tccaaataag taatggtttt attgtggcat agaaagacta 45840 gagtaggccgggtgcagtgg cttatgcctg taatcccaga actttgggag gccaaggcat 45900 gtggatcactggaggtcagg agttcaagac cagcctggcc aacatggtga aaccctgtat 45960 ctactaaaagtacaaaaatt agccgggcat ggtggtatgt gcctgtagtt ccagctactc 46020 aagaggctgaggcaggacaa tttcttgaac ccagaagacg gaggttgcag tgagctgaga 46080 tcatatgccactgcactcca gcctgggcga cagagcaaga gtctgtctca aaacaaaaaa 46140 aagattagagtataaaaaag atggattcat ttctaatacc agttatgaca atttaagcca 46200 gttacttaggtcatgcaaaa agccatgttt ataattgcct taggaaaaat taaacctcac 46260 tgatacaaacatttaaaatt tccagttaga aatggagtta gtaattatgc aggaggttta 46320 tttatgaaatgcataaaaat taaatgtaca caagacctaa tagtgattta tttattggaa 46380 atgaaggtcttctttcaaag ggaagcagaa attcctcaga aaaagctgcc ggcctactct 46440 agtctttctatgccacagta aagccattac ttatttggat gttaatcaag ggacagatgt 46500 tgctctctacttccaagtct gatgcaaaat aggcatcaga ctttcctctc ttgtgtgctt 46560 tgaaaaggtgtggagaactt ggtgaactat tcaaagccta agacatcaac tgactacagt 46620 taagtataaagaacatcttg gtacatctag gattcctgtt ctcctcagta ttatccctaa 46680 tgtgagcatggagagtgaat gtcccttttt cagccacata tacatatagt agggaatcct 46740 caagttgaaaggatacttga tgtcttcctt ttagcctgtg gtttttgcta ggatctccat 46800 ttttctaaactgtatattaa ttactggcat taatgattag ttaaatagga gtattccaag 46860 tgttaaattcccctaaaatg ataaccactg taattaaatt aattgaacgt gcataggaga 46920 cattaactccagattgttta aagccagact gagttaaata gttatagatt ttatgtattt 46980 atttatttatttttaggttg agtctcgctc tgtcgcccag gttggagtgc aatggtatga 47040 cctcagctcactgcaacctc cgcctcccga gtagctagga ctacaggcat gcgccacaac 47100 acctggccaattttttttgt attttagtag agtcaggggt tcaccatgtg gcccaggcta 47160 gtctcaaactcctgagctca ggcagtctgc ccgcctcggc ctcacaaagt gctaggatta 47220 caggcgtgagccacaacgcc cagcctggta tataattttc tgtaggaaat ctggctcctt 47280 tgcccctataccattactgg gtaattagta actaatacag cttcctgaaa taaagcacag 47340 gaacaaatggatgtcttttt aaaggccata catagttgag gcaattttag tatatttccc 47400 agaaacacttaattcaagca ttagaatatc atctagtcgc attccctaat tttttacagg 47460 tgagacaactgatgtccaaa gagattaaaa atctagttta aggccgggtg cggtggctca 47520 cgcctgtaatcccagcgctt tggggaggct gaggtgggcg gatcacctga ggtcgggagt 47580 tcgagatcagcctgaccaac atggagaaac cctgtctcca ataaaaatac aaaattagcc 47640 gggcatggtggcacattcct gtaatcttag ctactcagga ggctgaggca ggagaatcgc 47700 ttgaacccgggaggcagagg ttgtagtgag ccaagatcac gccattgcac tccagcctgg 47760 gcaacaagagcaaaactcca tctaaaaaaa aaaaaaaaga agtctagttt aagatgaggg 47820 caataatccagtagtaaatc tggactaaaa tccatgtttt tttttttttt tttttttgga 47880 gacagagtcttgctctgttg cccaggctgg agtgcagtgg tgcaatctcg gctcactgca 47940 aactccgcctcctgggttca tgccattctc ctgcctcagc ctcccgagta gctggaacta 48000 caggcacctgccaccacgcc cggctaattc tttgtatttt tagtagagac ggggtttcac 48060 ccagcttagccaggatggtc tcgatcttct gaccttgtga tccacccgcc tcggcctccc 48120 aaagtactgggattacaggc gtgagccacg gcgcccggcc taaaatccat gttttaagat 48180 taattcaaattgtgtaaaga tgtatcacag agatttgtag taaggtaagt aatacatgag 48240 tttctttactaagaagacta tcagatacct acaaattgtt ttatactgat ttaaatcaga 48300 attaggtgtaagtaaattgt ttttaaagaa taataaagtt tacggccgag cacggtggct 48360 cacacctgtaatccccgcac tttgggaggc cagggcaggc agatcacgag gtcaggagat 48420 cgagactaccctggctaaca cggtgaaacc ccatctctac taaaaataga aaaaattagc 48480 cgggcatggtggcaggcacc tgtggtccca gctactcggg aggctgaggc aggagaatgg 48540 cgtgaacctgggaggcggag cttgcagtga gccgagatcg cgccactgca ctccagcctg 48600 ggcaatagaacagactccgt ctcaaaaaaa aaaaaaaaag aaaaaaagtt tatttaaaac 48660 attttctttgacacagttca agtggttttt aaaatccatc agtgaataaa tatgtgggag 48720 tttaaaatttatcatttgat cagtgaccaa ttaattcaaa tccaggaatc tgaaagggaa 48780 ttttaaagtagtcagtttca gtttcttaac agcatatagt ggaacatctt ttattacctg 48840 taataaggagtagagtggca aggcatcatt ataaatattg aagctgaaga tttattggga 48900 ttgttgtaacaaactttttg aatatgactc atgacatcaa gagtacctcg ttgatgaact 48960 aaaccagtataaagggcgag gaacaaattt gataaaaaca ggaaacttag agctggtttc 49020 ttccatgttttcaggtgggt taatgagtat cctatatgaa gatagacata ttgaacctta 49080 acactgacaatcttttgtta tgttaactgc aaatacatct gtaattttta atggaaatag 49140 caaaaactgtaatactgtta tagacaaata agaaataagc aataagtcat atctctgacc 49200 attcaccattcactactgtc atctaggtct tgactttttc tagtaaaagg tattgaggta 49260 tagtggaaagatgatggtta tggagtccaa caggtccaga tttgaattcc agttctagca 49320 caagtcgttttactttgctg gtcattggga taatagtacc ttattcaagt gttagaaaaa 49380 atgtccagtgactgccctgg tacatagtag ttgctaaata aataggactt ttaattattc 49440 catttacctacctctttaat ctcccaagca ctaataattg gtattttagt gtgtaatacg 49500 agtttcaataatgtgtcctc ttaggaaaat aagccattgg gcacctggga gattttccgt 49560 aagtatatgagtggaagaaa aggtgctatg tcttacattt tttttcccac aacagtggga 49620 aattttgttttcccactaca gtcaggcaat ttggagatgc tgaacaattt ttcttttttg 49680 atttatgaaagggattattc tgtggggcaa aacaaaacaa aaaaccaaag gaaaaaacca 49740 agtagaatgaatagacgggt ataaaaggat aagtaaaagt ctctctcccc tctgatagtc 49800 cttttcttcagcaacagcca ctattaatgg acatattagg atctactgag aatacaaaga 49860 acaggcctttccactggaaa agattaagct tattagtaag catgacattt tgttcataat 49920 ttacatacactctttttata gaactagata atagttcttt ttgaacttgg gtattcttca 49980 tccaaaccttggtttgccca 50000 10 17386 DNA Homo sapiens human DYXC1 chromosomal generegion, nucleotides 200001-217386 10 aaatgttagt acaatactga atgggaccaaggcagtgttt tttattttgt tcctcctatg 60 aatatgttaa tatcatccac agttcatacctcatgagttg gaatatcaca tgtccatgtc 120 acctagtatt ttttaatcta cttgaaatagttctgattaa agaataatct gaaaagtggt 180 gtggtgaaaa atgtagcaag attaagaaaactaagcctat cacttaaatc tacatttata 240 agatgtttga aatggtaaaa tgaggaacctactaaaagga atgataatta gaactagctt 300 tatttgaaat aaaatagctg agatgagaggattgcttgag gccaggagtt caagaccagc 360 ctgggcaaca tagtgagact ccatttaaaataaaaaaaaa ttagccaggc gtgatagtgc 420 gcacctgtag atccagctac tgggaaggctgaggcaggag gttcacctgt gctcatgagt 480 ttgaggggac agtgagctat gaccacgccactgcactcca gcctgggtga caccctgtct 540 ctacgaaaat aaaaatgaat aaaatagggccaggtgcggt agctcacacc tgtaatccca 600 gtactttggg aggacaaggc aggcggatcacttgaggtca ggagttcaag accagcctgg 660 ccaacagagg tgaaacccca tctctactaaaatataaaaa ttagccgggc gtggtgtcag 720 aggttgcagt gagccgagat cacgccactgcactccagcc tgggcaacag agtgaaactg 780 tctcaaaata aattaaaaaa taggattctaaaagttcaac catctgtaat aaccccaatc 840 acagacacag cagatcccca aatataagttgaagcactta acttaggttg gtaggctaaa 900 acaacatcta ctttagtagg ctcaaatacaaaaagctaca ttaaagcctt gtctttgttt 960 gtactgctat actggaatac ctgagactggctaatttata tttacttggc tcatggtcct 1020 gcaggttgta caagaagcat ccactggtgagggcttcagg ctgcttccac tcatggcaga 1080 aggtgaaggg gagtcagttt gtgcagagatcacatggtga gagagcagaa gcaagaaagt 1140 ggaaggtgcc aggctctttt gtacagccagcactcggggg aactctcatg gaacctaata 1200 taaggagaac tcacttacta ctccaggatggtgccaagcc attcatgaag gctccacccc 1260 catgatcgaa gcatctccca ttaggccccacctccaacag tggggatcaa atttcaacta 1320 aggtttaggg gacaaacgtc caaactacagcaagcccatc ctacagcaag gcccgagaag 1380 atacagtttg ttctcaatta tttgaagatacttacaaggt gagcatgtgt aaagtgattc 1440 acttattaat aatttgttca ttcaaggccgggggctgtgg ctcacgcctg taatcccagg 1500 actttgggag gccaaggcgg gcagatcgcgaggtgaagag atcgagacca tcctggccaa 1560 catcgtgaaa acccatctct actaaaaatacaaaaattag ctaggtgtgg aggcgcatgc 1620 ctgtagtccc agctgaggca ggctgaggcaggagaatcac ttgaacccgg caggcatagg 1680 ttgcagtgag ctgagatcgt gccactgcactccagcctgg tgacagagcg agatgtcgtc 1740 tcaaaaaaaa aaaaaagaaa ctatggcactaggaatacaa tagtataggt gggtgacaca 1800 aaatgggaat acttggtgat caagactgtgaaaatagcac tctgggtaga atgctggaag 1860 ataacatgct tgtgtttcca gcatcttcagtactggtgag acagagcgtc tcttaagtta 1920 ggtaatgctt gccttacatg atggtgattttaactctctg agcttagctc attttaggat 1980 ggatcatttt agtgagaact gaatctccatattacttaga gaagtaatat aaagaaaatg 2040 ctgggaagag aaggaacagc tgaacaatgccagggagagt caggtgatag cttagttttc 2100 ttggggacag tggatactga aacagttgccattcaaaatt gtcttcaaca gtattatgga 2160 tccgatgagc ttttgtgtaa tattctgggagccttactac atgtcacagt attatttcta 2220 agaaaaaaat atttcaggtt ccaacttaaaaatgaagttt ggggataaaa ccttatttaa 2280 aatagaactg tctttatgat tattatttttttgagatgga ctctcgctct ttcgcccagg 2340 cgggagtgca agtggcatga taccggctcactgcaacctc cacctcctgg gttacaagcg 2400 attctcctgc cttagcctcc tgggtagctgggattacagg tgcctgccgc catgcccggc 2460 taatttttgt attttaagta gagatggggtttcaccatgt tggccaggct ggtctcaaac 2520 tcaggtgatc tgcccgccac agcctcccaaagtgctggga ttacaggcgt gagccacagc 2580 gcccagccag aactgccttt atttacatgtttagcatcct ataagcatta ctatgcattt 2640 gacatataaa gaaaatatct ttataatttcagttatcatc aaatgacttg tgcacatgtt 2700 agaaaagaac ccaactttag agtataagtcaagagtcctg aatttaaggc ctctgagggg 2760 tttttaaacc ttctggcact gaaagcttccaaaggggatt tcagaaatga gttgctaaag 2820 gaagggttgg aaagattttc cagttccaatgctagactga gtgaaccaca agagaagcct 2880 aaggtccatg gttttcttat agaccagtagtattgtttca tcaatattta aaacaaatga 2940 acaagattcc agtaggtgac atccagtaagtctacttaat ggcacgcaca aatttggaga 3000 tggagttctc actgaaataa tccaccctcaaatgacctag cttcagaaag tgatcatccc 3060 caccacgtaa atgatgtgta tcccaatcactgaagattta agactgtgtg tgtaccccag 3120 tgactaaagt ataggttcct tcctttcacatagtaacaac ccattgctaa ctggatgcta 3180 aacatcaccc ctaaatactt aatttgctcctgttatctgg gcctacaaaa agatacttga 3240 aagtcggtat acagaaaatt tctggaagaactgcttaaga aagtgataac aatagttacc 3300 tctggggaat gggactagat gacttgaggatgacacacta tttttgtacc atcggcattt 3360 atttttataa taaaaaaata cactgggctcctatcagatc atgttcatca gactactgtt 3420 acagaaatgt ttaaaatcca ttacatctcagttgactact cttcaggata aaatctaaaa 3480 acctgagcat ataagaagat acttcatgaggtggttcctt tataaagcca tatctcttaa 3540 tcatcatgta ttatttagct tgatatacacactttaaaaa ttttggatat ctagcgtggc 3600 attctgtatt ttccagcaat cactaatacgttccttctta ccaaggtaag gttcacggta 3660 atagagagga tgggagtatc tgagactgtacattgctgat tccatcctgg ttttgacaag 3720 aattatcagg aaacctaatg ttaagaaaaaaaatccctac cacattttac caattagaga 3780 gatatctgag ttactgtttc tatttttaaatactctttga gaaagcttag tttcagtgtt 3840 tagataagaa caacaaaagg tggttcaattctggaatggg acatacagta gaatggggct 3900 gggaaagaga gactttgaac tactaaccataatgagggta ctgggcacag atgaaggtat 3960 caagaagaat tttttttttt tagacagaatctcgctctgt cacccaggct ggagtgcagt 4020 ggtgccgatc tcggctcaat gcaacctccacctccagggt tcaagtgatt ctcctgtctc 4080 agcctcccaa gtagctggca ttacaggtgcgtgccaccac acccagctaa tttttgtatt 4140 tttagtagag acagggtttc accctgttggccaggctggt cttgaactcc tgacctcagg 4200 tgatccaccc acctcagcct cccaaagtgctaggattaca ggcgtcagcc actggcagct 4260 ggccaggaag aattttatgt tgctattttgttaaggaagt aaagccatct ttccatcttc 4320 gatagaattc aacagttaat gcctaaaacaaagaccttta agtggcatta taaatgtttt 4380 agagatatcg agataaatac caaaataaccagctgaaaga atgcttaagt gattgttttt 4440 ggggagagga aatagggaga gcaggggaacaatttttttt tttaattcct tgtggaatgt 4500 cttctgaaat aatgtacata tgcaattttgataaaaagat tagaatatgg ggccagctgt 4560 ggtgcctcat gccgtaatcc cagcactttgggaggccaag gcaggtggat catctgaggt 4620 caggagttcg acaccagcct ggtcaacatggtcaagcccc aactaaaaat acaaaaatta 4680 gctggctgtg gtggcatggg cctgtaattccagctactct ggaggctgag gcaggagaat 4740 ctcttgaacc caggaggcgg aggttgtggtgagctgagat tgcgccactg cactccagca 4800 tgggcgacag agagagactc tgtctcaaaaaaaaaaaaaa aaaaaaaaag ataagaatat 4860 ggaaaaacaa agtggcccag taagagagaagtctatatta gccactgtgg taaaaacaga 4920 taagcagaca ctcaactcag aatcagtagtgggtgctgaa ctctgtcagc acaaatgaga 4980 gattcaaact aagaatttaa ttagtgttgctaaaatatca cctttctttt acagataagg 5040 aaaatgaggc acattgttga acaattcactaaagatcaga gccagtcaca aaatatattt 5100 tctagagttg agtcctattt tataggactaagggaaattc aaattaggca agagaagtta 5160 ccgtagactg aaaaaactgc tgcaattatttttcttcctg tgtcccatcc cactatgagg 5220 ttggcattta tttccccacc tcttgaatctggcctggccc agtgacttgc tttcatgaaa 5280 agaatgtggt ggaagtgaca gtatgcaaattccaagccct tgtctcaaag ggccttgcat 5340 atttgctccc tctcttggaa cccggcctatgccaagtgaa caagccctag ctggcctgtt 5400 ggaggaagag aaaactcaga agagctgagaagacttggcc tacagctagt tgaaccccag 5460 acatgagagc ccagcctagg tcaatagagctatccaccca atctgcagct gtgtaagtga 5520 gctcagtgga gatgagaact gcccagttgaaatgtagacc tgtaaattat aataaatgga 5580 gttttaagcc actacagttt tgaggtggccttttacacag caatggctga cagagttgtc 5640 atgtttacat aaaaataggt taaaacaagtcacacaaagc agaataaggc tgaaatttgt 5700 ggtataactc aagatttcaa gtagttaggaaagattcaaa ctgggtcact aaaacatcaa 5760 gagctccaaa gagaactgtt ctaaatgtccagagatttct gtctaggtga catcactaga 5820 cagaactgat cctactgttg gaacctcttggcattaaaca gccctgactg ttagtggaag 5880 tacaaatctc ctaggaatta gagttttttgacccactcta gaaccttagg tagggtgtgg 5940 aggaaaagaa tgcatcctgt gaggagatcaaggggttttc taggttgctg tcttttaggg 6000 atccttctaa gtagacagag gatggaagaaggggtgattc ttacctatta gaaggggctc 6060 tctttacccc tcatcagcat tttatctcaataaactgtga ataggccctg gttacaggga 6120 tcttgccact taaagattca atcttttagactggcaatga ggattcagac aactcaatct 6180 ttgtgtaaat acttggtaaa gcaacaggacacagaagagg aatgctggaa aaatctggtt 6240 tatgaaaaca gaaatcaaac caagttactaaccaacctcc ccgtcccctc caggcacaca 6300 aaaacatttg cctttgtact ctgccaatgcttgatttaat tataatacac actcaagtgg 6360 ctgtaaaaaa acccaacaga acagaaaccatttaacatct gaatagtgat ttatgaacag 6420 atttcctctg acaaatgggg ccagctattcttaaggcttg ccaaatagct gttagatgtc 6480 taaatttttg tatgtgcctg cgtttgtatgtggttacact gtaaagtaat gacagactga 6540 ggctttgatt tcagaacttc agatgtatcaaaaatacaga tttttaatat ttgattttat 6600 atttgtatgt ttatcttctt aaattgaagagattatacat ctcagatctg taggagttga 6660 tgtatacttg gtcaaacatt gcctaactcaatgtttttct ttttttttaa gtaaaaaata 6720 agtttgaaaa ctgtaactcc ctaggttttttccagcctcc agttccagtt ggctagtcat 6780 ttcttctctc tcaacgctgt gattttttttaaggtcttaa tatttgaagg aagtcaacag 6840 tcatttattc cgaattaaac ttgaagttaataaagtttca attcgtaatt tttccaaacc 6900 aaccaatgta aaaacccaga ttttcctgaattgagtcatg taaggatttt tgtaagtgac 6960 aaaaaaatac atgttaagac tgtggaaaaatggagaaaag gcctgaataa aatcaggagt 7020 taattactta aaaaatggca tatgccaggctgggcgcggt ggctcacgcc tgcaatccca 7080 gcacttttgg gaggctgagg cgggtggatcatctgaggtc aggagttcga gaccagcctg 7140 gccaacacgg tgaaaccctg tctctacttaaaatacaaaa attagccggg tatggtggcg 7200 gatgcctgta atcccagcta ctcgggaggctgaggcagga gaattgcttg aacacaggga 7260 ggtggaggtt gcagtgagcc aagatcgtgccactgcactc cagcctgggc agcagagtga 7320 gactctgtct aaaaagataa taataataattgcatatgcc ttagagtgag ttttaaaagt 7380 gtaaatgttt tgtgtgtaaa agcattaaaaactagtttca acagcagtaa atacattttt 7440 cctttgtgaa aatgaagacc cttacagtttaaccataaac ttaaaatagc taatctaaaa 7500 acagacatgt tactttactt tttagtgagaaacaccacca ccaaatagaa acaccaccac 7560 caaaaactgc tttgggtatt ggatatttatgtgggttttt tgtttgtctg ttttttgaga 7620 gaaggacttg ccatatggta ggctggtctcaaactcctgg gctcaggtga tcctcctgcc 7680 tcaggcttct gagtagctgg gattaaaagtgcacaccact gcactgggct aggatcttta 7740 tgtttttatc tcactttaga ggatataggaaaaaagatat ttggactaca aaaagggaat 7800 attgcagtaa tataattaat ctgtaattaagtaattcctt attaacctag ttgaaaatag 7860 acatagttta atgaggatgt gttgtctttagactatttct atataattta ttttctataa 7920 caaacaaaag cacttaccac agaacaccatacagaatggt aaaactggat aaataaacct 7980 gaattctttg tggctcaaca tgctgtaataaaaacaaata ttattaaaaa atattaatta 8040 tcatgttata tgatagattg agaaagtaatatatttaata taaaatatat ttaacttgat 8100 ctatttattt tctaagtatt cagactgaatttcttgcttc agaaattcat cttatttttt 8160 agttataagg tgattacgat atggtaaaactaatcataaa atatgatgtc aatttgaaat 8220 tacaaagtac agttacattc taaaaacgggatttctattt caatccaagt aagtgaaatt 8280 agtcaaattt ggaataagga tacatacatttttattttag aatgtatttc tgtggtcctt 8340 caatttaaaa ttttggtagt attgattgactgattgactg agacagggtc ttgttttgtc 8400 acccagactg gagtgcagta gcacaatcatagctcactgc aaccttaaat tcctgggctc 8460 aagcagtcct tctgcctcag cttccccaatagctaggact acaggcacat gccatcatgc 8520 cctggtaatt ttaaattttt tttcagagagagggtcttgc tatgttgctc aggctggtca 8580 tgaactcctt gcttcaagca atcctcccaccttggccttc aaagtattga aattacaggc 8640 atgagcaact gtgcctggtc tgttttttttttttttaaag caaataaaat tagtccaagt 8700 tcttaaaaat tgagtgtaat ccttattaagcaaactacat atctaaagta ttcactctag 8760 tgcctccata attactacta cttgtatcttctaagataat tcccactaac aaaagttaat 8820 ggcacctcca aaacataaag tttactttttgaagaattta atttgatttc ttggtaacat 8880 aaaaaatttt agccttttga acaaataaaatcttacctat aaacaagcag tgtccacagc 8940 acagtcacca aaagtatccg gtatctctttggtgctagat agcagccatg aataaagaag 9000 ggtaagtgag tacccaagat aactggaaatccttgactga agtaccagtg ccatggatga 9060 gaaccataaa atgttcccaa gttctgcagcacgttaaatt tcaaaaaatt aaattgaacc 9120 agagtccact ggcaccgttg aaggaaaaataaatagaaat gtgttagtgc caagtagtaa 9180 tctttggcat taggggattg atacaattttgacattaaat cagaattgaa gtctaaaaac 9240 caggcaatag tttacattaa taattttttttttttttttt tttttttaag atggagtctt 9300 gctctgtcgc ccaggctgga gtgcagtggcgcgatctcgg ctcactgcaa gctccgcctc 9360 gcgggttcac gccattctcc tgcctcagcctcccgagtag ctgggactac aggcgcccgc 9420 caccacgccc ggctaatttt ttctatttttagtagagacg gggtttcacc atgttagcca 9480 ggatggtctc aatctcctga cctcgtgatctgcctgcctc ggcctcccaa agtgctgcga 9540 ttataggtgt gagccaccat gcctggcctaataattttaa ttaatgactg tatgaaatcc 9600 ttcttaactg ttattttttc ttctttaagtattaatgtgt tccttgttaa tttgtaaaac 9660 tagatttttg agattcaaag tgagaatcaaacttatattt tggcagtcta agtttgtgtt 9720 tttatttcaa gtttttgggg tacagatggcttctggttac atgaataagt tctttagagg 9780 tgatttctag gattttggtc cacccatcacccaagcaatg tacactgtac ccaatatgta 9840 ctcgaaataa gaatttctca cccctctctcacccttcccc accctgagtc accagagtcc 9900 attatatcat tcttatgtct ttgcatcccatagcttagct cccacttata agtaagaaca 9960 tatgatattt ggctttccat tcctgagttatttcacttag aataatggcc tccagctcca 10020 tccaagtttt atatccagtt aagagataaagaggatagta gacatatttt tcggactgtg 10080 tggtacttta caatgtgaca tattacctgtgaagataaag ctttgaaaac attacaattt 10140 gaattacagc gtaaagctga caataatgacagaaacagca acaggtaaca ttcagtgctc 10200 acttaataat tccctgcctt aaaatgtactctcctgaata ttagctagga gtactaattc 10260 ttttatgtag aaagcacaac aaattgaaccaaaggcttat taggatatgc ctagaagtct 10320 tttgtaatgt atcccatatc atttaaaaaatcatttgcct ctgttctaaa gtattaatgg 10380 attaaaaata aaaatagctg ttagcttaatatacttttac ttacttggcc aaaaaaaata 10440 cgatcaatca tcagagacaa actcaaagtaacaaagctga aaaacaaaaa tagcatagtg 10500 attcacattt ggagcttgct gaaaatccactattagcata tggctttgta cgtgccttgc 10560 atcaaaagcc actataaaaa tgctttacagtttcaccaac tgaatataga tttacacatt 10620 ttgaaaggta tctactgaaa aagatcagtagataagatta tataatcgat taatattgta 10680 aaaaatatat taataaaaag attattgaaagactactgct gtataacaaa ttaccccaaa 10740 acttgttaac ttaaactatg aatatttaccatttcatagt tcctgtggat caagaaccta 10800 ggtgttgctt agctgggtgc ctctggctcgaggtcgctca tgaattgtag tcaagctctt 10860 agcaggggct acagtttcat ctgaaggttcaattacaggt ggagagatca gcttccaaat 10920 ttgctcacat ggttgctggt ggggctaagttcctcaacat atggccgttt ccttaaagct 10980 gcctcatgac ataattaact ggcttaacccagggtaagtc agccaagagt gagtgagaca 11040 ggcacccaag atggaagcca taatctttttatttatgtat tcttttcttt tttttagaga 11100 cagggtcttg ctctgtcacc caggctggagtgcagtagtg tgtgatcatg gctcactgca 11160 gccttgacct cctgggctca agtgatcctcccacctcagc cttccaagta actaggacta 11220 caggtgtgtg ccgccatgac tggataatttttggattttc tgtagagatg gggtctcact 11280 atattaccca actggtctca aactccgggcctcaagcagt acttccccat tggcctccca 11340 aaatgctggg attacagata taagccactgtgcctggcca ccatagtctt ttcataaccc 11400 agtcttgtaa gtgatatccc atcccttctgctgtattcta ctcattagaa ttgagtcgac 11460 aaatctagcc catgttcaag ggggaggggattatacaaag acataaatag caggaggatg 11520 ggatcactgg aggccatctc agagactgcctccaacaaac acatatacag aaaaatacgc 11580 tatgaaggta aagctctatg aatcatcactacatgaacac aactgtgtac gtgccataca 11640 gagcaggata aagagtatta gcagcaccaccttgtccctc caatcagtca gtccctacct 11700 cctccccaaa agtaacccaa aggtaacccttcctcttccc aaaggtaacc actatcctaa 11760 tttctgataa catagatgag ttttatctttttttgaattt tataagaata ggatcatacc 11820 atatgtgctc atgtctaaat tcctttagtcattgtgcttg tgagattgaa ccaagttttt 11880 ttgcgtgctg tagttcattc ctttacaatactgtgtattg taactatgta taccacactg 11940 tatgtattcc ttctattgat ggacactgtgcttccatttc cagctattgt gaatagtgct 12000 gcaatgaaca ttcttttaca catcttttggtatccatata tgtgcatttc tgttagacat 12060 atacctagga ttggaattgg tgggccctaaggtagcggtc cctaaccttt ttggcaccag 12120 ggtctggttt cttgaaagac agttttcccacaaacaggtt gcgggggtgg gagtggggca 12180 tggtttctgg atgaaactgt tccacctcagatcactggac attagatgct catacggagc 12240 acaacctaga tcccttgcat gtgcagttcacagtagggtt cacacttctg taagaatgtg 12300 acaggaggtg gagctcaggc agtaatgcttgcttgcttgc tcacctcctg ctgtgcagcc 12360 cagttcctaa gaggccatgg actggggccagtccacagcc ttgggactgg tgacccctgc 12420 cctaagttgt aagtgcaact atgtatttatttagcttttg taagtactta aaagttttcc 12480 aaaatagtgt attagtttgc agtcccacaggaatatataa gttccacatc attttagcca 12540 tttgggtgga tgtatagtat agtagtatttcatggtggct ttactttgtt tttccttgat 12600 aacaaatgaa atgagtctct ttatatttattggccatttt aatatttttt gaagtacctg 12660 atgaaacctt ttcaataatt tttctatgagttatcttttt cttatagatt tttaaaagtt 12720 ttatatataa tctggatgta aggttttatttttgagatgg agcctcactc tgttgcccag 12780 gctggagtgc agtggtgcaa tttcagttcattgcaacgtc tacctctggg gttcaatcgt 12840 ttctcctgcc tcagcctccc aagtagctgggattataggc atgtgccaca atgcccagct 12900 aatttttttg tatttttagc agagacagggtttcatcata ttggccaggc tggtcttgaa 12960 ctcctgacct caggtgatct gcctgcctcagcctcccaaa gtgctgggat tataggcgtg 13020 agccatcgtg cccaaccact agaacactttaaatcactgg gtaagaatta caatccctaa 13080 ctgatgatga ttcaacctac gatttttcaactttaaaatg gtacccatac agccattctg 13140 tttttcactt tcagtacagt attcaatgaattacatgaga tattcaaata ttttattatg 13200 aaataggctt tgtgttagat gattttgctcaactgtaggc taatgtaagc gttctgagca 13260 cgtttatggt aggctaagct gtgatgttcagtacgttaga tgtgttaagt gcatttttga 13320 cgtagaatat tttctttgtt atttattttgtttagagaca ggttatcact ctgtttccca 13380 ggctggagtg cagtggaatg atcatagctcactgcaacct tgaactcctg ggttgaaggg 13440 atcctcctgc ctcatcctcc caagtagctaggaccacagg cgtgcctagt gccacctata 13500 cttggccaat ttttaaattt ttttgttgagatggggtctc attatgttgc tcaggttgtt 13560 cttgaactcc tggtctccca gggcactgggattacaggtg tgagccactg tgccttgcct 13620 gacttatgat attttcaacc tgcaatgagtttatcaagat gtaaccctga gtcaaggagc 13680 atctgtattg ttatatcttt ttcccccacagactttgact ttgagagcag acactgtatc 13740 ttactcactt ctgaattatc aaatgctggatacaaagtag gttaaatgct tattaaatga 13800 ataagttatt atcatgctgc tgatgagattaaaaaggctt tctatctccc tcagtggtaa 13860 agccgatagg aactgagccc ctgctatctctctgacctca ttattacatt ctcccaaact 13920 cactctcttt tagccacatc agtctccttgctgttccttg aacatgccca gcatacttag 13980 tacttggctg gcccctttgc ctggaatactctctcatcaa gtaactacat ggttcactct 14040 ctcaactcct ttaagttttg gctccagtgtcaccttatca tggtgatctt tcccaactac 14100 cctatttaaa aataacagct cccccattaccccaagcact ggcattctat ccttcttatc 14160 ccacaattat ttttccctgt attaccatcacttgacaaat atatatttac tcttatcttt 14220 ttagctgtct gtctctccct actagaatgtaaacttcatg aaggcaggta ctttttttgg 14280 ttaaactgat gcatctccta catctggaacactgcctggc acatagtagg attaaataat 14340 tcctgaatga atgaatacat ttaatgcaatgttattaata catctgagaa acgacaacag 14400 tagcaactga gatgcaagat aatttagtccttttcagatt gctacccgaa aaatacttgt 14460 gactagtgaa tactagtaca gtcatgcattgcttaacaat ggggatacat tctgagaact 14520 gcatcattag gcagtttcat cattgtgcaaacatcataga gtgcacttac acaagcctag 14580 atggtacagc ttacagacat ctaggctatatggtatagcc tactgctcct aggctacaaa 14640 cctatacagc atgatagtat gctgaatattgtaagcaatt gcaacacaat gctatgtatc 14700 tgtgtatcta actatagcta aacaggctgggcatggtggc ccatgcctgt atttccagca 14760 ctttgggagg ccaaggtggg tggatcacctgaggtcagga gtttgagact agctggccaa 14820 catggtgaaa ccccaactcg actaaaaataaaaaaattag ccaggcgtgg tggcaggcgc 14880 ctgtaatccc agctgtttgg gaggctgaggcaggagaatc acttgaacct gggaggcgga 14940 ggctgcagtg aagtgagaat gcaccactgcactccagcct aggtgacaga gtgagactcc 15000 gtctcaaata aaaaaatata tatagccaaacagagaaact aaagtacact aaaatacggt 15060 aatataatct tatgggacca ctgtcataaatgcagtccag tgctaaccaa aatgtcatta 15120 tgcggtgcat gattgtatat taaaaagattactgttgtaa gagtcagaat gcagtcatcc 15180 cttcagtaaa taattattcg gggtagtctactagatactt gggatacaac tcatcctagg 15240 agctcatagt gtagttagaa gatgtgggtttcaataccag tatagcaacc agcccaatga 15300 ctttgactaa tacattttaa atttctgcgagcctcctgtt ttctctacta caaaataaaa 15360 acatatattg cctagactga agtattatgaaaattatgag gtaatatgtg aaaacacatt 15420 atgaattata aagccttata caaatgtaaaagaatcaagt atctctaaaa tatatgtgag 15480 aaatatttag gaaataaagc attggaaaacactaagttag aaataattac aaaagcactc 15540 agttaagcaa attaaaatag ttataatcaggatcataaat aaaaaatata agttttgcat 15600 tattctattt ccttggacta agagttctcactgacattag aagataaaat aattaactga 15660 aagatgtaaa atcttgttcg taatctgtgatttgtaggct actaaaataa atggatggat 15720 tattgccaca cttaccctac aggtaaaaaatgatgtagaa taagatcaag ctttcttggt 15780 tcttgacaga aatgtctgaa gagcaaaggtgtccacagaa tgacagctgt gggacgaatt 15840 atgaaggcaa gtgccaccag ggatgagtatttgacactat aagaggaaaa tgtgtgataa 15900 gacaagtggg aaattaactt gaagttatctatcatttaca ctgtgatttg acattttcct 15960 tttggtataa atagctatat gaacttttttttgttttgtt ttgttttttt tgagacagag 16020 tctcactctg tcacccaggc tggagtgcagtggcatgatc ttggctcacg gcaacttctg 16080 cctcccaggt gcaagtgatt ctcctgcctcagcatcccga gtagctggga ttacaggtgt 16140 gtaccaccat gcccgactaa ttttttgtattttcagtaga gatggggttt caccttgttg 16200 gccaggctgg cctcaaactc ctgacgtcaggtgatctgcc cacctcagcc tcctaaagtg 16260 ctgggattac aggctaatcc ccatgccaggctaatttttt gtatttttag tgggagacag 16320 ggttttacca tgttggccag gctggtctcaaactcctgac ctcaggcgat ccgccagcct 16380 cagcctccta aagtgctggg attacaggcaggagccacag tgcctggcct aaatagctat 16440 attaactttt gcaggttact tacgctttctgggtcttagt ttttcttatc ttttaaaaaa 16500 ggtaatatct aaagccgttt tcagtgctcatcttctaatt ctagtatttt caaataagaa 16560 gttatcatat gtcttaatgc cagtcttgtgtgctaaaaag catgcttttt acctcataac 16620 tttgccaatt actttcttga ttgaaaaaaaaatgatcaag tttctcctaa ggagctataa 16680 gaaagtcata aagagaggct ttctctaagaaaaagcatga gcatttaaag aaacaggatt 16740 atttaggcag tgatgggctc agagtatttagaattttgtt ttgaaagtta attttagcca 16800 agtgaaatat atatgcatac aactgataaaaggcctactg tataaactgt atgatcatgg 16860 atagaaatac agatttttat taacaggacttctctaaact aatggttgaa agagacaatt 16920 tgataattta atcatgagga ctatggatagtatattatta tgtggaaaaa tacttagtcc 16980 tgtaaaaaat taaaagaaag caaaataagacaacctatat taccattata tacctattaa 17040 ctaataaaaa taactataaa gaaatctgtaggccaggtgt ggtggctcag gcctgcaatc 17100 ccagcacttt gggaggccga ggtgggtggatcacctgaag tcaggagttc aagaccagtc 17160 tggccaaaat ggtgaaaccc tgtctctactaaagatagaa aaaaattagc tgggtgtggt 17220 ggcaggtgcc tgtaatccca gctacttgggaggctgaggc aggagaatca cttgaacctg 17280 ggaagtggag gttgcaatga gctgagatcatgccattgca ctctagcctg ggcaacaaga 17340 atgaaactcc atctcaaaaa aaagaaaaaaaaaaaagaat gaattc 17386 11 25 DNA Artificial Sequence Description ofArtificial Sequence RT-PCR primer 11 gttgacagaa tgctgttcca cgtcg 25 1225 DNA Artificial Sequence Description of Artificial Sequence RT-PCRprimer 12 caagctgagg cacgaagagc aatga 25 13 1263 DNA Pan troglodytes CDS(1)..(1260) 13 atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aagact gcc 48 Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys ThrAla 1 5 10 15 gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gacacg gac 96 Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp ThrAsp 20 25 30 gtg ttc tgc atg gaa aac tat ctg aag gtc aac ttt cct cca ttttta 144 Val Phe Cys Met Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu35 40 45 ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca192 Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 5055 60 aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg240 Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 6570 75 80 gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag atg atg288 Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 8590 95 caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa336 Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100105 110 gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat384 Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115120 125 gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata432 Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130135 140 gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa480 Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu 145150 155 160 gcc tgg aaa gaa tat caa aga aaa gct gag gag caa aaa aaa attcag 528 Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln165 170 175 aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa gaaaga 576 Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg180 185 190 aaa aaa ata aaa tat aag agt ctt act aga aat ttg gca tct agaaat 624 Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn195 200 205 ctt gct cca aaa ggg aga aat tca gaa aat ata ttt act gag aagtta 672 Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu210 215 220 aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaaatc 720 Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240 aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tcacaa gta 768 Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser GlnVal 245 250 255 gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cgaaga gca 816 Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg ArgAla 260 265 270 atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaagaa aag 864 Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu GluLys 275 280 285 aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gcaaca gaa 912 Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala ThrGlu 290 295 300 aac tat ttg gca gct atc aat gca tat aat tta gcc ata agacta aat 960 Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg LeuAsn 305 310 315 320 aat aag atg cca cta ttg tat ttg aac cgg gct gct tgccac cta aaa 1008 Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys HisLeu Lys 325 330 335 cta aaa aac tta cac aag gct att gaa gat tct tct aaggca ctg gaa 1056 Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys AlaLeu Glu 340 345 350 tta ttg atg cca cct gtt aca gac aat gct aat gca agaatg aag gca 1104 Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg MetLys Ala 355 360 365 cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttgtat gta gaa 1152 His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu TyrVal Glu 370 375 380 ggc cta cag gat tat gaa gcg gca ctt aag att gat ccatcc aac aaa 1200 Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro SerAsn Lys 385 390 395 400 att gta caa att gat gct gag aag att cgg aat gtaatt caa gga aca 1248 Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val IleGln Gly Thr 405 410 415 gaa cta aaa tct taa 1263 Glu Leu Lys Ser 420 14420 PRT Pan troglodytes 14 Met Pro Leu Gln Val Ser Asp Tyr Ser Trp GlnGln Thr Lys Thr Ala 1 5 10 15 Val Phe Leu Ser Leu Pro Leu Lys Gly ValCys Val Arg Asp Thr Asp 20 25 30 Val Phe Cys Met Glu Asn Tyr Leu Lys ValAsn Phe Pro Pro Phe Leu 35 40 45 Phe Glu Ala Phe Leu Tyr Ala Pro Ile AspAsp Glu Ser Ser Lys Ala 50 55 60 Lys Ile Gly Asn Asp Thr Ile Val Phe ThrLeu Tyr Lys Lys Glu Ala 65 70 75 80 Ala Met Trp Glu Thr Leu Ser Val ThrGly Val Asp Lys Glu Met Met 85 90 95 Gln Arg Ile Arg Glu Lys Ser Ile LeuGln Ala Gln Glu Arg Ala Lys 100 105 110 Glu Ala Thr Glu Ala Lys Ala AlaAla Lys Arg Glu Asp Gln Lys Tyr 115 120 125 Ala Leu Ser Val Met Met LysIle Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140 Glu Asp Met Lys Glu AsnGlu Arg Ile Lys Ala Thr Lys Glu Leu Glu 145 150 155 160 Ala Trp Lys GluTyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175 Arg Glu GluLys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190 Lys LysIle Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205 LeuAla Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 225 230235 240 Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val245 250 255 Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg ArgAla 260 265 270 Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu GluGlu Lys 275 280 285 Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu PheAla Thr Glu 290 295 300 Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu AlaIle Arg Leu Asn 305 310 315 320 Asn Lys Met Pro Leu Leu Tyr Leu Asn ArgAla Ala Cys His Leu Lys 325 330 335 Leu Lys Asn Leu His Lys Ala Ile GluAsp Ser Ser Lys Ala Leu Glu 340 345 350 Leu Leu Met Pro Pro Val Thr AspAsn Ala Asn Ala Arg Met Lys Ala 355 360 365 His Val Arg Arg Gly Thr AlaPhe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380 Gly Leu Gln Asp Tyr GluAla Ala Leu Lys Ile Asp Pro Ser Asn Lys 385 390 395 400 Ile Val Gln IleAsp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415 Glu Leu LysSer 420 15 1263 DNA Gorilla gorilla CDS (1)..(1260) 15 atg ccc ctt caggtt agc gat tac agc tgg cag cag acg aag act gtg 48 Met Pro Leu Gln ValSer Asp Tyr Ser Trp Gln Gln Thr Lys Thr Val 1 5 10 15 gtc ttt ctg tctctg ccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96 Val Phe Leu Ser LeuPro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30 gtg ttc tgc acg gaaaac tat ctg aag gtc aac ttt cct cca ttt tta 144 Val Phe Cys Thr Glu AsnTyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 ttt gag gca ttt ctt tatgct ccc ata gac gat gag agc agc aaa gca 192 Phe Glu Ala Phe Leu Tyr AlaPro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60 aag att ggg aat gac acc attgtc ttc acc ttg tat aaa aaa gaa gcg 240 Lys Ile Gly Asn Asp Thr Ile ValPhe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80 gcc atg tgg gag acc ctt tctgtg acg ggt gtt gac aaa gag atg atg 288 Ala Met Trp Glu Thr Leu Ser ValThr Gly Val Asp Lys Glu Met Met 85 90 95 caa aga att aga gaa aaa tct atttta caa gca caa gag aga gca aaa 336 Gln Arg Ile Arg Glu Lys Ser Ile LeuGln Ala Gln Glu Arg Ala Lys 100 105 110 gaa gct aca gaa gca aaa gct gcagca aag cgg gaa gat caa aaa tat 384 Glu Ala Thr Glu Ala Lys Ala Ala AlaLys Arg Glu Asp Gln Lys Tyr 115 120 125 gca cta agt gtc atg atg aag attgaa gaa gaa gag agg aaa aaa ata 432 Ala Leu Ser Val Met Met Lys Ile GluGlu Glu Glu Arg Lys Lys Ile 130 135 140 gaa gat atg aaa gaa aat gaa cggata aaa gcc act aaa gaa ttg gaa 480 Glu Asp Met Lys Glu Asn Glu Arg IleLys Ala Thr Lys Glu Leu Glu 145 150 155 160 gcc tgg aaa gaa tat caa agaaaa gct gag gag caa aaa gaa att cag 528 Ala Trp Lys Glu Tyr Gln Arg LysAla Glu Glu Gln Lys Glu Ile Gln 165 170 175 aga gaa gag aag tta tgt caaaaa gaa aag caa att aaa gaa gaa aga 576 Arg Glu Glu Lys Leu Cys Gln LysGlu Lys Gln Ile Lys Glu Glu Arg 180 185 190 aaa aaa tta aaa tat aag agtctt act aga aat ttg gca tct aga aat 624 Lys Lys Leu Lys Tyr Lys Ser LeuThr Arg Asn Leu Ala Ser Arg Asn 195 200 205 ctt gct cca aaa ggg aga aattca gaa aat ata ttt act gag aag tta 672 Leu Ala Pro Lys Gly Arg Asn SerGlu Asn Ile Phe Thr Glu Lys Leu 210 215 220 aag gaa gac agt att cct gctcct cgc tct gtt ggc agt att aaa atc 720 Lys Glu Asp Ser Ile Pro Ala ProArg Ser Val Gly Ser Ile Lys Ile 225 230 235 240 aac ttt acc cct cga gtattc cca aca gct ctt cgt gaa tca caa gta 768 Asn Phe Thr Pro Arg Val PhePro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255 gca gaa gag gag gag tggcta cac aaa caa gct gag gca cga aga gca 816 Ala Glu Glu Glu Glu Trp LeuHis Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270 atg aat act gac ata gctgaa ctt tgc gat tta aaa gaa gaa gaa aag 864 Met Asn Thr Asp Ile Ala GluLeu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285 aac cca gaa tgg ttg aaggat aaa gga aac aaa ttg ttt gca aca gaa 912 Asn Pro Glu Trp Leu Lys AspLys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300 aac tat ttg gca gct atcaat gca tat aat tta gcc ata aga cta aat 960 Asn Tyr Leu Ala Ala Ile AsnAla Tyr Asn Leu Ala Ile Arg Leu Asn 305 310 315 320 aat aag atg cca ctattg tat ttg aac cgg gct gct tgc cac cta aaa 1008 Asn Lys Met Pro Leu LeuTyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335 cta aaa aac tta cacaag gct att gaa gat tct tct aag gca ctg gaa 1056 Leu Lys Asn Leu His LysAla Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350 tta ttg atg cca cctgtt aca gac aat gct aat gca aga atg aag gca 1104 Leu Leu Met Pro Pro ValThr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365 cat gta cga cgt ggaaca gca ttc tgt caa cta gaa ttg tat gta gaa 1152 His Val Arg Arg Gly ThrAla Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380 ggc cta cag gat tatgaa gcg gca ctt aag att gat cca tcc aac aaa 1200 Gly Leu Gln Asp Tyr GluAla Ala Leu Lys Ile Asp Pro Ser Asn Lys 385 390 395 400 att gta caa attgat gct gag aag att cgg aat gta att caa gga aca 1248 Ile Val Gln Ile AspAla Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415 gaa cta aaa tcttaa 1263 Glu Leu Lys Ser 420 16 420 PRT Gorilla gorilla 16 Met Pro LeuGln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Val 1 5 10 15 Val PheLeu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30 Val PheCys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 Phe GluAla Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60 Lys IleGly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80 AlaMet Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95 GlnArg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120125 Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130135 140 Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160 Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys GluIle Gln 165 170 175 Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile LysGlu Glu Arg 180 185 190 Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn LeuAla Ser Arg Asn 195 200 205 Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn IlePhe Thr Glu Lys Leu 210 215 220 Lys Glu Asp Ser Ile Pro Ala Pro Arg SerVal Gly Ser Ile Lys Ile 225 230 235 240 Asn Phe Thr Pro Arg Val Phe ProThr Ala Leu Arg Glu Ser Gln Val 245 250 255 Ala Glu Glu Glu Glu Trp LeuHis Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270 Met Asn Thr Asp Ile AlaGlu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285 Asn Pro Glu Trp LeuLys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300 Asn Tyr Leu AlaAla Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 305 310 315 320 Asn LysMet Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335 LeuLys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360365 His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370375 380 Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400 Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile GlnGly Thr 405 410 415 Glu Leu Lys Ser 420 17 1263 DNA Pongo pygmaeus CDS(1)..(1260) 17 atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aagact gcg 48 Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys ThrAla 1 5 10 15 gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gacacg gac 96 Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp ThrAsp 20 25 30 gtg ttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca ttttta 144 Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu35 40 45 ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca192 Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 5055 60 aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg240 Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 6570 75 80 gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag acg atg288 Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Thr Met 8590 95 caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa336 Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100105 110 gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat384 Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115120 125 gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata432 Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130135 140 gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa480 Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu 145150 155 160 gcc tgg aaa gaa tat caa aga aaa gct gag gag cac aaa aaa attcag 528 Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu His Lys Lys Ile Gln165 170 175 aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa gaaaga 576 Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg180 185 190 aaa aaa tta aaa tac aag agt ctt act aga aat tcg gca tct agaaac 624 Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn Ser Ala Ser Arg Asn195 200 205 ctt gct cca aaa gga aga aat tca gaa aat ata ttt act gag aagtta 672 Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu210 215 220 aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaaatc 720 Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240 aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tcacaa gta 768 Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser GlnVal 245 250 255 gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cgaaga gca 816 Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg ArgAla 260 265 270 atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaagaa aag 864 Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu GluLys 275 280 285 aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gcaaca gaa 912 Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala ThrGlu 290 295 300 aac tat ttg gca gct atc aat gca tat aat tta gcc ata agacta aat 960 Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg LeuAsn 305 310 315 320 aat aag atg cca cta ttg tat ttg aac cgg gct gct tgccac cta aaa 1008 Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys HisLeu Lys 325 330 335 cta aaa aac tta cac aag gct att gaa gat tct tct aaggca ctg gaa 1056 Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys AlaLeu Glu 340 345 350 tta ttg atg cca cct gtt aca gac aat gct aat gca agaatg aag gca 1104 Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg MetLys Ala 355 360 365 cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttgtat gta gaa 1152 His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu TyrVal Glu 370 375 380 ggc cta cag gat tat gaa gcg gca ctt aag att gat ccatcc aac aaa 1200 Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro SerAsn Lys 385 390 395 400 att gta caa att gat gct gag aag att cgg aat gtaatt caa gga aca 1248 Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val IleGln Gly Thr 405 410 415 gaa cta aaa tct taa 1263 Glu Leu Lys Ser 420 18420 PRT Pongo pygmaeus 18 Met Pro Leu Gln Val Ser Asp Tyr Ser Trp GlnGln Thr Lys Thr Ala 1 5 10 15 Val Phe Leu Ser Leu Pro Leu Lys Gly ValCys Val Arg Asp Thr Asp 20 25 30 Val Phe Cys Thr Glu Asn Tyr Leu Lys ValAsn Phe Pro Pro Phe Leu 35 40 45 Phe Glu Ala Phe Leu Tyr Ala Pro Ile AspAsp Glu Ser Ser Lys Ala 50 55 60 Lys Ile Gly Asn Asp Thr Ile Val Phe ThrLeu Tyr Lys Lys Glu Ala 65 70 75 80 Ala Met Trp Glu Thr Leu Ser Val ThrGly Val Asp Lys Glu Thr Met 85 90 95 Gln Arg Ile Arg Glu Lys Ser Ile LeuGln Ala Gln Glu Arg Ala Lys 100 105 110 Glu Ala Thr Glu Ala Lys Ala AlaAla Lys Arg Glu Asp Gln Lys Tyr 115 120 125 Ala Leu Ser Val Met Met LysIle Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140 Glu Asp Met Lys Glu AsnGlu Arg Ile Lys Ala Thr Lys Glu Leu Glu 145 150 155 160 Ala Trp Lys GluTyr Gln Arg Lys Ala Glu Glu His Lys Lys Ile Gln 165 170 175 Arg Glu GluLys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190 Lys LysLeu Lys Tyr Lys Ser Leu Thr Arg Asn Ser Ala Ser Arg Asn 195 200 205 LeuAla Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 225 230235 240 Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val245 250 255 Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg ArgAla 260 265 270 Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu GluGlu Lys 275 280 285 Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu PheAla Thr Glu 290 295 300 Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu AlaIle Arg Leu Asn 305 310 315 320 Asn Lys Met Pro Leu Leu Tyr Leu Asn ArgAla Ala Cys His Leu Lys 325 330 335 Leu Lys Asn Leu His Lys Ala Ile GluAsp Ser Ser Lys Ala Leu Glu 340 345 350 Leu Leu Met Pro Pro Val Thr AspAsn Ala Asn Ala Arg Met Lys Ala 355 360 365 His Val Arg Arg Gly Thr AlaPhe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380 Gly Leu Gln Asp Tyr GluAla Ala Leu Lys Ile Asp Pro Ser Asn Lys 385 390 395 400 Ile Val Gln IleAsp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415 Glu Leu LysSer 420 19 1263 DNA Pan paniscus CDS (1)..(1260) 19 atg ccc ctt cag gttagc gat tac agc tgg cag cag acg aag act gcg 48 Met Pro Leu Gln Val SerAsp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15 gtc ttt ctg tct ctgccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96 Val Phe Leu Ser Leu ProLeu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30 gtg ttc tgc acg gaa aactat ctg aag gtc aac ttt cct cca ttt tta 144 Val Phe Cys Thr Glu Asn TyrLeu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 ttt gag gca ttt ctt tat gctccc ata gac gat gag agc agc aaa gca 192 Phe Glu Ala Phe Leu Tyr Ala ProIle Asp Asp Glu Ser Ser Lys Ala 50 55 60 aag att ggg aat gac acc att gtcttc acc ttg tat aaa aaa gaa gcg 240 Lys Ile Gly Asn Asp Thr Ile Val PheThr Leu Tyr Lys Lys Glu Ala 65 70 75 80 gcc atg tgg gag acc ctt tct gtgacg ggt gtt gac aaa gag atg atg 288 Ala Met Trp Glu Thr Leu Ser Val ThrGly Val Asp Lys Glu Met Met 85 90 95 caa aga att aga gaa aaa tct att ttacaa gca caa gag aga gca aaa 336 Gln Arg Ile Arg Glu Lys Ser Ile Leu GlnAla Gln Glu Arg Ala Lys 100 105 110 gaa gct aca gaa gca aaa gct gca gcaaag cgg gaa gat caa aaa tat 384 Glu Ala Thr Glu Ala Lys Ala Ala Ala LysArg Glu Asp Gln Lys Tyr 115 120 125 gca cta agt gtc atg atg aag att gaagaa gaa gag agg aaa aaa ata 432 Ala Leu Ser Val Met Met Lys Ile Glu GluGlu Glu Arg Lys Lys Ile 130 135 140 gaa gat atg aaa gaa aat gaa cgg ataaaa gcc act aaa gaa ttg gaa 480 Glu Asp Met Lys Glu Asn Glu Arg Ile LysAla Thr Lys Glu Leu Glu 145 150 155 160 gcc tgg aaa gaa tat caa aga aaagct gag gag caa aaa aaa att cag 528 Ala Trp Lys Glu Tyr Gln Arg Lys AlaGlu Glu Gln Lys Lys Ile Gln 165 170 175 aga gaa gag aaa tta tgt caa aaagaa aag caa att aaa gaa gaa aga 576 Arg Glu Glu Lys Leu Cys Gln Lys GluLys Gln Ile Lys Glu Glu Arg 180 185 190 aaa aaa ata aaa tat aag agt cttact aga aat ttg gca tct aga aat 624 Lys Lys Ile Lys Tyr Lys Ser Leu ThrArg Asn Leu Ala Ser Arg Asn 195 200 205 ctt gct cca aaa ggg aga aat tcagaa aat ata ttt act gag aag tta 672 Leu Ala Pro Lys Gly Arg Asn Ser GluAsn Ile Phe Thr Glu Lys Leu 210 215 220 aag gaa gac agt att cct gct cctcgc tct gtt ggc agt att aaa atc 720 Lys Glu Asp Ser Ile Pro Ala Pro ArgSer Val Gly Ser Ile Lys Ile 225 230 235 240 aac ttt acc cct cga gta ttccca aca gct ctt cgt gaa tca caa gta 768 Asn Phe Thr Pro Arg Val Phe ProThr Ala Leu Arg Glu Ser Gln Val 245 250 255 gca gaa gag gag gag tgg ctgcac aaa caa gct gag gca cga aga gca 816 Ala Glu Glu Glu Glu Trp Leu HisLys Gln Ala Glu Ala Arg Arg Ala 260 265 270 atg aat act gac ata gct gaactt tgc gat tta aaa gaa gaa gaa aag 864 Met Asn Thr Asp Ile Ala Glu LeuCys Asp Leu Lys Glu Glu Glu Lys 275 280 285 aac cca gaa tgg ttg aag gataaa gga aac aaa ttg ttt gca aca gaa 912 Asn Pro Glu Trp Leu Lys Asp LysGly Asn Lys Leu Phe Ala Thr Glu 290 295 300 aac tat ttg gca gct atc aatgca tat aat tta gcc ata aga cta aat 960 Asn Tyr Leu Ala Ala Ile Asn AlaTyr Asn Leu Ala Ile Arg Leu Asn 305 310 315 320 aat aag atg cca cta ttgtat ttg aac cgg gct gct tgc cac cta aaa 1008 Asn Lys Met Pro Leu Leu TyrLeu Asn Arg Ala Ala Cys His Leu Lys 325 330 335 cta aaa aac tta cac aaggct att gaa gat tct tct aag gca ctg gaa 1056 Leu Lys Asn Leu His Lys AlaIle Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350 tta ttg atg cca cct gttaca gac aat gct aat gca aga atg aag gca 1104 Leu Leu Met Pro Pro Val ThrAsp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365 cat gta cga cgt gga acagca ttc tgt caa cta gaa ttg tat gta gaa 1152 His Val Arg Arg Gly Thr AlaPhe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380 ggc cta cag gat tat gaagcg gca ctt aag att gat cca tcc aac aaa 1200 Gly Leu Gln Asp Tyr Glu AlaAla Leu Lys Ile Asp Pro Ser Asn Lys 385 390 395 400 att gta caa att gatgct gag aag att cgg aat gta att caa gga aca 1248 Ile Val Gln Ile Asp AlaGlu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415 gaa cta aaa tct taa1263 Glu Leu Lys Ser 420 20 420 PRT Pan paniscus 20 Met Pro Leu Gln ValSer Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15 Val Phe Leu SerLeu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30 Val Phe Cys ThrGlu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45 Phe Glu Ala PheLeu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60 Lys Ile Gly AsnAsp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80 Ala Met TrpGlu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95 Gln Arg IleArg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110 Glu AlaThr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125 AlaLeu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu 145 150155 160 Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln165 170 175 Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu GluArg 180 185 190 Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala SerArg Asn 195 200 205 Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe ThrGlu Lys Leu 210 215 220 Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val GlySer Ile Lys Ile 225 230 235 240 Asn Phe Thr Pro Arg Val Phe Pro Thr AlaLeu Arg Glu Ser Gln Val 245 250 255 Ala Glu Glu Glu Glu Trp Leu His LysGln Ala Glu Ala Arg Arg Ala 260 265 270 Met Asn Thr Asp Ile Ala Glu LeuCys Asp Leu Lys Glu Glu Glu Lys 275 280 285 Asn Pro Glu Trp Leu Lys AspLys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300 Asn Tyr Leu Ala Ala IleAsn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 305 310 315 320 Asn Lys Met ProLeu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335 Leu Lys AsnLeu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350 Leu LeuMet Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365 HisVal Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys 385 390395 400 Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr405 410 415 Glu Leu Lys Ser 420 21 15 PRT Homo sapiens 21 Cys Ala ThrGlu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys 1 5 10 15 22 20 DNAArtificial Sequence PCR PRIMER EKN1-1F 22 aacagactgc ctggtgctct 20 23 23DNA Artificial Sequence PCR PRIMER EKN1-1R 23 cacaccaaag tttgagaacc act23 24 20 DNA Artificial Sequence PCR PRIMER EKN1-2.1R 24 aagatgagcctgttgctcgt 20 25 22 DNA Artificial Sequence PCR PRIMER EKN1-2.1F 25caagcagagg gtatgggtct ac 22 26 19 DNA Artificial Sequence PCR PRIMEREKN1-2R 26 agaagcttcg gaccacacc 19 27 20 DNA Artificial Sequence PCRPRIMER EKN1-3F 27 cgcgtgctta atttgtgtaa 20 28 23 DNA Artificial SequencePCR PRIMER EKN1-3R 28 tcccctacac aatataggtg ctt 23 29 22 DNA ArtificialSequence PCR PRIMER EKN1-4F 29 aaagaaatct catcctgggt ca 22 30 21 DNAArtificial Sequence PCR PRIMER EKN1-4R 30 gaaaatgctg aggaagtcca g 21 3124 DNA Artificial Sequence PCR PRIMER EKN1-5F 31 caatggcaag agtttagaggtatg 24 32 22 DNA Artificial Sequence PCR PRIMER EKN1-5R 32 tcaatgtgccaaaacagtaa cc 22 33 20 DNA Artificial Sequence PCR PRIMER EKN1-6F 33tgtttaggat ttgggggtga 20 34 26 DNA Artificial Sequence PCR PRIMEREKN1-6R 34 ggaaattcta aaacatattc atgacg 26 35 20 DNA Artificial SequencePCR PRIMER EKN1-7F 35 ccactggagg aagatggaaa 20 36 25 DNA ArtificialSequence PCR PRIMER EKN1-7R 36 tgtcttcata catgataaag ctcat 25 37 21 DNAArtificial Sequence PCR PRIMER EKN1-8F 37 ggtaagccat cctctttgtc a 21 3825 DNA Artificial Sequence PCR PRIMER EKN1-8R 38 tcaactgaac agaaaaagatcatca 25 39 20 DNA Artificial Sequence PCR PRIMER EKN1-9F 39 ctccccaagtgttgggatta 20 40 21 DNA Artificial Sequence PCR PRIMER EKN1-9R 40tggagtcctt aaaagtcacg a 21 41 26 DNA Artificial Sequence PCR PRIMEREKN1-10F 41 ggtacttgtt ctgaaccatg ctacta 26 42 27 DNA ArtificialSequence PCR Primer 126403-F 42 caagggcaag cttaattcag taacaca 27

1. An isolated, purified DYXC1 nucleic acid comprising SEQ ID NO:1 or acomplement thereof; homologs and variants thereof, and fragmentsthereof.
 2. The isolated nucleic acid according to claim 1, which ismammalian.
 3. The isolated nucleic acid according to claim 2, which ishuman.
 4. The isolated nucleic acid according to claim 1, wherein saidnucleic acid hybridises under high stringency conditions to a nucleotidesequence of SEQ ID NO:1 or a complement thereof.
 5. The isolated nucleicacid according to claim 4, wherein said high stringency conditionscomprise 6×NaCl/sodium citrate (SSC) at about 45° C. for a hybridisationstep, followed by a wash of 2×SSC at 50° C.
 6. The isolated nucleic acidaccording to claim 1, wherein said fragment is a primer or a probehybridising specifically to a nucleic acid having the sequence of SEQ IDNO:1 or a complement thereof.
 7. A vector comprising the nucleic acid ofclaim
 1. 8. A host cell comprising the vector of claim
 7. 9. An isolatednucleic acid molecule encoding DYXC1 amino acid sequence of SEQ ID NO:3.10. An isolated DYXC1 nucleic acid comprising at least one singlenucleotide polymorphism in any one of the following positions as definedby SEQ ID NO:1: 4 (C preferably to T), 271 (G preferably to A), 572 (Gpreferably to A), 1249 (G preferably to T), and 1259 (C preferably toG), or as defined by SEQ ID NO:2: 205 (C preferably to T), 366 (Gpreferably to A), and 367 (G preferably to A).
 11. A method for thediagnosis of a single nucleotide polymorphism in DYXC1 gene in asubject, which method comprises determining the sequence of the nucleicacid of the subject at one or more of positions 4, 271, 572, 1249 and1259 in the DYXC1 gene as defined in SEQ ID NO:1 and positions 205, 366,and 367 as defined in SEQ ID NO:2 and determining the status of thesubject by reference to polymorphism in DYXC1 gene.
 12. The methodaccording to claim 11, wherein the nucleic acid region containing thepotential single nucleotide polymorphism is amplified by polymerasechain reaction prior to determining the sequence.
 13. The methodaccording to claim 11, in which the sequence is determined by a methodselected from allele specific amplification, allele specifichybridisation, SSCP, oligonucleotide ligation assay and restrictionfragment length polymorphism (RFLP).
 14. The method according to any oneof claims 11-13 for assessing the predisposition of an individual todyslexia.
 15. An allele-specific primer or probe capable of detecting aDYXC1 gene polymorphism at one or more of positions 4, 271, 572 and 1249in the DYXC1 gene as defined in SEQ ID NO:1 and positions 205, 366, and367 as defined in SEQ ID NO:2.
 16. An isolated and purified DYXC1polypeptide comprising the amino acid sequence of SEQ ID NO:3 or splicevariants thereof.
 17. Method of producing a DYXC1 polypeptide accordingto claim 16, said method comprising the steps of: culturing a host cellof claim 8 comprising a polynucleotide encoding said polypeptideoperably associated with a promoter sequence such that the nucleic acidsequence encoding said polypeptide is expressed; and isolating saidpolypeptide from said host cell or from a growth medium in which saidhost cell is cultured.
 18. Method of producing antibodies comprising:immunising a mammal with the isolated and purified DYXC1 protein ofclaim 16 or an antigenic fragment thereof.
 19. Use of the isolated andpurified DYXC1 protein of claim 16 or an antigenic fragment thereof asan antigen.
 20. An antibody produced by the method of claim
 18. 21. Theantibody of claim 20 which is labeled with a detectable label.
 22. A kitfor use in the diagnostics of dyslexia or in assessing thepredisposition of an individual to dyslexia, comprising a container; andin said container: a compound, preferably labeled, capable of detectingDYXC1 gene or allelic variants thereof.
 23. The kit according to claim22, wherein said compound is a primer or probe.
 24. The kit according toclaim 22, wherein said compound is an antibody as defined in claim 20.25. The kit according to claim 22 further comprising instructions forusing the kit.
 26. A method for identifying a mutant DYXC1 nucleotidesequence in a suspected mutant DYXC1 allele which comprises comparingthe nucleotide sequence of the suspected mutant DYXC1 allele with awild-type DYXC1 nucleotide sequence, wherein a difference between thesuspected mutant and the wild-type sequence identifies a mutant DYXC1nucleotide sequence.
 27. The method according to claim 26 wherein thesequence of said suspected mutant DYXC1 allele is compared with thesequence of one or more wild-type DYXC1 gene sequences selected from thesequences set forth in SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:6, SEQ IDNO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 and wild-type allelicvariants thereof.
 28. The isolated nucleic acid according to claim 2,which is from a primate.
 29. The isolated nucleic acid according toclaim 28, wherein said nucleic acid is selected from the groupconsisting of sequences set forth in SEQ ID NOS:13, 15, 17 and
 19. 30.An isolated and purified polypeptide comprising the amino acid sequenceselected from the group consisting of sequences set forth in SEQ IDNOS:14, 16, 18, and
 20. 31. A method of identifying a compound thatmodulates the expression of DYXC1, the method comprising: (f) incubatinga cell that can express DYXC1 gene with a compound under conditions andfor a time sufficient required for the cell to express DYXC1 gene, whenthe compound is not present; (g) incubating a control cell under thesame conditions and for the same time without the compound; (h)measuring expression of DYXC1 gene in the cell in the presence of thecompound; (i) measuring expression of DYXC1 gene in the control cell;and (j) comparing the amount of expression of DYXC1 gene in the presenceand absence of the compound, wherein a difference in the level ofexpression indicates that the compound modulates the expression of DYXC1gene
 32. A method of identifying a compound that modulates DYXC1activity, the method comprising: (f) incubating a cell that has saidactivity with a compound under conditions and for a time sufficientrequired for the cell to express said activity, when the compound is notpresent; (g) incubating a control cell under the same conditions and forthe same time without the compound; (h) measuring said activity in thecell in the presence of the compound; (i) measuring said activity in thecontrol cell; and (j) comparing the amount of said acitivity in thepresence and absence of the compound, wherein a difference in the levelof activity indicates that the compound modulates the activity of saidgene
 33. Method for affinity purification of a substance that binds tothe DYXC1 comprising the following steps: a) contacting a sourcesuspected to contain said substance with an immobilized DYXC1 underconditions whereby said substance to be purified is selectively adsorbedonto the immobilized DYXC1; (b) washing the immobilized DYXC1 and itssupport to remove non-adsorbed material; and (c) eluting said substancefrom the immobilized DYXC1 to which they are adsorbed with an elutionbuffer.